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Protein

Hemagglutinin-esterase

Gene

HE

Organism
Bovine torovirus
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Structural protein that makes short spikes at the surface of the virus. Contains receptor binding and receptor-destroying activities. Mediates de-O-acetylation of N-acetyl-9-di-O-acetylneuraminic acid, which is probably the receptor determinant recognized by the virus on the surface of erythrocytes and susceptible cells. Also hydrolyzes 5-N-acetyl-4-O-acetylneuraminic acid and N-acetyl-9-O-acetylneuraminic acid, but displays a substrate preference for N-acetyl-9-di-O-acetylneuraminic acid. This receptor-destroying activity is important for virus release as it probably helps preventing self-aggregation and ensures the efficient spread of the progeny virus from cell to cell. May serve as a secondary viral attachment protein for initiating infection, the spike protein being the major one. Seems to be a 'luxury' protein that is not absolutely necessary for virus infection in culture. However, its presence in the virus may alter its pathogenicity. May become a target for both the humoral and the cellular branches of the immune system.UniRule annotation

Catalytic activityi

N-acetyl-O-acetylneuraminate + H2O = N-acetylneuraminate + acetate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHemagglutininUniRule annotation, HydrolaseUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Hemagglutinin-esteraseUniRule annotation (EC:3.1.1.53UniRule annotation)
Short name:
HE proteinUniRule annotation
Alternative name(s):
E3 glycoproteinUniRule annotation
Gene namesi
Name:HEUniRule annotationImported
OrganismiBovine torovirusImported
Taxonomic identifieri74501 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageNidoviralesCoronaviridaeTorovirinaeTorovirus

Subcellular locationi

  • Virion membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation
  • Host cell membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation
  • Note: In infected cells becomes incorporated into the envelope of virions during virus assembly at the endoplasmic reticulum and cis Golgi. However, some may escape incorporation into virions and subsequently migrate to the cell surface.UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei391 – 415HelicalUniRule annotationAdd BLAST25

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membraneUniRule annotation, Host membrane, Membrane, Viral envelope proteinUniRule annotation, Virion

Structurei

3D structure databases

ProteinModelPortaliQ70KM6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 376Hema_esteraseInterPro annotationAdd BLAST374
Domaini122 – 259Hema_HEFGInterPro annotationAdd BLAST138

Sequence similaritiesi

Belongs to the influenza type C/coronaviruses hemagglutinin-esterase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Family and domain databases

InterProiView protein in InterPro
IPR008980 Capsid_hemagglutn
IPR007142 Hemagglutn-estrase_core
IPR003860 Hemagglutn-estrase_hemagglutn
PfamiView protein in Pfam
PF03996 Hema_esterase, 1 hit
PF02710 Hema_HEFG, 1 hit
SUPFAMiSSF49818 SSF49818, 1 hit

Sequencei

Sequence statusi: Complete.

Q70KM6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSLIFFFPS FAFSATPVTP YYGPGHITSD WCGFGDSRSD CNNPYFPSSL
60 70 80 90 100
DIPQQLCSKF SSKSSSSMFI SLHWNNSVDF VAYNYSNCGV EKVFYEGVNF
110 120 130 140 150
SPHRQYSCYH EGTEGWVENK IRFYTQLYKM ASTSRCIKLI DLESPSDWPS
160 170 180 190 200
NRLGHCLSGR RIPDNPKLLV LNSNIPTFVQ FQLPSVSGDV RCDKHLVPFC
210 220 230 240 250
YLDHGCFTAD RYCHPFGGFY ESSSFYFGYY DNNKYSGSEF HNFVCKYLLM
260 270 280 290 300
EPGVYNASTA GKFLVFPTKS YCMDTINFTV PVQAVQSIWS QNRLSDDAIG
310 320 330 340 350
LACKAPYCIF FNKTHPYLAP NGSDENHGDD EVRTMMQGLL VNSSCVSPQG
360 370 380 390 400
STPLALYSSQ MIYSPNYGSC PQYYKLFETS SDENVDVISS AYFVATWVLL
410
VLVIILIFIL ISFCLSSY
Length:418
Mass (Da):47,274
Last modified:July 5, 2004 - v1
Checksum:i84C4F4CCA1E48BFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ575381 Genomic RNA Translation: CAE01347.1

Similar proteinsi

Entry informationi

Entry nameiQ70KM6_9NIDO
AccessioniPrimary (citable) accession number: Q70KM6
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: June 20, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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