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Protein

Inactive ubiquitin carboxyl-terminal hydrolase 50

Gene

USP50

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Has no peptidase activity.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Protein family/group databases

MEROPSiC19.058.

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive ubiquitin carboxyl-terminal hydrolase 50
Alternative name(s):
Inactive ubiquitin-specific peptidase 50
Gene namesi
Name:USP50
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:20079. USP50.

Pathology & Biotechi

Organism-specific databases

DisGeNETi373509.
OpenTargetsiENSG00000170236.

Polymorphism and mutation databases

DMDMi74723115.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002495271 – 339Inactive ubiquitin carboxyl-terminal hydrolase 50Add BLAST339

Proteomic databases

PaxDbiQ70EL3.
PRIDEiQ70EL3.

PTM databases

iPTMnetiQ70EL3.
PhosphoSitePlusiQ70EL3.

Expressioni

Tissue specificityi

Weakly expressed in a few tissues.1 Publication

Gene expression databases

BgeeiENSG00000170236.
CleanExiHS_USP50.
ExpressionAtlasiQ70EL3. baseline and differential.

Organism-specific databases

HPAiHPA039470.

Interactioni

Protein-protein interaction databases

BioGridi131884. 25 interactors.
IntActiQ70EL3. 21 interactors.
STRINGi9606.ENSP00000434676.

Structurei

3D structure databases

ProteinModelPortaliQ70EL3.
SMRiQ70EL3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 339USPAdd BLAST296

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 USP domain.Curated

Phylogenomic databases

eggNOGiKOG1868. Eukaryota.
ENOG410XP8T. LUCA.
GeneTreeiENSGT00860000133682.
HOGENOMiHOG000231498.
HOVERGENiHBG098592.
InParanoidiQ70EL3.
PhylomeDBiQ70EL3.
TreeFamiTF106277.

Family and domain databases

InterProiIPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q70EL3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSQPSLPAD DFDIYHVLAE CTDYYDTLPV KEADGNQPHF QGVTGLWNLG
60 70 80 90 100
NTCCVNAISQ CLCSILPLVE YFLTGKYITA LQKFLLPSDC SEVATAFAYL
110 120 130 140 150
MTDMWLGDSD CVSPEIFWSA LGNLYPAFTK KMQQDAQEFL ICVLNELHEA
160 170 180 190 200
LKKYHYSRRR SYEKGSTQRC CRKWITTETS IITQLFEEQL NYSIVCLKCE
210 220 230 240 250
KCTYKNEVFT VFSLPIPSKY ECSLRDCLQC FFQQDALTWN NEIHCSFCET
260 270 280 290 300
KQETAVRASI SKAPKIIIFH LKRFDIQGTT KRKLRTDIHY PLTNLDLTPY
310 320 330
ICSIFRKYPK YNLCAVVNHF GDLDGGHYTA FCKNSVTQA
Length:339
Mass (Da):38,955
Last modified:July 5, 2004 - v1
Checksum:iB41D707864CBB5AC
GO
Isoform 2 (identifier: Q70EL3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     83-88: KFLLPS → N

Show »
Length:334
Mass (Da):38,383
Checksum:i9D0EFB3A9EBDD9E3
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05424883 – 88KFLLPS → N in isoform 2. Curated6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ583818 mRNA. Translation: CAE47745.2.
BN000339 mRNA. Translation: CAE48395.1.
AC012170 Genomic DNA. No translation available.
CCDSiCCDS53944.1. [Q70EL3-2]
RefSeqiNP_987090.2. NM_203494.4. [Q70EL3-2]
UniGeneiHs.677758.

Genome annotation databases

EnsembliENST00000532404; ENSP00000434676; ENSG00000170236. [Q70EL3-2]
GeneIDi373509.
KEGGihsa:373509.
UCSCiuc021sky.2. human. [Q70EL3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ583818 mRNA. Translation: CAE47745.2.
BN000339 mRNA. Translation: CAE48395.1.
AC012170 Genomic DNA. No translation available.
CCDSiCCDS53944.1. [Q70EL3-2]
RefSeqiNP_987090.2. NM_203494.4. [Q70EL3-2]
UniGeneiHs.677758.

3D structure databases

ProteinModelPortaliQ70EL3.
SMRiQ70EL3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131884. 25 interactors.
IntActiQ70EL3. 21 interactors.
STRINGi9606.ENSP00000434676.

Protein family/group databases

MEROPSiC19.058.

PTM databases

iPTMnetiQ70EL3.
PhosphoSitePlusiQ70EL3.

Polymorphism and mutation databases

DMDMi74723115.

Proteomic databases

PaxDbiQ70EL3.
PRIDEiQ70EL3.

Protocols and materials databases

DNASUi373509.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000532404; ENSP00000434676; ENSG00000170236. [Q70EL3-2]
GeneIDi373509.
KEGGihsa:373509.
UCSCiuc021sky.2. human. [Q70EL3-1]

Organism-specific databases

CTDi373509.
DisGeNETi373509.
GeneCardsiUSP50.
H-InvDBHIX0038100.
HGNCiHGNC:20079. USP50.
HPAiHPA039470.
neXtProtiNX_Q70EL3.
OpenTargetsiENSG00000170236.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1868. Eukaryota.
ENOG410XP8T. LUCA.
GeneTreeiENSGT00860000133682.
HOGENOMiHOG000231498.
HOVERGENiHBG098592.
InParanoidiQ70EL3.
PhylomeDBiQ70EL3.
TreeFamiTF106277.

Miscellaneous databases

GenomeRNAii373509.
PROiQ70EL3.

Gene expression databases

BgeeiENSG00000170236.
CleanExiHS_USP50.
ExpressionAtlasiQ70EL3. baseline and differential.

Family and domain databases

InterProiIPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUBP50_HUMAN
AccessioniPrimary (citable) accession number: Q70EL3
Secondary accession number(s): E9PP86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Although the active site residues are conserved, lacks the conserved Asp/Asn residue which is normally found 7-9 residues after the catalytic His.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.