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Q70VB1

- GPC6A_RAT

UniProt

Q70VB1 - GPC6A_RAT

Protein

G-protein coupled receptor family C group 6 member A

Gene

Gprc6a

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca2+ and Mg2+. Activated by extracellular calcium and osteocalin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinates nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalents ions and its responsiveness to anabolic steroids By similarity.By similarity

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW

    GO - Biological processi

    1. calcium-mediated signaling Source: Ensembl
    2. response to amino acid Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G-protein coupled receptor family C group 6 member A
    Gene namesi
    Name:Gprc6a
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 20

    Organism-specific databases

    RGDi735077. Gprc6a.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 928908G-protein coupled receptor family C group 6 member APRO_0000043198Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi332 – 3321N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi555 – 5551N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ70VB1.
    PRIDEiQ70VB1.

    PTM databases

    PhosphoSiteiQ70VB1.

    Expressioni

    Tissue specificityi

    High expression in soft palate. Weak expression in kidney, liver, lung and brain. No expression detected in heart, testis, skeketal muscle amd spleen.1 Publication

    Gene expression databases

    GenevestigatoriQ70VB1.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000000451.

    Structurei

    3D structure databases

    ProteinModelPortaliQ70VB1.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 594574ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini616 – 63015CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini652 – 66918ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini691 – 70616CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini728 – 75023ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini772 – 78413CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini806 – 8127ExtracellularSequence Analysis
    Topological domaini834 – 92895CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei595 – 61521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei631 – 65121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei670 – 69021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei707 – 72721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei751 – 77121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei785 – 80521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei813 – 83321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG295353.
    GeneTreeiENSGT00750000117484.
    HOGENOMiHOG000063697.
    HOVERGENiHBG096042.
    InParanoidiQ70VB1.
    KOiK04622.
    OMAiETHWAPV.
    OrthoDBiEOG7DZ8J8.
    PhylomeDBiQ70VB1.
    TreeFamiTF331269.

    Family and domain databases

    InterProiIPR001828. ANF_lig-bd_rcpt.
    IPR000337. GPCR_3.
    IPR011500. GPCR_3_9-Cys_dom.
    IPR017978. GPCR_3_C.
    IPR017979. GPCR_3_CS.
    IPR028082. Peripla_BP_I.
    [Graphical view]
    PfamiPF00003. 7tm_3. 1 hit.
    PF01094. ANF_receptor. 1 hit.
    PF07562. NCD3G. 1 hit.
    [Graphical view]
    PRINTSiPR00248. GPCRMGR.
    SUPFAMiSSF53822. SSF53822. 1 hit.
    PROSITEiPS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
    PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q70VB1-1 [UniParc]FASTAAdd to Basket

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    MALSFVFITC FMILLDTSQS CHTPDDFVAI TSPGHIMIGG LFAIHEKMLS    50
    SDDHPRQPQI QKCVGFEISV FLQTLAMIHS IEMINNSSLL SGVKLGYEIY 100
    DTCTEVTAAM AATLRFLSKF NCSRETVIFQ CDYSSYVPRV KAIIGAGYSE 150
    ISMAVSRMLN LQLMPQVSYE STAEILSDKI RFPSFLRTVP SDFYQTKAMA 200
    HLIRQSGWNW VGAITTDDDY GRLALNTFAI QAAENNVCIA FKEVLPAFLS 250
    DNTIEVRINQ TLEKIIAEAQ VNVIVVFLRK FHVFNLFNKA IERKISKIWI 300
    ASDNWSTAAK IITIPNVKKL GKVVGFTFRR GNMSSFHSFL QTLHMYPSDN 350
    NKPLHEFAML FSACKHIKDG DLSQCISNYS QATWTYDTTK TIETHLFKRN 400
    DFLWHYTEPG LIHSIQLAVL ALGHAIRDLC QDRDCQKPNA FQPWELLAVL 450
    KNVTFTDGKN SFHFDAHGDL NTGYEVVLWK ETNGLMTVTK MAEYDLQHDV 500
    FITTNQETKH EFRKLKQILS KCSKECIPGQ MKKATGSQHS CCYECVNCPE 550
    NHYSNETDMD HCLVCNNETH WAPVRSTMCF EKEVEYLDWD DSLALLLIAL 600
    SLLGIAFVLA VGIIFTRNLK TPVVKSSGGL VVCYVMLACH ALNFASTGFF 650
    IGEPQDFTCK TRQTLFGVSF TLCVSCILTK SLKILLAFSF DPTLKTFLKC 700
    LYRPVPIVLT CTGIQVVICT LWLVLAAPTV EENTSLPRVI ILECEEGSAL 750
    AFGTMLGYIA VLAFICFVFA FKGRKLPENY NEAKFLTFGM LIYFIAWITF 800
    IPVYATTFGK YLPAVEIIVI LISNYGILCC TFFPKCYIIL CKQKTNTKSV 850
    FLQMVYNYSA HSVDSLALSH VSLDSASHST ATTNPRPGNK TAACQNYKHL 900
    PVQVLAHTGM EKTMHASKTL HQKRSSSI 928
    Length:928
    Mass (Da):104,353
    Last modified:July 5, 2004 - v1
    Checksum:i0B13BF36E6A60BC4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ535460 mRNA. Translation: CAD59483.1.
    RefSeqiNP_001258035.1. NM_001271106.1.
    UniGeneiRn.140864.

    Genome annotation databases

    EnsembliENSRNOT00000000451; ENSRNOP00000000451; ENSRNOG00000000401.
    GeneIDi294394.
    KEGGirno:294394.
    UCSCiRGD:735077. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ535460 mRNA. Translation: CAD59483.1 .
    RefSeqi NP_001258035.1. NM_001271106.1.
    UniGenei Rn.140864.

    3D structure databases

    ProteinModelPortali Q70VB1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000000451.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q70VB1.

    Proteomic databases

    PaxDbi Q70VB1.
    PRIDEi Q70VB1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000000451 ; ENSRNOP00000000451 ; ENSRNOG00000000401 .
    GeneIDi 294394.
    KEGGi rno:294394.
    UCSCi RGD:735077. rat.

    Organism-specific databases

    CTDi 222545.
    RGDi 735077. Gprc6a.

    Phylogenomic databases

    eggNOGi NOG295353.
    GeneTreei ENSGT00750000117484.
    HOGENOMi HOG000063697.
    HOVERGENi HBG096042.
    InParanoidi Q70VB1.
    KOi K04622.
    OMAi ETHWAPV.
    OrthoDBi EOG7DZ8J8.
    PhylomeDBi Q70VB1.
    TreeFami TF331269.

    Miscellaneous databases

    NextBioi 638109.
    PROi Q70VB1.

    Gene expression databases

    Genevestigatori Q70VB1.

    Family and domain databases

    InterProi IPR001828. ANF_lig-bd_rcpt.
    IPR000337. GPCR_3.
    IPR011500. GPCR_3_9-Cys_dom.
    IPR017978. GPCR_3_C.
    IPR017979. GPCR_3_CS.
    IPR028082. Peripla_BP_I.
    [Graphical view ]
    Pfami PF00003. 7tm_3. 1 hit.
    PF01094. ANF_receptor. 1 hit.
    PF07562. NCD3G. 1 hit.
    [Graphical view ]
    PRINTSi PR00248. GPCRMGR.
    SUPFAMi SSF53822. SSF53822. 1 hit.
    PROSITEi PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
    PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, GLYCOSYLATION.
      Strain: Wistar.
      Tissue: Circumvallate papilla.

    Entry informationi

    Entry nameiGPC6A_RAT
    AccessioniPrimary (citable) accession number: Q70VB1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3