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Q70PU1

- PGSC2_DROSI

UniProt

Q70PU1 - PGSC2_DROSI

Protein

Peptidoglycan-recognition protein SC2

Gene

PGRP-SC2

Organism
Drosophila simulans (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    N-acetylmuramyl-L-alanine amidase involved in innate immunity by degrading bacterial peptidoglycans (PGN). Probably plays a scavenger role by digesting biologically active PGN into biologically inactive fragments. Has no direct bacteriolytic activity By similarity.By similarity

    Catalytic activityi

    Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

    Cofactori

    Zinc.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi51 – 511ZincBy similarity
    Metal bindingi85 – 851ZincBy similarity
    Metal bindingi159 – 1591ZincBy similarity
    Metal bindingi167 – 1671ZincBy similarity

    GO - Molecular functioni

    1. N-acetylmuramoyl-L-alanine amidase activity Source: UniProtKB-EC
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. innate immune response Source: UniProtKB-KW
    2. peptidoglycan catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Immunity, Innate immunity

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptidoglycan-recognition protein SC2 (EC:3.5.1.28)
    Gene namesi
    Name:PGRP-SC2
    ORF Names:GD10595
    OrganismiDrosophila simulans (Fruit fly)
    Taxonomic identifieri7240 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000304: Chromosome 2R, UP000000304: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0068645. Dsim\PGRP-SC2.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 184164Peptidoglycan-recognition protein SC2PRO_0000023913Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi57 ↔ 63By similarity

    Keywords - PTMi

    Disulfide bond

    Structurei

    3D structure databases

    ProteinModelPortaliQ70PU1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    KOiK01446.
    OrthoDBiEOG757CZ5.
    PhylomeDBiQ70PU1.

    Family and domain databases

    Gene3Di3.40.80.10. 1 hit.
    InterProiIPR002502. Amidase_domain.
    IPR017331. Peptidoglycan_recognition.
    IPR015510. PGRP.
    IPR006619. PGRP_domain_met/bac.
    [Graphical view]
    PANTHERiPTHR11022. PTHR11022. 1 hit.
    PfamiPF01510. Amidase_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037945. PGRPs. 1 hit.
    SMARTiSM00644. Ami_2. 1 hit.
    SM00701. PGRP. 1 hit.
    [Graphical view]
    SUPFAMiSSF55846. SSF55846. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q70PU1-1 [UniParc]FASTAAdd to Basket

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    MANKALILLA VLFCAQAVLG VTIVSKSEWG GRSATSKTSL ASYLSYAVIH    50
    HTAGNYCSTK AACITQLKNI QAYHMDSLGW ADIGYNFLIG GDGNVYEGRG 100
    WNVMGAHATN WNSKSIGISF LGNYNTNTLT SAQITAAKGL LSDAVSRGQI 150
    VSGYILYGHR QVGSTECPGT NIWNEIRTWS NWKA 184
    Length:184
    Mass (Da):19,788
    Last modified:July 5, 2004 - v1
    Checksum:iBF4070F2313D53C5
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti12 – 121L → V in strain: 08FG. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ556611 Genomic DNA. Translation: CAD89176.1.
    CM000362 Genomic DNA. Translation: EDX06229.1.
    DQ138765 Genomic DNA. Translation: ABA86371.1.
    DQ138766 Genomic DNA. Translation: ABA86372.1.
    EU313688 Genomic DNA. Translation: ABY56488.1.
    EU313689 Genomic DNA. Translation: ABY56489.1.
    EU313690 Genomic DNA. Translation: ABY56490.1.
    EU313691 Genomic DNA. Translation: ABY56491.1.
    EU313692 Genomic DNA. Translation: ABY56492.1.
    EU313693 Genomic DNA. Translation: ABY56493.1.
    EU313694 Genomic DNA. Translation: ABY56494.1.
    EU313695 Genomic DNA. Translation: ABY56495.1.
    EU313696 Genomic DNA. Translation: ABY56496.1.
    EU313697 Genomic DNA. Translation: ABY56497.1.
    EU313698 Genomic DNA. Translation: ABY56498.1.
    EU313699 Genomic DNA. Translation: ABY56499.1.
    EU313700 Genomic DNA. Translation: ABY56500.1.
    EU313701 Genomic DNA. Translation: ABY56501.1.
    EU313702 Genomic DNA. Translation: ABY56502.1.
    EU313703 Genomic DNA. Translation: ABY56503.1.
    RefSeqiXP_002080644.1. XM_002080608.1.
    UniGeneiDsi.3330.

    Genome annotation databases

    EnsemblMetazoaiFBtr0210505; FBpp0208997; FBgn0068645.
    GeneIDi6733590.
    KEGGidsi:Dsim_GD10595.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ556611 Genomic DNA. Translation: CAD89176.1 .
    CM000362 Genomic DNA. Translation: EDX06229.1 .
    DQ138765 Genomic DNA. Translation: ABA86371.1 .
    DQ138766 Genomic DNA. Translation: ABA86372.1 .
    EU313688 Genomic DNA. Translation: ABY56488.1 .
    EU313689 Genomic DNA. Translation: ABY56489.1 .
    EU313690 Genomic DNA. Translation: ABY56490.1 .
    EU313691 Genomic DNA. Translation: ABY56491.1 .
    EU313692 Genomic DNA. Translation: ABY56492.1 .
    EU313693 Genomic DNA. Translation: ABY56493.1 .
    EU313694 Genomic DNA. Translation: ABY56494.1 .
    EU313695 Genomic DNA. Translation: ABY56495.1 .
    EU313696 Genomic DNA. Translation: ABY56496.1 .
    EU313697 Genomic DNA. Translation: ABY56497.1 .
    EU313698 Genomic DNA. Translation: ABY56498.1 .
    EU313699 Genomic DNA. Translation: ABY56499.1 .
    EU313700 Genomic DNA. Translation: ABY56500.1 .
    EU313701 Genomic DNA. Translation: ABY56501.1 .
    EU313702 Genomic DNA. Translation: ABY56502.1 .
    EU313703 Genomic DNA. Translation: ABY56503.1 .
    RefSeqi XP_002080644.1. XM_002080608.1.
    UniGenei Dsi.3330.

    3D structure databases

    ProteinModelPortali Q70PU1.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0210505 ; FBpp0208997 ; FBgn0068645 .
    GeneIDi 6733590.
    KEGGi dsi:Dsim_GD10595.

    Organism-specific databases

    FlyBasei FBgn0068645. Dsim\PGRP-SC2.

    Phylogenomic databases

    KOi K01446.
    OrthoDBi EOG757CZ5.
    PhylomeDBi Q70PU1.

    Family and domain databases

    Gene3Di 3.40.80.10. 1 hit.
    InterProi IPR002502. Amidase_domain.
    IPR017331. Peptidoglycan_recognition.
    IPR015510. PGRP.
    IPR006619. PGRP_domain_met/bac.
    [Graphical view ]
    PANTHERi PTHR11022. PTHR11022. 1 hit.
    Pfami PF01510. Amidase_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037945. PGRPs. 1 hit.
    SMARTi SM00644. Ami_2. 1 hit.
    SM00701. PGRP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55846. SSF55846. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The evolution of parasite recognition genes in the innate immune system: purifying selection on Drosophila melanogaster peptidoglycan recognition proteins."
      Jiggins F.M., Hurst G.D.D.
      J. Mol. Evol. 57:598-605(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: C167.4.
    2. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Intragenic Hill-Robertson interference influences selection intensity on synonymous mutations in Drosophila."
      Comeron J.M., Guthrie T.B.
      Mol. Biol. Evol. 22:2519-2530(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 8-178.
      Strain: Ky-a and Ky-b.
    4. "A new test for selection applied to codon usage in Drosophila simulans and D. mauritiana."
      Llopart A., Mabille A., Peters-Hall J.R., Comeron J.M., Kliman R.M.
      J. Mol. Evol. 66:224-231(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 8-178, VARIANT VAL-12.
      Strain: 01FG, 02FG, 03FG, 04FG, 05FG, 06FG, 07FG, 08FG, 09FG, 10FG, 11FG, 12FG, 13FG, 14FG, 15FG and 16FG.

    Entry informationi

    Entry nameiPGSC2_DROSI
    AccessioniPrimary (citable) accession number: Q70PU1
    Secondary accession number(s): B2XZX6, B4QG79, Q2XY96
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3