Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

S-adenosylmethionine mitochondrial carrier protein

Gene

SLC25A26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. Specifically mediates the transport of S-adenosylmethionine (SAM) into the mitochondria.1 Publication

Enzyme regulationi

Strongly inhibited by tannic acid and Bromocresol Purple.1 Publication

GO - Molecular functioni

  1. S-adenosyl-L-methionine transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  1. S-adenosyl-L-methionine transmembrane transport Source: GOC
  2. S-adenosyl-L-methionine transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

S-adenosyl-L-methionine

Protein family/group databases

TCDBi2.A.29.18.3. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
S-adenosylmethionine mitochondrial carrier protein
Alternative name(s):
Mitochondrial S-adenosylmethionine transporter
Solute carrier family 25 member 26
Gene namesi
Name:SLC25A26
Synonyms:SAMC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:20661. SLC25A26.

Subcellular locationi

Mitochondrion inner membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei49 – 6921Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei85 – 10521Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei142 – 16221Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei182 – 20221Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB
  3. mitochondrion Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134987831.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 274274S-adenosylmethionine mitochondrial carrier proteinPRO_0000317587Add
BLAST

Proteomic databases

MaxQBiQ70HW3.
PaxDbiQ70HW3.
PRIDEiQ70HW3.

PTM databases

PhosphoSiteiQ70HW3.

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in testis, with moderate expression in brain, heart, kidney, lung, skeletal muscle, pancreas, small intestine and liver, and low expression in spleen.1 Publication

Gene expression databases

BgeeiQ70HW3.
CleanExiHS_SLC25A26.
ExpressionAtlasiQ70HW3. baseline and differential.
GenevestigatoriQ70HW3.

Organism-specific databases

HPAiHPA026887.

Interactioni

Protein-protein interaction databases

BioGridi125423. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ70HW3.
SMRiQ70HW3. Positions 6-274.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati4 – 7774Solcar 1Add
BLAST
Repeati86 – 16883Solcar 2Add
BLAST
Repeati177 – 26589Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG247316.
GeneTreeiENSGT00550000074950.
HOGENOMiHOG000038810.
HOVERGENiHBG108456.
InParanoidiQ70HW3.
KOiK15111.
PhylomeDBiQ70HW3.
TreeFamiTF313186.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q70HW3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDRPGFVAAL VAGGVAGVSV DLILFPLDTI KTRLQSPQGF NKAGGFHGIY
60 70 80 90 100
AGVPSAAIGS FPNAAAFFIT YEYVKWFLHA DSSSYLTPMK HMLAASAGEV
110 120 130 140 150
VACLIRVPSE VVKQRAQVSA STRTFQIFSN ILYEEGIQGL YRGYKSTVLR
160 170 180 190 200
EIPFSLVQFP LWESLKALWS WRQDHVVDSW QSAVCGAFAG GFAAAVTTPL
210 220 230 240 250
DVAKTRITLA KAGSSTADGN VLSVLHGVWR SQGLAGLFAG VFPRMAAISL
260 270
GGFIFLGAYD RTHSLLLEVG RKSP
Length:274
Mass (Da):29,381
Last modified:July 5, 2004 - v1
Checksum:i21ECA1E60C9BDDAD
GO
Isoform 2 (identifier: Q70HW3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: Missing.

Show »
Length:186
Mass (Da):20,116
Checksum:i8024D5D11F6CF22B
GO
Isoform 3 (identifier: Q70HW3-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: Missing.
     152-154: IPF → EED
     155-274: Missing.

Note: No experimental confirmation available.

Show »
Length:66
Mass (Da):7,405
Checksum:i68F03A11822C5C3E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti208 – 2081T → A in BAF84562. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti208 – 2081T → M.2 Publications
Corresponds to variant rs13874 [ dbSNP | Ensembl ].
VAR_058973

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8888Missing in isoform 2 and isoform 3. 2 PublicationsVSP_031062Add
BLAST
Alternative sequencei152 – 1543IPF → EED in isoform 3. 1 PublicationVSP_031063
Alternative sequencei155 – 274120Missing in isoform 3. 1 PublicationVSP_031064Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ580932 mRNA. Translation: CAE45652.1.
AK092495 mRNA. Translation: BAG52559.1.
AK096876 mRNA. Translation: BAG53388.1.
AK291873 mRNA. Translation: BAF84562.1.
CH471055 Genomic DNA. Translation: EAW65449.1.
CH471055 Genomic DNA. Translation: EAW65451.1.
BC003399 mRNA. No translation available.
BC012852 mRNA. Translation: AAH12852.2.
CCDSiCCDS2905.2. [Q70HW3-1]
CCDS54604.1. [Q70HW3-2]
RefSeqiNP_001158268.1. NM_001164796.1. [Q70HW3-2]
NP_775742.4. NM_173471.3.
UniGeneiHs.379386.

Genome annotation databases

EnsembliENST00000336733; ENSP00000336801; ENSG00000144741. [Q70HW3-2]
GeneIDi115286.
KEGGihsa:115286.
UCSCiuc011bfs.2. human. [Q70HW3-1]

Polymorphism databases

DMDMi74749739.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ580932 mRNA. Translation: CAE45652.1.
AK092495 mRNA. Translation: BAG52559.1.
AK096876 mRNA. Translation: BAG53388.1.
AK291873 mRNA. Translation: BAF84562.1.
CH471055 Genomic DNA. Translation: EAW65449.1.
CH471055 Genomic DNA. Translation: EAW65451.1.
BC003399 mRNA. No translation available.
BC012852 mRNA. Translation: AAH12852.2.
CCDSiCCDS2905.2. [Q70HW3-1]
CCDS54604.1. [Q70HW3-2]
RefSeqiNP_001158268.1. NM_001164796.1. [Q70HW3-2]
NP_775742.4. NM_173471.3.
UniGeneiHs.379386.

3D structure databases

ProteinModelPortaliQ70HW3.
SMRiQ70HW3. Positions 6-274.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125423. 3 interactions.

Protein family/group databases

TCDBi2.A.29.18.3. the mitochondrial carrier (mc) family.

PTM databases

PhosphoSiteiQ70HW3.

Polymorphism databases

DMDMi74749739.

Proteomic databases

MaxQBiQ70HW3.
PaxDbiQ70HW3.
PRIDEiQ70HW3.

Protocols and materials databases

DNASUi115286.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336733; ENSP00000336801; ENSG00000144741. [Q70HW3-2]
GeneIDi115286.
KEGGihsa:115286.
UCSCiuc011bfs.2. human. [Q70HW3-1]

Organism-specific databases

CTDi115286.
GeneCardsiGC03P066120.
HGNCiHGNC:20661. SLC25A26.
HPAiHPA026887.
MIMi611037. gene.
neXtProtiNX_Q70HW3.
PharmGKBiPA134987831.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG247316.
GeneTreeiENSGT00550000074950.
HOGENOMiHOG000038810.
HOVERGENiHBG108456.
InParanoidiQ70HW3.
KOiK15111.
PhylomeDBiQ70HW3.
TreeFamiTF313186.

Miscellaneous databases

ChiTaRSiSLC25A26. human.
GenomeRNAii115286.
NextBioi79552.
PROiQ70HW3.
SOURCEiSearch...

Gene expression databases

BgeeiQ70HW3.
CleanExiHS_SLC25A26.
ExpressionAtlasiQ70HW3. baseline and differential.
GenevestigatoriQ70HW3.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of the human mitochondrial S-adenosylmethionine transporter: bacterial expression, reconstitution, functional characterization and tissue distribution."
    Agrimi G., Di Noia M.A., Marobbio C.M.T., Fiermonte G., Lasorsa F.M., Palmieri F.
    Biochem. J. 379:183-190(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, ENZYME REGULATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT MET-208.
    Tissue: Placenta and Skeletal muscle.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT MET-208.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Ovary and Placenta.

Entry informationi

Entry nameiSAMC_HUMAN
AccessioniPrimary (citable) accession number: Q70HW3
Secondary accession number(s): A8K758
, B3KRZ7, Q7Z786, Q96E68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2004
Last modified: January 7, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.