Reviewed,
UniProtKB/Swiss-Prot Q70IA6 (MOB2_HUMAN)
Last modified
June 16, 2009.
Version 45.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Mps one binder kinase activator-like 2 Alternative name(s): Mob2 homolog HCCA2 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 237 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Stimulates the autophosphorylation and kinase activity of STK38 and STK38L. Ref.4 |
| Subunit structure | Binds STK38 and STK38L. |
| Subcellular location | |
| Post-translational modification | Phosphorylated. |
| Sequence similarities | Belongs to the MOB1/phocein family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm Nucleus |
| Coding sequence diversity | Alternative splicing |
| Ligand | Metal-binding Zinc |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Cellular component | nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell perinuclear region of cytoplasmInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | protein binding Inferred from electronic annotation. Source: InterPro zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q70IA6-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q70IA6-2) The sequence of this isoform differs from the canonical sequence as follows: 133-142: GREFPSSFES → ENSPAPLSPW 143-237: Missing. | ||||||
| Note: No experimental confirmation available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 237 | 237 | Mps one binder kinase activator-like 2 | PRO_0000193568 | |||||
Sites | |||||||||
| Metal binding | 78 | 1 | Zinc By similarity | ||||||
| Metal binding | 83 | 1 | Zinc By similarity | ||||||
| Metal binding | 157 | 1 | Zinc By similarity | ||||||
| Metal binding | 162 | 1 | Zinc By similarity | ||||||
Natural variations | |||||||||
| Alternative sequence | 133 – 142 | 10 | GREFPSSFES → ENSPAPLSPW in isoform 2. | VSP_012298 | |||||
| Alternative sequence | 143 – 237 | 95 | Missing in isoform 2. | VSP_012299 | |||||
Experimental info | |||||||||
| Sequence conflict | 49 | 1 | E → K in BAB71443. Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Characterization of the human Mob-1 like proteins." Florindo C.S., Tavares A.A. Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). |
| [2] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain. |
| [4] | "Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases." Devroe E., Erdjument-Bromage H., Tempst P., Silver P.A. J. Biol. Chem. 279:24444-24451(2004) [PubMed: 15067004] [Abstract] Cited for: FUNCTION, INTERACTION WITH STK3 AND STK38L, MASS SPECTROMETRY, SUBCELLULAR LOCATION. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AJ580639 mRNA. Translation: CAE45271.1. AK057350 mRNA. Translation: BAB71443.1. BC047291 mRNA. Translation: AAH47291.1. BC067785 mRNA. Translation: AAH67785.1. | |
| IPI | IPI00418248. IPI00514453. |
| RefSeq | NP_443731.2. |
| UniGene | Hs.370360 |
3D structure databases | |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | Q70IA6. |
Genome annotation databases | |
| Ensembl | ENSG00000182208. Homo sapiens. [Contig view] |
| GeneID | 81532. |
| KEGG | hsa:81532. |
Organism-specific databases | |
| GeneCards | GC11M001447. |
| H-InvDB | HIX0017208. |
| MIM | 611969. gene. |
Phylogenomic databases | |
| HOGENOM | Q70IA6. |
| HOVERGEN | Q70IA6. |
Gene expression databases | |
| ArrayExpress | Q70IA6. |
| Bgee | Q70IA6. |
| GermOnline | ENSG00000182208. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR005301. Mob1_phocein. [Graphical view] |
| Gene3D | G3DSA:1.20.140.30. Mob1_phocein. 1 hit. |
| PANTHER | PTHR22599. Mob1_phocein. 1 hit. |
| Pfam | PF03637. Mob1_phocein. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 71756. |
| SOURCE | Search... |
Entry information
| Entry name | MOB2_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q70IA6 Secondary accession number(s): Q96M67 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 11 Human chromosome 11: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


