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Protein

G-protein coupled receptor family C group 6 member A

Gene

Gprc6a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca2+ and Mg2+. Activated by extracellular calcium and osteocalcin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalent ions and its responsiveness to anabolic steroids (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-416476. G alpha (q) signalling events.
R-RNO-420499. Class C/3 (Metabotropic glutamate/pheromone receptors).

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor family C group 6 member A
Gene namesi
Name:Gprc6a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi735077. Gprc6a.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 594ExtracellularSequence analysisAdd BLAST574
Transmembranei595 – 615HelicalSequence analysisAdd BLAST21
Topological domaini616 – 630CytoplasmicSequence analysisAdd BLAST15
Transmembranei631 – 651HelicalSequence analysisAdd BLAST21
Topological domaini652 – 669ExtracellularSequence analysisAdd BLAST18
Transmembranei670 – 690HelicalSequence analysisAdd BLAST21
Topological domaini691 – 706CytoplasmicSequence analysisAdd BLAST16
Transmembranei707 – 727HelicalSequence analysisAdd BLAST21
Topological domaini728 – 750ExtracellularSequence analysisAdd BLAST23
Transmembranei751 – 771HelicalSequence analysisAdd BLAST21
Topological domaini772 – 784CytoplasmicSequence analysisAdd BLAST13
Transmembranei785 – 805HelicalSequence analysisAdd BLAST21
Topological domaini806 – 812ExtracellularSequence analysis7
Transmembranei813 – 833HelicalSequence analysisAdd BLAST21
Topological domaini834 – 928CytoplasmicSequence analysisAdd BLAST95

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000004319821 – 928G-protein coupled receptor family C group 6 member AAdd BLAST908

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi332N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi555N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ70VB1.
PRIDEiQ70VB1.

PTM databases

PhosphoSitePlusiQ70VB1.

Expressioni

Tissue specificityi

High expression in soft palate. Weak expression in kidney, liver, lung and brain. No expression detected in heart, testis, skeketal muscle amd spleen.1 Publication

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000451.

Structurei

3D structure databases

ProteinModelPortaliQ70VB1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1056. Eukaryota.
ENOG410XR6W. LUCA.
GeneTreeiENSGT00760000118884.
HOGENOMiHOG000063697.
HOVERGENiHBG096042.
InParanoidiQ70VB1.
KOiK04622.
OMAiYLPAVEI.
OrthoDBiEOG091G01NA.
PhylomeDBiQ70VB1.
TreeFamiTF331269.

Family and domain databases

InterProiView protein in InterPro
IPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR028082. Peripla_BP_I.
PfamiView protein in Pfam
PF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
PRINTSiPR00248. GPCRMGR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiView protein in PROSITE
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q70VB1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSFVFITC FMILLDTSQS CHTPDDFVAI TSPGHIMIGG LFAIHEKMLS
60 70 80 90 100
SDDHPRQPQI QKCVGFEISV FLQTLAMIHS IEMINNSSLL SGVKLGYEIY
110 120 130 140 150
DTCTEVTAAM AATLRFLSKF NCSRETVIFQ CDYSSYVPRV KAIIGAGYSE
160 170 180 190 200
ISMAVSRMLN LQLMPQVSYE STAEILSDKI RFPSFLRTVP SDFYQTKAMA
210 220 230 240 250
HLIRQSGWNW VGAITTDDDY GRLALNTFAI QAAENNVCIA FKEVLPAFLS
260 270 280 290 300
DNTIEVRINQ TLEKIIAEAQ VNVIVVFLRK FHVFNLFNKA IERKISKIWI
310 320 330 340 350
ASDNWSTAAK IITIPNVKKL GKVVGFTFRR GNMSSFHSFL QTLHMYPSDN
360 370 380 390 400
NKPLHEFAML FSACKHIKDG DLSQCISNYS QATWTYDTTK TIETHLFKRN
410 420 430 440 450
DFLWHYTEPG LIHSIQLAVL ALGHAIRDLC QDRDCQKPNA FQPWELLAVL
460 470 480 490 500
KNVTFTDGKN SFHFDAHGDL NTGYEVVLWK ETNGLMTVTK MAEYDLQHDV
510 520 530 540 550
FITTNQETKH EFRKLKQILS KCSKECIPGQ MKKATGSQHS CCYECVNCPE
560 570 580 590 600
NHYSNETDMD HCLVCNNETH WAPVRSTMCF EKEVEYLDWD DSLALLLIAL
610 620 630 640 650
SLLGIAFVLA VGIIFTRNLK TPVVKSSGGL VVCYVMLACH ALNFASTGFF
660 670 680 690 700
IGEPQDFTCK TRQTLFGVSF TLCVSCILTK SLKILLAFSF DPTLKTFLKC
710 720 730 740 750
LYRPVPIVLT CTGIQVVICT LWLVLAAPTV EENTSLPRVI ILECEEGSAL
760 770 780 790 800
AFGTMLGYIA VLAFICFVFA FKGRKLPENY NEAKFLTFGM LIYFIAWITF
810 820 830 840 850
IPVYATTFGK YLPAVEIIVI LISNYGILCC TFFPKCYIIL CKQKTNTKSV
860 870 880 890 900
FLQMVYNYSA HSVDSLALSH VSLDSASHST ATTNPRPGNK TAACQNYKHL
910 920
PVQVLAHTGM EKTMHASKTL HQKRSSSI
Length:928
Mass (Da):104,353
Last modified:July 5, 2004 - v1
Checksum:i0B13BF36E6A60BC4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ535460 mRNA. Translation: CAD59483.1.
RefSeqiNP_001258035.1. NM_001271106.1.
UniGeneiRn.140864.

Genome annotation databases

EnsembliENSRNOT00000000451; ENSRNOP00000000451; ENSRNOG00000000401.
GeneIDi294394.
KEGGirno:294394.
UCSCiRGD:735077. rat.

Similar proteinsi

Entry informationi

Entry nameiGPC6A_RAT
AccessioniPrimary (citable) accession number: Q70VB1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 5, 2004
Last modified: November 22, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families