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Protein

G-protein coupled receptor family C group 6 member A

Gene

Gprc6a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca2+ and Mg2+. Activated by extracellular calcium and osteocalin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinates nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalents ions and its responsiveness to anabolic steroids (By similarity).By similarity

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW

GO - Biological processi

  1. calcium-mediated signaling Source: Ensembl
  2. response to amino acid Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_236177. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_263374. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor family C group 6 member A
Gene namesi
Name:Gprc6a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 20

Organism-specific databases

RGDi735077. Gprc6a.

Subcellular locationi

Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 594574ExtracellularSequence AnalysisAdd
BLAST
Transmembranei595 – 61521HelicalSequence AnalysisAdd
BLAST
Topological domaini616 – 63015CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei631 – 65121HelicalSequence AnalysisAdd
BLAST
Topological domaini652 – 66918ExtracellularSequence AnalysisAdd
BLAST
Transmembranei670 – 69021HelicalSequence AnalysisAdd
BLAST
Topological domaini691 – 70616CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei707 – 72721HelicalSequence AnalysisAdd
BLAST
Topological domaini728 – 75023ExtracellularSequence AnalysisAdd
BLAST
Transmembranei751 – 77121HelicalSequence AnalysisAdd
BLAST
Topological domaini772 – 78413CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei785 – 80521HelicalSequence AnalysisAdd
BLAST
Topological domaini806 – 8127ExtracellularSequence Analysis
Transmembranei813 – 83321HelicalSequence AnalysisAdd
BLAST
Topological domaini834 – 92895CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 928908G-protein coupled receptor family C group 6 member APRO_0000043198Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi332 – 3321N-linked (GlcNAc...)Sequence Analysis
Glycosylationi555 – 5551N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ70VB1.
PRIDEiQ70VB1.

PTM databases

PhosphoSiteiQ70VB1.

Expressioni

Tissue specificityi

High expression in soft palate. Weak expression in kidney, liver, lung and brain. No expression detected in heart, testis, skeketal muscle amd spleen.1 Publication

Gene expression databases

GenevestigatoriQ70VB1.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000451.

Structurei

3D structure databases

ProteinModelPortaliQ70VB1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG295353.
GeneTreeiENSGT00760000118884.
HOGENOMiHOG000063697.
HOVERGENiHBG096042.
InParanoidiQ70VB1.
KOiK04622.
OMAiETHWAPV.
OrthoDBiEOG7DZ8J8.
PhylomeDBiQ70VB1.
TreeFamiTF331269.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q70VB1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSFVFITC FMILLDTSQS CHTPDDFVAI TSPGHIMIGG LFAIHEKMLS
60 70 80 90 100
SDDHPRQPQI QKCVGFEISV FLQTLAMIHS IEMINNSSLL SGVKLGYEIY
110 120 130 140 150
DTCTEVTAAM AATLRFLSKF NCSRETVIFQ CDYSSYVPRV KAIIGAGYSE
160 170 180 190 200
ISMAVSRMLN LQLMPQVSYE STAEILSDKI RFPSFLRTVP SDFYQTKAMA
210 220 230 240 250
HLIRQSGWNW VGAITTDDDY GRLALNTFAI QAAENNVCIA FKEVLPAFLS
260 270 280 290 300
DNTIEVRINQ TLEKIIAEAQ VNVIVVFLRK FHVFNLFNKA IERKISKIWI
310 320 330 340 350
ASDNWSTAAK IITIPNVKKL GKVVGFTFRR GNMSSFHSFL QTLHMYPSDN
360 370 380 390 400
NKPLHEFAML FSACKHIKDG DLSQCISNYS QATWTYDTTK TIETHLFKRN
410 420 430 440 450
DFLWHYTEPG LIHSIQLAVL ALGHAIRDLC QDRDCQKPNA FQPWELLAVL
460 470 480 490 500
KNVTFTDGKN SFHFDAHGDL NTGYEVVLWK ETNGLMTVTK MAEYDLQHDV
510 520 530 540 550
FITTNQETKH EFRKLKQILS KCSKECIPGQ MKKATGSQHS CCYECVNCPE
560 570 580 590 600
NHYSNETDMD HCLVCNNETH WAPVRSTMCF EKEVEYLDWD DSLALLLIAL
610 620 630 640 650
SLLGIAFVLA VGIIFTRNLK TPVVKSSGGL VVCYVMLACH ALNFASTGFF
660 670 680 690 700
IGEPQDFTCK TRQTLFGVSF TLCVSCILTK SLKILLAFSF DPTLKTFLKC
710 720 730 740 750
LYRPVPIVLT CTGIQVVICT LWLVLAAPTV EENTSLPRVI ILECEEGSAL
760 770 780 790 800
AFGTMLGYIA VLAFICFVFA FKGRKLPENY NEAKFLTFGM LIYFIAWITF
810 820 830 840 850
IPVYATTFGK YLPAVEIIVI LISNYGILCC TFFPKCYIIL CKQKTNTKSV
860 870 880 890 900
FLQMVYNYSA HSVDSLALSH VSLDSASHST ATTNPRPGNK TAACQNYKHL
910 920
PVQVLAHTGM EKTMHASKTL HQKRSSSI
Length:928
Mass (Da):104,353
Last modified:July 5, 2004 - v1
Checksum:i0B13BF36E6A60BC4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ535460 mRNA. Translation: CAD59483.1.
RefSeqiNP_001258035.1. NM_001271106.1.
UniGeneiRn.140864.

Genome annotation databases

EnsembliENSRNOT00000000451; ENSRNOP00000000451; ENSRNOG00000000401.
GeneIDi294394.
KEGGirno:294394.
UCSCiRGD:735077. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ535460 mRNA. Translation: CAD59483.1.
RefSeqiNP_001258035.1. NM_001271106.1.
UniGeneiRn.140864.

3D structure databases

ProteinModelPortaliQ70VB1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000451.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ70VB1.

Proteomic databases

PaxDbiQ70VB1.
PRIDEiQ70VB1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000000451; ENSRNOP00000000451; ENSRNOG00000000401.
GeneIDi294394.
KEGGirno:294394.
UCSCiRGD:735077. rat.

Organism-specific databases

CTDi222545.
RGDi735077. Gprc6a.

Phylogenomic databases

eggNOGiNOG295353.
GeneTreeiENSGT00760000118884.
HOGENOMiHOG000063697.
HOVERGENiHBG096042.
InParanoidiQ70VB1.
KOiK04622.
OMAiETHWAPV.
OrthoDBiEOG7DZ8J8.
PhylomeDBiQ70VB1.
TreeFamiTF331269.

Enzyme and pathway databases

ReactomeiREACT_236177. Class C/3 (Metabotropic glutamate/pheromone receptors).
REACT_263374. G alpha (q) signalling events.

Miscellaneous databases

NextBioi638109.
PROiQ70VB1.

Gene expression databases

GenevestigatoriQ70VB1.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, GLYCOSYLATION.
    Strain: Wistar.
    Tissue: Circumvallate papilla.

Entry informationi

Entry nameiGPC6A_RAT
AccessioniPrimary (citable) accession number: Q70VB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 5, 2004
Last modified: January 7, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.