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Protein

Forkhead box protein O6

Gene

Foxo6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional activator.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi88 – 182Fork-headPROSITE-ProRule annotationAdd BLAST95

GO - Molecular functioni

GO - Biological processi

  • memory Source: ParkinsonsUK-UCL
  • positive regulation of dendritic spine development Source: ParkinsonsUK-UCL
  • regulation of transcription from RNA polymerase II promoter Source: ParkinsonsUK-UCL
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein O6
Gene namesi
Name:Foxo6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2676586. Foxo6.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Nucleus PROSITE-ProRule annotation1 Publication

  • Note: When phosphorylated, translocated from nucleus to cytoplasm. High nuclear localization after stimulation with growth factors.

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleus Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi26T → A: No IGF1-induced increase in cytoplasmic localization. 1 Publication1
Mutagenesisi184S → A: No IGF1-induced increase in cytoplasmic localization. Increased transactivation activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003174141 – 559Forkhead box protein O6Add BLAST559

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei184Phosphoserine1 Publication1

Post-translational modificationi

Phosphorylation of Ser-184 is be important in regulating the transacriptional activity.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ70KY4.
PaxDbiQ70KY4.
PRIDEiQ70KY4.

PTM databases

iPTMnetiQ70KY4.
PhosphoSitePlusiQ70KY4.

Expressioni

Tissue specificityi

Expressed in brain in areas of the nucleus accumbens, cingulate cortex, parts of the amygdala and in the hippocampus.1 Publication

Developmental stagei

Expressed in developing brain in a specific temporal and spatial pattern.1 Publication

Gene expression databases

BgeeiENSMUSG00000052135.
CleanExiMM_FOXO6.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099716.

Structurei

3D structure databases

ProteinModelPortaliQ70KY4.
SMRiQ70KY4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi305 – 362Gly-richAdd BLAST58
Compositional biasi383 – 490Ala-richAdd BLAST108
Compositional biasi386 – 501Pro-richAdd BLAST116
Compositional biasi540 – 544Poly-Pro5

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2294. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00790000123003.
HOGENOMiHOG000251635.
HOVERGENiHBG057789.
InParanoidiQ70KY4.
KOiK17847.
OMAiQPAMSLM.
OrthoDBiEOG091G06K3.
TreeFamiTF315583.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR032067. FOXO-TAD.
IPR032068. FOXO_KIX-bd.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
PF16676. FOXO-TAD. 1 hit.
PF16675. FOXO_KIX_bdg. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q70KY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAKLRAHQV DVDPDFAPQS RPRSCTWPLP QPDLAGDEDG ALGAGVAEGS
60 70 80 90 100
EDCGPERRAT APAMAPAPPL GAEVGPLRKA KSSRRNAWGN LSYADLITKA
110 120 130 140 150
IESAPDKRLT LSQIYDWMVR YVPYFKDKGD SNSSAGWKNS IRHNLSLHTR
160 170 180 190 200
FIRVQNEGTG KSSWWMLNPE GGKTGKTPRR RAVSMDNGAK FLRIKGKASK
210 220 230 240 250
KKQLHLPERS PDDSPPGAPV PGPLSASAKW AASPASHASD DYEAWADFRG
260 270 280 290 300
SRRPLLGEAA ELEDDEALEA LAPSSPLMYP SPASALSPAL GARCPGELPR
310 320 330 340 350
LAELGGPLGL HGGGVAGLPD ALLDGAQDAY GPRARAGTPS YFGSCKASAY
360 370 380 390 400
GGGGGFGPPA LGSLRRLPMQ TIQENKQASF VQAAAPFRPG ALPALLPPPP
410 420 430 440 450
PAPRPGPLLG APGELALAGA AAAYPGKGAA PYAPPAPSRS ALAHPISLMT
460 470 480 490 500
LPGEAGAAGL APPAHAAAFG GPPGGLLLDA LPGPYAAAAA GPLGAGPDRF
510 520 530 540 550
PADLDLDMFS GSLECDVESI ILNDFMDSDE MDFNFDSALP PPPPGLAGAP

PPNQSWVPG
Length:559
Mass (Da):57,595
Last modified:July 5, 2004 - v1
Checksum:iA6FD814864572215
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ571690 mRNA. Translation: CAE00176.1.
AL626767 Genomic DNA. Translation: CAM23894.1.
CCDSiCCDS18588.1.
RefSeqiNP_918949.1. NM_194060.1.
UniGeneiMm.277090.

Genome annotation databases

EnsembliENSMUST00000102656; ENSMUSP00000099716; ENSMUSG00000052135.
GeneIDi329934.
KEGGimmu:329934.
UCSCiuc008unc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ571690 mRNA. Translation: CAE00176.1.
AL626767 Genomic DNA. Translation: CAM23894.1.
CCDSiCCDS18588.1.
RefSeqiNP_918949.1. NM_194060.1.
UniGeneiMm.277090.

3D structure databases

ProteinModelPortaliQ70KY4.
SMRiQ70KY4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099716.

PTM databases

iPTMnetiQ70KY4.
PhosphoSitePlusiQ70KY4.

Proteomic databases

MaxQBiQ70KY4.
PaxDbiQ70KY4.
PRIDEiQ70KY4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102656; ENSMUSP00000099716; ENSMUSG00000052135.
GeneIDi329934.
KEGGimmu:329934.
UCSCiuc008unc.1. mouse.

Organism-specific databases

CTDi100132074.
MGIiMGI:2676586. Foxo6.

Phylogenomic databases

eggNOGiKOG2294. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00790000123003.
HOGENOMiHOG000251635.
HOVERGENiHBG057789.
InParanoidiQ70KY4.
KOiK17847.
OMAiQPAMSLM.
OrthoDBiEOG091G06K3.
TreeFamiTF315583.

Miscellaneous databases

ChiTaRSiFoxo6. mouse.
PROiQ70KY4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000052135.
CleanExiMM_FOXO6.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR032067. FOXO-TAD.
IPR032068. FOXO_KIX-bd.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
PF16676. FOXO-TAD. 1 hit.
PF16675. FOXO_KIX_bdg. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFOXO6_MOUSE
AccessioniPrimary (citable) accession number: Q70KY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.