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Protein

Serine/threonine-protein kinase Smg1

Gene

nonC

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Serine/threonine protein kinase involved in mRNA surveillance. Recognizes the substrate consensus sequence [ST]-Q. Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons, probably by phosphorylating Upf1.2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mn2+By similarity

GO - Molecular functioni

GO - Biological processi

  • DNA repair Source: GO_Central
  • neuromuscular synaptic transmission Source: FlyBase
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: UniProtKB
  • peptidyl-serine phosphorylation Source: UniProtKB
  • phosphorylation Source: FlyBase
  • protein autophosphorylation Source: UniProtKB
  • response to stress Source: UniProtKB
  • synapse organization Source: FlyBase
  • synaptic vesicle transport Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Nonsense-mediated mRNA decay

Keywords - Ligandi

ATP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
SignaLinkiQ70PP2.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase Smg1 (EC:2.7.11.1)
Gene namesi
Name:nonC
Synonyms:Smg1
ORF Names:CG32743
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0263968. nonC.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 32183218Serine/threonine-protein kinase Smg1PRO_0000229795Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei70 – 701Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ70PP2.
PRIDEiQ70PP2.

PTM databases

iPTMnetiQ70PP2.

Expressioni

Gene expression databases

BgeeiQ70PP2.
GenevisibleiQ70PP2. DM.

Interactioni

Subunit structurei

Component of a post-splicing multiprotein NMD complex.By similarity

Protein-protein interaction databases

BioGridi58110. 2 interactions.
STRINGi7227.FBpp0070933.

Structurei

3D structure databases

ProteinModelPortaliQ70PP2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1117 – 1692576FATPROSITE-ProRule annotationAdd
BLAST
Repeati1643 – 167836HEATAdd
BLAST
Domaini1923 – 2247325PI3K/PI4KPROSITE-ProRule annotationAdd
BLAST
Domaini3186 – 321833FATCPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.Curated
Contains 1 FAT domain.PROSITE-ProRule annotation
Contains 1 FATC domain.PROSITE-ProRule annotation
Contains 1 HEAT repeat.Curated
Contains 1 PI3K/PI4K domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0891. Eukaryota.
COG5032. LUCA.
InParanoidiQ70PP2.
KOiK08873.
OMAiPWKVIIP.
OrthoDBiEOG7RV9F7.
PhylomeDBiQ70PP2.

Family and domain databases

Gene3Di1.10.1070.11. 2 hits.
InterProiIPR016024. ARM-type_fold.
IPR003152. FATC_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR014009. PIK_FAT.
IPR031559. SMG1.
[Graphical view]
PfamiPF02260. FATC. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
PF15785. SMG1. 1 hit.
[Graphical view]
SMARTiSM01343. FATC. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q70PP2-1) [UniParc]FASTAAdd to basket

Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKNAIHPENC NGAGTEEEAS SAFHAEIDRV LLNNNGNHGD SSNEGGGGNG
60 70 80 90 100
SGRGGATGSG NIAGLGGSES MWSPGGGKSH DVAQAFANAL LLRNMNHVVG
110 120 130 140 150
KGQPVVQNHR KAYQCKGDTI NPMANGEDLR LSKIIRRLIN ENNPTVSLEL
160 170 180 190 200
CSKLDQAVRT PINMGYMTCS FVWILDNMLT LYKQCPPPVL EECSKTLGLI
210 220 230 240 250
GFINRKSYPI YEEFIVKNYK SSKRMQKYMI MALRATLSCD TKCELHMYAD
260 270 280 290 300
KIMLLLKDFL ENAESADIFI VVSNTLVQFA ASYAETFECH FTDVVDIVIG
310 320 330 340 350
WQLEAGQPTD LKTHCAQVLE QLTPFFSKQI DFSYGLLDQF VEDITTLEEG
360 370 380 390 400
EPANTAERVG AFVGAFNTLL KCLARMQIFV GMPTCECIVK MAVDHLIKIM
410 420 430 440 450
PTLHLNTEAL VNINELICIC LLNNFTGLDP ILLEQVLLDQ VKRMISLTEL
460 470 480 490 500
QRQSVLYLLL CTVRRLRARL TPSLVHFIFQ SNPYMTKVRL RSPGETSYKL
510 520 530 540 550
LLRTCQETLL IRNVPLLQQA YKYLVDDIDA CLEKLLITAP RSKARKASVL
560 570 580 590 600
LVFHLSALAA LAKQTSSIIG MYACKPSILE LLLTNCRAHE LKFWSKYPAA
610 620 630 640 650
QQAIFGLLVV HCQANHNFRT NSSLLRDQEL SAENTSPTAN SFASILRFLD
660 670 680 690 700
SVLGQAHQLA PQNLRVLLQW IQMLLRECRE KIDLLMEQEN FRGICRNIAA
710 720 730 740 750
TASKLVPLES AACIQTVLDY GLERLEKYPK LLILYRDTAL QQLQMLSTNY
760 770 780 790 800
HAPYFQIYAQ LPLHLTLTGG ESSMPGMASR RVSVWQQRIS QYSAVRDNVF
810 820 830 840 850
RDFFDRVQKP EQDSLIHCLR ELFVRSCQVA PQDERQMNLS QCTKRCQRLA
860 870 880 890 900
IAWLQFEAAR YCVDQRLRTT VGKPQETFLG FEAIIMRHAR LLSGCAKEIE
910 920 930 940 950
RSALDDLSLE ELLSMQSNLS LLLGFLDALE KLIYNAAEGS AFALRPPEKQ
960 970 980 990 1000
VAAFFRLNNP TCQSWFNRIR IGVVIIAMHV QQPELVIRYA QQILVNSKTQ
1010 1020 1030 1040 1050
DPTYSQAIVY MAWSLVSCQE ADSLRGLRLW ARGKSCKSYK WLKYAADQAA
1060 1070 1080 1090 1100
GKRESALAGY RTILAEKELQ SELEPHTRQF VVSQMMQCLQ DLGQWSQLVE
1110 1120 1130 1140 1150
LKQQQMTRPE DRELNPFLQR SNVEVNALER LLAKSEESCS SMDALGGVFQ
1160 1170 1180 1190 1200
QLSLWPSNWD ESVSSSGLSE RASFSSIHMR QRTEDIVLHK LLEDRCVPDQ
1210 1220 1230 1240 1250
AKNLLDTQWR DSLLNPSFDQ RSCKELTLLR HIVQGVSGGQ ELSLLPVSSG
1260 1270 1280 1290 1300
RCQNRSKFIS SAILMRCLAW TQLLRQHCAP GSWETLCLDA AAAAREEGNL
1310 1320 1330 1340 1350
QLAETLLTQF FGQPIGEIAA LFSLEQGVQT DNPEMLRGYS ELVKCLHLQQ
1360 1370 1380 1390 1400
QQSQTHSGDL SSSIDVCAAL CLNIQKSNNQ PAAGADLLLN LADWIAVRTC
1410 1420 1430 1440 1450
NGLTTNQSPV LIQLLDQLPE CPLTCDSSQP LAIPQAERMV ARLVHSCLQQ
1460 1470 1480 1490 1500
RPNYAEALIA YGNWCYRWGK KVADSCCVLT QADATAISQA LDIPQPLESE
1510 1520 1530 1540 1550
KLDELLQALS TEQPPANCVE VCPDAARARD DEAAKNRLRR LTFLADKTPE
1560 1570 1580 1590 1600
ALDAILQIWR RAIANTYDYY KDAARSYFQY LSFKSGSGPE KPEGEGVVSQ
1610 1620 1630 1640 1650
RERLHVDDSN LVTTTLRLLR LIVKHASGLQ EVLEQGLHTT PIAPWKVIIP
1660 1670 1680 1690 1700
QLFSRLNHHE PYVRKSVCDL LCRLAKSRPQ LVIFPAVVGA NREQQDATAP
1710 1720 1730 1740 1750
PATARPTTED ACCYGYLLGE LSKQAPEAVQ HVKLMVKELR RVCLLWDEYW
1760 1770 1780 1790 1800
IHSLAHIYNT YVSRVSALAT DFRPDDHEGK NNRFNVWRPQ LLADLEALVA
1810 1820 1830 1840 1850
VTSRPPETTY ERSFRKRFDA PIRLTVDALR HRRYPEAWDK LKQLYHILQS
1860 1870 1880 1890 1900
NMIRGSGSTL KMQSISPVLC GIGRMRISMP GLDAHGPDGD QVYIESVESS
1910 1920 1930 1940 1950
VCVLPTKTKP KKVAFYGSNG QRYTFLFKGM EDLHLDERIM QFLSISNAIM
1960 1970 1980 1990 2000
ACRSDAPGNG CYRAHHYSVI PLGPQSGLIS WVDGVTPVFA LYKKWQQRRS
2010 2020 2030 2040 2050
QVAGNAGAGA VANVPRRFTD LFYNKLSPLL AKHNMQVSDP RRQWPISVLL
2060 2070 2080 2090 2100
QVLDELSQET PNDLLARELW CQAGNAAEWR QSVRRFVRCM SVMSMIGYVI
2110 2120 2130 2140 2150
GLGDRHLDNV LINLGSGDIV HIDYNVCFEK GRTLRIPEKV PFRLTQNLVQ
2160 2170 2180 2190 2200
AMGITGIEGP FRLGCEYVLK VMRKERETLL TLLEAFVYDP LVDWTTNDDA
2210 2220 2230 2240 2250
QALRRSLNAK LQESADGGGA GGLGVGDLKY HKKDKNKGKP LDSDVKRQPF
2260 2270 2280 2290 2300
LSKLGMLQKY WSTNKTELMP QLEEMEQEVG NLQAAQAKQV VAEEELVKLN
2310 2320 2330 2340 2350
QRSALIAEIK SLGTAIESHS FNTASLRNAV RRGHSEALAL LSTERLPDFG
2360 2370 2380 2390 2400
RVQCILRSYG QCLQLYHLLD LQGQLVKLQM ESNSENAREF SALTEALQLS
2410 2420 2430 2440 2450
GLDSMRSQLN ELLGRMDMVA QKSSKHLQEY AGVMNFYPEQ SHRQNLFVRF
2460 2470 2480 2490 2500
HDSFATYIQN GYTADSTTNT NSPSSSIICK ADVVGVAEAM EYSWERLGCQ
2510 2520 2530 2540 2550
LHEASKLYAA NQAQALTLGA PTTALLSMIV QSGCSQLLLK ASLVRTLDRA
2560 2570 2580 2590 2600
GGAFAAYEQV ALASHDDGLL HHQLLFIHLV RTMLQGVLVM TKEEDQHLAQ
2610 2620 2630 2640 2650
LESLLSALSH LKKMFEYDLP ANLYRLLLLQ PNLGKLSALC HLSASSLAQL
2660 2670 2680 2690 2700
FLEATMENGH KPPDQFPVER RFLLTLQPVY DQFLLASTSL DSLVSSMQSM
2710 2720 2730 2740 2750
LEDVHDVQTQ QIMELGLMRS CHTELNDECF FGLVSEALES SRTCDVREMA
2760 2770 2780 2790 2800
RPMLGFIHRL QVEKLAGLLP ILTRNFYTAV GPQCLPTASC GDPAQADHLC
2810 2820 2830 2840 2850
ESLFISLQSD GALLQQQAEI ALLSQQVDLH TLAASAQYWA YSEALGSQLR
2860 2870 2880 2890 2900
CGPHIVSRPK LTAAIGECWL ELDQKLTALQ QLQAGLESQL SQLQTQRSNW
2910 2920 2930 2940 2950
NRNHIDNLLR MEQCNKQRTM SHVALLQKMT DGAGAVARLE QNAIVVGEEG
2960 2970 2980 2990 3000
QALVDHLEQW LAAHGQWQAS SSRISAVEQS MVELLDPEGA IDHYWLENVQ
3010 3020 3030 3040 3050
GLLEEQTCKV HREIAAIEGE QQSKHRFICT LLKETLRLLE NMPRFHVQSL
3060 3070 3080 3090 3100
CSEAQAQGQG KMEYANVQLL SDHLREGQGL MQSLYMRLQE LRKDICSDRR
3110 3120 3130 3140 3150
VLQPSMLQNW RHQLEMILTL AKQEVNEFFK GLEDFMQHAG ETDSYEIFTH
3160 3170 3180 3190 3200
AKGSGNVHEQ KRNAYGVSVW KKIRMKLEGR DPDSNQRSTV AEQVDYVIRE
3210
ACNPENLAVL YEGWTPWV
Note: No experimental confirmation available.
Length:3,218
Mass (Da):361,587
Last modified:April 4, 2006 - v2
Checksum:iBE6ADBB9A38DA3CA
GO
Isoform 2 (identifier: Q70PP2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2159-2162: GPFR → KRCS
     2163-3218: Missing.

Show »
Length:2,162
Mass (Da):243,091
Checksum:i7EDEDAA2BDAE787A
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei2159 – 21624GPFR → KRCS in isoform 2. 1 PublicationVSP_017754
Alternative sequencei2163 – 32181056Missing in isoform 2. 1 PublicationVSP_017755Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ556818 mRNA. Translation: CAD89223.1.
AE014298 Genomic DNA. Translation: AAF46207.2.
BT011117 mRNA. Translation: AAR82784.1.
RefSeqiNP_001284967.1. NM_001298038.1. [Q70PP2-1]
NP_727132.1. NM_167095.3. [Q70PP2-1]

Genome annotation databases

EnsemblMetazoaiFBtr0070972; FBpp0070933; FBgn0263968. [Q70PP2-1]
FBtr0343321; FBpp0309979; FBgn0263968. [Q70PP2-1]
GeneIDi31625.
KEGGidme:Dmel_CG32743.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ556818 mRNA. Translation: CAD89223.1.
AE014298 Genomic DNA. Translation: AAF46207.2.
BT011117 mRNA. Translation: AAR82784.1.
RefSeqiNP_001284967.1. NM_001298038.1. [Q70PP2-1]
NP_727132.1. NM_167095.3. [Q70PP2-1]

3D structure databases

ProteinModelPortaliQ70PP2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi58110. 2 interactions.
STRINGi7227.FBpp0070933.

PTM databases

iPTMnetiQ70PP2.

Proteomic databases

PaxDbiQ70PP2.
PRIDEiQ70PP2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0070972; FBpp0070933; FBgn0263968. [Q70PP2-1]
FBtr0343321; FBpp0309979; FBgn0263968. [Q70PP2-1]
GeneIDi31625.
KEGGidme:Dmel_CG32743.

Organism-specific databases

CTDi31625.
FlyBaseiFBgn0263968. nonC.

Phylogenomic databases

eggNOGiKOG0891. Eukaryota.
COG5032. LUCA.
InParanoidiQ70PP2.
KOiK08873.
OMAiPWKVIIP.
OrthoDBiEOG7RV9F7.
PhylomeDBiQ70PP2.

Enzyme and pathway databases

ReactomeiR-DME-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
SignaLinkiQ70PP2.

Miscellaneous databases

GenomeRNAii31625.
PROiQ70PP2.

Gene expression databases

BgeeiQ70PP2.
GenevisibleiQ70PP2. DM.

Family and domain databases

Gene3Di1.10.1070.11. 2 hits.
InterProiIPR016024. ARM-type_fold.
IPR003152. FATC_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR014009. PIK_FAT.
IPR031559. SMG1.
[Graphical view]
PfamiPF02260. FATC. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
PF15785. SMG1. 1 hit.
[Graphical view]
SMARTiSM01343. FATC. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nonsense-mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathways."
    Gatfield D., Ciccarelli F.D., Bork P., Izaurralde E.
    EMBO J. 22:3960-3970(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
    Strain: Berkeley.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2062-3218 (ISOFORM 1).
    Strain: Berkeley.
    Tissue: Embryo.
  5. "Smg1 nonsense mutations do not abolish nonsense-mediated mRNA decay in Drosophila melanogaster."
    Chen Z., Smith K.R., Batterham P., Robin C.
    Genetics 171:403-406(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE LACK OF INVOLVEMENT IN NONSENSE-MEDIATED MRNA DECAY.
  6. "Nonsense-mediated mRNA decay factors act in concert to regulate common mRNA targets."
    Rehwinkel J., Letunic I., Raes J., Bork P., Izaurralde E.
    RNA 11:1530-1544(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Phosphoproteome analysis of Drosophila melanogaster embryos."
    Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
    J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-70, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryo.

Entry informationi

Entry nameiSMG1_DROME
AccessioniPrimary (citable) accession number: Q70PP2
Secondary accession number(s): Q6NP14, Q9W3V6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: July 6, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Caution

According to some authors (PubMed:15965240) it may not be directly involved in NMD, as mutants do not abolish NMD. However, other data clearly show its involvement in NMD (PubMed:12881430 and PubMed:16199763).1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.