Q70UP6 (ADH2_CERRO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alcohol dehydrogenase 2
EC=1.1.1.1

Gene names

Name:

ADH2

Organism

Ceratitis rosa (Natal fruit fly) (Pterandrus rosa)

Taxonomic identifier

56958 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Tephritoidea › Tephritidae › Ceratitis › Pterandrus

Protein attributes

Sequence length	258 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	An alcohol + NAD+ = an aldehyde or ketone + NADH.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Molecular function	alcohol dehydrogenase (NAD) activity Inferred from sequence or structural similarity. Source: UniProtKB nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 258	258	Alcohol dehydrogenase 2		PRO_0000277840
Regions
	Nucleotide binding	9 – 33	25	NAD By similarity
Sites
	Active site	150	1	Proton acceptor By similarity
	Binding site	137	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q70UP6 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 65269A34F96DE474	FASTA	258	27,968
	10 20 30 40 50 60 MGLSGKNVIF VGGLGFIGYE ACKQLMAKNM ASFFVFDVLD KPEDIKALQA LNPKTKVYYT 70 80 90 100 110 120 KFDITSKQSI KSALADVVSK VKYIDALING AGILTDLNVE LTMNINLIGL INTTLEGLPL 130 140 150 160 170 180 MDKNKQGRGG VIVNIASVLG LEPCPPAAAY CASKFGVMGF SRSIGDPYYY NITGVAVVTF 190 200 210 220 230 240 CPGLTETPLK NNIGSKYTFE YSKKISEELN NTKTQKPEVC GAHLAQVVES HENGGIYISN 250 QGTLAKVTPT VYWQPTYH

References

[1]	"Exploring the evolutionary history of the alcohol dehydrogenase gene (Adh) duplication in species of the family tephritidae." Goulielmos G.N., Loukas M., Bondinas G., Zouros E. J. Mol. Evol. 57:170-180(2003) [PubMed: 14562961] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ539539 Genomic DNA. Translation: CAD62451.1.
3D structure databases
HSSP	HSSP built from PDB template 1SO8 based on UniProtKB Q99714.
ProteinModelPortal	Q70UP6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR002426. ADH_Ceratitis-type. IPR002424. ADH_insect. IPR002198. DH_sc/Rdtase_SDR. IPR016040. NAD(P)-bd_dom. IPR020904. Sc_DH/Rdtase_CS. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR01169. CERATITISADH. PR01167. INSADHFAMILY. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADH2_CERRO

Accession

Primary (citable) accession number: Q70UP6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 20, 2007
Last sequence update:	July 5, 2004
Last modified:	December 14, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)