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Protein

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Gene

SDH2

Organism
Uromyces fabae (Rust fungus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

Protein has several cofactor binding sites:

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (SDH2)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi105Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi110Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi113Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi125Iron-sulfur 1 (2Fe-2S)By similarity1
Metal bindingi196Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi199Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi202Iron-sulfur 2 (4Fe-4S)By similarity1
Metal bindingi206Iron-sulfur 3 (3Fe-4S)By similarity1
Binding sitei211Ubiquinone; shared with DHSDBy similarity1
Metal bindingi253Iron-sulfur 3 (3Fe-4S)By similarity1
Metal bindingi259Iron-sulfur 3 (3Fe-4S)By similarity1
Metal bindingi263Iron-sulfur 2 (4Fe-4S)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Transport, Tricarboxylic acid cycle
Ligand2Fe-2S, 3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC:1.3.5.1)
Alternative name(s):
Iron-sulfur subunit of complex II
Short name:
Ip
Gene namesi
Name:SDH2
Synonyms:sucDH1
OrganismiUromyces fabae (Rust fungus)
Taxonomic identifieri55588 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaPucciniomycotinaPucciniomycetesPuccinialesPucciniaceaeUromyces

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000010351? – 283Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Transit peptidei1 – ?Mitochondrion

Proteomic databases

PRIDEiQ70KF8

Interactioni

Subunit structurei

Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ70KF8
SMRiQ70KF8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini66 – 1452Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd BLAST80
Domaini186 – 2164Fe-4S ferredoxin-typePROSITE-ProRule annotationAdd BLAST31

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Family and domain databases

CDDicd00207 fer2, 1 hit
Gene3Di1.10.1060.10, 1 hit
3.10.20.30, 1 hit
InterProiView protein in InterPro
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR006058 2Fe2S_fd_BS
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR012675 Beta-grasp_dom_sf
IPR009051 Helical_ferredxn
IPR004489 Succ_DH/fum_Rdtase_Fe-S
IPR025192 Succ_DH/fum_Rdtase_N
PfamiView protein in Pfam
PF13085 Fer2_3, 1 hit
SUPFAMiSSF46548 SSF46548, 1 hit
SSF54292 SSF54292, 1 hit
TIGRFAMsiTIGR00384 dhsB, 1 hit
PROSITEiView protein in PROSITE
PS00197 2FE2S_FER_1, 1 hit
PS51085 2FE2S_FER_2, 1 hit
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q70KF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINIPNSIRP FIRSANRTPC YLRSISSSSS SSFATPAEEH AGKQPSSAVP
60 70 80 90 100
VKEFSIYRWN PDEPSKKPTL QTYSIDLKKC GPMVLDALIK IKNELDPTLT
110 120 130 140 150
FRRSCREGIC GSCAMNIDGV NTLACLKRIN KETSAPVKIY PLPHMYIIKD
160 170 180 190 200
LVPDMTHFYK QYKSIEPFLK NDNPPAQGEF LQSPEDRKKL DGMYECILCA
210 220 230 240 250
CCSTSCPSYW WNQDEYLGPA VLMQAYRWMA DSRDSYGEDR KEKLQNTLSL
260 270 280
YRCHTIFNCT KTCPKGLNPA KAISHIKREM ASA
Length:283
Mass (Da):32,104
Last modified:July 5, 2004 - v1
Checksum:i058945BABE06185F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ575686 Genomic DNA Translation: CAE02642.1

Similar proteinsi

Entry informationi

Entry nameiSDHB_UROFA
AccessioniPrimary (citable) accession number: Q70KF8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

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