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Protein

Inhibitor of nuclear factor kappa-B kinase-interacting protein

Gene

IKBIP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Target of p53/TP53 with pro-apoptotic function.1 Publication

GO - Biological processi

  • response to X-ray Source: BHF-UCL
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibitor of nuclear factor kappa-B kinase-interacting protein
Short name:
I kappa-B kinase-interacting protein
Short name:
IKBKB-interacting protein
Short name:
IKK-interacting protein
Gene namesi
Name:IKBIP
Synonyms:IKIP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:26430. IKBIP.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei46 – 62HelicalSequence analysisAdd BLAST17

GO - Cellular componenti

  • endoplasmic reticulum Source: HGNC
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi121457.
OpenTargetsiENSG00000166130.
PharmGKBiPA165512948.

Polymorphism and mutation databases

BioMutaiIKBIP.
DMDMi74712656.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003422611 – 350Inhibitor of nuclear factor kappa-B kinase-interacting proteinAdd BLAST350

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi144N-linked (GlcNAc...)1 Publication1
Glycosylationi328N-linked (GlcNAc...)1 Publication1

Post-translational modificationi

Isoform 4 may be phosphorylated at Thr-362 by similarity with mouse isoform 1.
N-glycosylated. Isoform 4 is glycosylated at Asn-154.2 Publications

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ70UQ0.
MaxQBiQ70UQ0.
PeptideAtlasiQ70UQ0.
PRIDEiQ70UQ0.

PTM databases

iPTMnetiQ70UQ0.
PhosphoSitePlusiQ70UQ0.
SwissPalmiQ70UQ0.

Expressioni

Tissue specificityi

Expressed in vein endothelial cells. Isoform 4 is expressed in lung, kidney, spleen, thymus and skeletal muscle.1 Publication

Inductioni

By X-ray irradiation.1 Publication

Gene expression databases

BgeeiENSG00000166130.
GenevisibleiQ70UQ0. HS.

Organism-specific databases

HPAiHPA038677.
HPA038678.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
C9orf16Q9BUW73EBI-2557212,EBI-752084
KRT15P190123EBI-2557212,EBI-739566
MYOGP151733EBI-2557212,EBI-3906629
NUP62P371983EBI-2557212,EBI-347978
TFIP11Q9UBB93EBI-2557212,EBI-1105213
TPM3Q5VU623EBI-2557212,EBI-10184033

Protein-protein interaction databases

BioGridi125730. 69 interactors.
IntActiQ70UQ0. 27 interactors.
MINTiMINT-8417675.

Structurei

3D structure databases

ProteinModelPortaliQ70UQ0.
SMRiQ70UQ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili184 – 217Sequence analysisAdd BLAST34

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00500000045001.
HOGENOMiHOG000113024.
HOVERGENiHBG080784.
InParanoidiQ70UQ0.
OMAiEECKTHL.
OrthoDBiEOG091G09QS.
PhylomeDBiQ70UQ0.
TreeFamiTF331715.

Family and domain databases

InterProiIPR024152. Inh_kappa-B_kinase-int.
[Graphical view]
PANTHERiPTHR21734. PTHR21734. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q70UQ0-1) [UniParc]FASTAAdd to basket
Also known as: IKIP2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSEVKSRKKS GPKGAPAAEP GKRSEGGKTP VARSSGGGGW ADPRTCLSLL
60 70 80 90 100
SLGTCLGLAW FVFQQSEKFA KVENQYQLLK LETNEFQQLQ SKISLISEKW
110 120 130 140 150
QKSEAIMEQL KSFQIIAHLK RLQEEINEVK TWSNRITEKQ DILNNSLTTL
160 170 180 190 200
SQDITKVDQS TTSMAKDVGL KITSVKTDIR RISGLVTDVI SLTDSVQELE
210 220 230 240 250
NKIEKVEKNT VKNIGDLLSS SIDRTATLRK TASENSQRIN SVKKTLTELK
260 270 280 290 300
SDFDKHTDRF LSLEGDRAKV LKTVTFANDL KPKVYNLKKD FSRLEPLVND
310 320 330 340 350
LTLRIGRLVT DLLQREKEIA FLSEKISNLT IVQAEIKDIK DEIAHISDMN
Length:350
Mass (Da):39,309
Last modified:July 5, 2004 - v1
Checksum:i98BDA498C7BA1D0A
GO
Isoform 2 (identifier: Q70UQ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: Missing.

Show »
Length:244
Mass (Da):27,769
Checksum:iB79E47CAF0588F29
GO
Isoform 3 (identifier: Q70UQ0-3) [UniParc]FASTAAdd to basket
Also known as: IKIP3

The sequence of this isoform differs from the canonical sequence as follows:
     60-70: WFVFQQSEKFA → CGRNLKLSWNN
     71-350: Missing.

Show »
Length:70
Mass (Da):7,141
Checksum:iB6627F6EBF24973C
GO
Isoform 4 (identifier: Q70UQ0-4) [UniParc]FASTAAdd to basket
Also known as: IKIP1

The sequence of this isoform differs from the canonical sequence as follows:
     100-350: WQKSEAIMEQ...DEIAHISDMN → LESTESILQE...IENKGIGGDF

Show »
Length:377
Mass (Da):43,084
Checksum:i405E03A48B3FEF09
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051067265G → S.Corresponds to variant rs1048906dbSNPEnsembl.1
Isoform 4 (identifier: Q70UQ0-4)
Natural varianti122Q → H.Corresponds to variant rs12322444dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0344071 – 106Missing in isoform 2. 2 PublicationsAdd BLAST106
Alternative sequenceiVSP_03440860 – 70WFVFQQSEKFA → CGRNLKLSWNN in isoform 3. 2 PublicationsAdd BLAST11
Alternative sequenceiVSP_03440971 – 350Missing in isoform 3. 2 PublicationsAdd BLAST280
Alternative sequenceiVSP_034410100 – 350WQKSE…ISDMN → LESTESILQEATSSMSLMTQ FEQEVSNLQDIMHDIQNNEE VLTQRMQSLNEKFQNITDFW KRSLEEMNINTDIFKSEAKH IHSQVTVQINSAEQEIKLLT ERLKDLEDSTLRNIRTVKRQ EEEDLLRVEEQLGSDTKAIE KLEEEQHALFARDEDLTNKL SDYEPKVEECKTHLPTIESA IHSVLRVSQDLIETEKKMED LTMQMFNMEDDMLKAVSEIM EMQKTLEGIQYDNSILKMQN ELDILKEKVHDFIAYSSTGE KGTLKEYNIENKGIGGDF in isoform 4. 3 PublicationsAdd BLAST251

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ539425 mRNA. Translation: CAD62380.1.
AJ539426 mRNA. Translation: CAD62381.1.
AJ539427 mRNA. Translation: CAD62382.1.
AJ539427 mRNA. Translation: CAD62383.1.
AK055613 mRNA. Translation: BAB70970.1.
AK123069 mRNA. Translation: BAC85528.1.
CH471054 Genomic DNA. Translation: EAW97601.1.
BC029415 mRNA. Translation: AAH29415.2.
BC051372 mRNA. Translation: AAH51372.2.
BC058933 mRNA. Translation: AAH58933.1.
CCDSiCCDS41822.1. [Q70UQ0-3]
CCDS9067.1. [Q70UQ0-1]
CCDS9068.1. [Q70UQ0-4]
RefSeqiNP_710154.1. NM_153687.3. [Q70UQ0-4]
NP_963906.1. NM_201612.2. [Q70UQ0-1]
NP_963907.1. NM_201613.2. [Q70UQ0-3]
UniGeneiHs.252543.

Genome annotation databases

EnsembliENST00000299157; ENSP00000299157; ENSG00000166130. [Q70UQ0-4]
ENST00000342502; ENSP00000343471; ENSG00000166130. [Q70UQ0-1]
ENST00000393042; ENSP00000376762; ENSG00000166130. [Q70UQ0-3]
GeneIDi121457.
KEGGihsa:121457.
UCSCiuc001tfv.5. human. [Q70UQ0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ539425 mRNA. Translation: CAD62380.1.
AJ539426 mRNA. Translation: CAD62381.1.
AJ539427 mRNA. Translation: CAD62382.1.
AJ539427 mRNA. Translation: CAD62383.1.
AK055613 mRNA. Translation: BAB70970.1.
AK123069 mRNA. Translation: BAC85528.1.
CH471054 Genomic DNA. Translation: EAW97601.1.
BC029415 mRNA. Translation: AAH29415.2.
BC051372 mRNA. Translation: AAH51372.2.
BC058933 mRNA. Translation: AAH58933.1.
CCDSiCCDS41822.1. [Q70UQ0-3]
CCDS9067.1. [Q70UQ0-1]
CCDS9068.1. [Q70UQ0-4]
RefSeqiNP_710154.1. NM_153687.3. [Q70UQ0-4]
NP_963906.1. NM_201612.2. [Q70UQ0-1]
NP_963907.1. NM_201613.2. [Q70UQ0-3]
UniGeneiHs.252543.

3D structure databases

ProteinModelPortaliQ70UQ0.
SMRiQ70UQ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125730. 69 interactors.
IntActiQ70UQ0. 27 interactors.
MINTiMINT-8417675.

PTM databases

iPTMnetiQ70UQ0.
PhosphoSitePlusiQ70UQ0.
SwissPalmiQ70UQ0.

Polymorphism and mutation databases

BioMutaiIKBIP.
DMDMi74712656.

Proteomic databases

EPDiQ70UQ0.
MaxQBiQ70UQ0.
PeptideAtlasiQ70UQ0.
PRIDEiQ70UQ0.

Protocols and materials databases

DNASUi121457.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299157; ENSP00000299157; ENSG00000166130. [Q70UQ0-4]
ENST00000342502; ENSP00000343471; ENSG00000166130. [Q70UQ0-1]
ENST00000393042; ENSP00000376762; ENSG00000166130. [Q70UQ0-3]
GeneIDi121457.
KEGGihsa:121457.
UCSCiuc001tfv.5. human. [Q70UQ0-1]

Organism-specific databases

CTDi121457.
DisGeNETi121457.
GeneCardsiIKBIP.
HGNCiHGNC:26430. IKBIP.
HPAiHPA038677.
HPA038678.
MIMi609861. gene.
neXtProtiNX_Q70UQ0.
OpenTargetsiENSG00000166130.
PharmGKBiPA165512948.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00500000045001.
HOGENOMiHOG000113024.
HOVERGENiHBG080784.
InParanoidiQ70UQ0.
OMAiEECKTHL.
OrthoDBiEOG091G09QS.
PhylomeDBiQ70UQ0.
TreeFamiTF331715.

Miscellaneous databases

GenomeRNAii121457.
PROiQ70UQ0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166130.
GenevisibleiQ70UQ0. HS.

Family and domain databases

InterProiIPR024152. Inh_kappa-B_kinase-int.
[Graphical view]
PANTHERiPTHR21734. PTHR21734. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIKIP_HUMAN
AccessioniPrimary (citable) accession number: Q70UQ0
Secondary accession number(s): Q6ZWH4
, Q70UP9, Q86V91, Q96ND2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Shares a common promoter with APAF1 from which the 2 genes are transcribed in opposite directions.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.