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Q70VB1

- GPC6A_RAT

UniProt

Q70VB1 - GPC6A_RAT

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Protein
G-protein coupled receptor family C group 6 member A
Gene
Gprc6a
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca2+ and Mg2+. Activated by extracellular calcium and osteocalin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinates nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalents ions and its responsiveness to anabolic steroids By similarity.1 Publication

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW

GO - Biological processi

  1. calcium-mediated signaling Source: Ensembl
  2. response to amino acid Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor family C group 6 member A
Gene namesi
Name:Gprc6a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 20

Organism-specific databases

RGDi735077. Gprc6a.

Subcellular locationi

Cell membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 594574Extracellular Reviewed prediction
Add
BLAST
Transmembranei595 – 61521Helical; Reviewed prediction
Add
BLAST
Topological domaini616 – 63015Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei631 – 65121Helical; Reviewed prediction
Add
BLAST
Topological domaini652 – 66918Extracellular Reviewed prediction
Add
BLAST
Transmembranei670 – 69021Helical; Reviewed prediction
Add
BLAST
Topological domaini691 – 70616Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei707 – 72721Helical; Reviewed prediction
Add
BLAST
Topological domaini728 – 75023Extracellular Reviewed prediction
Add
BLAST
Transmembranei751 – 77121Helical; Reviewed prediction
Add
BLAST
Topological domaini772 – 78413Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei785 – 80521Helical; Reviewed prediction
Add
BLAST
Topological domaini806 – 8127Extracellular Reviewed prediction
Transmembranei813 – 83321Helical; Reviewed prediction
Add
BLAST
Topological domaini834 – 92895Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Chaini21 – 928908G-protein coupled receptor family C group 6 member A
PRO_0000043198Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi332 – 3321N-linked (GlcNAc...) Reviewed prediction
Glycosylationi555 – 5551N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ70VB1.
PRIDEiQ70VB1.

PTM databases

PhosphoSiteiQ70VB1.

Expressioni

Tissue specificityi

High expression in soft palate. Weak expression in kidney, liver, lung and brain. No expression detected in heart, testis, skeketal muscle amd spleen.1 Publication

Gene expression databases

GenevestigatoriQ70VB1.

Interactioni

Subunit structurei

Homodimer; disulfide-linked By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000451.

Structurei

3D structure databases

ProteinModelPortaliQ70VB1.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG295353.
GeneTreeiENSGT00750000117484.
HOGENOMiHOG000063697.
HOVERGENiHBG096042.
InParanoidiQ70VB1.
KOiK04622.
OMAiETHWAPV.
OrthoDBiEOG7DZ8J8.
PhylomeDBiQ70VB1.
TreeFamiTF331269.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q70VB1-1 [UniParc]FASTAAdd to Basket

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MALSFVFITC FMILLDTSQS CHTPDDFVAI TSPGHIMIGG LFAIHEKMLS    50
SDDHPRQPQI QKCVGFEISV FLQTLAMIHS IEMINNSSLL SGVKLGYEIY 100
DTCTEVTAAM AATLRFLSKF NCSRETVIFQ CDYSSYVPRV KAIIGAGYSE 150
ISMAVSRMLN LQLMPQVSYE STAEILSDKI RFPSFLRTVP SDFYQTKAMA 200
HLIRQSGWNW VGAITTDDDY GRLALNTFAI QAAENNVCIA FKEVLPAFLS 250
DNTIEVRINQ TLEKIIAEAQ VNVIVVFLRK FHVFNLFNKA IERKISKIWI 300
ASDNWSTAAK IITIPNVKKL GKVVGFTFRR GNMSSFHSFL QTLHMYPSDN 350
NKPLHEFAML FSACKHIKDG DLSQCISNYS QATWTYDTTK TIETHLFKRN 400
DFLWHYTEPG LIHSIQLAVL ALGHAIRDLC QDRDCQKPNA FQPWELLAVL 450
KNVTFTDGKN SFHFDAHGDL NTGYEVVLWK ETNGLMTVTK MAEYDLQHDV 500
FITTNQETKH EFRKLKQILS KCSKECIPGQ MKKATGSQHS CCYECVNCPE 550
NHYSNETDMD HCLVCNNETH WAPVRSTMCF EKEVEYLDWD DSLALLLIAL 600
SLLGIAFVLA VGIIFTRNLK TPVVKSSGGL VVCYVMLACH ALNFASTGFF 650
IGEPQDFTCK TRQTLFGVSF TLCVSCILTK SLKILLAFSF DPTLKTFLKC 700
LYRPVPIVLT CTGIQVVICT LWLVLAAPTV EENTSLPRVI ILECEEGSAL 750
AFGTMLGYIA VLAFICFVFA FKGRKLPENY NEAKFLTFGM LIYFIAWITF 800
IPVYATTFGK YLPAVEIIVI LISNYGILCC TFFPKCYIIL CKQKTNTKSV 850
FLQMVYNYSA HSVDSLALSH VSLDSASHST ATTNPRPGNK TAACQNYKHL 900
PVQVLAHTGM EKTMHASKTL HQKRSSSI 928
Length:928
Mass (Da):104,353
Last modified:July 5, 2004 - v1
Checksum:i0B13BF36E6A60BC4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ535460 mRNA. Translation: CAD59483.1.
RefSeqiNP_001258035.1. NM_001271106.1.
UniGeneiRn.140864.

Genome annotation databases

EnsembliENSRNOT00000000451; ENSRNOP00000000451; ENSRNOG00000000401.
GeneIDi294394.
KEGGirno:294394.
UCSCiRGD:735077. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ535460 mRNA. Translation: CAD59483.1 .
RefSeqi NP_001258035.1. NM_001271106.1.
UniGenei Rn.140864.

3D structure databases

ProteinModelPortali Q70VB1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000000451.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q70VB1.

Proteomic databases

PaxDbi Q70VB1.
PRIDEi Q70VB1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000000451 ; ENSRNOP00000000451 ; ENSRNOG00000000401 .
GeneIDi 294394.
KEGGi rno:294394.
UCSCi RGD:735077. rat.

Organism-specific databases

CTDi 222545.
RGDi 735077. Gprc6a.

Phylogenomic databases

eggNOGi NOG295353.
GeneTreei ENSGT00750000117484.
HOGENOMi HOG000063697.
HOVERGENi HBG096042.
InParanoidi Q70VB1.
KOi K04622.
OMAi ETHWAPV.
OrthoDBi EOG7DZ8J8.
PhylomeDBi Q70VB1.
TreeFami TF331269.

Miscellaneous databases

NextBioi 638109.
PROi Q70VB1.

Gene expression databases

Genevestigatori Q70VB1.

Family and domain databases

InterProi IPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR028082. Peripla_BP_I.
[Graphical view ]
Pfami PF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view ]
PRINTSi PR00248. GPCRMGR.
SUPFAMi SSF53822. SSF53822. 1 hit.
PROSITEi PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, GLYCOSYLATION.
    Strain: Wistar.
    Tissue: Circumvallate papilla.

Entry informationi

Entry nameiGPC6A_RAT
AccessioniPrimary (citable) accession number: Q70VB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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