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Protein

Forkhead box protein O6

Gene

Foxo6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional activator.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi88 – 182Fork-headPROSITE-ProRule annotationAdd BLAST95

GO - Molecular functioni

GO - Biological processi

  • anatomical structure morphogenesis Source: GO_Central
  • memory Source: ParkinsonsUK-UCL
  • positive regulation of dendritic spine development Source: ParkinsonsUK-UCL
  • regulation of transcription by RNA polymerase II Source: ParkinsonsUK-UCL
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein O6
Gene namesi
Name:Foxo6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2676586 Foxo6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi26T → A: No IGF1-induced increase in cytoplasmic localization. 1 Publication1
Mutagenesisi184S → A: No IGF1-induced increase in cytoplasmic localization. Increased transactivation activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003174141 – 559Forkhead box protein O6Add BLAST559

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei184Phosphoserine1 Publication1

Post-translational modificationi

Phosphorylation of Ser-184 is be important in regulating the transacriptional activity.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ70KY4
PaxDbiQ70KY4
PRIDEiQ70KY4

PTM databases

iPTMnetiQ70KY4
PhosphoSitePlusiQ70KY4

Expressioni

Tissue specificityi

Expressed in brain in areas of the nucleus accumbens, cingulate cortex, parts of the amygdala and in the hippocampus.1 Publication

Developmental stagei

Expressed in developing brain in a specific temporal and spatial pattern.1 Publication

Gene expression databases

BgeeiENSMUSG00000052135
CleanExiMM_FOXO6

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099716

Structurei

3D structure databases

ProteinModelPortaliQ70KY4
SMRiQ70KY4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi305 – 362Gly-richAdd BLAST58
Compositional biasi383 – 490Ala-richAdd BLAST108
Compositional biasi386 – 501Pro-richAdd BLAST116
Compositional biasi540 – 544Poly-Pro5

Phylogenomic databases

eggNOGiKOG2294 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00910000144016
HOGENOMiHOG000251635
HOVERGENiHBG057789
InParanoidiQ70KY4
KOiK17847
OMAiDGEFDAW
OrthoDBiEOG091G06K3
TreeFamiTF315583

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR032067 FOXO-TAD
IPR032068 FOXO_KIX-bd
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PF16676 FOXO-TAD, 1 hit
PF16675 FOXO_KIX_bdg, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q70KY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAKLRAHQV DVDPDFAPQS RPRSCTWPLP QPDLAGDEDG ALGAGVAEGS
60 70 80 90 100
EDCGPERRAT APAMAPAPPL GAEVGPLRKA KSSRRNAWGN LSYADLITKA
110 120 130 140 150
IESAPDKRLT LSQIYDWMVR YVPYFKDKGD SNSSAGWKNS IRHNLSLHTR
160 170 180 190 200
FIRVQNEGTG KSSWWMLNPE GGKTGKTPRR RAVSMDNGAK FLRIKGKASK
210 220 230 240 250
KKQLHLPERS PDDSPPGAPV PGPLSASAKW AASPASHASD DYEAWADFRG
260 270 280 290 300
SRRPLLGEAA ELEDDEALEA LAPSSPLMYP SPASALSPAL GARCPGELPR
310 320 330 340 350
LAELGGPLGL HGGGVAGLPD ALLDGAQDAY GPRARAGTPS YFGSCKASAY
360 370 380 390 400
GGGGGFGPPA LGSLRRLPMQ TIQENKQASF VQAAAPFRPG ALPALLPPPP
410 420 430 440 450
PAPRPGPLLG APGELALAGA AAAYPGKGAA PYAPPAPSRS ALAHPISLMT
460 470 480 490 500
LPGEAGAAGL APPAHAAAFG GPPGGLLLDA LPGPYAAAAA GPLGAGPDRF
510 520 530 540 550
PADLDLDMFS GSLECDVESI ILNDFMDSDE MDFNFDSALP PPPPGLAGAP

PPNQSWVPG
Length:559
Mass (Da):57,595
Last modified:July 5, 2004 - v1
Checksum:iA6FD814864572215
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ571690 mRNA Translation: CAE00176.1
AL626767 Genomic DNA No translation available.
CCDSiCCDS18588.1
RefSeqiNP_918949.1, NM_194060.1
UniGeneiMm.277090

Genome annotation databases

EnsembliENSMUST00000102656; ENSMUSP00000099716; ENSMUSG00000052135
GeneIDi329934
KEGGimmu:329934
UCSCiuc008unc.1 mouse

Similar proteinsi

Entry informationi

Entry nameiFOXO6_MOUSE
AccessioniPrimary (citable) accession number: Q70KY4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health