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Q70PW6

- PGSB2_DROSI

UniProt

Q70PW6 - PGSB2_DROSI

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Protein

Peptidoglycan-recognition protein SB2

Gene

PGRP-SB2

Organism
Drosophila simulans (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

N-acetylmuramyl-L-alanine amidase involved in innate immunity by degrading bacterial peptidoglycans (PGN). Probably plays a scavenger role by digesting biologically active PGN into biologically inactive fragments. Has no direct bacteriolytic activity (By similarity).By similarity

Catalytic activityi

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

Cofactori

Zn2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi48 – 481ZincBy similarity
Metal bindingi81 – 811ZincBy similarity
Metal bindingi155 – 1551ZincBy similarity
Metal bindingi163 – 1631ZincBy similarity

GO - Molecular functioni

  1. N-acetylmuramoyl-L-alanine amidase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. innate immune response Source: UniProtKB-KW
  2. peptidoglycan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Immunity, Innate immunity

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidoglycan-recognition protein SB2 (EC:3.5.1.28)
Gene namesi
Name:PGRP-SB2
OrganismiDrosophila simulans (Fruit fly)
Taxonomic identifieri7240 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0068647. Dsim\PGRP-SB2.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 182165Peptidoglycan-recognition protein SB2PRO_0000023909Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi54 ↔ 60By similarity
Glycosylationi149 – 1491N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ70PW6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

OrthoDBiEOG757CZ5.

Family and domain databases

Gene3Di3.40.80.10. 1 hit.
InterProiIPR002502. Amidase_domain.
IPR017331. Peptidoglycan_recognition.
IPR015510. PGRP.
IPR006619. PGRP_domain_met/bac.
[Graphical view]
PANTHERiPTHR11022. PTHR11022. 1 hit.
PfamiPF01510. Amidase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF037945. PGRPs. 1 hit.
SMARTiSM00644. Ami_2. 1 hit.
SM00701. PGRP. 1 hit.
[Graphical view]
SUPFAMiSSF55846. SSF55846. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q70PW6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLQLALVLC GLTLALGQIV PRSSWCPVPI SPRIPRLMVP VRLIIIHHTV
60 70 80 90 100
TAPCFNPHQC QLVLRQIRAD HMRRKFRDIG YNFLIGGDGR IYEGLGFGIR
110 120 130 140 150
GEHAPRYNSQ SIGIAFIGNF QTGLPPSQML QAARTLIQIA VQRRQVSPNY
160 170 180
SLVGHCQTKA TACPGRHLLN ELKKWPRWQP KP
Length:182
Mass (Da):20,512
Last modified:July 5, 2004 - v1
Checksum:iC74D0CEFD5561BC4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ556586 Genomic DNA. Translation: CAD89151.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ556586 Genomic DNA. Translation: CAD89151.1 .

3D structure databases

ProteinModelPortali Q70PW6.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

FlyBasei FBgn0068647. Dsim\PGRP-SB2.

Phylogenomic databases

OrthoDBi EOG757CZ5.

Family and domain databases

Gene3Di 3.40.80.10. 1 hit.
InterProi IPR002502. Amidase_domain.
IPR017331. Peptidoglycan_recognition.
IPR015510. PGRP.
IPR006619. PGRP_domain_met/bac.
[Graphical view ]
PANTHERi PTHR11022. PTHR11022. 1 hit.
Pfami PF01510. Amidase_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF037945. PGRPs. 1 hit.
SMARTi SM00644. Ami_2. 1 hit.
SM00701. PGRP. 1 hit.
[Graphical view ]
SUPFAMi SSF55846. SSF55846. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The evolution of parasite recognition genes in the innate immune system: purifying selection on Drosophila melanogaster peptidoglycan recognition proteins."
    Jiggins F.M., Hurst G.D.D.
    J. Mol. Evol. 57:598-605(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiPGSB2_DROSI
AccessioniPrimary (citable) accession number: Q70PW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: July 5, 2004
Last modified: November 26, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3