Q70IA6 (MOB2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
MOB kinase activator 2

Alternative name(s):
HCCA2
Mob2 homolog
Mps one binder kinase activator-like 2

Gene names

Name:	MOB2
Synonyms:	HCCA2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	237 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Stimulates the autophosphorylation and kinase activity of STK38 and STK38L. Ref.4
Subunit structure	Binds STK38 and STK38L.
Subcellular location	Nucleus. Cytoplasm › perinuclear region Ref.4.
Post-translational modification	Phosphorylated.
Sequence similarities	Belongs to the MOB1/phocein family.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing
Ligand	Metal-binding Zinc
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from direct assay. Source: HPA nucleolus Inferred from direct assay. Source: HPA perinuclear region of cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q70IA6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q70IA6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     133-142: GREFPSSFES → ENSPAPLSPW
     143-237: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q70IA6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MDWLMG → MLGDHCSLPEDQARPGQSPQSGLCCKMVLQAVSKVLR

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 237	237	MOB kinase activator 2		PRO_0000193568
Sites
	Metal binding	78	1	Zinc By similarity
	Metal binding	83	1	Zinc By similarity
	Metal binding	157	1	Zinc By similarity
	Metal binding	162	1	Zinc By similarity
Natural variations
	Alternative sequence	1 – 6	6	MDWLMG → MLGDHCSLPEDQARPGQSPQ SGLCCKMVLQAVSKVLR in isoform 3.		VSP_044472
	Alternative sequence	133 – 142	10	GREFPSSFES → ENSPAPLSPW in isoform 2.		VSP_012298
	Alternative sequence	143 – 237	95	Missing in isoform 2.		VSP_012299
Experimental info
	Sequence conflict	49	1	E → K in BAB71443. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 878A3E6E49294689	FASTA	237	26,927
	10 20 30 40 50 60 MDWLMGKSKA KPNGKKPAAE ERKAYLEPEH TKARITDFQF KELVVLPREI DLNEWLASNT 70 80 90 100 110 120 TTFFHHINLQ YSTISEFCTG ETCQTMAVCN TQYYWYDERG KKVKCTAPQY VDFVMSSVQK 130 140 150 160 170 180 LVTDEDVFPT KYGREFPSSF ESLVRKICRH LFHVLAHIYW AHFKETLALE LHGHLNTLYV 190 200 210 220 230 HFILFAREFN LLDPKETAIM DDLTEVLCSG AGGVHSGGSG DGAGSGGPGA QNHVKER
	Isoform 2 [UniParc]. Checksum: 1C519E331CFE4F56	FASTA	142	16,500
	10 20 30 40 50 60 MDWLMGKSKA KPNGKKPAAE ERKAYLEPEH TKARITDFQF KELVVLPREI DLNEWLASNT 70 80 90 100 110 120 TTFFHHINLQ YSTISEFCTG ETCQTMAVCN TQYYWYDERG KKVKCTAPQY VDFVMSSVQK 130 140 LVTDEDVFPT KYENSPAPLS PW
	Isoform 3 [UniParc]. Checksum: 17A89611E89F12B5	FASTA	268	30,158
	10 20 30 40 50 60 MLGDHCSLPE DQARPGQSPQ SGLCCKMVLQ AVSKVLRKSK AKPNGKKPAA EERKAYLEPE 70 80 90 100 110 120 HTKARITDFQ FKELVVLPRE IDLNEWLASN TTTFFHHINL QYSTISEFCT GETCQTMAVC 130 140 150 160 170 180 NTQYYWYDER GKKVKCTAPQ YVDFVMSSVQ KLVTDEDVFP TKYGREFPSS FESLVRKICR 190 200 210 220 230 240 HLFHVLAHIY WAHFKETLAL ELHGHLNTLY VHFILFAREF NLLDPKETAI MDDLTEVLCS 250 260 GAGGVHSGGS GDGAGSGGPG AQNHVKER

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of the human Mob-1 like proteins." Florindo C.S., Tavares A.A. Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Colon and Testis.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[4]	"Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases." Devroe E., Erdjument-Bromage H., Tempst P., Silver P.A. J. Biol. Chem. 279:24444-24451(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH STK3 AND STK38L, MASS SPECTROMETRY, SUBCELLULAR LOCATION.
[5]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ580639 mRNA. Translation: CAE45271.1. AK057350 mRNA. Translation: BAB71443.1. AK296658 mRNA. Translation: BAG59255.1. BC047291 mRNA. Translation: AAH47291.1. BC067785 mRNA. Translation: AAH67785.1.
IPI	IPI00418248. IPI00514453. IPI00939594.
RefSeq	NP_001165694.1. NM_001172223.1. NP_443731.2. NM_053005.4.
UniGene	Hs.370360.
3D structure databases
ProteinModelPortal	Q70IA6.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q70IA6. 1 interaction.
Polymorphism databases
DMDM	56749258.
Proteomic databases
PaxDb	Q70IA6.
PRIDE	Q70IA6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000329957; ENSP00000328694; ENSG00000182208.
GeneID	81532.
KEGG	hsa:81532.
UCSC	uc001lto.2. human.
Organism-specific databases
CTD	81532.
GeneCards	GC11M001490.
HGNC	HGNC:24904. MOB2.
HPA	HPA046313.
MIM	611969. gene.
neXtProt	NX_Q70IA6.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG318998.
HOGENOM	HOG000164685.
HOVERGEN	HBG052489.
InParanoid	Q70IA6.
Gene expression databases
Bgee	Q70IA6.
Genevestigator	Q70IA6.
GermOnline	ENSG00000182208. Homo sapiens.
Family and domain databases
Gene3D	1.20.140.30. 1 hit.
InterPro	IPR005301. Mob1_phocein. [Graphical view]
PANTHER	PTHR22599. PTHR22599. 1 hit.
Pfam	PF03637. Mob1_phocein. 1 hit. [Graphical view]
SUPFAM	SSF101152. Mob1_phocein. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	Mob2. human.
GenomeRNAi	81532.
NextBio	71756.
SOURCE	Search...

Entry information

Entry name

MOB2_HUMAN

Accession

Primary (citable) accession number: Q70IA6
Secondary accession number(s): B4DKP3, Q96M67

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 21, 2004
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.