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Q70HW3 (SAMC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
S-adenosylmethionine mitochondrial carrier protein
Alternative name(s):
Mitochondrial S-adenosylmethionine transporter
Solute carrier family 25 member 26
Gene names
Name:SLC25A26
Synonyms:SAMC
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length274 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. Specifically mediates the transport of S-adenosylmethionine (SAM) into the mitochondria. Ref.1

Enzyme regulation

Strongly inhibited by tannic acid and Bromocresol Purple. Ref.1

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein Ref.1.

Tissue specificity

Widely expressed. Highly expressed in testis, with moderate expression in brain, heart, kidney, lung, skeletal muscle, pancreas, small intestine and liver, and low expression in spleen. Ref.1

Sequence similarities

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]

Contains 3 Solcar repeats.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q70HW3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q70HW3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: Missing.
Isoform 3 (identifier: Q70HW3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: Missing.
     152-154: IPF → EED
     155-274: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 274274S-adenosylmethionine mitochondrial carrier protein
PRO_0000317587

Regions

Transmembrane5 – 2521Helical; Name=1; Potential
Transmembrane49 – 6921Helical; Name=2; Potential
Transmembrane85 – 10521Helical; Name=3; Potential
Transmembrane142 – 16221Helical; Name=4; Potential
Transmembrane182 – 20221Helical; Name=5; Potential
Transmembrane238 – 25821Helical; Name=6; Potential
Repeat4 – 7774Solcar 1
Repeat86 – 16883Solcar 2
Repeat177 – 26589Solcar 3

Natural variations

Alternative sequence1 – 8888Missing in isoform 2 and isoform 3.
VSP_031062
Alternative sequence152 – 1543IPF → EED in isoform 3.
VSP_031063
Alternative sequence155 – 274120Missing in isoform 3.
VSP_031064
Natural variant2081T → M. Ref.2 Ref.3
Corresponds to variant rs13874 [ dbSNP | Ensembl ].
VAR_058973

Experimental info

Sequence conflict2081T → A in BAF84562. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 21ECA1E60C9BDDAD

FASTA27429,381
        10         20         30         40         50         60 
MDRPGFVAAL VAGGVAGVSV DLILFPLDTI KTRLQSPQGF NKAGGFHGIY AGVPSAAIGS 

        70         80         90        100        110        120 
FPNAAAFFIT YEYVKWFLHA DSSSYLTPMK HMLAASAGEV VACLIRVPSE VVKQRAQVSA 

       130        140        150        160        170        180 
STRTFQIFSN ILYEEGIQGL YRGYKSTVLR EIPFSLVQFP LWESLKALWS WRQDHVVDSW 

       190        200        210        220        230        240 
QSAVCGAFAG GFAAAVTTPL DVAKTRITLA KAGSSTADGN VLSVLHGVWR SQGLAGLFAG 

       250        260        270 
VFPRMAAISL GGFIFLGAYD RTHSLLLEVG RKSP 

« Hide

Isoform 2 [UniParc].

Checksum: 8024D5D11F6CF22B
Show »

FASTA18620,116
Isoform 3 [UniParc].

Checksum: 68F03A11822C5C3E
Show »

FASTA667,405

References

« Hide 'large scale' references
[1]"Identification of the human mitochondrial S-adenosylmethionine transporter: bacterial expression, reconstitution, functional characterization and tissue distribution."
Agrimi G., Di Noia M.A., Marobbio C.M.T., Fiermonte G., Lasorsa F.M., Palmieri F.
Biochem. J. 379:183-190(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, ENZYME REGULATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT MET-208.
Tissue: Placenta and Skeletal muscle.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT MET-208.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
Tissue: Ovary and Placenta.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ580932 mRNA. Translation: CAE45652.1.
AK092495 mRNA. Translation: BAG52559.1.
AK096876 mRNA. Translation: BAG53388.1.
AK291873 mRNA. Translation: BAF84562.1.
CH471055 Genomic DNA. Translation: EAW65449.1.
CH471055 Genomic DNA. Translation: EAW65451.1.
BC003399 mRNA. No translation available.
BC012852 mRNA. Translation: AAH12852.2.
CCDSCCDS2905.2. [Q70HW3-1]
CCDS54604.1. [Q70HW3-2]
RefSeqNP_001158268.1. NM_001164796.1. [Q70HW3-2]
NP_775742.4. NM_173471.3.
UniGeneHs.379386.

3D structure databases

ProteinModelPortalQ70HW3.
SMRQ70HW3. Positions 6-274.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125423. 2 interactions.

Protein family/group databases

TCDB2.A.29.18.3. the mitochondrial carrier (mc) family.

PTM databases

PhosphoSiteQ70HW3.

Polymorphism databases

DMDM74749739.

Proteomic databases

MaxQBQ70HW3.
PaxDbQ70HW3.
PRIDEQ70HW3.

Protocols and materials databases

DNASU115286.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000336733; ENSP00000336801; ENSG00000144741. [Q70HW3-2]
GeneID115286.
KEGGhsa:115286.
UCSCuc011bfs.2. human. [Q70HW3-1]

Organism-specific databases

CTD115286.
GeneCardsGC03P066120.
HGNCHGNC:20661. SLC25A26.
HPAHPA026887.
MIM611037. gene.
neXtProtNX_Q70HW3.
PharmGKBPA134987831.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG247316.
HOGENOMHOG000038810.
HOVERGENHBG108456.
InParanoidQ70HW3.
KOK15111.
PhylomeDBQ70HW3.
TreeFamTF313186.

Gene expression databases

ArrayExpressQ70HW3.
BgeeQ70HW3.
CleanExHS_SLC25A26.
GenevestigatorQ70HW3.

Family and domain databases

Gene3D1.50.40.10. 1 hit.
InterProIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMSSF103506. SSF103506. 1 hit.
PROSITEPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSLC25A26. human.
GenomeRNAi115286.
NextBio79552.
PROQ70HW3.
SOURCESearch...

Entry information

Entry nameSAMC_HUMAN
AccessionPrimary (citable) accession number: Q70HW3
Secondary accession number(s): A8K758 expand/collapse secondary AC list , B3KRZ7, Q7Z786, Q96E68
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM