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Q70EL1

- UBP54_HUMAN

UniProt

Q70EL1 - UBP54_HUMAN

Protein

Inactive ubiquitin carboxyl-terminal hydrolase 54

Gene

USP54

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 4 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Has no peptidase activity.

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. ubiquitinyl hydrolase activity Source: InterPro

    GO - Biological processi

    1. ubiquitin-dependent protein catabolic process Source: InterPro

    Protein family/group databases

    MEROPSiC19.080.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inactive ubiquitin carboxyl-terminal hydrolase 54
    Alternative name(s):
    Inactive ubiquitin-specific peptidase 54
    Gene namesi
    Name:USP54
    Synonyms:C10orf29
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:23513. USP54.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134959960.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 16841684Inactive ubiquitin carboxyl-terminal hydrolase 54PRO_0000249530Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei671 – 6711Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ70EL1.
    PaxDbiQ70EL1.
    PRIDEiQ70EL1.

    Expressioni

    Tissue specificityi

    Weakly expressed in a few tissues.1 Publication

    Gene expression databases

    ArrayExpressiQ70EL1.
    BgeeiQ70EL1.
    CleanExiHS_USP54.
    GenevestigatoriQ70EL1.

    Organism-specific databases

    HPAiHPA047663.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ATXN1P542533EBI-946185,EBI-930964

    Protein-protein interaction databases

    BioGridi127739. 11 interactions.
    IntActiQ70EL1. 20 interactions.
    MINTiMINT-6946944.

    Structurei

    3D structure databases

    ProteinModelPortaliQ70EL1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini31 – 352322USPAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili736 – 77035Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi559 – 57012Poly-SerAdd
    BLAST
    Compositional biasi866 – 8694Poly-Gln

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 USP domain.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG291259.
    HOVERGENiHBG108646.
    InParanoidiQ70EL1.
    OMAiNCGERIR.
    PhylomeDBiQ70EL1.
    TreeFamiTF336130.

    Family and domain databases

    Gene3Di1.20.58.280. 1 hit.
    InterProiIPR007330. MIT.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS50235. USP_3. 1 hit.
    [Graphical view]

    Sequences (7)i

    Sequence statusi: Complete.

    This entry describes 7 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q70EL1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSWKRNYFSG GRGSVQGMFA PRSSTSIAPS KGLSNEPGQN SCFLNSALQV     50
    LWHLDIFRRS FRQLTTHKCM GDSCIFCALK GIFNQFQCSS EKVLPSDTLR 100
    SALAKTFQDE QRFQLGIMDD AAECFENLLM RIHFHIADET KEDICTAQHC 150
    ISHQKFAMTL FEQCVCTSCG ATSDPLPFIQ MVHYISTTSL CNQAICMLER 200
    REKPSPSMFG ELLQNASTMG DLRNCPSNCG ERIRIRRVLM NAPQIITIGL 250
    VWDSDHSDLA EDVIHSLGTC LKLGDLFFRV TDDRAKQSEL YLVGMICYYG 300
    KHYSTFFFQT KIRKWMYFDD AHVKEIGPKW KDVVTKCIKG HYQPLLLLYA 350
    DPQGTPVSTQ DLPPQAEFQS YSRTCYDSED SGREPSISSD TRTDSSTESY 400
    PYKHSHHESV VSHFSSDSQG TVIYNVENDS MSQSSRDTGH LTDSECNQKH 450
    TSKKGSLIER KRSSGRVRRK GDEPQASGYH SEGETLKEKQ APRNASKPSS 500
    STNRLRDFKE TVSNMIHNRP SLASQTNVGS HCRGRGGDQP DKKPPRTLPL 550
    HSRDWEIEST SSESKSSSSS KYRPTWRPKR ESLNIDSIFS KDKRKHCGYT 600
    QLSPFSEDSA KEFIPDEPSK PPSYDIKFGG PSPQYKRWGP ARPGSHLLEQ 650
    HPRLIQRMES GYESSERNSS SPVSLDAALP ESSNVYRDPS AKRSAGLVPS 700
    WRHIPKSHSS SILEVDSTAS MGGWTKSQPF SGEEISSKSE LDELQEEVAR 750
    RAQEQELRRK REKELEAAKG FNPHPSRFMD LDELQNQGRS DGFERSLQEA 800
    ESVFEESLHL EQKGDCAAAL ALCNEAISKL RLALHGASCS THSRALVDKK 850
    LQISIRKARS LQDRMQQQQS PQQPSQPSAC LPTQAGTLSQ PTSEQPIPLQ 900
    VLLSQEAQLE SGMDTEFGAS SFFHSPASCH ESHSSLSPES SAPQHSSPSR 950
    SALKLLTSVE VDNIEPSAFH RQGLPKAPGW TEKNSHHSWE PLDAPEGKLQ 1000
    GSRCDNSSCS KLPPQEGRGI AQEQLFQEKK DPANPSPVMP GIATSERGDE 1050
    HSLGCSPSNS SAQPSLPLYR TCHPIMPVAS SFVLHCPDPV QKTNQCLQGQ 1100
    SLKTSLTLKV DRGSEETYRP EFPSTKGLVR SLAEQFQRMQ GVSMRDSTGF 1150
    KDRSLSGSLR KNSSPSDSKP PFSQGQEKGH WPWAKQQSSL EGGDRPLSWE 1200
    ESTEHSSLAL NSGLPNGETS SGGQPRLAEP DIYQEKLSQV RDVRSKDLGS 1250
    STDLGTSLPL DSWVNITRFC DSQLKHGAPR PGMKSSPHDS HTCVTYPERN 1300
    HILLHPHWNQ DTEQETSELE SLYQASLQAS QAGCSGWGQQ DTAWHPLSQT 1350
    GSADGMGRRL HSAHDPGLSK TSTAEMEHGL HEARTVRTSQ ATPCRGLSRE 1400
    CGEDEQYSAE NLRRISRSLS GTVVSEREEA PVSSHSFDSS NVRKPLETGH 1450
    RCSSSSSLPV IHDPSVFLLG PQLYLPQPQF LSPDVLMPTM AGEPNRLPGT 1500
    SRSVQQFLAM CDRGETSQGA KYTGRTLNYQ SLPHRSRTDN SWAPWSETNQ 1550
    HIGTRFLTTP GCNPQLTYTA TLPERSKGLQ VPHTQSWSDL FHSPSHPPIV 1600
    HPVYPPSSSL HVPLRSAWNS DPVPGSRTPG PRRVDMPPDD DWRQSSYASH 1650
    SGHRRTVGEG FLFVLSDAPR REQIRARVLQ HSQW 1684
    Length:1,684
    Mass (Da):187,388
    Last modified:November 25, 2008 - v4
    Checksum:i853D9CFCB35C63C4
    GO
    Isoform 2 (identifier: Q70EL1-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         383-403: REPSISSDTRTDSSTESYPYK → EQPGSLPLLSPHPMRSNSWDS
         404-1684: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:403
    Mass (Da):45,703
    Checksum:i2749CBBCC8AF37A9
    GO
    Isoform 3 (identifier: Q70EL1-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         893-893: S → R
         894-1684: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:893
    Mass (Da):100,476
    Checksum:i7D1C84A450FEB447
    GO
    Isoform 4 (identifier: Q70EL1-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         126-275: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,534
    Mass (Da):170,581
    Checksum:iB00DC48D0DE75BC3
    GO
    Isoform 5 (identifier: Q70EL1-8) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-912: Missing.

    Show »
    Length:772
    Mass (Da):84,938
    Checksum:iA41B0ACF854B4AF2
    GO
    Isoform 6 (identifier: Q70EL1-9) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-912: Missing.
         1391-1437: Missing.

    Show »
    Length:725
    Mass (Da):79,771
    Checksum:i98EFA86D1005C89F
    GO
    Isoform 7 (identifier: Q70EL1-10) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-912: Missing.
         1386-1390: Missing.

    Show »
    Length:767
    Mass (Da):84,366
    Checksum:iC622D8C5CE11DDF3
    GO

    Sequence cautioni

    The sequence BX649087 differs from that shown. Reason: Frameshift at position 508.
    The sequence BAC04393.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAG53943.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAO03507.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAO03508.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAO03509.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti110 – 1112EQ → KE in BX649087. (PubMed:17974005)Curated
    Sequence conflicti191 – 1911C → S in CAE47747. (PubMed:14715245)Curated
    Sequence conflicti226 – 2261P → L in BX649087. (PubMed:17974005)Curated
    Sequence conflicti733 – 7331E → G in BX649087. (PubMed:17974005)Curated
    Sequence conflicti1345 – 13451H → P in BAC04393. (PubMed:14702039)Curated
    Sequence conflicti1425 – 14251S → P in BAC86566. (PubMed:14702039)Curated
    Sequence conflicti1438 – 14381D → H in AAI30634. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti505 – 5051L → V in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036360
    Natural varianti976 – 9761K → E.
    Corresponds to variant rs1618542 [ dbSNP | Ensembl ].
    VAR_047258
    Natural varianti1231 – 12311D → N.
    Corresponds to variant rs4619071 [ dbSNP | Ensembl ].
    VAR_047259
    Natural varianti1367 – 13671G → D.
    Corresponds to variant rs7083344 [ dbSNP | Ensembl ].
    VAR_047260

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 912912Missing in isoform 5, isoform 6 and isoform 7. 2 PublicationsVSP_035674Add
    BLAST
    Alternative sequencei126 – 275150Missing in isoform 4. CuratedVSP_029922Add
    BLAST
    Alternative sequencei383 – 40321REPSI…SYPYK → EQPGSLPLLSPHPMRSNSWD S in isoform 2. 1 PublicationVSP_026525Add
    BLAST
    Alternative sequencei404 – 16841281Missing in isoform 2. 1 PublicationVSP_026526Add
    BLAST
    Alternative sequencei893 – 8931S → R in isoform 3. 1 PublicationVSP_035675
    Alternative sequencei894 – 1684791Missing in isoform 3. 1 PublicationVSP_035676Add
    BLAST
    Alternative sequencei1386 – 13905Missing in isoform 7. 1 PublicationVSP_035677
    Alternative sequencei1391 – 143747Missing in isoform 6. 2 PublicationsVSP_035678Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ583820 mRNA. Translation: CAE47747.1.
    AK094637 mRNA. Translation: BAC04393.1. Different initiation.
    AK123711 mRNA. Translation: BAG53943.1. Different initiation.
    AK126497 mRNA. Translation: BAC86566.1.
    AK127213 mRNA. Translation: BAC86886.1.
    AK127267 mRNA. Translation: BAC86907.1.
    BX649087 mRNA. No translation available.
    AC073389 Genomic DNA. No translation available.
    AL359074 Genomic DNA. Translation: CAO03506.1.
    AL359074 Genomic DNA. Translation: CAO03507.1. Sequence problems.
    AL359074 Genomic DNA. Translation: CAO03508.1. Sequence problems.
    AL359074 Genomic DNA. Translation: CAO03509.1. Sequence problems.
    BC064967 mRNA. Translation: AAH64967.1.
    BC130633 mRNA. Translation: AAI30634.1.
    CCDSiCCDS7329.2. [Q70EL1-1]
    RefSeqiNP_689799.3. NM_152586.3. [Q70EL1-1]
    UniGeneiHs.657355.

    Genome annotation databases

    EnsembliENST00000339859; ENSP00000345216; ENSG00000166348. [Q70EL1-1]
    ENST00000408019; ENSP00000386080; ENSG00000166348. [Q70EL1-1]
    GeneIDi159195.
    KEGGihsa:159195.
    UCSCiuc001juk.3. human. [Q70EL1-8]
    uc001jul.3. human. [Q70EL1-9]
    uc001juo.3. human. [Q70EL1-1]
    uc001jup.3. human. [Q70EL1-6]

    Polymorphism databases

    DMDMi215274237.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ583820 mRNA. Translation: CAE47747.1 .
    AK094637 mRNA. Translation: BAC04393.1 . Different initiation.
    AK123711 mRNA. Translation: BAG53943.1 . Different initiation.
    AK126497 mRNA. Translation: BAC86566.1 .
    AK127213 mRNA. Translation: BAC86886.1 .
    AK127267 mRNA. Translation: BAC86907.1 .
    BX649087 mRNA. No translation available.
    AC073389 Genomic DNA. No translation available.
    AL359074 Genomic DNA. Translation: CAO03506.1 .
    AL359074 Genomic DNA. Translation: CAO03507.1 . Sequence problems.
    AL359074 Genomic DNA. Translation: CAO03508.1 . Sequence problems.
    AL359074 Genomic DNA. Translation: CAO03509.1 . Sequence problems.
    BC064967 mRNA. Translation: AAH64967.1 .
    BC130633 mRNA. Translation: AAI30634.1 .
    CCDSi CCDS7329.2. [Q70EL1-1 ]
    RefSeqi NP_689799.3. NM_152586.3. [Q70EL1-1 ]
    UniGenei Hs.657355.

    3D structure databases

    ProteinModelPortali Q70EL1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127739. 11 interactions.
    IntActi Q70EL1. 20 interactions.
    MINTi MINT-6946944.

    Protein family/group databases

    MEROPSi C19.080.

    Polymorphism databases

    DMDMi 215274237.

    Proteomic databases

    MaxQBi Q70EL1.
    PaxDbi Q70EL1.
    PRIDEi Q70EL1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000339859 ; ENSP00000345216 ; ENSG00000166348 . [Q70EL1-1 ]
    ENST00000408019 ; ENSP00000386080 ; ENSG00000166348 . [Q70EL1-1 ]
    GeneIDi 159195.
    KEGGi hsa:159195.
    UCSCi uc001juk.3. human. [Q70EL1-8 ]
    uc001jul.3. human. [Q70EL1-9 ]
    uc001juo.3. human. [Q70EL1-1 ]
    uc001jup.3. human. [Q70EL1-6 ]

    Organism-specific databases

    CTDi 159195.
    GeneCardsi GC10M075257.
    HGNCi HGNC:23513. USP54.
    HPAi HPA047663.
    neXtProti NX_Q70EL1.
    PharmGKBi PA134959960.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG291259.
    HOVERGENi HBG108646.
    InParanoidi Q70EL1.
    OMAi NCGERIR.
    PhylomeDBi Q70EL1.
    TreeFami TF336130.

    Miscellaneous databases

    ChiTaRSi USP54. human.
    GenomeRNAii 159195.
    NextBioi 87894.
    PROi Q70EL1.

    Gene expression databases

    ArrayExpressi Q70EL1.
    Bgeei Q70EL1.
    CleanExi HS_USP54.
    Genevestigatori Q70EL1.

    Family and domain databases

    Gene3Di 1.20.58.280. 1 hit.
    InterProi IPR007330. MIT.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases."
      Quesada V., Diaz-Perales A., Gutierrez-Fernandez A., Garabaya C., Cal S., Lopez-Otin C.
      Biochem. Biophys. Res. Commun. 314:54-62(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), LACK OF ENZYME ACTIVITY, TISSUE SPECIFICITY.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5; 6 AND 7).
      Tissue: Amygdala, Hippocampus, Lung and Uterus.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Fetal liver.
    4. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
      Tissue: Skin.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-671, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-505.

    Entry informationi

    Entry nameiUBP54_HUMAN
    AccessioniPrimary (citable) accession number: Q70EL1
    Secondary accession number(s): A1L4Q4
    , A3KFK3, A3KFK5, A3KFK6, A3KFK7, A6PVS4, A6PVS5, A6PVS6, A6PVS7, B3KVY1, B9ZVM1, Q5F2F4, Q6P1N6, Q6ZSP1, Q6ZSR1, Q6ZTM0, Q8N1X2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2006
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 83 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. Peptidase families
      Classification of peptidase families and list of entries
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3