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Q70VB1 (GPC6A_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
G-protein coupled receptor family C group 6 member A
Gene names
Name:Gprc6a
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length928 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca2+ and Mg2+. Activated by extracellular calcium and osteocalin. Seems to act through a G(q)/G11 and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinates nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalents ions and its responsiveness to anabolic steroids By similarity. Ref.1

Subunit structure

Homodimer; disulfide-linked By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein Ref.1.

Tissue specificity

High expression in soft palate. Weak expression in kidney, liver, lung and brain. No expression detected in heart, testis, skeketal muscle amd spleen. Ref.1

Post-translational modification

N-glycosylated. Ref.1

Sequence similarities

Belongs to the G-protein coupled receptor 3 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 928908G-protein coupled receptor family C group 6 member A
PRO_0000043198

Regions

Topological domain21 – 594574Extracellular Potential
Transmembrane595 – 61521Helical; Potential
Topological domain616 – 63015Cytoplasmic Potential
Transmembrane631 – 65121Helical; Potential
Topological domain652 – 66918Extracellular Potential
Transmembrane670 – 69021Helical; Potential
Topological domain691 – 70616Cytoplasmic Potential
Transmembrane707 – 72721Helical; Potential
Topological domain728 – 75023Extracellular Potential
Transmembrane751 – 77121Helical; Potential
Topological domain772 – 78413Cytoplasmic Potential
Transmembrane785 – 80521Helical; Potential
Topological domain806 – 8127Extracellular Potential
Transmembrane813 – 83321Helical; Potential
Topological domain834 – 92895Cytoplasmic Potential

Amino acid modifications

Glycosylation3321N-linked (GlcNAc...) Potential
Glycosylation5551N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q70VB1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 0B13BF36E6A60BC4

FASTA928104,353
        10         20         30         40         50         60 
MALSFVFITC FMILLDTSQS CHTPDDFVAI TSPGHIMIGG LFAIHEKMLS SDDHPRQPQI 

        70         80         90        100        110        120 
QKCVGFEISV FLQTLAMIHS IEMINNSSLL SGVKLGYEIY DTCTEVTAAM AATLRFLSKF 

       130        140        150        160        170        180 
NCSRETVIFQ CDYSSYVPRV KAIIGAGYSE ISMAVSRMLN LQLMPQVSYE STAEILSDKI 

       190        200        210        220        230        240 
RFPSFLRTVP SDFYQTKAMA HLIRQSGWNW VGAITTDDDY GRLALNTFAI QAAENNVCIA 

       250        260        270        280        290        300 
FKEVLPAFLS DNTIEVRINQ TLEKIIAEAQ VNVIVVFLRK FHVFNLFNKA IERKISKIWI 

       310        320        330        340        350        360 
ASDNWSTAAK IITIPNVKKL GKVVGFTFRR GNMSSFHSFL QTLHMYPSDN NKPLHEFAML 

       370        380        390        400        410        420 
FSACKHIKDG DLSQCISNYS QATWTYDTTK TIETHLFKRN DFLWHYTEPG LIHSIQLAVL 

       430        440        450        460        470        480 
ALGHAIRDLC QDRDCQKPNA FQPWELLAVL KNVTFTDGKN SFHFDAHGDL NTGYEVVLWK 

       490        500        510        520        530        540 
ETNGLMTVTK MAEYDLQHDV FITTNQETKH EFRKLKQILS KCSKECIPGQ MKKATGSQHS 

       550        560        570        580        590        600 
CCYECVNCPE NHYSNETDMD HCLVCNNETH WAPVRSTMCF EKEVEYLDWD DSLALLLIAL 

       610        620        630        640        650        660 
SLLGIAFVLA VGIIFTRNLK TPVVKSSGGL VVCYVMLACH ALNFASTGFF IGEPQDFTCK 

       670        680        690        700        710        720 
TRQTLFGVSF TLCVSCILTK SLKILLAFSF DPTLKTFLKC LYRPVPIVLT CTGIQVVICT 

       730        740        750        760        770        780 
LWLVLAAPTV EENTSLPRVI ILECEEGSAL AFGTMLGYIA VLAFICFVFA FKGRKLPENY 

       790        800        810        820        830        840 
NEAKFLTFGM LIYFIAWITF IPVYATTFGK YLPAVEIIVI LISNYGILCC TFFPKCYIIL 

       850        860        870        880        890        900 
CKQKTNTKSV FLQMVYNYSA HSVDSLALSH VSLDSASHST ATTNPRPGNK TAACQNYKHL 

       910        920 
PVQVLAHTGM EKTMHASKTL HQKRSSSI 

« Hide

References

[1]"The rat GPRC6A: cloning and characterization."
Wellendorph P., Burhenne N., Christiansen B., Walter B., Schmale H., Brauner-Osborne H.
Gene 396:257-267(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, GLYCOSYLATION.
Strain: Wistar.
Tissue: Circumvallate papilla.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ535460 mRNA. Translation: CAD59483.1.
RefSeqNP_001258035.1. NM_001271106.1.
UniGeneRn.140864.

3D structure databases

ProteinModelPortalQ70VB1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000000451.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ70VB1.

Proteomic databases

PaxDbQ70VB1.
PRIDEQ70VB1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000000451; ENSRNOP00000000451; ENSRNOG00000000401.
GeneID294394.
KEGGrno:294394.
UCSCRGD:735077. rat.

Organism-specific databases

CTD222545.
RGD735077. Gprc6a.

Phylogenomic databases

eggNOGNOG295353.
GeneTreeENSGT00750000117484.
HOGENOMHOG000063697.
HOVERGENHBG096042.
InParanoidQ70VB1.
KOK04622.
OMAETHWAPV.
OrthoDBEOG7DZ8J8.
PhylomeDBQ70VB1.
TreeFamTF331269.

Gene expression databases

GenevestigatorQ70VB1.

Family and domain databases

InterProIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSPR00248. GPCRMGR.
SUPFAMSSF53822. SSF53822. 1 hit.
PROSITEPS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio638109.
PROQ70VB1.

Entry information

Entry nameGPC6A_RAT
AccessionPrimary (citable) accession number: Q70VB1
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries