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Protein

Inactive ubiquitin carboxyl-terminal hydrolase 54

Gene

USP54

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has no peptidase activity.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Protein family/group databases

MEROPSiC19.080.

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive ubiquitin carboxyl-terminal hydrolase 54
Alternative name(s):
Inactive ubiquitin-specific peptidase 54
Gene namesi
Name:USP54
Synonyms:C10orf29
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23513. USP54.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000166348.
PharmGKBiPA134959960.

Polymorphism and mutation databases

BioMutaiUSP54.
DMDMi215274237.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002495301 – 1684Inactive ubiquitin carboxyl-terminal hydrolase 54Add BLAST1684

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12Omega-N-methylarginineBy similarity1
Modified residuei481PhosphoserineBy similarity1
Modified residuei603PhosphoserineCombined sources1
Modified residuei632PhosphoserineCombined sources1
Modified residuei671PhosphoserineCombined sources1
Modified residuei674PhosphoserineBy similarity1
Modified residuei1189PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ70EL1.
MaxQBiQ70EL1.
PaxDbiQ70EL1.
PeptideAtlasiQ70EL1.
PRIDEiQ70EL1.

PTM databases

iPTMnetiQ70EL1.
PhosphoSitePlusiQ70EL1.

Expressioni

Tissue specificityi

Weakly expressed in a few tissues.1 Publication

Gene expression databases

BgeeiENSG00000166348.
CleanExiHS_USP54.
ExpressionAtlasiQ70EL1. baseline and differential.
GenevisibleiQ70EL1. HS.

Organism-specific databases

HPAiHPA047663.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ATXN1P542533EBI-946185,EBI-930964
EIF4E2O605733EBI-946185,EBI-398610
NXT2Q9NPJ83EBI-946185,EBI-752122

Protein-protein interaction databases

BioGridi127739. 40 interactors.
IntActiQ70EL1. 102 interactors.
MINTiMINT-6946944.
STRINGi9606.ENSP00000345216.

Structurei

3D structure databases

ProteinModelPortaliQ70EL1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 352USPAdd BLAST322

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili736 – 770Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi559 – 570Poly-SerAdd BLAST12
Compositional biasi866 – 869Poly-Gln4

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 USP domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1887. Eukaryota.
ENOG410XSNE. LUCA.
GeneTreeiENSGT00440000033513.
HOVERGENiHBG108646.
InParanoidiQ70EL1.
OMAiQSYSRTC.
OrthoDBiEOG091G00Q6.
PhylomeDBiQ70EL1.
TreeFamiTF336130.

Family and domain databases

Gene3Di1.20.58.280. 1 hit.
InterProiIPR007330. MIT.
IPR001394. Peptidase_C19_UCH.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS50235. USP_3. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q70EL1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSWKRNYFSG GRGSVQGMFA PRSSTSIAPS KGLSNEPGQN SCFLNSALQV
60 70 80 90 100
LWHLDIFRRS FRQLTTHKCM GDSCIFCALK GIFNQFQCSS EKVLPSDTLR
110 120 130 140 150
SALAKTFQDE QRFQLGIMDD AAECFENLLM RIHFHIADET KEDICTAQHC
160 170 180 190 200
ISHQKFAMTL FEQCVCTSCG ATSDPLPFIQ MVHYISTTSL CNQAICMLER
210 220 230 240 250
REKPSPSMFG ELLQNASTMG DLRNCPSNCG ERIRIRRVLM NAPQIITIGL
260 270 280 290 300
VWDSDHSDLA EDVIHSLGTC LKLGDLFFRV TDDRAKQSEL YLVGMICYYG
310 320 330 340 350
KHYSTFFFQT KIRKWMYFDD AHVKEIGPKW KDVVTKCIKG HYQPLLLLYA
360 370 380 390 400
DPQGTPVSTQ DLPPQAEFQS YSRTCYDSED SGREPSISSD TRTDSSTESY
410 420 430 440 450
PYKHSHHESV VSHFSSDSQG TVIYNVENDS MSQSSRDTGH LTDSECNQKH
460 470 480 490 500
TSKKGSLIER KRSSGRVRRK GDEPQASGYH SEGETLKEKQ APRNASKPSS
510 520 530 540 550
STNRLRDFKE TVSNMIHNRP SLASQTNVGS HCRGRGGDQP DKKPPRTLPL
560 570 580 590 600
HSRDWEIEST SSESKSSSSS KYRPTWRPKR ESLNIDSIFS KDKRKHCGYT
610 620 630 640 650
QLSPFSEDSA KEFIPDEPSK PPSYDIKFGG PSPQYKRWGP ARPGSHLLEQ
660 670 680 690 700
HPRLIQRMES GYESSERNSS SPVSLDAALP ESSNVYRDPS AKRSAGLVPS
710 720 730 740 750
WRHIPKSHSS SILEVDSTAS MGGWTKSQPF SGEEISSKSE LDELQEEVAR
760 770 780 790 800
RAQEQELRRK REKELEAAKG FNPHPSRFMD LDELQNQGRS DGFERSLQEA
810 820 830 840 850
ESVFEESLHL EQKGDCAAAL ALCNEAISKL RLALHGASCS THSRALVDKK
860 870 880 890 900
LQISIRKARS LQDRMQQQQS PQQPSQPSAC LPTQAGTLSQ PTSEQPIPLQ
910 920 930 940 950
VLLSQEAQLE SGMDTEFGAS SFFHSPASCH ESHSSLSPES SAPQHSSPSR
960 970 980 990 1000
SALKLLTSVE VDNIEPSAFH RQGLPKAPGW TEKNSHHSWE PLDAPEGKLQ
1010 1020 1030 1040 1050
GSRCDNSSCS KLPPQEGRGI AQEQLFQEKK DPANPSPVMP GIATSERGDE
1060 1070 1080 1090 1100
HSLGCSPSNS SAQPSLPLYR TCHPIMPVAS SFVLHCPDPV QKTNQCLQGQ
1110 1120 1130 1140 1150
SLKTSLTLKV DRGSEETYRP EFPSTKGLVR SLAEQFQRMQ GVSMRDSTGF
1160 1170 1180 1190 1200
KDRSLSGSLR KNSSPSDSKP PFSQGQEKGH WPWAKQQSSL EGGDRPLSWE
1210 1220 1230 1240 1250
ESTEHSSLAL NSGLPNGETS SGGQPRLAEP DIYQEKLSQV RDVRSKDLGS
1260 1270 1280 1290 1300
STDLGTSLPL DSWVNITRFC DSQLKHGAPR PGMKSSPHDS HTCVTYPERN
1310 1320 1330 1340 1350
HILLHPHWNQ DTEQETSELE SLYQASLQAS QAGCSGWGQQ DTAWHPLSQT
1360 1370 1380 1390 1400
GSADGMGRRL HSAHDPGLSK TSTAEMEHGL HEARTVRTSQ ATPCRGLSRE
1410 1420 1430 1440 1450
CGEDEQYSAE NLRRISRSLS GTVVSEREEA PVSSHSFDSS NVRKPLETGH
1460 1470 1480 1490 1500
RCSSSSSLPV IHDPSVFLLG PQLYLPQPQF LSPDVLMPTM AGEPNRLPGT
1510 1520 1530 1540 1550
SRSVQQFLAM CDRGETSQGA KYTGRTLNYQ SLPHRSRTDN SWAPWSETNQ
1560 1570 1580 1590 1600
HIGTRFLTTP GCNPQLTYTA TLPERSKGLQ VPHTQSWSDL FHSPSHPPIV
1610 1620 1630 1640 1650
HPVYPPSSSL HVPLRSAWNS DPVPGSRTPG PRRVDMPPDD DWRQSSYASH
1660 1670 1680
SGHRRTVGEG FLFVLSDAPR REQIRARVLQ HSQW
Length:1,684
Mass (Da):187,388
Last modified:November 25, 2008 - v4
Checksum:i853D9CFCB35C63C4
GO
Isoform 2 (identifier: Q70EL1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     383-403: REPSISSDTRTDSSTESYPYK → EQPGSLPLLSPHPMRSNSWDS
     404-1684: Missing.

Note: No experimental confirmation available.
Show »
Length:403
Mass (Da):45,703
Checksum:i2749CBBCC8AF37A9
GO
Isoform 3 (identifier: Q70EL1-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     893-893: S → R
     894-1684: Missing.

Note: No experimental confirmation available.
Show »
Length:893
Mass (Da):100,476
Checksum:i7D1C84A450FEB447
GO
Isoform 4 (identifier: Q70EL1-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     126-275: Missing.

Note: No experimental confirmation available.
Show »
Length:1,534
Mass (Da):170,581
Checksum:iB00DC48D0DE75BC3
GO
Isoform 5 (identifier: Q70EL1-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-912: Missing.

Show »
Length:772
Mass (Da):84,938
Checksum:iA41B0ACF854B4AF2
GO
Isoform 6 (identifier: Q70EL1-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-912: Missing.
     1391-1437: Missing.

Show »
Length:725
Mass (Da):79,771
Checksum:i98EFA86D1005C89F
GO
Isoform 7 (identifier: Q70EL1-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-912: Missing.
     1386-1390: Missing.

Show »
Length:767
Mass (Da):84,366
Checksum:iC622D8C5CE11DDF3
GO

Sequence cautioni

The sequence BAC04393 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAG53943 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BX649087 differs from that shown. Reason: Frameshift at position 508.Curated
The sequence CAO03507 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAO03508 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAO03509 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti110 – 111EQ → KE in BX649087 (PubMed:17974005).Curated2
Sequence conflicti191C → S in CAE47747 (PubMed:14715245).Curated1
Sequence conflicti226P → L in BX649087 (PubMed:17974005).Curated1
Sequence conflicti733E → G in BX649087 (PubMed:17974005).Curated1
Sequence conflicti1345H → P in BAC04393 (PubMed:14702039).Curated1
Sequence conflicti1425S → P in BAC86566 (PubMed:14702039).Curated1
Sequence conflicti1438D → H in AAI30634 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036360505L → V in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_047258976K → E.Corresponds to variant rs1618542dbSNPEnsembl.1
Natural variantiVAR_0472591231D → N.Corresponds to variant rs4619071dbSNPEnsembl.1
Natural variantiVAR_0472601367G → D.Corresponds to variant rs7083344dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0356741 – 912Missing in isoform 5, isoform 6 and isoform 7. 2 PublicationsAdd BLAST912
Alternative sequenceiVSP_029922126 – 275Missing in isoform 4. CuratedAdd BLAST150
Alternative sequenceiVSP_026525383 – 403REPSI…SYPYK → EQPGSLPLLSPHPMRSNSWD S in isoform 2. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_026526404 – 1684Missing in isoform 2. 1 PublicationAdd BLAST1281
Alternative sequenceiVSP_035675893S → R in isoform 3. 1 Publication1
Alternative sequenceiVSP_035676894 – 1684Missing in isoform 3. 1 PublicationAdd BLAST791
Alternative sequenceiVSP_0356771386 – 1390Missing in isoform 7. 1 Publication5
Alternative sequenceiVSP_0356781391 – 1437Missing in isoform 6. 2 PublicationsAdd BLAST47

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ583820 mRNA. Translation: CAE47747.1.
AK094637 mRNA. Translation: BAC04393.1. Different initiation.
AK123711 mRNA. Translation: BAG53943.1. Different initiation.
AK126497 mRNA. Translation: BAC86566.1.
AK127213 mRNA. Translation: BAC86886.1.
AK127267 mRNA. Translation: BAC86907.1.
BX649087 mRNA. No translation available.
AC073389 Genomic DNA. No translation available.
AL359074 Genomic DNA. Translation: CAO03506.1.
AL359074 Genomic DNA. Translation: CAO03507.1. Sequence problems.
AL359074 Genomic DNA. Translation: CAO03508.1. Sequence problems.
AL359074 Genomic DNA. Translation: CAO03509.1. Sequence problems.
BC064967 mRNA. Translation: AAH64967.1.
BC130633 mRNA. Translation: AAI30634.1.
CCDSiCCDS7329.2. [Q70EL1-1]
RefSeqiNP_001307366.1. NM_001320437.1.
NP_689799.3. NM_152586.3. [Q70EL1-1]
XP_016871263.1. XM_017015774.1. [Q70EL1-1]
XP_016871264.1. XM_017015775.1. [Q70EL1-1]
XP_016871265.1. XM_017015776.1. [Q70EL1-1]
XP_016871266.1. XM_017015777.1. [Q70EL1-1]
UniGeneiHs.657355.
Hs.712514.

Genome annotation databases

EnsembliENST00000339859; ENSP00000345216; ENSG00000166348. [Q70EL1-1]
ENST00000422491; ENSP00000407368; ENSG00000166348. [Q70EL1-9]
GeneIDi159195.
KEGGihsa:159195.
UCSCiuc001juo.4. human. [Q70EL1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ583820 mRNA. Translation: CAE47747.1.
AK094637 mRNA. Translation: BAC04393.1. Different initiation.
AK123711 mRNA. Translation: BAG53943.1. Different initiation.
AK126497 mRNA. Translation: BAC86566.1.
AK127213 mRNA. Translation: BAC86886.1.
AK127267 mRNA. Translation: BAC86907.1.
BX649087 mRNA. No translation available.
AC073389 Genomic DNA. No translation available.
AL359074 Genomic DNA. Translation: CAO03506.1.
AL359074 Genomic DNA. Translation: CAO03507.1. Sequence problems.
AL359074 Genomic DNA. Translation: CAO03508.1. Sequence problems.
AL359074 Genomic DNA. Translation: CAO03509.1. Sequence problems.
BC064967 mRNA. Translation: AAH64967.1.
BC130633 mRNA. Translation: AAI30634.1.
CCDSiCCDS7329.2. [Q70EL1-1]
RefSeqiNP_001307366.1. NM_001320437.1.
NP_689799.3. NM_152586.3. [Q70EL1-1]
XP_016871263.1. XM_017015774.1. [Q70EL1-1]
XP_016871264.1. XM_017015775.1. [Q70EL1-1]
XP_016871265.1. XM_017015776.1. [Q70EL1-1]
XP_016871266.1. XM_017015777.1. [Q70EL1-1]
UniGeneiHs.657355.
Hs.712514.

3D structure databases

ProteinModelPortaliQ70EL1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127739. 40 interactors.
IntActiQ70EL1. 102 interactors.
MINTiMINT-6946944.
STRINGi9606.ENSP00000345216.

Protein family/group databases

MEROPSiC19.080.

PTM databases

iPTMnetiQ70EL1.
PhosphoSitePlusiQ70EL1.

Polymorphism and mutation databases

BioMutaiUSP54.
DMDMi215274237.

Proteomic databases

EPDiQ70EL1.
MaxQBiQ70EL1.
PaxDbiQ70EL1.
PeptideAtlasiQ70EL1.
PRIDEiQ70EL1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339859; ENSP00000345216; ENSG00000166348. [Q70EL1-1]
ENST00000422491; ENSP00000407368; ENSG00000166348. [Q70EL1-9]
GeneIDi159195.
KEGGihsa:159195.
UCSCiuc001juo.4. human. [Q70EL1-1]

Organism-specific databases

CTDi159195.
GeneCardsiUSP54.
HGNCiHGNC:23513. USP54.
HPAiHPA047663.
neXtProtiNX_Q70EL1.
OpenTargetsiENSG00000166348.
PharmGKBiPA134959960.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1887. Eukaryota.
ENOG410XSNE. LUCA.
GeneTreeiENSGT00440000033513.
HOVERGENiHBG108646.
InParanoidiQ70EL1.
OMAiQSYSRTC.
OrthoDBiEOG091G00Q6.
PhylomeDBiQ70EL1.
TreeFamiTF336130.

Miscellaneous databases

ChiTaRSiUSP54. human.
GenomeRNAii159195.
PROiQ70EL1.

Gene expression databases

BgeeiENSG00000166348.
CleanExiHS_USP54.
ExpressionAtlasiQ70EL1. baseline and differential.
GenevisibleiQ70EL1. HS.

Family and domain databases

Gene3Di1.20.58.280. 1 hit.
InterProiIPR007330. MIT.
IPR001394. Peptidase_C19_UCH.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUBP54_HUMAN
AccessioniPrimary (citable) accession number: Q70EL1
Secondary accession number(s): A1L4Q4
, A3KFK3, A3KFK5, A3KFK6, A3KFK7, A6PVS4, A6PVS5, A6PVS6, A6PVS7, B3KVY1, B9ZVM1, Q5F2F4, Q6P1N6, Q6ZSP1, Q6ZSR1, Q6ZTM0, Q8N1X2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: November 25, 2008
Last modified: November 30, 2016
This is version 102 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Although the active site residues are conserved, it lacks the conserved His residue which is normally found 9 residues before the catalytic His.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.