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Q70PU1

- PGSC2_DROSI

UniProt

Q70PU1 - PGSC2_DROSI

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Protein
Peptidoglycan-recognition protein SC2
Gene
PGRP-SC2, GD10595
Organism
Drosophila simulans (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

N-acetylmuramyl-L-alanine amidase involved in innate immunity by degrading bacterial peptidoglycans (PGN). Probably plays a scavenger role by digesting biologically active PGN into biologically inactive fragments. Has no direct bacteriolytic activity By similarity.

Catalytic activityi

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

Cofactori

Zinc By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi51 – 511Zinc By similarity
Metal bindingi85 – 851Zinc By similarity
Metal bindingi159 – 1591Zinc By similarity
Metal bindingi167 – 1671Zinc By similarity

GO - Molecular functioni

  1. N-acetylmuramoyl-L-alanine amidase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. innate immune response Source: UniProtKB-KW
  2. peptidoglycan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Immunity, Innate immunity

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidoglycan-recognition protein SC2 (EC:3.5.1.28)
Gene namesi
Name:PGRP-SC2
ORF Names:GD10595
OrganismiDrosophila simulans (Fruit fly)
Taxonomic identifieri7240 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000304: Chromosome 2R, UP000000304: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0068645. Dsim\PGRP-SC2.

Subcellular locationi

Secreted Reviewed prediction

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Chaini21 – 184164Peptidoglycan-recognition protein SC2
PRO_0000023913Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi57 ↔ 63 By similarity

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliQ70PU1.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

KOiK01446.
OrthoDBiEOG757CZ5.
PhylomeDBiQ70PU1.

Family and domain databases

Gene3Di3.40.80.10. 1 hit.
InterProiIPR002502. Amidase_domain.
IPR017331. Peptidoglycan_recognition.
IPR015510. PGRP.
IPR006619. PGRP_domain_met/bac.
[Graphical view]
PANTHERiPTHR11022. PTHR11022. 1 hit.
PfamiPF01510. Amidase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF037945. PGRPs. 1 hit.
SMARTiSM00644. Ami_2. 1 hit.
SM00701. PGRP. 1 hit.
[Graphical view]
SUPFAMiSSF55846. SSF55846. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q70PU1-1 [UniParc]FASTAAdd to Basket

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MANKALILLA VLFCAQAVLG VTIVSKSEWG GRSATSKTSL ASYLSYAVIH    50
HTAGNYCSTK AACITQLKNI QAYHMDSLGW ADIGYNFLIG GDGNVYEGRG 100
WNVMGAHATN WNSKSIGISF LGNYNTNTLT SAQITAAKGL LSDAVSRGQI 150
VSGYILYGHR QVGSTECPGT NIWNEIRTWS NWKA 184
Length:184
Mass (Da):19,788
Last modified:July 5, 2004 - v1
Checksum:iBF4070F2313D53C5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti12 – 121L → V in strain: 08FG. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ556611 Genomic DNA. Translation: CAD89176.1.
CM000362 Genomic DNA. Translation: EDX06229.1.
DQ138765 Genomic DNA. Translation: ABA86371.1.
DQ138766 Genomic DNA. Translation: ABA86372.1.
EU313688 Genomic DNA. Translation: ABY56488.1.
EU313689 Genomic DNA. Translation: ABY56489.1.
EU313690 Genomic DNA. Translation: ABY56490.1.
EU313691 Genomic DNA. Translation: ABY56491.1.
EU313692 Genomic DNA. Translation: ABY56492.1.
EU313693 Genomic DNA. Translation: ABY56493.1.
EU313694 Genomic DNA. Translation: ABY56494.1.
EU313695 Genomic DNA. Translation: ABY56495.1.
EU313696 Genomic DNA. Translation: ABY56496.1.
EU313697 Genomic DNA. Translation: ABY56497.1.
EU313698 Genomic DNA. Translation: ABY56498.1.
EU313699 Genomic DNA. Translation: ABY56499.1.
EU313700 Genomic DNA. Translation: ABY56500.1.
EU313701 Genomic DNA. Translation: ABY56501.1.
EU313702 Genomic DNA. Translation: ABY56502.1.
EU313703 Genomic DNA. Translation: ABY56503.1.
RefSeqiXP_002080644.1. XM_002080608.1.
UniGeneiDsi.3330.

Genome annotation databases

EnsemblMetazoaiFBtr0210505; FBpp0208997; FBgn0068645.
GeneIDi6733590.
KEGGidsi:Dsim_GD10595.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ556611 Genomic DNA. Translation: CAD89176.1 .
CM000362 Genomic DNA. Translation: EDX06229.1 .
DQ138765 Genomic DNA. Translation: ABA86371.1 .
DQ138766 Genomic DNA. Translation: ABA86372.1 .
EU313688 Genomic DNA. Translation: ABY56488.1 .
EU313689 Genomic DNA. Translation: ABY56489.1 .
EU313690 Genomic DNA. Translation: ABY56490.1 .
EU313691 Genomic DNA. Translation: ABY56491.1 .
EU313692 Genomic DNA. Translation: ABY56492.1 .
EU313693 Genomic DNA. Translation: ABY56493.1 .
EU313694 Genomic DNA. Translation: ABY56494.1 .
EU313695 Genomic DNA. Translation: ABY56495.1 .
EU313696 Genomic DNA. Translation: ABY56496.1 .
EU313697 Genomic DNA. Translation: ABY56497.1 .
EU313698 Genomic DNA. Translation: ABY56498.1 .
EU313699 Genomic DNA. Translation: ABY56499.1 .
EU313700 Genomic DNA. Translation: ABY56500.1 .
EU313701 Genomic DNA. Translation: ABY56501.1 .
EU313702 Genomic DNA. Translation: ABY56502.1 .
EU313703 Genomic DNA. Translation: ABY56503.1 .
RefSeqi XP_002080644.1. XM_002080608.1.
UniGenei Dsi.3330.

3D structure databases

ProteinModelPortali Q70PU1.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0210505 ; FBpp0208997 ; FBgn0068645 .
GeneIDi 6733590.
KEGGi dsi:Dsim_GD10595.

Organism-specific databases

FlyBasei FBgn0068645. Dsim\PGRP-SC2.

Phylogenomic databases

KOi K01446.
OrthoDBi EOG757CZ5.
PhylomeDBi Q70PU1.

Family and domain databases

Gene3Di 3.40.80.10. 1 hit.
InterProi IPR002502. Amidase_domain.
IPR017331. Peptidoglycan_recognition.
IPR015510. PGRP.
IPR006619. PGRP_domain_met/bac.
[Graphical view ]
PANTHERi PTHR11022. PTHR11022. 1 hit.
Pfami PF01510. Amidase_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF037945. PGRPs. 1 hit.
SMARTi SM00644. Ami_2. 1 hit.
SM00701. PGRP. 1 hit.
[Graphical view ]
SUPFAMi SSF55846. SSF55846. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The evolution of parasite recognition genes in the innate immune system: purifying selection on Drosophila melanogaster peptidoglycan recognition proteins."
    Jiggins F.M., Hurst G.D.D.
    J. Mol. Evol. 57:598-605(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C167.4.
  2. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Intragenic Hill-Robertson interference influences selection intensity on synonymous mutations in Drosophila."
    Comeron J.M., Guthrie T.B.
    Mol. Biol. Evol. 22:2519-2530(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 8-178.
    Strain: Ky-a and Ky-b.
  4. "A new test for selection applied to codon usage in Drosophila simulans and D. mauritiana."
    Llopart A., Mabille A., Peters-Hall J.R., Comeron J.M., Kliman R.M.
    J. Mol. Evol. 66:224-231(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 8-178, VARIANT VAL-12.
    Strain: 01FG, 02FG, 03FG, 04FG, 05FG, 06FG, 07FG, 08FG, 09FG, 10FG, 11FG, 12FG, 13FG, 14FG, 15FG and 16FG.

Entry informationi

Entry nameiPGSC2_DROSI
AccessioniPrimary (citable) accession number: Q70PU1
Secondary accession number(s): B2XZX6, B4QG79, Q2XY96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi