Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q70KF8 (SDHB_UROFA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

EC=1.3.5.1
Alternative name(s):
Iron-sulfur subunit of complex II
Short name=Ip
Gene names
Name:SDH2
Synonyms:sucDH1
OrganismUromyces fabae (Rust fungus)
Taxonomic identifier55588 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaBasidiomycotaPucciniomycotinaPucciniomycetesPuccinialesPucciniaceaeUromyces

Protein attributes

Sequence length283 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) By similarity.

Catalytic activity

Succinate + a quinone = fumarate + a quinol.

Cofactor

Binds 1 2Fe-2S cluster By similarity.

Binds 1 3Fe-4S cluster By similarity.

Binds 1 4Fe-4S cluster By similarity.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.

Subunit structure

Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit By similarity.

Subcellular location

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side By similarity.

Sequence similarities

Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

Contains 1 2Fe-2S ferredoxin-type domain.

Contains 1 4Fe-4S ferredoxin-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion
Chain? – 283Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialPRO_0000010351

Regions

Domain66 – 145802Fe-2S ferredoxin-type
Domain186 – 216314Fe-4S ferredoxin-type

Sites

Metal binding1051Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding1101Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding1131Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding1251Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding1961Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1991Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding2021Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding2061Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2531Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2591Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2631Iron-sulfur 2 (4Fe-4S) By similarity
Binding site2111Ubiquinone; shared with DHSD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q70KF8 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 058945BABE06185F

FASTA28332,104
        10         20         30         40         50         60 
MINIPNSIRP FIRSANRTPC YLRSISSSSS SSFATPAEEH AGKQPSSAVP VKEFSIYRWN 

        70         80         90        100        110        120 
PDEPSKKPTL QTYSIDLKKC GPMVLDALIK IKNELDPTLT FRRSCREGIC GSCAMNIDGV 

       130        140        150        160        170        180 
NTLACLKRIN KETSAPVKIY PLPHMYIIKD LVPDMTHFYK QYKSIEPFLK NDNPPAQGEF 

       190        200        210        220        230        240 
LQSPEDRKKL DGMYECILCA CCSTSCPSYW WNQDEYLGPA VLMQAYRWMA DSRDSYGEDR 

       250        260        270        280 
KEKLQNTLSL YRCHTIFNCT KTCPKGLNPA KAISHIKREM ASA 

« Hide

References

[1]"Prelude to transformation: characterization of the beta-tubulin and succinate dehydrogenase genes from the rust fungus Uromyces fabae."
Wirsel S.G.R., Voegele R.T., Baenninger R., Hahn M., Mendgen K.W.
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ575686 Genomic DNA. Translation: CAE02642.1.

3D structure databases

ProteinModelPortalQ70KF8.
SMRQ70KF8. Positions 51-282.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00223; UER01006.

Family and domain databases

Gene3D3.10.20.30. 1 hit.
InterProIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamPF13085. Fer2_3. 1 hit.
[Graphical view]
SUPFAMSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsTIGR00384. dhsB. 1 hit.
PROSITEPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSDHB_UROFA
AccessionPrimary (citable) accession number: Q70KF8
Entry history
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways