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Q70HW3

- SAMC_HUMAN

UniProt

Q70HW3 - SAMC_HUMAN

Protein

S-adenosylmethionine mitochondrial carrier protein

Gene

SLC25A26

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. Specifically mediates the transport of S-adenosylmethionine (SAM) into the mitochondria.1 Publication

    Enzyme regulationi

    Strongly inhibited by tannic acid and Bromocresol Purple.1 Publication

    GO - Molecular functioni

    1. S-adenosyl-L-methionine transmembrane transporter activity Source: UniProtKB

    GO - Biological processi

    1. S-adenosyl-L-methionine transmembrane transport Source: GOC
    2. S-adenosyl-L-methionine transport Source: UniProtKB

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Protein family/group databases

    TCDBi2.A.29.18.3. the mitochondrial carrier (mc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    S-adenosylmethionine mitochondrial carrier protein
    Alternative name(s):
    Mitochondrial S-adenosylmethionine transporter
    Solute carrier family 25 member 26
    Gene namesi
    Name:SLC25A26
    Synonyms:SAMC
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:20661. SLC25A26.

    Subcellular locationi

    Mitochondrion inner membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB
    3. mitochondrion Source: HPA

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134987831.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 274274S-adenosylmethionine mitochondrial carrier proteinPRO_0000317587Add
    BLAST

    Proteomic databases

    MaxQBiQ70HW3.
    PaxDbiQ70HW3.
    PRIDEiQ70HW3.

    PTM databases

    PhosphoSiteiQ70HW3.

    Expressioni

    Tissue specificityi

    Widely expressed. Highly expressed in testis, with moderate expression in brain, heart, kidney, lung, skeletal muscle, pancreas, small intestine and liver, and low expression in spleen.1 Publication

    Gene expression databases

    ArrayExpressiQ70HW3.
    BgeeiQ70HW3.
    CleanExiHS_SLC25A26.
    GenevestigatoriQ70HW3.

    Organism-specific databases

    HPAiHPA026887.

    Interactioni

    Protein-protein interaction databases

    BioGridi125423. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ70HW3.
    SMRiQ70HW3. Positions 6-274.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei5 – 2521Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei49 – 6921Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei85 – 10521Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei142 – 16221Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei182 – 20221Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati4 – 7774Solcar 1Add
    BLAST
    Repeati86 – 16883Solcar 2Add
    BLAST
    Repeati177 – 26589Solcar 3Add
    BLAST

    Sequence similaritiesi

    Contains 3 Solcar repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG247316.
    HOGENOMiHOG000038810.
    HOVERGENiHBG108456.
    InParanoidiQ70HW3.
    KOiK15111.
    PhylomeDBiQ70HW3.
    TreeFamiTF313186.

    Family and domain databases

    Gene3Di1.50.40.10. 1 hit.
    InterProiIPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view]
    PfamiPF00153. Mito_carr. 3 hits.
    [Graphical view]
    SUPFAMiSSF103506. SSF103506. 1 hit.
    PROSITEiPS50920. SOLCAR. 3 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q70HW3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDRPGFVAAL VAGGVAGVSV DLILFPLDTI KTRLQSPQGF NKAGGFHGIY    50
    AGVPSAAIGS FPNAAAFFIT YEYVKWFLHA DSSSYLTPMK HMLAASAGEV 100
    VACLIRVPSE VVKQRAQVSA STRTFQIFSN ILYEEGIQGL YRGYKSTVLR 150
    EIPFSLVQFP LWESLKALWS WRQDHVVDSW QSAVCGAFAG GFAAAVTTPL 200
    DVAKTRITLA KAGSSTADGN VLSVLHGVWR SQGLAGLFAG VFPRMAAISL 250
    GGFIFLGAYD RTHSLLLEVG RKSP 274
    Length:274
    Mass (Da):29,381
    Last modified:July 5, 2004 - v1
    Checksum:i21ECA1E60C9BDDAD
    GO
    Isoform 2 (identifier: Q70HW3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-88: Missing.

    Show »
    Length:186
    Mass (Da):20,116
    Checksum:i8024D5D11F6CF22B
    GO
    Isoform 3 (identifier: Q70HW3-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-88: Missing.
         152-154: IPF → EED
         155-274: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:66
    Mass (Da):7,405
    Checksum:i68F03A11822C5C3E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti208 – 2081T → A in BAF84562. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti208 – 2081T → M.2 Publications
    Corresponds to variant rs13874 [ dbSNP | Ensembl ].
    VAR_058973

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 8888Missing in isoform 2 and isoform 3. 2 PublicationsVSP_031062Add
    BLAST
    Alternative sequencei152 – 1543IPF → EED in isoform 3. 1 PublicationVSP_031063
    Alternative sequencei155 – 274120Missing in isoform 3. 1 PublicationVSP_031064Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ580932 mRNA. Translation: CAE45652.1.
    AK092495 mRNA. Translation: BAG52559.1.
    AK096876 mRNA. Translation: BAG53388.1.
    AK291873 mRNA. Translation: BAF84562.1.
    CH471055 Genomic DNA. Translation: EAW65449.1.
    CH471055 Genomic DNA. Translation: EAW65451.1.
    BC003399 mRNA. No translation available.
    BC012852 mRNA. Translation: AAH12852.2.
    CCDSiCCDS2905.2. [Q70HW3-1]
    CCDS54604.1. [Q70HW3-2]
    RefSeqiNP_001158268.1. NM_001164796.1. [Q70HW3-2]
    NP_775742.4. NM_173471.3.
    UniGeneiHs.379386.

    Genome annotation databases

    EnsembliENST00000336733; ENSP00000336801; ENSG00000144741. [Q70HW3-2]
    GeneIDi115286.
    KEGGihsa:115286.
    UCSCiuc011bfs.2. human. [Q70HW3-1]

    Polymorphism databases

    DMDMi74749739.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ580932 mRNA. Translation: CAE45652.1 .
    AK092495 mRNA. Translation: BAG52559.1 .
    AK096876 mRNA. Translation: BAG53388.1 .
    AK291873 mRNA. Translation: BAF84562.1 .
    CH471055 Genomic DNA. Translation: EAW65449.1 .
    CH471055 Genomic DNA. Translation: EAW65451.1 .
    BC003399 mRNA. No translation available.
    BC012852 mRNA. Translation: AAH12852.2 .
    CCDSi CCDS2905.2. [Q70HW3-1 ]
    CCDS54604.1. [Q70HW3-2 ]
    RefSeqi NP_001158268.1. NM_001164796.1. [Q70HW3-2 ]
    NP_775742.4. NM_173471.3.
    UniGenei Hs.379386.

    3D structure databases

    ProteinModelPortali Q70HW3.
    SMRi Q70HW3. Positions 6-274.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125423. 2 interactions.

    Protein family/group databases

    TCDBi 2.A.29.18.3. the mitochondrial carrier (mc) family.

    PTM databases

    PhosphoSitei Q70HW3.

    Polymorphism databases

    DMDMi 74749739.

    Proteomic databases

    MaxQBi Q70HW3.
    PaxDbi Q70HW3.
    PRIDEi Q70HW3.

    Protocols and materials databases

    DNASUi 115286.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000336733 ; ENSP00000336801 ; ENSG00000144741 . [Q70HW3-2 ]
    GeneIDi 115286.
    KEGGi hsa:115286.
    UCSCi uc011bfs.2. human. [Q70HW3-1 ]

    Organism-specific databases

    CTDi 115286.
    GeneCardsi GC03P066120.
    HGNCi HGNC:20661. SLC25A26.
    HPAi HPA026887.
    MIMi 611037. gene.
    neXtProti NX_Q70HW3.
    PharmGKBi PA134987831.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG247316.
    HOGENOMi HOG000038810.
    HOVERGENi HBG108456.
    InParanoidi Q70HW3.
    KOi K15111.
    PhylomeDBi Q70HW3.
    TreeFami TF313186.

    Miscellaneous databases

    ChiTaRSi SLC25A26. human.
    GenomeRNAii 115286.
    NextBioi 79552.
    PROi Q70HW3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q70HW3.
    Bgeei Q70HW3.
    CleanExi HS_SLC25A26.
    Genevestigatori Q70HW3.

    Family and domain databases

    Gene3Di 1.50.40.10. 1 hit.
    InterProi IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view ]
    Pfami PF00153. Mito_carr. 3 hits.
    [Graphical view ]
    SUPFAMi SSF103506. SSF103506. 1 hit.
    PROSITEi PS50920. SOLCAR. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of the human mitochondrial S-adenosylmethionine transporter: bacterial expression, reconstitution, functional characterization and tissue distribution."
      Agrimi G., Di Noia M.A., Marobbio C.M.T., Fiermonte G., Lasorsa F.M., Palmieri F.
      Biochem. J. 379:183-190(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, ENZYME REGULATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT MET-208.
      Tissue: Placenta and Skeletal muscle.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT MET-208.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Ovary and Placenta.

    Entry informationi

    Entry nameiSAMC_HUMAN
    AccessioniPrimary (citable) accession number: Q70HW3
    Secondary accession number(s): A8K758
    , B3KRZ7, Q7Z786, Q96E68
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3