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Protein

MOB kinase activator 3C

Gene

MOB3C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May regulate the activity of kinases.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi82 – 821ZincBy similarity
Metal bindingi87 – 871ZincBy similarity
Metal bindingi164 – 1641ZincBy similarity
Metal bindingi169 – 1691ZincBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
MOB kinase activator 3C
Alternative name(s):
Mob1 homolog 2C
Mps one binder kinase activator-like 2C
Gene namesi
Name:MOB3C
Synonyms:MOBKL2C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:29800. MOB3C.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134928770.

Polymorphism and mutation databases

BioMutaiMOB3C.
DMDMi56749259.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 216216MOB kinase activator 3CPRO_0000193574Add
BLAST

Proteomic databases

PaxDbiQ70IA8.
PeptideAtlasiQ70IA8.
PRIDEiQ70IA8.

PTM databases

iPTMnetiQ70IA8.
PhosphoSiteiQ70IA8.

Expressioni

Gene expression databases

BgeeiENSG00000142961.
CleanExiHS_MOBKL2C.
ExpressionAtlasiQ70IA8. baseline and differential.
GenevisibleiQ70IA8. HS.

Organism-specific databases

HPAiHPA046866.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CMTM3Q96MX03EBI-9679267,EBI-7247651
FAM118AQ9NWS63EBI-9679267,EBI-8638992
KRT40Q6A1623EBI-9679267,EBI-10171697
NT5C2P499023EBI-9679267,EBI-742084
SIAH1Q8IUQ43EBI-9679267,EBI-747107
TDO2P487753EBI-9679267,EBI-743494
TFCP2Q128003EBI-9679267,EBI-717422
TNIP1Q150253EBI-9679267,EBI-357849
ZBTB10Q96DT73EBI-9679267,EBI-10235384

Protein-protein interaction databases

BioGridi127181. 14 interactions.
IntActiQ70IA8. 10 interactions.
STRINGi9606.ENSP00000271139.

Structurei

3D structure databases

ProteinModelPortaliQ70IA8.
SMRiQ70IA8. Positions 13-214.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MOB1/phocein family.Curated

Phylogenomic databases

eggNOGiKOG1903. Eukaryota.
ENOG410XSM4. LUCA.
GeneTreeiENSGT00550000074456.
HOVERGENiHBG052489.
InParanoidiQ70IA8.
PhylomeDBiQ70IA8.
TreeFamiTF300789.

Family and domain databases

Gene3Di1.20.140.30. 1 hit.
InterProiIPR005301. MOB_kinase_act_fam.
[Graphical view]
PANTHERiPTHR22599. PTHR22599. 1 hit.
PfamiPF03637. Mob1_phocein. 1 hit.
[Graphical view]
SMARTiSM01388. Mob1_phocein. 1 hit.
[Graphical view]
SUPFAMiSSF101152. SSF101152. 1 hit.

Sequencei

Sequence statusi: Complete.

Q70IA8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALCLKQVFA KDKTFRPRKR FEPGTQRFEL YKKAQASLKS GLDLRSVVRL
60 70 80 90 100
PPGENIDDWI AVHVVDFFNR INLIYGTMAE RCSETSCPVM AGGPRYEYRW
110 120 130 140 150
QDERQYRRPA KLSAPRYMAL LMDWIEGLIN DEEVFPTRVG VPFPKNFQQV
160 170 180 190 200
CTKILTRLFR VFVHVYIHHF DSILSMGAEA HVNTCYKHFY YFIREFSLVD
210
QRELEPLREM TERICH
Length:216
Mass (Da):25,623
Last modified:July 5, 2004 - v1
Checksum:iC1FF52784622BAA4
GO

Sequence cautioni

The sequence BAC03434 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC03752 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAI14766 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ580637 mRNA. Translation: CAE45269.1.
AK090453 mRNA. Translation: BAC03434.1. Different initiation.
AL136373 Genomic DNA. Translation: CAI14766.1. Different initiation.
AL136373 Genomic DNA. Translation: CAI14767.1. Sequence problems.
CH471059 Genomic DNA. Translation: EAX06899.1.
BC121169 mRNA. Translation: AAI21170.1.
AK091808 mRNA. Translation: BAC03752.1. Different initiation.
CCDSiCCDS540.1.
RefSeqiNP_958805.1. NM_201403.2.
UniGeneiHs.632401.

Genome annotation databases

EnsembliENST00000319928; ENSP00000315113; ENSG00000142961.
ENST00000371940; ENSP00000361008; ENSG00000142961.
GeneIDi148932.
KEGGihsa:148932.
UCSCiuc001cqf.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ580637 mRNA. Translation: CAE45269.1.
AK090453 mRNA. Translation: BAC03434.1. Different initiation.
AL136373 Genomic DNA. Translation: CAI14766.1. Different initiation.
AL136373 Genomic DNA. Translation: CAI14767.1. Sequence problems.
CH471059 Genomic DNA. Translation: EAX06899.1.
BC121169 mRNA. Translation: AAI21170.1.
AK091808 mRNA. Translation: BAC03752.1. Different initiation.
CCDSiCCDS540.1.
RefSeqiNP_958805.1. NM_201403.2.
UniGeneiHs.632401.

3D structure databases

ProteinModelPortaliQ70IA8.
SMRiQ70IA8. Positions 13-214.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127181. 14 interactions.
IntActiQ70IA8. 10 interactions.
STRINGi9606.ENSP00000271139.

PTM databases

iPTMnetiQ70IA8.
PhosphoSiteiQ70IA8.

Polymorphism and mutation databases

BioMutaiMOB3C.
DMDMi56749259.

Proteomic databases

PaxDbiQ70IA8.
PeptideAtlasiQ70IA8.
PRIDEiQ70IA8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319928; ENSP00000315113; ENSG00000142961.
ENST00000371940; ENSP00000361008; ENSG00000142961.
GeneIDi148932.
KEGGihsa:148932.
UCSCiuc001cqf.4. human.

Organism-specific databases

CTDi148932.
GeneCardsiMOB3C.
HGNCiHGNC:29800. MOB3C.
HPAiHPA046866.
neXtProtiNX_Q70IA8.
PharmGKBiPA134928770.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1903. Eukaryota.
ENOG410XSM4. LUCA.
GeneTreeiENSGT00550000074456.
HOVERGENiHBG052489.
InParanoidiQ70IA8.
PhylomeDBiQ70IA8.
TreeFamiTF300789.

Miscellaneous databases

GenomeRNAii148932.
PROiQ70IA8.

Gene expression databases

BgeeiENSG00000142961.
CleanExiHS_MOBKL2C.
ExpressionAtlasiQ70IA8. baseline and differential.
GenevisibleiQ70IA8. HS.

Family and domain databases

Gene3Di1.20.140.30. 1 hit.
InterProiIPR005301. MOB_kinase_act_fam.
[Graphical view]
PANTHERiPTHR22599. PTHR22599. 1 hit.
PfamiPF03637. Mob1_phocein. 1 hit.
[Graphical view]
SMARTiSM01388. Mob1_phocein. 1 hit.
[Graphical view]
SUPFAMiSSF101152. SSF101152. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMOB3C_HUMAN
AccessioniPrimary (citable) accession number: Q70IA8
Secondary accession number(s): D3DQ22
, Q0VA98, Q5TC10, Q5TC11, Q8NAZ2, Q8NF28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.