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Protein

Alcohol dehydrogenase 1

Gene

ADH1

Organism
Ceratitis cosyra (Mango fruit fly) (Trypeta cosyra)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei137SubstrateBy similarity1
Active sitei150Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 33NADBy similarityAdd BLAST25

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 1 (EC:1.1.1.1)
Gene namesi
Name:ADH1
OrganismiCeratitis cosyra (Mango fruit fly) (Trypeta cosyra)
Taxonomic identifieri194917 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaTephritoideaTephritidaeCeratitisCeratalaspis

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002778381 – 257Alcohol dehydrogenase 1Add BLAST257

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ70UN9.
SMRiQ70UN9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiView protein in InterPro
IPR002426. ADH_Ceratitis-type.
IPR002424. ADH_insect.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PRINTSiPR01169. CERATITISADH.
PR01167. INSADHFAMILY.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00061. ADH_SHORT. 1 hit.

Sequencei

Sequence statusi: Complete.

Q70UN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVAGKNVVF VGGLGFIGYE ACKTLITRDL ASLFVFDILD KPEAVKALEE
60 70 80 90 100
INPKTKVYYT KFDITSKDNI KQSLADVIAK VQYIDVLVNG AGILNDPNVE
110 120 130 140 150
WTMNINLIGL INTTLEAIPL MDKNKKGRGG VIVNIASVLG LEPGPPAAIY
160 170 180 190 200
CASKFGVMGF SRSLGDPHYY EHTGIAVVTF CPGLTDTPLK NNVATKYTFD
210 220 230 240 250
YSKEIGEKLN HSKTQKPEVC GAHLAQVIEL RDNGAIYISN QGTLTKVKPS

VYWEPTY
Length:257
Mass (Da):28,052
Last modified:July 5, 2004 - v1
Checksum:i62DE72372695D348
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ539546 Genomic DNA. Translation: CAD62458.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ539546 Genomic DNA. Translation: CAD62458.1.

3D structure databases

ProteinModelPortaliQ70UN9.
SMRiQ70UN9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiView protein in InterPro
IPR002426. ADH_Ceratitis-type.
IPR002424. ADH_insect.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PRINTSiPR01169. CERATITISADH.
PR01167. INSADHFAMILY.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00061. ADH_SHORT. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADH1_CERCO
AccessioniPrimary (citable) accession number: Q70UN9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: July 5, 2004
Last modified: February 15, 2017
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.