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Q70HW3

- SAMC_HUMAN

UniProt

Q70HW3 - SAMC_HUMAN

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Protein
S-adenosylmethionine mitochondrial carrier protein
Gene
SLC25A26, SAMC
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. Specifically mediates the transport of S-adenosylmethionine (SAM) into the mitochondria.1 Publication

Enzyme regulationi

Strongly inhibited by tannic acid and Bromocresol Purple.1 Publication

GO - Molecular functioni

  1. S-adenosyl-L-methionine transmembrane transporter activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. S-adenosyl-L-methionine transmembrane transport Source: GOC
  2. S-adenosyl-L-methionine transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

S-adenosyl-L-methionine

Protein family/group databases

TCDBi2.A.29.18.3. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
S-adenosylmethionine mitochondrial carrier protein
Alternative name(s):
Mitochondrial S-adenosylmethionine transporter
Solute carrier family 25 member 26
Gene namesi
Synonyms:SAMC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:20661. SLC25A26.

Subcellular locationi

Mitochondrion inner membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521Helical; Name=1; Reviewed prediction
Add
BLAST
Transmembranei49 – 6921Helical; Name=2; Reviewed prediction
Add
BLAST
Transmembranei85 – 10521Helical; Name=3; Reviewed prediction
Add
BLAST
Transmembranei142 – 16221Helical; Name=4; Reviewed prediction
Add
BLAST
Transmembranei182 – 20221Helical; Name=5; Reviewed prediction
Add
BLAST
Transmembranei238 – 25821Helical; Name=6; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB
  3. mitochondrion Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134987831.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 274274S-adenosylmethionine mitochondrial carrier protein
PRO_0000317587Add
BLAST

Proteomic databases

MaxQBiQ70HW3.
PaxDbiQ70HW3.
PRIDEiQ70HW3.

PTM databases

PhosphoSiteiQ70HW3.

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in testis, with moderate expression in brain, heart, kidney, lung, skeletal muscle, pancreas, small intestine and liver, and low expression in spleen.1 Publication

Gene expression databases

ArrayExpressiQ70HW3.
BgeeiQ70HW3.
CleanExiHS_SLC25A26.
GenevestigatoriQ70HW3.

Organism-specific databases

HPAiHPA026887.

Interactioni

Protein-protein interaction databases

BioGridi125423. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ70HW3.
SMRiQ70HW3. Positions 6-274.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati4 – 7774Solcar 1
Add
BLAST
Repeati86 – 16883Solcar 2
Add
BLAST
Repeati177 – 26589Solcar 3
Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG247316.
HOGENOMiHOG000038810.
HOVERGENiHBG108456.
InParanoidiQ70HW3.
KOiK15111.
PhylomeDBiQ70HW3.
TreeFamiTF313186.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q70HW3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDRPGFVAAL VAGGVAGVSV DLILFPLDTI KTRLQSPQGF NKAGGFHGIY    50
AGVPSAAIGS FPNAAAFFIT YEYVKWFLHA DSSSYLTPMK HMLAASAGEV 100
VACLIRVPSE VVKQRAQVSA STRTFQIFSN ILYEEGIQGL YRGYKSTVLR 150
EIPFSLVQFP LWESLKALWS WRQDHVVDSW QSAVCGAFAG GFAAAVTTPL 200
DVAKTRITLA KAGSSTADGN VLSVLHGVWR SQGLAGLFAG VFPRMAAISL 250
GGFIFLGAYD RTHSLLLEVG RKSP 274
Length:274
Mass (Da):29,381
Last modified:July 5, 2004 - v1
Checksum:i21ECA1E60C9BDDAD
GO
Isoform 2 (identifier: Q70HW3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: Missing.

Show »
Length:186
Mass (Da):20,116
Checksum:i8024D5D11F6CF22B
GO
Isoform 3 (identifier: Q70HW3-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: Missing.
     152-154: IPF → EED
     155-274: Missing.

Note: No experimental confirmation available.

Show »
Length:66
Mass (Da):7,405
Checksum:i68F03A11822C5C3E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti208 – 2081T → M.2 Publications
Corresponds to variant rs13874 [ dbSNP | Ensembl ].
VAR_058973

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8888Missing in isoform 2 and isoform 3.
VSP_031062Add
BLAST
Alternative sequencei152 – 1543IPF → EED in isoform 3.
VSP_031063
Alternative sequencei155 – 274120Missing in isoform 3.
VSP_031064Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti208 – 2081T → A in BAF84562. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ580932 mRNA. Translation: CAE45652.1.
AK092495 mRNA. Translation: BAG52559.1.
AK096876 mRNA. Translation: BAG53388.1.
AK291873 mRNA. Translation: BAF84562.1.
CH471055 Genomic DNA. Translation: EAW65449.1.
CH471055 Genomic DNA. Translation: EAW65451.1.
BC003399 mRNA. No translation available.
BC012852 mRNA. Translation: AAH12852.2.
CCDSiCCDS2905.2. [Q70HW3-1]
CCDS54604.1. [Q70HW3-2]
RefSeqiNP_001158268.1. NM_001164796.1. [Q70HW3-2]
NP_775742.4. NM_173471.3.
UniGeneiHs.379386.

Genome annotation databases

EnsembliENST00000336733; ENSP00000336801; ENSG00000144741. [Q70HW3-2]
GeneIDi115286.
KEGGihsa:115286.
UCSCiuc011bfs.2. human. [Q70HW3-1]

Polymorphism databases

DMDMi74749739.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ580932 mRNA. Translation: CAE45652.1 .
AK092495 mRNA. Translation: BAG52559.1 .
AK096876 mRNA. Translation: BAG53388.1 .
AK291873 mRNA. Translation: BAF84562.1 .
CH471055 Genomic DNA. Translation: EAW65449.1 .
CH471055 Genomic DNA. Translation: EAW65451.1 .
BC003399 mRNA. No translation available.
BC012852 mRNA. Translation: AAH12852.2 .
CCDSi CCDS2905.2. [Q70HW3-1 ]
CCDS54604.1. [Q70HW3-2 ]
RefSeqi NP_001158268.1. NM_001164796.1. [Q70HW3-2 ]
NP_775742.4. NM_173471.3.
UniGenei Hs.379386.

3D structure databases

ProteinModelPortali Q70HW3.
SMRi Q70HW3. Positions 6-274.
ModBasei Search...

Protein-protein interaction databases

BioGridi 125423. 2 interactions.

Protein family/group databases

TCDBi 2.A.29.18.3. the mitochondrial carrier (mc) family.

PTM databases

PhosphoSitei Q70HW3.

Polymorphism databases

DMDMi 74749739.

Proteomic databases

MaxQBi Q70HW3.
PaxDbi Q70HW3.
PRIDEi Q70HW3.

Protocols and materials databases

DNASUi 115286.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000336733 ; ENSP00000336801 ; ENSG00000144741 . [Q70HW3-2 ]
GeneIDi 115286.
KEGGi hsa:115286.
UCSCi uc011bfs.2. human. [Q70HW3-1 ]

Organism-specific databases

CTDi 115286.
GeneCardsi GC03P066120.
HGNCi HGNC:20661. SLC25A26.
HPAi HPA026887.
MIMi 611037. gene.
neXtProti NX_Q70HW3.
PharmGKBi PA134987831.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG247316.
HOGENOMi HOG000038810.
HOVERGENi HBG108456.
InParanoidi Q70HW3.
KOi K15111.
PhylomeDBi Q70HW3.
TreeFami TF313186.

Miscellaneous databases

ChiTaRSi SLC25A26. human.
GenomeRNAii 115286.
NextBioi 79552.
PROi Q70HW3.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q70HW3.
Bgeei Q70HW3.
CleanExi HS_SLC25A26.
Genevestigatori Q70HW3.

Family and domain databases

Gene3Di 1.50.40.10. 1 hit.
InterProi IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view ]
Pfami PF00153. Mito_carr. 3 hits.
[Graphical view ]
SUPFAMi SSF103506. SSF103506. 1 hit.
PROSITEi PS50920. SOLCAR. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of the human mitochondrial S-adenosylmethionine transporter: bacterial expression, reconstitution, functional characterization and tissue distribution."
    Agrimi G., Di Noia M.A., Marobbio C.M.T., Fiermonte G., Lasorsa F.M., Palmieri F.
    Biochem. J. 379:183-190(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, ENZYME REGULATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT MET-208.
    Tissue: Placenta and Skeletal muscle.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT MET-208.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Ovary and Placenta.

Entry informationi

Entry nameiSAMC_HUMAN
AccessioniPrimary (citable) accession number: Q70HW3
Secondary accession number(s): A8K758
, B3KRZ7, Q7Z786, Q96E68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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