Reviewed, UniProtKB/Swiss-Prot Q70PW6 (PGSB2_DROSI)

Names and origin

Protein names

Recommended name:
    Peptidoglycan-recognition protein SB2
    EC=3.5.1.28

Gene names

Name:

PGRP-SB2

Organism

Drosophila simulans (Fruit fly)

Taxonomic identifier

7240 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	182 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	N-acetylmuramyl-L-alanine amidase involved in innate immunity by degrading bacterial peptidoglycans (PGN). Probably plays a scavenger role by digesting biologically active PGN into biologically inactive fragments. Has no direct bacteriolytic activity By similarity.
Catalytic activity	Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.
Cofactor	Zinc By similarity.
Subcellular location	Secreted Potential.
Sequence similarities	Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

Ontologies

Keywords
Biological process	Immune response Innate immunity
Cellular component	Secreted
Domain	Signal
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological process	innate immune response Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Ref.1 Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	N-acetylmuramoyl-L-alanine amidase activity Inferred from electronic annotation. Source: EC protein binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Chain	18 – 182	165	Peptidoglycan-recognition protein SB2		PRO_0000023909
Sites
	Metal binding	48	1	Zinc By similarity
	Metal binding	81	1	Zinc By similarity
	Metal binding	155	1	Zinc By similarity
	Metal binding	163	1	Zinc By similarity
Amino acid modifications
	Glycosylation	149	1	N-linked (GlcNAc...) Potential
	Disulfide bond	54 ↔ 60		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q70PW6-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: C74D0CEFD5561BC4	FASTA	182	20,512
	10 20 30 40 50 60 MKLQLALVLC GLTLALGQIV PRSSWCPVPI SPRIPRLMVP VRLIIIHHTV TAPCFNPHQC 70 80 90 100 110 120 QLVLRQIRAD HMRRKFRDIG YNFLIGGDGR IYEGLGFGIR GEHAPRYNSQ SIGIAFIGNF 130 140 150 160 170 180 QTGLPPSQML QAARTLIQIA VQRRQVSPNY SLVGHCQTKA TACPGRHLLN ELKKWPRWQP KP

References

[1]	"The evolution of parasite recognition genes in the innate immune system: purifying selection on Drosophila melanogaster peptidoglycan recognition proteins." Jiggins F.M., Hurst G.D.D. J. Mol. Evol. 57:598-605(2003) [PubMed: 14738318] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ556586 Genomic DNA. Translation: CAD89151.1.
3D structure databases
HSSP	HSSP built from PDB template 1ARO based on UniProtKB P00806.
ModBase	Search...
Organism-specific databases
FlyBase	FBgn0068647. Dsim\PGRP-SB2.
Enzyme and pathway databases
BRENDA	3.5.1.28. 189309.
Family and domain databases
InterPro	IPR002502. Amidase_2. IPR017331. Peptidoglycan_recognition. IPR015510. PGRP. IPR006619. PGRP_met/bac. [Graphical view]
Gene3D	G3DSA:3.40.80.10. Amidase_2. 1 hit.
PANTHER	PTHR11022. PGRPs. 1 hit.
Pfam	PF01510. Amidase_2. 1 hit. [Graphical view]
PIRSF	PIRSF037945. PGRPs. 1 hit.
SMART	SM00644. Ami_2. 1 hit. SM00701. PGRP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGSB2_DROSI

Accession

Primary (citable) accession number: Q70PW6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2005
Last sequence update:	July 5, 2004
Last modified:	June 16, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project