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Protein

Solute carrier family 10 member 6

Gene

Slc10a6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transports sulfoconjugated steroid hormones, as well as taurolithocholic acid-3-sulfate and sulfoconjugated pyrenes in a sodium-dependent manner.1 Publication

GO - Molecular functioni

GO - Biological processi

  • sodium-dependent organic anion transport Source: RGD
  • sodium ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-RNO-425366. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

Protein family/group databases

TCDBi2.A.28.1.3. the bile acid:na(+) symporter (bass) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 10 member 6
Alternative name(s):
Sodium-dependent organic anion transporter
Gene namesi
Name:Slc10a6
Synonyms:Soat
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi727800. Slc10a6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232ExtracellularSequence analysisAdd
BLAST
Transmembranei33 – 5321HelicalSequence analysisAdd
BLAST
Topological domaini54 – 6714CytoplasmicSequence analysisAdd
BLAST
Transmembranei68 – 8821HelicalSequence analysisAdd
BLAST
Topological domaini89 – 979ExtracellularSequence analysis
Transmembranei98 – 11821HelicalSequence analysisAdd
BLAST
Topological domaini119 – 1268CytoplasmicSequence analysis
Transmembranei127 – 14721HelicalSequence analysisAdd
BLAST
Topological domaini148 – 15912ExtracellularSequence analysisAdd
BLAST
Transmembranei160 – 18021HelicalSequence analysisAdd
BLAST
Topological domaini181 – 19515CytoplasmicSequence analysisAdd
BLAST
Transmembranei196 – 21621HelicalSequence analysisAdd
BLAST
Topological domaini217 – 2248ExtracellularSequence analysis
Transmembranei225 – 24521HelicalSequence analysisAdd
BLAST
Topological domaini246 – 26520CytoplasmicSequence analysisAdd
BLAST
Transmembranei266 – 28318HelicalSequence analysisAdd
BLAST
Topological domaini284 – 2841ExtracellularSequence analysis
Transmembranei285 – 30521HelicalSequence analysisAdd
BLAST
Topological domaini306 – 37065CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 370370Solute carrier family 10 member 6PRO_0000309217Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi8 – 81N-linked (GlcNAc...)Sequence analysis
Glycosylationi14 – 141N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ70EX6.
PRIDEiQ70EX6.

Expressioni

Tissue specificityi

Highly expressed in heart, lung, spleen and adrenal gland. Moderately expressed in skeletal muscle, testis and small intestine.1 Publication

Gene expression databases

GenevisibleiQ70EX6. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002819.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2718. Eukaryota.
COG0385. LUCA.
GeneTreeiENSGT00550000074505.
HOGENOMiHOG000234524.
HOVERGENiHBG006537.
InParanoidiQ70EX6.
KOiK14346.
OMAiCLTIPVA.
OrthoDBiEOG7XWPNW.
PhylomeDBiQ70EX6.
TreeFamiTF315811.

Family and domain databases

InterProiIPR002657. BilAc:Na_symport/Acr3.
IPR030203. SLC10A6.
[Graphical view]
PANTHERiPTHR10361. PTHR10361. 1 hit.
PTHR10361:SF4. PTHR10361:SF4. 1 hit.
PfamiPF01758. SBF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q70EX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSADCEGNST CPANSTEEDP PVGMEGQGSL KLVFTVLSAV MVGLVMFSFG
60 70 80 90 100
CSVESRKLWL HLRRPWGIAV GLLCQFGLMP LTAYLLAIGF GLKPFQAIAV
110 120 130 140 150
LIMGSCPGGT VSNVLTFWVD GDMDLSISMT TCSTVAALGM MPLCLYVYTR
160 170 180 190 200
SWTLPQSLTI PYQSIGITLV SLVVPVASGI YVNYRWPKQA TFILKVGAAV
210 220 230 240 250
GGMLLLVVAV TGVVLAKGWN IDVTLLVISC IFPLVGHVMG FLLAFLTHQS
260 270 280 290 300
WQRCRTISIE TGAQNIQLCI AMMQLSFSAE YLVQLLNFAL AYGLFQVLHG
310 320 330 340 350
LLIVAAYQAY KRRQKSQYRR QHPECQDISS EKQPRETSAF LDKGAEAAVT
360 370
LGLEQHHRTA ELTSHVPSCE
Length:370
Mass (Da):40,310
Last modified:July 5, 2004 - v1
Checksum:i27CBA6E42B0733D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ583503 mRNA. Translation: CAE47478.1.
RefSeqiNP_932166.1. NM_198049.1.
UniGeneiRn.231621.

Genome annotation databases

EnsembliENSRNOT00000002819; ENSRNOP00000002819; ENSRNOG00000002057.
ENSRNOT00000088508; ENSRNOP00000072386; ENSRNOG00000002057.
GeneIDi289459.
KEGGirno:289459.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ583503 mRNA. Translation: CAE47478.1.
RefSeqiNP_932166.1. NM_198049.1.
UniGeneiRn.231621.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002819.

Protein family/group databases

TCDBi2.A.28.1.3. the bile acid:na(+) symporter (bass) family.

Proteomic databases

PaxDbiQ70EX6.
PRIDEiQ70EX6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000002819; ENSRNOP00000002819; ENSRNOG00000002057.
ENSRNOT00000088508; ENSRNOP00000072386; ENSRNOG00000002057.
GeneIDi289459.
KEGGirno:289459.

Organism-specific databases

CTDi345274.
RGDi727800. Slc10a6.

Phylogenomic databases

eggNOGiKOG2718. Eukaryota.
COG0385. LUCA.
GeneTreeiENSGT00550000074505.
HOGENOMiHOG000234524.
HOVERGENiHBG006537.
InParanoidiQ70EX6.
KOiK14346.
OMAiCLTIPVA.
OrthoDBiEOG7XWPNW.
PhylomeDBiQ70EX6.
TreeFamiTF315811.

Enzyme and pathway databases

ReactomeiR-RNO-425366. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

Miscellaneous databases

PROiQ70EX6.

Gene expression databases

GenevisibleiQ70EX6. RN.

Family and domain databases

InterProiIPR002657. BilAc:Na_symport/Acr3.
IPR030203. SLC10A6.
[Graphical view]
PANTHERiPTHR10361. PTHR10361. 1 hit.
PTHR10361:SF4. PTHR10361:SF4. 1 hit.
PfamiPF01758. SBF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of a sodium-dependent organic anion transporter from rat adrenal gland."
    Geyer J., Godoy J.R., Petzinger E.
    Biochem. Biophys. Res. Commun. 316:300-306(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: Wistar.
    Tissue: Adrenal gland.

Entry informationi

Entry nameiSOAT_RAT
AccessioniPrimary (citable) accession number: Q70EX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.