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Q70KF8

- SDHB_UROFA

UniProt

Q70KF8 - SDHB_UROFA

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Protein

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Gene

SDH2

Organism
Uromyces fabae (Rust fungus)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

Binds 1 2Fe-2S cluster.By similarity
Binds 1 3Fe-4S cluster.By similarity
Binds 1 4Fe-4S cluster.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi105 – 1051Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi110 – 1101Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi113 – 1131Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi125 – 1251Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi196 – 1961Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi199 – 1991Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi202 – 2021Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi206 – 2061Iron-sulfur 3 (3Fe-4S)By similarity
Binding sitei211 – 2111Ubiquinone; shared with DHSDBy similarity
Metal bindingi253 – 2531Iron-sulfur 3 (3Fe-4S)By similarity
Metal bindingi259 – 2591Iron-sulfur 3 (3Fe-4S)By similarity
Metal bindingi263 – 2631Iron-sulfur 2 (4Fe-4S)By similarity

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
  2. 3 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  3. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  4. electron carrier activity Source: InterPro
  5. metal ion binding Source: UniProtKB-KW
  6. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

GO - Biological processi

  1. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport, Tricarboxylic acid cycle

Keywords - Ligandi

2Fe-2S, 3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC:1.3.5.1)
Alternative name(s):
Iron-sulfur subunit of complex II
Short name:
Ip
Gene namesi
Name:SDH2
Synonyms:sucDH1
OrganismiUromyces fabae (Rust fungus)
Taxonomic identifieri55588 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaPucciniomycotinaPucciniomycetesPuccinialesPucciniaceaeUromyces

Subcellular locationi

Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity; Matrix side By similarity

GO - Cellular componenti

  1. mitochondrial inner membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 283Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialPRO_0000010351
Transit peptidei1 – ?Mitochondrion

Interactioni

Subunit structurei

Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ70KF8.
SMRiQ70KF8. Positions 51-282.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini66 – 145802Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd
BLAST
Domaini186 – 216314Fe-4S ferredoxin-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 2Fe-2S ferredoxin-type domain.PROSITE-ProRule annotation
Contains 1 4Fe-4S ferredoxin-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamiPF13085. Fer2_3. 1 hit.
[Graphical view]
SUPFAMiSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR00384. dhsB. 1 hit.
PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q70KF8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MINIPNSIRP FIRSANRTPC YLRSISSSSS SSFATPAEEH AGKQPSSAVP
60 70 80 90 100
VKEFSIYRWN PDEPSKKPTL QTYSIDLKKC GPMVLDALIK IKNELDPTLT
110 120 130 140 150
FRRSCREGIC GSCAMNIDGV NTLACLKRIN KETSAPVKIY PLPHMYIIKD
160 170 180 190 200
LVPDMTHFYK QYKSIEPFLK NDNPPAQGEF LQSPEDRKKL DGMYECILCA
210 220 230 240 250
CCSTSCPSYW WNQDEYLGPA VLMQAYRWMA DSRDSYGEDR KEKLQNTLSL
260 270 280
YRCHTIFNCT KTCPKGLNPA KAISHIKREM ASA
Length:283
Mass (Da):32,104
Last modified:July 5, 2004 - v1
Checksum:i058945BABE06185F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ575686 Genomic DNA. Translation: CAE02642.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ575686 Genomic DNA. Translation: CAE02642.1 .

3D structure databases

ProteinModelPortali Q70KF8.
SMRi Q70KF8. Positions 51-282.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER01006 .

Family and domain databases

Gene3Di 3.10.20.30. 1 hit.
InterProi IPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view ]
Pfami PF13085. Fer2_3. 1 hit.
[Graphical view ]
SUPFAMi SSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsi TIGR00384. dhsB. 1 hit.
PROSITEi PS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Prelude to transformation: characterization of the beta-tubulin and succinate dehydrogenase genes from the rust fungus Uromyces fabae."
    Wirsel S.G.R., Voegele R.T., Baenninger R., Hahn M., Mendgen K.W.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiSDHB_UROFA
AccessioniPrimary (citable) accession number: Q70KF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3