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Protein

Peptidoglycan-recognition protein SC2

Gene

PGRP-SC2

Organism
Drosophila simulans (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

N-acetylmuramyl-L-alanine amidase involved in innate immunity by degrading bacterial peptidoglycans (PGN). Probably plays a scavenger role by digesting biologically active PGN into biologically inactive fragments. Has no direct bacteriolytic activity (By similarity).By similarity

Catalytic activityi

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

Cofactori

Zn2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi51 – 511ZincBy similarity
Metal bindingi85 – 851ZincBy similarity
Metal bindingi159 – 1591ZincBy similarity
Metal bindingi167 – 1671ZincBy similarity

GO - Molecular functioni

  1. N-acetylmuramoyl-L-alanine amidase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. innate immune response Source: UniProtKB-KW
  2. peptidoglycan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Immunity, Innate immunity

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidoglycan-recognition protein SC2 (EC:3.5.1.28)
Gene namesi
Name:PGRP-SC2
ORF Names:GD10595
OrganismiDrosophila simulans (Fruit fly)
Taxonomic identifieri7240 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000304: Chromosome 2R, UP000000304: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0068645. Dsim\PGRP-SC2.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 184164Peptidoglycan-recognition protein SC2PRO_0000023913Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi57 ↔ 63By similarity

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliQ70PU1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

KOiK01446.
OrthoDBiEOG757CZ5.
PhylomeDBiQ70PU1.

Family and domain databases

Gene3Di3.40.80.10. 1 hit.
InterProiIPR002502. Amidase_domain.
IPR017331. Peptidoglycan_recognition.
IPR015510. PGRP.
IPR006619. PGRP_domain_met/bac.
[Graphical view]
PANTHERiPTHR11022. PTHR11022. 1 hit.
PfamiPF01510. Amidase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF037945. PGRPs. 1 hit.
SMARTiSM00644. Ami_2. 1 hit.
SM00701. PGRP. 1 hit.
[Graphical view]
SUPFAMiSSF55846. SSF55846. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q70PU1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MANKALILLA VLFCAQAVLG VTIVSKSEWG GRSATSKTSL ASYLSYAVIH
60 70 80 90 100
HTAGNYCSTK AACITQLKNI QAYHMDSLGW ADIGYNFLIG GDGNVYEGRG
110 120 130 140 150
WNVMGAHATN WNSKSIGISF LGNYNTNTLT SAQITAAKGL LSDAVSRGQI
160 170 180
VSGYILYGHR QVGSTECPGT NIWNEIRTWS NWKA
Length:184
Mass (Da):19,788
Last modified:July 5, 2004 - v1
Checksum:iBF4070F2313D53C5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti12 – 121L → V in strain: 08FG. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ556611 Genomic DNA. Translation: CAD89176.1.
CM000362 Genomic DNA. Translation: EDX06229.1.
DQ138765 Genomic DNA. Translation: ABA86371.1.
DQ138766 Genomic DNA. Translation: ABA86372.1.
EU313688 Genomic DNA. Translation: ABY56488.1.
EU313689 Genomic DNA. Translation: ABY56489.1.
EU313690 Genomic DNA. Translation: ABY56490.1.
EU313691 Genomic DNA. Translation: ABY56491.1.
EU313692 Genomic DNA. Translation: ABY56492.1.
EU313693 Genomic DNA. Translation: ABY56493.1.
EU313694 Genomic DNA. Translation: ABY56494.1.
EU313695 Genomic DNA. Translation: ABY56495.1.
EU313696 Genomic DNA. Translation: ABY56496.1.
EU313697 Genomic DNA. Translation: ABY56497.1.
EU313698 Genomic DNA. Translation: ABY56498.1.
EU313699 Genomic DNA. Translation: ABY56499.1.
EU313700 Genomic DNA. Translation: ABY56500.1.
EU313701 Genomic DNA. Translation: ABY56501.1.
EU313702 Genomic DNA. Translation: ABY56502.1.
EU313703 Genomic DNA. Translation: ABY56503.1.
RefSeqiXP_002080644.1. XM_002080608.1.
UniGeneiDsi.3330.

Genome annotation databases

EnsemblMetazoaiFBtr0210505; FBpp0208997; FBgn0068645.
GeneIDi6733590.
KEGGidsi:Dsim_GD10595.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ556611 Genomic DNA. Translation: CAD89176.1.
CM000362 Genomic DNA. Translation: EDX06229.1.
DQ138765 Genomic DNA. Translation: ABA86371.1.
DQ138766 Genomic DNA. Translation: ABA86372.1.
EU313688 Genomic DNA. Translation: ABY56488.1.
EU313689 Genomic DNA. Translation: ABY56489.1.
EU313690 Genomic DNA. Translation: ABY56490.1.
EU313691 Genomic DNA. Translation: ABY56491.1.
EU313692 Genomic DNA. Translation: ABY56492.1.
EU313693 Genomic DNA. Translation: ABY56493.1.
EU313694 Genomic DNA. Translation: ABY56494.1.
EU313695 Genomic DNA. Translation: ABY56495.1.
EU313696 Genomic DNA. Translation: ABY56496.1.
EU313697 Genomic DNA. Translation: ABY56497.1.
EU313698 Genomic DNA. Translation: ABY56498.1.
EU313699 Genomic DNA. Translation: ABY56499.1.
EU313700 Genomic DNA. Translation: ABY56500.1.
EU313701 Genomic DNA. Translation: ABY56501.1.
EU313702 Genomic DNA. Translation: ABY56502.1.
EU313703 Genomic DNA. Translation: ABY56503.1.
RefSeqiXP_002080644.1. XM_002080608.1.
UniGeneiDsi.3330.

3D structure databases

ProteinModelPortaliQ70PU1.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0210505; FBpp0208997; FBgn0068645.
GeneIDi6733590.
KEGGidsi:Dsim_GD10595.

Organism-specific databases

FlyBaseiFBgn0068645. Dsim\PGRP-SC2.

Phylogenomic databases

KOiK01446.
OrthoDBiEOG757CZ5.
PhylomeDBiQ70PU1.

Family and domain databases

Gene3Di3.40.80.10. 1 hit.
InterProiIPR002502. Amidase_domain.
IPR017331. Peptidoglycan_recognition.
IPR015510. PGRP.
IPR006619. PGRP_domain_met/bac.
[Graphical view]
PANTHERiPTHR11022. PTHR11022. 1 hit.
PfamiPF01510. Amidase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF037945. PGRPs. 1 hit.
SMARTiSM00644. Ami_2. 1 hit.
SM00701. PGRP. 1 hit.
[Graphical view]
SUPFAMiSSF55846. SSF55846. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The evolution of parasite recognition genes in the innate immune system: purifying selection on Drosophila melanogaster peptidoglycan recognition proteins."
    Jiggins F.M., Hurst G.D.D.
    J. Mol. Evol. 57:598-605(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C167.4.
  2. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Intragenic Hill-Robertson interference influences selection intensity on synonymous mutations in Drosophila."
    Comeron J.M., Guthrie T.B.
    Mol. Biol. Evol. 22:2519-2530(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 8-178.
    Strain: Ky-a and Ky-b.
  4. "A new test for selection applied to codon usage in Drosophila simulans and D. mauritiana."
    Llopart A., Mabille A., Peters-Hall J.R., Comeron J.M., Kliman R.M.
    J. Mol. Evol. 66:224-231(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 8-178, VARIANT VAL-12.
    Strain: 01FG, 02FG, 03FG, 04FG, 05FG, 06FG, 07FG, 08FG, 09FG, 10FG, 11FG, 12FG, 13FG, 14FG, 15FG and 16FG.

Entry informationi

Entry nameiPGSC2_DROSI
AccessioniPrimary (citable) accession number: Q70PU1
Secondary accession number(s): B2XZX6, B4QG79, Q2XY96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: July 5, 2004
Last modified: January 7, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.