Reviewed, UniProtKB/Swiss-Prot Q70UP5 (ADH2_CERCO)

Names and origin

Protein names

Recommended name:
    Alcohol dehydrogenase 2
    EC=1.1.1.1

Gene names

Name:

ADH2

Organism

Ceratitis cosyra (Mango fruit fly)

Taxonomic identifier

194917 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Tephritoidea › Tephritidae › Ceratitis › Ceratalaspis

Protein attributes

Sequence length	258 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	An alcohol + NAD+ = an aldehyde or ketone + NADH.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alcohol dehydrogenase activity Inferred from electronic annotation. Source: EC binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 258	258	Alcohol dehydrogenase 2		PRO_0000277839
Regions
	Nucleotide binding	9 – 33	25	NAD By similarity
Sites
	Active site	150	1	Proton acceptor By similarity
	Binding site	137	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q70UP5-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 43B04144B00D107B	FASTA	258	28,010
	10 20 30 40 50 60 MGLSGKNVIF VGGLGFIGYE ACKQLMAKNM ASFFVFDVLD KPEDIKALQA LNPKTKVYYT 70 80 90 100 110 120 KFDITSKQSI KSALADVVSK VKYIDALING AGILTDLNVE LTMNINLIGL INTTLEALPL 130 140 150 160 170 180 MDKNKQGRGG VIVNIASVLG LEPCPPAAVY CASKFGVMGF SRSIGDPYYY NITGVAVVTF 190 200 210 220 230 240 CPGLTETPLK NNIGSKYTFE YSKKISEELN NTKTQKPEVC GAHLAQVVES HENGGIYISN 250 QGTLAKVTPT VYWQPTYH

References

[1]	"Exploring the evolutionary history of the alcohol dehydrogenase gene (Adh) duplication in species of the family tephritidae." Goulielmos G.N., Loukas M., Bondinas G., Zouros E. J. Mol. Evol. 57:170-180(2003) [PubMed: 14562961] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ539540 Genomic DNA. Translation: CAD62452.1.
3D structure databases
HSSP	HSSP built from PDB template 1B16 based on UniProtKB P10807.
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.1.1.1. 317387.
Family and domain databases
InterPro	IPR002426. Ceratitis_ADH. IPR002198. DH_sc/Rdtase_SDR. IPR002424. Insect_AlcDH_fam. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR19410. ADH_short_C2. 1 hit.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR01169. CERATITISADH. PR01167. INSADHFAMILY. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADH2_CERCO

Accession

Primary (citable) accession number: Q70UP5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 20, 2007
Last sequence update:	July 5, 2004
Last modified:	June 16, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)