Q70HW3 (SAMC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
S-adenosylmethionine mitochondrial carrier protein

Alternative name(s):
Mitochondrial S-adenosylmethionine transporter
Solute carrier family 25 member 26

Gene names

Name:	SLC25A26
Synonyms:	SAMC

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	274 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. Specifically mediates the transport of S-adenosylmethionine (SAM) into the mitochondria. Ref.1
Enzyme regulation	Strongly inhibited by tannic acid and Bromocresol Purple. Ref.1
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein Ref.1.
Tissue specificity	Widely expressed. Highly expressed in testis, with moderate expression in brain, heart, kidney, lung, skeletal muscle, pancreas, small intestine and liver, and low expression in spleen. Ref.1
Sequence similarities	Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification] Contains 3 Solcar repeats.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Transmembrane Transmembrane helix
Ligand	S-adenosyl-L-methionine
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from direct assay Ref.1. Source: UniProtKB nucleus Inferred from direct assay. Source: HPA
Molecular_function	S-adenosyl-L-methionine transmembrane transporter activity Inferred from mutant phenotype Ref.1. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q70HW3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q70HW3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: Missing.

Isoform 3 (identifier: Q70HW3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: Missing.
     152-154: IPF → EED
     155-274: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 274	274	S-adenosylmethionine mitochondrial carrier protein		PRO_0000317587
Regions
	Transmembrane	5 – 25	21	Helical; Name=1; Potential
	Transmembrane	49 – 69	21	Helical; Name=2; Potential
	Transmembrane	85 – 105	21	Helical; Name=3; Potential
	Transmembrane	142 – 162	21	Helical; Name=4; Potential
	Transmembrane	182 – 202	21	Helical; Name=5; Potential
	Transmembrane	238 – 258	21	Helical; Name=6; Potential
	Repeat	4 – 77	74	Solcar 1
	Repeat	86 – 168	83	Solcar 2
	Repeat	177 – 265	89	Solcar 3
Natural variations
	Alternative sequence	1 – 88	88	Missing in isoform 2 and isoform 3.		VSP_031062
	Alternative sequence	152 – 154	3	IPF → EED in isoform 3.		VSP_031063
	Alternative sequence	155 – 274	120	Missing in isoform 3.		VSP_031064
	Natural variant	208	1	T → M. Ref.2 Ref.3 Corresponds to variant rs13874 [ dbSNP | Ensembl ].		VAR_058973
Experimental info
	Sequence conflict	208	1	T → A in BAF84562. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 21ECA1E60C9BDDAD	FASTA	274	29,381
	10 20 30 40 50 60 MDRPGFVAAL VAGGVAGVSV DLILFPLDTI KTRLQSPQGF NKAGGFHGIY AGVPSAAIGS 70 80 90 100 110 120 FPNAAAFFIT YEYVKWFLHA DSSSYLTPMK HMLAASAGEV VACLIRVPSE VVKQRAQVSA 130 140 150 160 170 180 STRTFQIFSN ILYEEGIQGL YRGYKSTVLR EIPFSLVQFP LWESLKALWS WRQDHVVDSW 190 200 210 220 230 240 QSAVCGAFAG GFAAAVTTPL DVAKTRITLA KAGSSTADGN VLSVLHGVWR SQGLAGLFAG 250 260 270 VFPRMAAISL GGFIFLGAYD RTHSLLLEVG RKSP
	Isoform 2 [UniParc]. Checksum: 8024D5D11F6CF22B	FASTA	186	20,116
	10 20 30 40 50 60 MKHMLAASAG EVVACLIRVP SEVVKQRAQV SASTRTFQIF SNILYEEGIQ GLYRGYKSTV 70 80 90 100 110 120 LREIPFSLVQ FPLWESLKAL WSWRQDHVVD SWQSAVCGAF AGGFAAAVTT PLDVAKTRIT 130 140 150 160 170 180 LAKAGSSTAD GNVLSVLHGV WRSQGLAGLF AGVFPRMAAI SLGGFIFLGA YDRTHSLLLE VGRKSP
	Isoform 3 [UniParc]. Checksum: 68F03A11822C5C3E	FASTA	66	7,405
	10 20 30 40 50 60 MKHMLAASAG EVVACLIRVP SEVVKQRAQV SASTRTFQIF SNILYEEGIQ GLYRGYKSTV LREEED

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of the human mitochondrial S-adenosylmethionine transporter: bacterial expression, reconstitution, functional characterization and tissue distribution." Agrimi G., Di Noia M.A., Marobbio C.M.T., Fiermonte G., Lasorsa F.M., Palmieri F. Biochem. J. 379:183-190(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, ENZYME REGULATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT MET-208. Tissue: Placenta and Skeletal muscle.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT MET-208.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Ovary and Placenta.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ580932 mRNA. Translation: CAE45652.1. AK092495 mRNA. Translation: BAG52559.1. AK096876 mRNA. Translation: BAG53388.1. AK291873 mRNA. Translation: BAF84562.1. CH471055 Genomic DNA. Translation: EAW65449.1. CH471055 Genomic DNA. Translation: EAW65451.1. BC003399 mRNA. No translation available. BC012852 mRNA. Translation: AAH12852.2.
IPI	IPI00465034. IPI00549230. IPI00883595.
RefSeq	NP_001158268.1. NM_001164796.1. NP_775742.4. NM_173471.3.
UniGene	Hs.379386.
3D structure databases
ProteinModelPortal	Q70HW3.
ModBase	Search...
PTM databases
PhosphoSite	Q70HW3.
Polymorphism databases
DMDM	74749739.
Proteomic databases
PaxDb	Q70HW3.
PRIDE	Q70HW3.
Protocols and materials databases
DNASU	115286.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000336733; ENSP00000336801; ENSG00000144741.
GeneID	115286.
KEGG	hsa:115286.
UCSC	uc011bfs.2. human.
Organism-specific databases
CTD	115286.
GeneCards	GC03P066120.
HGNC	HGNC:20661. SLC25A26.
HPA	HPA026887.
MIM	611037. gene.
neXtProt	NX_Q70HW3.
PharmGKB	PA134987831.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG247316.
HOGENOM	HOG000038810.
HOVERGEN	HBG108456.
InParanoid	Q70HW3.
KO	K15111.
Gene expression databases
ArrayExpress	Q70HW3.
Bgee	Q70HW3.
CleanEx	HS_SLC25A26.
Genevestigator	Q70HW3.
Family and domain databases
Gene3D	1.50.40.10. 1 hit.
InterPro	IPR018108. Mitochondrial_sb/sol_carrier. IPR023395. Mt_carrier_dom. [Graphical view]
Pfam	PF00153. Mito_carr. 3 hits. [Graphical view]
SUPFAM	SSF103506. Mitoch_carrier. 1 hit.
PROSITE	PS50920. SOLCAR. 3 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SLC25A26. human.
GenomeRNAi	115286.
NextBio	79552.
SOURCE	Search...

Entry information

Entry name

SAMC_HUMAN

Accession

Primary (citable) accession number: Q70HW3
Secondary accession number(s): A8K758 , B3KRZ7, Q7Z786, Q96E68

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.