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Protein

Cyclic AMP-responsive element-binding protein 3-like protein 2

Gene

CREB3L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes (By similarity). In a neuroblastoma cell line, protects cells from ER stress-induced death (PubMed:17178827). In vitro activates transcription of target genes via direct binding to the CRE site (PubMed:17178827).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation, Unfolded protein response

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic AMP-responsive element-binding protein 3-like protein 2
Short name:
cAMP-responsive element-binding protein 3-like protein 2
Alternative name(s):
BBF2 human homolog on chromosome 7
Cleaved into the following chain:
Gene namesi
Name:CREB3L2
Synonyms:BBF2H7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:23720. CREB3L2.

Subcellular locationi

  • Endoplasmic reticulum membrane By similarity; Single-pass type II membrane protein

  • Note: ER membrane resident protein. Upon ER stress, translocated to the Golgi apparatus where it is cleaved. The cytosolic N-terminal fragment (processed cyclic AMP-responsive element-binding protein 3-like protein 1) is transported into the nucleus.By similarity
Chain Processed cyclic AMP-responsive element-binding protein 3-like protein 2 :
  • Nucleus

  • Note: Upon ER stress, translocated into the nucleus.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 379379CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei380 – 40021Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini401 – 520120LumenalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum Source: UniProtKB
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving CREB3L2 is found in low grade fibromyxoid sarcoma (LGFMS). Translocation t(7;16)(q33;p11) with FUS.

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

Orphaneti79105. Myxofibrosarcoma.
PharmGKBiPA134914841.

Polymorphism and mutation databases

BioMutaiCREB3L2.
DMDMi296439387.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 520520Cyclic AMP-responsive element-binding protein 3-like protein 2PRO_0000288067Add
BLAST
Chaini1 – ?Processed cyclic AMP-responsive element-binding protein 3-like protein 2PRO_0000296209

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei191 – 1911Phosphoserine1 Publication
Glycosylationi480 – 4801N-linked (GlcNAc...)Sequence Analysis
Glycosylationi504 – 5041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi517 – 5171N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Upon ER stress, translocated to the Golgi apparatus, where it is processed by regulated intramembrane proteolysis (RIP) to release the cytosol-facing N-terminal transcription factor domain. The cleavage is performed sequentially by site-1 and site-2 proteases (S1P/MBTPS1 and S2P/MBTPS2).By similarity
N-glycosylated.1 Publication
Ubiquitinated by HRD1/SYVN1; undergoes 'Lys-48'-linked ubiquitination, followed by rapid proteasomal degradation under normal conditions. Upon ER stress, SYVN1 E3 ubiquitin-protein ligase dissociates from its substrate, ubiquitination does not occur and CREB3L2 is stabilized.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ70SY1.
PaxDbiQ70SY1.
PRIDEiQ70SY1.

PTM databases

PhosphoSiteiQ70SY1.

Expressioni

Tissue specificityi

Widely expressed with highest levels in placenta, lung, spleen and intestine, and lowest levels in heart, brain, skeletal muscle, thymus, colon and leukocytes. In fetal tissues, the weakest expression is detected in brain and heart.1 Publication

Inductioni

Up-regulated by ER stress at the transcipt and protein levels, the increase at the protein level is much higher than at the transcript level. This induction is accompanied by increased proteolytic cleavage that releases the N-terminal transcription factor domain.1 Publication

Gene expression databases

BgeeiQ70SY1.
CleanExiHS_CREB3L2.
ExpressionAtlasiQ70SY1. baseline and differential.
GenevestigatoriQ70SY1.

Organism-specific databases

HPAiHPA015068.

Interactioni

Subunit structurei

Binds DNA as a dimer.By similarity

Protein-protein interaction databases

BioGridi122277. 19 interactions.
IntActiQ70SY1. 11 interactions.
STRINGi9606.ENSP00000329140.

Structurei

3D structure databases

ProteinModelPortaliQ70SY1.
SMRiQ70SY1. Positions 264-352.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini294 – 35764bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni296 – 32530Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni336 – 35722Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi427 – 4304S1P recognition1 Publication

Sequence similaritiesi

Belongs to the bZIP family. ATF subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG294764.
GeneTreeiENSGT00520000055538.
HOGENOMiHOG000060150.
HOVERGENiHBG057480.
InParanoidiQ70SY1.
KOiK09048.
OMAiHFTEFLD.
OrthoDBiEOG7327QN.
PhylomeDBiQ70SY1.
TreeFamiTF316079.

Family and domain databases

InterProiIPR029804. BBF2H7.
IPR004827. bZIP.
[Graphical view]
PANTHERiPTHR22952:SF96. PTHR22952:SF96. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q70SY1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVLESGEQG VLQWDRKLSE LSEPGDGEAL MYHTHFSELL DEFSQNVLGQ
60 70 80 90 100
LLNDPFLSEK SVSMEVEPSP TSPAPLIQAE HSYSLCEEPR AQSPFTHITT
110 120 130 140 150
SDSFNDDEVE SEKWYLSTDF PSTSIKTEPV TDEPPPGLVP SVTLTITAIS
160 170 180 190 200
TPLEKEEPPL EMNTGVDSSC QTIIPKIKLE PHEVDQFLNF SPKEAPVDHL
210 220 230 240 250
HLPPTPPSSH GSDSEGSLSP NPRLHPFSLP QTHSPSRAAP RAPSALSSSP
260 270 280 290 300
LLTAPHKLQG SGPLVLTEEE KRTLIAEGYP IPTKLPLSKS EEKALKKIRR
310 320 330 340 350
KIKNKISAQE SRRKKKEYMD SLEKKVESCS TENLELRKKV EVLENTNRTL
360 370 380 390 400
LQQLQKLQTL VMGKVSRTCK LAGTQTGTCL MVVVLCFAVA FGSFFQGYGP
410 420 430 440 450
YPSATKMALP SQHSLQEPYT ASVVRSRNLL IYEEHSPPEE SSSPGSAGEL
460 470 480 490 500
GGWDRGSSLL RVSGLESRPD VDLPHFIISN ETSLEKSVLL ELQQHLVSAK
510 520
LEGNETLKVV ELDRRVNTTF
Length:520
Mass (Da):57,415
Last modified:May 18, 2010 - v3
Checksum:i64699072EEB454D3
GO
Isoform 2 (identifier: Q70SY1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     424-520: VRSRNLLIYE...ELDRRVNTTF → GKTACGKLGR...FCESPMFKKW

Note: No experimental confirmation available.

Show »
Length:460
Mass (Da):50,843
Checksum:i8762472720C306F0
GO
Isoform 3 (identifier: Q70SY1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     195-248: APVDHLHLPP...APRAPSALSS → GLSALPVSLW...FLKNKNFASK
     249-520: Missing.

Note: No experimental confirmation available.

Show »
Length:248
Mass (Da):27,722
Checksum:i8AF3A941E7068506
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti100 – 1001Missing .3 Publications
VAR_062385
Natural varianti130 – 1301V → I.3 Publications
Corresponds to variant rs273957 [ dbSNP | Ensembl ].
VAR_062386

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei195 – 24854APVDH…SALSS → GLSALPVSLWVMDMVSGSTE REYGERAGMSLYHRCCSWLY EIALFLKNKNFASK in isoform 3. 1 PublicationVSP_025634Add
BLAST
Alternative sequencei249 – 520272Missing in isoform 3. 1 PublicationVSP_025635Add
BLAST
Alternative sequencei424 – 52097VRSRN…VNTTF → GKTACGKLGRVLFYFPRAGF LSLPKGIFCESPMFKKW in isoform 2. 1 PublicationVSP_025636Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ549092 mRNA. Translation: CAD79342.1.
AJ549387 mRNA. Translation: CAD79347.1.
AK131517 mRNA. Translation: BAD18659.1.
CH236950 Genomic DNA. Translation: EAL24050.1.
BC063666 mRNA. Translation: AAH63666.1.
BC110813 mRNA. Translation: AAI10814.1.
CCDSiCCDS34760.1. [Q70SY1-1]
CCDS59083.1. [Q70SY1-3]
RefSeqiNP_001240704.1. NM_001253775.1. [Q70SY1-3]
NP_919047.2. NM_194071.3. [Q70SY1-1]
UniGeneiHs.490273.

Genome annotation databases

EnsembliENST00000330387; ENSP00000329140; ENSG00000182158. [Q70SY1-1]
ENST00000452463; ENSP00000410314; ENSG00000182158. [Q70SY1-3]
ENST00000456390; ENSP00000403550; ENSG00000182158. [Q70SY1-2]
GeneIDi64764.
KEGGihsa:64764.
UCSCiuc003vtv.3. human. [Q70SY1-1]
uc003vtx.2. human. [Q70SY1-2]
uc003vty.4. human. [Q70SY1-3]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ549092 mRNA. Translation: CAD79342.1.
AJ549387 mRNA. Translation: CAD79347.1.
AK131517 mRNA. Translation: BAD18659.1.
CH236950 Genomic DNA. Translation: EAL24050.1.
BC063666 mRNA. Translation: AAH63666.1.
BC110813 mRNA. Translation: AAI10814.1.
CCDSiCCDS34760.1. [Q70SY1-1]
CCDS59083.1. [Q70SY1-3]
RefSeqiNP_001240704.1. NM_001253775.1. [Q70SY1-3]
NP_919047.2. NM_194071.3. [Q70SY1-1]
UniGeneiHs.490273.

3D structure databases

ProteinModelPortaliQ70SY1.
SMRiQ70SY1. Positions 264-352.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122277. 19 interactions.
IntActiQ70SY1. 11 interactions.
STRINGi9606.ENSP00000329140.

PTM databases

PhosphoSiteiQ70SY1.

Polymorphism and mutation databases

BioMutaiCREB3L2.
DMDMi296439387.

Proteomic databases

MaxQBiQ70SY1.
PaxDbiQ70SY1.
PRIDEiQ70SY1.

Protocols and materials databases

DNASUi64764.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330387; ENSP00000329140; ENSG00000182158. [Q70SY1-1]
ENST00000452463; ENSP00000410314; ENSG00000182158. [Q70SY1-3]
ENST00000456390; ENSP00000403550; ENSG00000182158. [Q70SY1-2]
GeneIDi64764.
KEGGihsa:64764.
UCSCiuc003vtv.3. human. [Q70SY1-1]
uc003vtx.2. human. [Q70SY1-2]
uc003vty.4. human. [Q70SY1-3]

Organism-specific databases

CTDi64764.
GeneCardsiGC07M137559.
HGNCiHGNC:23720. CREB3L2.
HPAiHPA015068.
MIMi608834. gene.
neXtProtiNX_Q70SY1.
Orphaneti79105. Myxofibrosarcoma.
PharmGKBiPA134914841.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG294764.
GeneTreeiENSGT00520000055538.
HOGENOMiHOG000060150.
HOVERGENiHBG057480.
InParanoidiQ70SY1.
KOiK09048.
OMAiHFTEFLD.
OrthoDBiEOG7327QN.
PhylomeDBiQ70SY1.
TreeFamiTF316079.

Miscellaneous databases

ChiTaRSiCREB3L2. human.
GenomeRNAii64764.
NextBioi66755.
PROiQ70SY1.
SOURCEiSearch...

Gene expression databases

BgeeiQ70SY1.
CleanExiHS_CREB3L2.
ExpressionAtlasiQ70SY1. baseline and differential.
GenevestigatoriQ70SY1.

Family and domain databases

InterProiIPR029804. BBF2H7.
IPR004827. bZIP.
[Graphical view]
PANTHERiPTHR22952:SF96. PTHR22952:SF96. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS THR-100 DEL AND ILE-130, TISSUE SPECIFICITY, CHROMOSOMAL TRANSLOCATION WITH FUS.
    Tissue: Lung and Placenta.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Tongue.
  3. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS THR-100 DEL AND ILE-130.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANTS THR-100 DEL AND ILE-130.
    Tissue: Brain and Skin.
  5. Cited for: CHROMOSOMAL TRANSLOCATION WITH FUS.
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-191, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "BBF2H7, a novel transmembrane bZIP transcription factor, is a new type of endoplasmic reticulum stress transducer."
    Kondo S., Saito A., Hino S., Murakami T., Ogata M., Kanemoto S., Nara S., Yamashita A., Yoshinaga K., Hara H., Imaizumi K.
    Mol. Cell. Biol. 27:1716-1729(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, GLYCOSYLATION, INDUCTION BY ER STRESS.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: UBIQUITINATION.

Entry informationi

Entry nameiCR3L2_HUMAN
AccessioniPrimary (citable) accession number: Q70SY1
Secondary accession number(s): Q6P454, Q6ZMR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 18, 2010
Last modified: May 27, 2015
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.