G-protein coupled receptor family C group 6 member A precursor

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Q70VB1 (GPC6A_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 65. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
G-protein coupled receptor family C group 6 member A

Gene names

Name:

Gprc6a

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	928 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca²⁺ and Mg²⁺. Activated by extracellular calcium and osteocalin. Seems to act through a G(q)/G₁₁ and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinates nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalents ions and its responsiveness to anabolic steroids By similarity. Ref.1
Subunit structure	Homodimer; disulfide-linked By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein Ref.1.
Tissue specificity	High expression in soft palate. Weak expression in kidney, liver, lung and brain. No expression detected in heart, testis, skeketal muscle amd spleen. Ref.1
Post-translational modification	N-glycosylated. Ref.1
Sequence similarities	Belongs to the G-protein coupled receptor 3 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Signal Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	calcium-mediated signaling Inferred from electronic annotation. Source: Compara response to amino acid stimulus Inferred from electronic annotation. Source: Compara
Cellular_component	cell surface Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from direct assay Ref.1. Source: UniProtKB
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 20

Potential

Chain

21 – 928

908

G-protein coupled receptor family C group 6 member A

PRO_0000043198

Regions

Topological domain

21 – 594

574

Extracellular Potential

Transmembrane

595 – 615

Helical; Potential

Topological domain

616 – 630

Cytoplasmic Potential

Transmembrane

631 – 651

Helical; Potential

Topological domain

652 – 669

Extracellular Potential

Transmembrane

670 – 690

Helical; Potential

Topological domain

691 – 706

Cytoplasmic Potential

Transmembrane

707 – 727

Helical; Potential

Topological domain

728 – 750

Extracellular Potential

Transmembrane

751 – 771

Helical; Potential

Topological domain

772 – 784

Cytoplasmic Potential

Transmembrane

785 – 805

Helical; Potential

Topological domain

806 – 812

Extracellular Potential

Transmembrane

813 – 833

Helical; Potential

Topological domain

834 – 928

Cytoplasmic Potential

Amino acid modifications

Glycosylation

332

N-linked (GlcNAc...) Potential

Glycosylation

555

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

Q70VB1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 0B13BF36E6A60BC4
Show »

FASTA

928

104,353

        10         20         30         40         50         60 
MALSFVFITC FMILLDTSQS CHTPDDFVAI TSPGHIMIGG LFAIHEKMLS SDDHPRQPQI 

        70         80         90        100        110        120 
QKCVGFEISV FLQTLAMIHS IEMINNSSLL SGVKLGYEIY DTCTEVTAAM AATLRFLSKF 

       130        140        150        160        170        180 
NCSRETVIFQ CDYSSYVPRV KAIIGAGYSE ISMAVSRMLN LQLMPQVSYE STAEILSDKI 

       190        200        210        220        230        240 
RFPSFLRTVP SDFYQTKAMA HLIRQSGWNW VGAITTDDDY GRLALNTFAI QAAENNVCIA 

       250        260        270        280        290        300 
FKEVLPAFLS DNTIEVRINQ TLEKIIAEAQ VNVIVVFLRK FHVFNLFNKA IERKISKIWI 

       310        320        330        340        350        360 
ASDNWSTAAK IITIPNVKKL GKVVGFTFRR GNMSSFHSFL QTLHMYPSDN NKPLHEFAML 

       370        380        390        400        410        420 
FSACKHIKDG DLSQCISNYS QATWTYDTTK TIETHLFKRN DFLWHYTEPG LIHSIQLAVL 

       430        440        450        460        470        480 
ALGHAIRDLC QDRDCQKPNA FQPWELLAVL KNVTFTDGKN SFHFDAHGDL NTGYEVVLWK 

       490        500        510        520        530        540 
ETNGLMTVTK MAEYDLQHDV FITTNQETKH EFRKLKQILS KCSKECIPGQ MKKATGSQHS 

       550        560        570        580        590        600 
CCYECVNCPE NHYSNETDMD HCLVCNNETH WAPVRSTMCF EKEVEYLDWD DSLALLLIAL 

       610        620        630        640        650        660 
SLLGIAFVLA VGIIFTRNLK TPVVKSSGGL VVCYVMLACH ALNFASTGFF IGEPQDFTCK 

       670        680        690        700        710        720 
TRQTLFGVSF TLCVSCILTK SLKILLAFSF DPTLKTFLKC LYRPVPIVLT CTGIQVVICT 

       730        740        750        760        770        780 
LWLVLAAPTV EENTSLPRVI ILECEEGSAL AFGTMLGYIA VLAFICFVFA FKGRKLPENY 

       790        800        810        820        830        840 
NEAKFLTFGM LIYFIAWITF IPVYATTFGK YLPAVEIIVI LISNYGILCC TFFPKCYIIL 

       850        860        870        880        890        900 
CKQKTNTKSV FLQMVYNYSA HSVDSLALSH VSLDSASHST ATTNPRPGNK TAACQNYKHL 

       910        920 
PVQVLAHTGM EKTMHASKTL HQKRSSSI

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References

[1]	"The rat GPRC6A: cloning and characterization." Wellendorph P., Burhenne N., Christiansen B., Walter B., Schmale H., Brauner-Osborne H. Gene 396:257-267(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, GLYCOSYLATION. Strain: Wistar. Tissue: Circumvallate papilla.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ535460 mRNA. Translation: CAD59483.1.
IPI	IPI00360869.
RefSeq	NP_001258035.1. NM_001271106.1. XP_001059232.1. XM_001059232.3.
UniGene	Rn.140864.
3D structure databases
ProteinModelPortal	Q70VB1.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000000451.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q70VB1.
Proteomic databases
PaxDb	Q70VB1.
PRIDE	Q70VB1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000000451; ENSRNOP00000000451; ENSRNOG00000000401.
GeneID	294394.
KEGG	rno:294394.
UCSC	RGD:735077. rat.
Organism-specific databases
CTD	222545.
RGD	735077. Gprc6a.
Phylogenomic databases
eggNOG	NOG295353.
GeneTree	ENSGT00690000101951.
HOGENOM	HOG000063697.
HOVERGEN	HBG096042.
InParanoid	Q70VB1.
KO	K04622.
OMA	ETHWAPV.
OrthoDB	EOG4NVZJP.
Gene expression databases
Genevestigator	Q70VB1.
Family and domain databases
InterPro	IPR001828. ANF_lig-bd_rcpt. IPR000337. GPCR_3. IPR011500. GPCR_3_9-Cys_dom. IPR017978. GPCR_3_C. IPR017979. GPCR_3_CS. [Graphical view]
Pfam	PF00003. 7tm_3. 1 hit. PF01094. ANF_receptor. 1 hit. PF07562. NCD3G. 1 hit. [Graphical view]
PRINTS	PR00248. GPCRMGR.
PROSITE	PS00979. G_PROTEIN_RECEP_F3_1. False negative. PS00980. G_PROTEIN_RECEP_F3_2. 1 hit. PS00981. G_PROTEIN_RECEP_F3_3. False negative. PS50259. G_PROTEIN_RECEP_F3_4. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	638109.

Entry information

Entry name

GPC6A_RAT

Accession

Primary (citable) accession number: Q70VB1

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	July 5, 2004
Last modified:	April 3, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents