Q70EL1 (UBP54_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inactive ubiquitin carboxyl-terminal hydrolase 54

Alternative name(s):
Inactive ubiquitin-specific peptidase 54

Gene names

Name:	USP54
Synonyms:	C10orf29

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1684 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Has no peptidase activity.
Tissue specificity	Weakly expressed in a few tissues. Ref.1
Sequence similarities	Belongs to the peptidase C19 family.
Caution	Although the active site residues are conserved, it lacks the conserved His residue which is normally found 9 residues before the catalytic His.
Sequence caution	The sequence BAC04393.1 differs from that shown. Reason: Erroneous initiation. The sequence BAG53943.1 differs from that shown. Reason: Erroneous initiation. The sequence BX649087 differs from that shown. Reason: Frameshift at position 508. The sequence CAO03507.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAO03508.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAO03509.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	ubiquitin thiolesterase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ATXN1	P54253	3	EBI-946185,EBI-930964

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q70EL1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q70EL1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     383-403: REPSISSDTRTDSSTESYPYK → EQPGSLPLLSPHPMRSNSWDS
     404-1684: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q70EL1-6)

The sequence of this isoform differs from the canonical sequence as follows:
     893-893: S → R
     894-1684: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q70EL1-7)

The sequence of this isoform differs from the canonical sequence as follows:
     126-275: Missing.

Note: No experimental confirmation available.

Isoform 5 (identifier: Q70EL1-8)

The sequence of this isoform differs from the canonical sequence as follows:
     1-912: Missing.

Isoform 6 (identifier: Q70EL1-9)

The sequence of this isoform differs from the canonical sequence as follows:
     1-912: Missing.
     1391-1437: Missing.

Isoform 7 (identifier: Q70EL1-10)

The sequence of this isoform differs from the canonical sequence as follows:
     1-912: Missing.
     1386-1390: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1684	1684	Inactive ubiquitin carboxyl-terminal hydrolase 54		PRO_0000249530
Regions
	Coiled coil	736 – 770	35	Potential
	Compositional bias	559 – 570	12	Poly-Ser
	Compositional bias	866 – 869	4	Poly-Gln
Amino acid modifications
	Modified residue	227	1	Phosphoserine By similarity
	Modified residue	671	1	Phosphoserine Ref.6
Natural variations
	Alternative sequence	1 – 912	912	Missing in isoform 5, isoform 6 and isoform 7.		VSP_035674
	Alternative sequence	126 – 275	150	Missing in isoform 4.		VSP_029922
	Alternative sequence	383 – 403	21	REPSI…SYPYK → EQPGSLPLLSPHPMRSNSWD S in isoform 2.		VSP_026525
	Alternative sequence	404 – 1684	1281	Missing in isoform 2.		VSP_026526
	Alternative sequence	893	1	S → R in isoform 3.		VSP_035675
	Alternative sequence	894 – 1684	791	Missing in isoform 3.		VSP_035676
	Alternative sequence	1386 – 1390	5	Missing in isoform 7.		VSP_035677
	Alternative sequence	1391 – 1437	47	Missing in isoform 6.		VSP_035678
	Natural variant	505	1	L → V in a breast cancer sample; somatic mutation. Ref.8		VAR_036360
	Natural variant	976	1	K → E. Corresponds to variant rs1618542 [ dbSNP | Ensembl ].		VAR_047258
	Natural variant	1231	1	D → N. Corresponds to variant rs4619071 [ dbSNP | Ensembl ].		VAR_047259
	Natural variant	1367	1	G → D. Corresponds to variant rs7083344 [ dbSNP | Ensembl ].		VAR_047260
Experimental info
	Sequence conflict	110 – 111	2	EQ → KE in BX649087. Ref.3
	Sequence conflict	191	1	C → S in CAE47747. Ref.1
	Sequence conflict	226	1	P → L in BX649087. Ref.3
	Sequence conflict	733	1	E → G in BX649087. Ref.3
	Sequence conflict	1345	1	H → P in BAC04393. Ref.2
	Sequence conflict	1425	1	S → P in BAC86566. Ref.2
	Sequence conflict	1438	1	D → H in AAI30634. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 25, 2008. Version 4. Checksum: 853D9CFCB35C63C4	FASTA	1,684	187,388
	10 20 30 40 50 60 MSWKRNYFSG GRGSVQGMFA PRSSTSIAPS KGLSNEPGQN SCFLNSALQV LWHLDIFRRS 70 80 90 100 110 120 FRQLTTHKCM GDSCIFCALK GIFNQFQCSS EKVLPSDTLR SALAKTFQDE QRFQLGIMDD 130 140 150 160 170 180 AAECFENLLM RIHFHIADET KEDICTAQHC ISHQKFAMTL FEQCVCTSCG ATSDPLPFIQ 190 200 210 220 230 240 MVHYISTTSL CNQAICMLER REKPSPSMFG ELLQNASTMG DLRNCPSNCG ERIRIRRVLM 250 260 270 280 290 300 NAPQIITIGL VWDSDHSDLA EDVIHSLGTC LKLGDLFFRV TDDRAKQSEL YLVGMICYYG 310 320 330 340 350 360 KHYSTFFFQT KIRKWMYFDD AHVKEIGPKW KDVVTKCIKG HYQPLLLLYA DPQGTPVSTQ 370 380 390 400 410 420 DLPPQAEFQS YSRTCYDSED SGREPSISSD TRTDSSTESY PYKHSHHESV VSHFSSDSQG 430 440 450 460 470 480 TVIYNVENDS MSQSSRDTGH LTDSECNQKH TSKKGSLIER KRSSGRVRRK GDEPQASGYH 490 500 510 520 530 540 SEGETLKEKQ APRNASKPSS STNRLRDFKE TVSNMIHNRP SLASQTNVGS HCRGRGGDQP 550 560 570 580 590 600 DKKPPRTLPL HSRDWEIEST SSESKSSSSS KYRPTWRPKR ESLNIDSIFS KDKRKHCGYT 610 620 630 640 650 660 QLSPFSEDSA KEFIPDEPSK PPSYDIKFGG PSPQYKRWGP ARPGSHLLEQ HPRLIQRMES 670 680 690 700 710 720 GYESSERNSS SPVSLDAALP ESSNVYRDPS AKRSAGLVPS WRHIPKSHSS SILEVDSTAS 730 740 750 760 770 780 MGGWTKSQPF SGEEISSKSE LDELQEEVAR RAQEQELRRK REKELEAAKG FNPHPSRFMD 790 800 810 820 830 840 LDELQNQGRS DGFERSLQEA ESVFEESLHL EQKGDCAAAL ALCNEAISKL RLALHGASCS 850 860 870 880 890 900 THSRALVDKK LQISIRKARS LQDRMQQQQS PQQPSQPSAC LPTQAGTLSQ PTSEQPIPLQ 910 920 930 940 950 960 VLLSQEAQLE SGMDTEFGAS SFFHSPASCH ESHSSLSPES SAPQHSSPSR SALKLLTSVE 970 980 990 1000 1010 1020 VDNIEPSAFH RQGLPKAPGW TEKNSHHSWE PLDAPEGKLQ GSRCDNSSCS KLPPQEGRGI 1030 1040 1050 1060 1070 1080 AQEQLFQEKK DPANPSPVMP GIATSERGDE HSLGCSPSNS SAQPSLPLYR TCHPIMPVAS 1090 1100 1110 1120 1130 1140 SFVLHCPDPV QKTNQCLQGQ SLKTSLTLKV DRGSEETYRP EFPSTKGLVR SLAEQFQRMQ 1150 1160 1170 1180 1190 1200 GVSMRDSTGF KDRSLSGSLR KNSSPSDSKP PFSQGQEKGH WPWAKQQSSL EGGDRPLSWE 1210 1220 1230 1240 1250 1260 ESTEHSSLAL NSGLPNGETS SGGQPRLAEP DIYQEKLSQV RDVRSKDLGS STDLGTSLPL 1270 1280 1290 1300 1310 1320 DSWVNITRFC DSQLKHGAPR PGMKSSPHDS HTCVTYPERN HILLHPHWNQ DTEQETSELE 1330 1340 1350 1360 1370 1380 SLYQASLQAS QAGCSGWGQQ DTAWHPLSQT GSADGMGRRL HSAHDPGLSK TSTAEMEHGL 1390 1400 1410 1420 1430 1440 HEARTVRTSQ ATPCRGLSRE CGEDEQYSAE NLRRISRSLS GTVVSEREEA PVSSHSFDSS 1450 1460 1470 1480 1490 1500 NVRKPLETGH RCSSSSSLPV IHDPSVFLLG PQLYLPQPQF LSPDVLMPTM AGEPNRLPGT 1510 1520 1530 1540 1550 1560 SRSVQQFLAM CDRGETSQGA KYTGRTLNYQ SLPHRSRTDN SWAPWSETNQ HIGTRFLTTP 1570 1580 1590 1600 1610 1620 GCNPQLTYTA TLPERSKGLQ VPHTQSWSDL FHSPSHPPIV HPVYPPSSSL HVPLRSAWNS 1630 1640 1650 1660 1670 1680 DPVPGSRTPG PRRVDMPPDD DWRQSSYASH SGHRRTVGEG FLFVLSDAPR REQIRARVLQ HSQW
	Isoform 2 [UniParc]. Checksum: 2749CBBCC8AF37A9	FASTA	403	45,703
	10 20 30 40 50 60 MSWKRNYFSG GRGSVQGMFA PRSSTSIAPS KGLSNEPGQN SCFLNSALQV LWHLDIFRRS 70 80 90 100 110 120 FRQLTTHKCM GDSCIFCALK GIFNQFQCSS EKVLPSDTLR SALAKTFQDE QRFQLGIMDD 130 140 150 160 170 180 AAECFENLLM RIHFHIADET KEDICTAQHC ISHQKFAMTL FEQCVCTSCG ATSDPLPFIQ 190 200 210 220 230 240 MVHYISTTSL CNQAICMLER REKPSPSMFG ELLQNASTMG DLRNCPSNCG ERIRIRRVLM 250 260 270 280 290 300 NAPQIITIGL VWDSDHSDLA EDVIHSLGTC LKLGDLFFRV TDDRAKQSEL YLVGMICYYG 310 320 330 340 350 360 KHYSTFFFQT KIRKWMYFDD AHVKEIGPKW KDVVTKCIKG HYQPLLLLYA DPQGTPVSTQ 370 380 390 400 DLPPQAEFQS YSRTCYDSED SGEQPGSLPL LSPHPMRSNS WDS
	Isoform 3 [UniParc]. Checksum: 7D1C84A450FEB447	FASTA	893	100,476
	10 20 30 40 50 60 MSWKRNYFSG GRGSVQGMFA PRSSTSIAPS KGLSNEPGQN SCFLNSALQV LWHLDIFRRS 70 80 90 100 110 120 FRQLTTHKCM GDSCIFCALK GIFNQFQCSS EKVLPSDTLR SALAKTFQDE QRFQLGIMDD 130 140 150 160 170 180 AAECFENLLM RIHFHIADET KEDICTAQHC ISHQKFAMTL FEQCVCTSCG ATSDPLPFIQ 190 200 210 220 230 240 MVHYISTTSL CNQAICMLER REKPSPSMFG ELLQNASTMG DLRNCPSNCG ERIRIRRVLM 250 260 270 280 290 300 NAPQIITIGL VWDSDHSDLA EDVIHSLGTC LKLGDLFFRV TDDRAKQSEL YLVGMICYYG 310 320 330 340 350 360 KHYSTFFFQT KIRKWMYFDD AHVKEIGPKW KDVVTKCIKG HYQPLLLLYA DPQGTPVSTQ 370 380 390 400 410 420 DLPPQAEFQS YSRTCYDSED SGREPSISSD TRTDSSTESY PYKHSHHESV VSHFSSDSQG 430 440 450 460 470 480 TVIYNVENDS MSQSSRDTGH LTDSECNQKH TSKKGSLIER KRSSGRVRRK GDEPQASGYH 490 500 510 520 530 540 SEGETLKEKQ APRNASKPSS STNRLRDFKE TVSNMIHNRP SLASQTNVGS HCRGRGGDQP 550 560 570 580 590 600 DKKPPRTLPL HSRDWEIEST SSESKSSSSS KYRPTWRPKR ESLNIDSIFS KDKRKHCGYT 610 620 630 640 650 660 QLSPFSEDSA KEFIPDEPSK PPSYDIKFGG PSPQYKRWGP ARPGSHLLEQ HPRLIQRMES 670 680 690 700 710 720 GYESSERNSS SPVSLDAALP ESSNVYRDPS AKRSAGLVPS WRHIPKSHSS SILEVDSTAS 730 740 750 760 770 780 MGGWTKSQPF SGEEISSKSE LDELQEEVAR RAQEQELRRK REKELEAAKG FNPHPSRFMD 790 800 810 820 830 840 LDELQNQGRS DGFERSLQEA ESVFEESLHL EQKGDCAAAL ALCNEAISKL RLALHGASCS 850 860 870 880 890 THSRALVDKK LQISIRKARS LQDRMQQQQS PQQPSQPSAC LPTQAGTLSQ PTR
	Isoform 4 [UniParc]. Checksum: B00DC48D0DE75BC3	FASTA	1,534	170,581
	10 20 30 40 50 60 MSWKRNYFSG GRGSVQGMFA PRSSTSIAPS KGLSNEPGQN SCFLNSALQV LWHLDIFRRS 70 80 90 100 110 120 FRQLTTHKCM GDSCIFCALK GIFNQFQCSS EKVLPSDTLR SALAKTFQDE QRFQLGIMDD 130 140 150 160 170 180 AAECFLFFRV TDDRAKQSEL YLVGMICYYG KHYSTFFFQT KIRKWMYFDD AHVKEIGPKW 190 200 210 220 230 240 KDVVTKCIKG HYQPLLLLYA DPQGTPVSTQ DLPPQAEFQS YSRTCYDSED SGREPSISSD 250 260 270 280 290 300 TRTDSSTESY PYKHSHHESV VSHFSSDSQG TVIYNVENDS MSQSSRDTGH LTDSECNQKH 310 320 330 340 350 360 TSKKGSLIER KRSSGRVRRK GDEPQASGYH SEGETLKEKQ APRNASKPSS STNRLRDFKE 370 380 390 400 410 420 TVSNMIHNRP SLASQTNVGS HCRGRGGDQP DKKPPRTLPL HSRDWEIEST SSESKSSSSS 430 440 450 460 470 480 KYRPTWRPKR ESLNIDSIFS KDKRKHCGYT QLSPFSEDSA KEFIPDEPSK PPSYDIKFGG 490 500 510 520 530 540 PSPQYKRWGP ARPGSHLLEQ HPRLIQRMES GYESSERNSS SPVSLDAALP ESSNVYRDPS 550 560 570 580 590 600 AKRSAGLVPS WRHIPKSHSS SILEVDSTAS MGGWTKSQPF SGEEISSKSE LDELQEEVAR 610 620 630 640 650 660 RAQEQELRRK REKELEAAKG FNPHPSRFMD LDELQNQGRS DGFERSLQEA ESVFEESLHL 670 680 690 700 710 720 EQKGDCAAAL ALCNEAISKL RLALHGASCS THSRALVDKK LQISIRKARS LQDRMQQQQS 730 740 750 760 770 780 PQQPSQPSAC LPTQAGTLSQ PTSEQPIPLQ VLLSQEAQLE SGMDTEFGAS SFFHSPASCH 790 800 810 820 830 840 ESHSSLSPES SAPQHSSPSR SALKLLTSVE VDNIEPSAFH RQGLPKAPGW TEKNSHHSWE 850 860 870 880 890 900 PLDAPEGKLQ GSRCDNSSCS KLPPQEGRGI AQEQLFQEKK DPANPSPVMP GIATSERGDE 910 920 930 940 950 960 HSLGCSPSNS SAQPSLPLYR TCHPIMPVAS SFVLHCPDPV QKTNQCLQGQ SLKTSLTLKV 970 980 990 1000 1010 1020 DRGSEETYRP EFPSTKGLVR SLAEQFQRMQ GVSMRDSTGF KDRSLSGSLR KNSSPSDSKP 1030 1040 1050 1060 1070 1080 PFSQGQEKGH WPWAKQQSSL EGGDRPLSWE ESTEHSSLAL NSGLPNGETS SGGQPRLAEP 1090 1100 1110 1120 1130 1140 DIYQEKLSQV RDVRSKDLGS STDLGTSLPL DSWVNITRFC DSQLKHGAPR PGMKSSPHDS 1150 1160 1170 1180 1190 1200 HTCVTYPERN HILLHPHWNQ DTEQETSELE SLYQASLQAS QAGCSGWGQQ DTAWHPLSQT 1210 1220 1230 1240 1250 1260 GSADGMGRRL HSAHDPGLSK TSTAEMEHGL HEARTVRTSQ ATPCRGLSRE CGEDEQYSAE 1270 1280 1290 1300 1310 1320 NLRRISRSLS GTVVSEREEA PVSSHSFDSS NVRKPLETGH RCSSSSSLPV IHDPSVFLLG 1330 1340 1350 1360 1370 1380 PQLYLPQPQF LSPDVLMPTM AGEPNRLPGT SRSVQQFLAM CDRGETSQGA KYTGRTLNYQ 1390 1400 1410 1420 1430 1440 SLPHRSRTDN SWAPWSETNQ HIGTRFLTTP GCNPQLTYTA TLPERSKGLQ VPHTQSWSDL 1450 1460 1470 1480 1490 1500 FHSPSHPPIV HPVYPPSSSL HVPLRSAWNS DPVPGSRTPG PRRVDMPPDD DWRQSSYASH 1510 1520 1530 SGHRRTVGEG FLFVLSDAPR REQIRARVLQ HSQW
	Isoform 5 [UniParc]. Checksum: A41B0ACF854B4AF2	FASTA	772	84,938
	10 20 30 40 50 60 MDTEFGASSF FHSPASCHES HSSLSPESSA PQHSSPSRSA LKLLTSVEVD NIEPSAFHRQ 70 80 90 100 110 120 GLPKAPGWTE KNSHHSWEPL DAPEGKLQGS RCDNSSCSKL PPQEGRGIAQ EQLFQEKKDP 130 140 150 160 170 180 ANPSPVMPGI ATSERGDEHS LGCSPSNSSA QPSLPLYRTC HPIMPVASSF VLHCPDPVQK 190 200 210 220 230 240 TNQCLQGQSL KTSLTLKVDR GSEETYRPEF PSTKGLVRSL AEQFQRMQGV SMRDSTGFKD 250 260 270 280 290 300 RSLSGSLRKN SSPSDSKPPF SQGQEKGHWP WAKQQSSLEG GDRPLSWEES TEHSSLALNS 310 320 330 340 350 360 GLPNGETSSG GQPRLAEPDI YQEKLSQVRD VRSKDLGSST DLGTSLPLDS WVNITRFCDS 370 380 390 400 410 420 QLKHGAPRPG MKSSPHDSHT CVTYPERNHI LLHPHWNQDT EQETSELESL YQASLQASQA 430 440 450 460 470 480 GCSGWGQQDT AWHPLSQTGS ADGMGRRLHS AHDPGLSKTS TAEMEHGLHE ARTVRTSQAT 490 500 510 520 530 540 PCRGLSRECG EDEQYSAENL RRISRSLSGT VVSEREEAPV SSHSFDSSNV RKPLETGHRC 550 560 570 580 590 600 SSSSSLPVIH DPSVFLLGPQ LYLPQPQFLS PDVLMPTMAG EPNRLPGTSR SVQQFLAMCD 610 620 630 640 650 660 RGETSQGAKY TGRTLNYQSL PHRSRTDNSW APWSETNQHI GTRFLTTPGC NPQLTYTATL 670 680 690 700 710 720 PERSKGLQVP HTQSWSDLFH SPSHPPIVHP VYPPSSSLHV PLRSAWNSDP VPGSRTPGPR 730 740 750 760 770 RVDMPPDDDW RQSSYASHSG HRRTVGEGFL FVLSDAPRRE QIRARVLQHS QW
	Isoform 6 [UniParc]. Checksum: 98EFA86D1005C89F	FASTA	725	79,771
	10 20 30 40 50 60 MDTEFGASSF FHSPASCHES HSSLSPESSA PQHSSPSRSA LKLLTSVEVD NIEPSAFHRQ 70 80 90 100 110 120 GLPKAPGWTE KNSHHSWEPL DAPEGKLQGS RCDNSSCSKL PPQEGRGIAQ EQLFQEKKDP 130 140 150 160 170 180 ANPSPVMPGI ATSERGDEHS LGCSPSNSSA QPSLPLYRTC HPIMPVASSF VLHCPDPVQK 190 200 210 220 230 240 TNQCLQGQSL KTSLTLKVDR GSEETYRPEF PSTKGLVRSL AEQFQRMQGV SMRDSTGFKD 250 260 270 280 290 300 RSLSGSLRKN SSPSDSKPPF SQGQEKGHWP WAKQQSSLEG GDRPLSWEES TEHSSLALNS 310 320 330 340 350 360 GLPNGETSSG GQPRLAEPDI YQEKLSQVRD VRSKDLGSST DLGTSLPLDS WVNITRFCDS 370 380 390 400 410 420 QLKHGAPRPG MKSSPHDSHT CVTYPERNHI LLHPHWNQDT EQETSELESL YQASLQASQA 430 440 450 460 470 480 GCSGWGQQDT AWHPLSQTGS ADGMGRRLHS AHDPGLSKTS TAEMEHGLHE ARTVRTSQDS 490 500 510 520 530 540 SNVRKPLETG HRCSSSSSLP VIHDPSVFLL GPQLYLPQPQ FLSPDVLMPT MAGEPNRLPG 550 560 570 580 590 600 TSRSVQQFLA MCDRGETSQG AKYTGRTLNY QSLPHRSRTD NSWAPWSETN QHIGTRFLTT 610 620 630 640 650 660 PGCNPQLTYT ATLPERSKGL QVPHTQSWSD LFHSPSHPPI VHPVYPPSSS LHVPLRSAWN 670 680 690 700 710 720 SDPVPGSRTP GPRRVDMPPD DDWRQSSYAS HSGHRRTVGE GFLFVLSDAP RREQIRARVL QHSQW
	Isoform 7 [UniParc]. Checksum: C622D8C5CE11DDF3	FASTA	767	84,366
	10 20 30 40 50 60 MDTEFGASSF FHSPASCHES HSSLSPESSA PQHSSPSRSA LKLLTSVEVD NIEPSAFHRQ 70 80 90 100 110 120 GLPKAPGWTE KNSHHSWEPL DAPEGKLQGS RCDNSSCSKL PPQEGRGIAQ EQLFQEKKDP 130 140 150 160 170 180 ANPSPVMPGI ATSERGDEHS LGCSPSNSSA QPSLPLYRTC HPIMPVASSF VLHCPDPVQK 190 200 210 220 230 240 TNQCLQGQSL KTSLTLKVDR GSEETYRPEF PSTKGLVRSL AEQFQRMQGV SMRDSTGFKD 250 260 270 280 290 300 RSLSGSLRKN SSPSDSKPPF SQGQEKGHWP WAKQQSSLEG GDRPLSWEES TEHSSLALNS 310 320 330 340 350 360 GLPNGETSSG GQPRLAEPDI YQEKLSQVRD VRSKDLGSST DLGTSLPLDS WVNITRFCDS 370 380 390 400 410 420 QLKHGAPRPG MKSSPHDSHT CVTYPERNHI LLHPHWNQDT EQETSELESL YQASLQASQA 430 440 450 460 470 480 GCSGWGQQDT AWHPLSQTGS ADGMGRRLHS AHDPGLSKTS TAEMEHGLHE ARTATPCRGL 490 500 510 520 530 540 SRECGEDEQY SAENLRRISR SLSGTVVSER EEAPVSSHSF DSSNVRKPLE TGHRCSSSSS 550 560 570 580 590 600 LPVIHDPSVF LLGPQLYLPQ PQFLSPDVLM PTMAGEPNRL PGTSRSVQQF LAMCDRGETS 610 620 630 640 650 660 QGAKYTGRTL NYQSLPHRSR TDNSWAPWSE TNQHIGTRFL TTPGCNPQLT YTATLPERSK 670 680 690 700 710 720 GLQVPHTQSW SDLFHSPSHP PIVHPVYPPS SSLHVPLRSA WNSDPVPGSR TPGPRRVDMP 730 740 750 760 PDDDWRQSSY ASHSGHRRTV GEGFLFVLSD APRREQIRAR VLQHSQW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases." Quesada V., Diaz-Perales A., Gutierrez-Fernandez A., Garabaya C., Cal S., Lopez-Otin C. Biochem. Biophys. Res. Commun. 314:54-62(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), LACK OF ENZYME ACTIVITY, TISSUE SPECIFICITY.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5; 6 AND 7). Tissue: Amygdala, Hippocampus, Lung and Uterus.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Fetal liver.
[4]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6). Tissue: Skin.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-671, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-505.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ583820 mRNA. Translation: CAE47747.1. AK094637 mRNA. Translation: BAC04393.1. Different initiation. AK123711 mRNA. Translation: BAG53943.1. Different initiation. AK126497 mRNA. Translation: BAC86566.1. AK127213 mRNA. Translation: BAC86886.1. AK127267 mRNA. Translation: BAC86907.1. BX649087 mRNA. No translation available. AC073389 Genomic DNA. No translation available. AL359074 Genomic DNA. Translation: CAO03506.1. AL359074 Genomic DNA. Translation: CAO03507.1. Sequence problems. AL359074 Genomic DNA. Translation: CAO03508.1. Sequence problems. AL359074 Genomic DNA. Translation: CAO03509.1. Sequence problems. BC064967 mRNA. Translation: AAH64967.1. BC130633 mRNA. Translation: AAI30634.1.
IPI	IPI00642778. IPI00852605. IPI00852839. IPI00877069. IPI00903012. IPI00914881. IPI00942140.
RefSeq	NP_689799.3. NM_152586.3.
UniGene	Hs.657355.
3D structure databases
ProteinModelPortal	Q70EL1.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q70EL1. 8 interactions.
MINT	MINT-6946944.
Protein family/group databases
MEROPS	C19.080.
Polymorphism databases
DMDM	215274237.
Proteomic databases
PaxDb	Q70EL1.
PRIDE	Q70EL1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000339859; ENSP00000345216; ENSG00000166348. ENST00000394811; ENSP00000378290; ENSG00000166348. ENST00000408019; ENSP00000386080; ENSG00000166348. ENST00000413442; ENSP00000404710; ENSG00000166348. ENST00000428547; ENSP00000408714; ENSG00000166348. ENST00000433394; ENSP00000407245; ENSG00000166348. ENST00000451492; ENSP00000402435; ENSG00000166348.
GeneID	159195.
KEGG	hsa:159195.
UCSC	uc001juk.3. human. uc001jul.3. human. uc001juo.3. human. uc001jup.3. human.
Organism-specific databases
CTD	159195.
GeneCards	GC10M075257.
HGNC	HGNC:23513. USP54.
HPA	HPA047663.
neXtProt	NX_Q70EL1.
PharmGKB	PA134959960.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG291259.
HOVERGEN	HBG108646.
InParanoid	Q70EL1.
OMA	CLPSQGG.
Gene expression databases
ArrayExpress	Q70EL1.
Bgee	Q70EL1.
CleanEx	HS_USP54.
Genevestigator	Q70EL1.
Family and domain databases
InterPro	IPR001394. Peptidase_C19. [Graphical view]
Pfam	PF00443. UCH. 1 hit. [Graphical view]
PROSITE	PS00972. UCH_2_1. False negative. PS00973. UCH_2_2. False negative. PS50235. UCH_2_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	USP54. human.
GenomeRNAi	159195.
NextBio	87894.

Entry information

Entry name

UBP54_HUMAN

Accession

Primary (citable) accession number: Q70EL1
Secondary accession number(s): A1L4Q4 , A3KFK3, A3KFK5, A3KFK6, A3KFK7, A6PVS4, A6PVS5, A6PVS6, A6PVS7, B3KVY1, B9ZVM1, Q5F2F4, Q6P1N6, Q6ZSP1, Q6ZSR1, Q6ZTM0, Q8N1X2

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2006
Last sequence update:	November 25, 2008
Last modified:	May 1, 2013
This is version 69 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.