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Protein

Ubiquitin carboxyl-terminal hydrolase 51

Gene

USP51

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Specifically deubiquitinates 'Lys-14' (H2AK13Ub) and 'Lys-16'(H2AK15Ub) of histone H2A regulating the DNA damage response at double-strand breaks (DSBs) (PubMed:27083998). USP51 is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1. Exhibits also activity for 'Lys-27' or 'Lys-63'-linked di-ubiquitin (PubMed:27083998).1 Publication

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei372NucleophilePROSITE-ProRule annotation1 Publication1
Active sitei665Proton acceptorPROSITE-ProRule annotation1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri234 – 294UBP-typePROSITE-ProRule annotationAdd BLAST61

GO - Molecular functioni

  • chromatin binding Source: UniProtKB
  • histone binding Source: UniProtKB
  • thiol-dependent ubiquitin-specific protease activity Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

  • DNA repair Source: UniProtKB-KW
  • histone deubiquitination Source: UniProtKB
  • protein deubiquitination Source: FlyBase
  • regulation of cell cycle process Source: UniProtKB
  • regulation of double-strand break repair via homologous recombination Source: UniProtKB
  • regulation of double-strand break repair via nonhomologous end joining Source: UniProtKB
  • regulation of response to DNA damage stimulus Source: UniProtKB
  • ubiquitin-dependent protein catabolic process Source: InterPro

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processDNA damage, DNA repair, Ubl conjugation pathway
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiC19.065

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 511 Publication (EC:3.4.19.121 Publication)
Alternative name(s):
Deubiquitinating enzyme 51
Ubiquitin thioesterase 51
Ubiquitin-specific-processing protease 51
Gene namesi
Name:USP51Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000247746.4
HGNCiHGNC:23086 USP51
neXtProtiNX_Q70EK9

Subcellular locationi

Keywords - Cellular componenti

Chromosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi372C → S: Abolishes ability to deubiquitinate histone H2A; when associated with 665-R. No decrease of total H2AK15ub levels following ionizing radiation; when associated with 665-R. 1 Publication1
Mutagenesisi665H → R: Abolishes ability to deubiquitinate histone H2A; when associated with 665-R. Suppresses ionizing radiation-induced H2AK13,15Ub; when associated with 372-R. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000247746
PharmGKBiPA134888611

Polymorphism and mutation databases

BioMutaiUSP51
DMDMi52000873

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000806801 – 711Ubiquitin carboxyl-terminal hydrolase 51Add BLAST711

Proteomic databases

EPDiQ70EK9
MaxQBiQ70EK9
PaxDbiQ70EK9
PeptideAtlasiQ70EK9
PRIDEiQ70EK9

PTM databases

iPTMnetiQ70EK9
PhosphoSitePlusiQ70EK9

Expressioni

Tissue specificityi

Expressed in prostate, brain, lung, aorta and kidney.1 Publication

Gene expression databases

BgeeiENSG00000247746
CleanExiHS_USP51
ExpressionAtlasiQ70EK9 baseline and differential
GenevisibleiQ70EK9 HS

Organism-specific databases

HPAiHPA001942

Interactioni

Subunit structurei

Interacts with H2A (PubMed:27083998).1 Publication

GO - Molecular functioni

  • histone binding Source: UniProtKB

Protein-protein interaction databases

BioGridi127720, 7 interactors
IntActiQ70EK9, 1 interactor
STRINGi9606.ENSP00000423333

Structurei

3D structure databases

ProteinModelPortaliQ70EK9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini363 – 706USPAdd BLAST344

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi97 – 144Pro-richAdd BLAST48

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri234 – 294UBP-typePROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1867 Eukaryota
ENOG410XQQ0 LUCA
GeneTreeiENSGT00890000139343
HOGENOMiHOG000007260
HOVERGENiHBG058014
InParanoidiQ70EK9
KOiK11366
OMAiSTKESRM
OrthoDBiEOG091G09GI
PhylomeDBiQ70EK9
TreeFamiTF323554

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001394 Peptidase_C19_UCH
IPR033383 USP51
IPR018200 USP_CS
IPR028889 USP_dom
IPR013083 Znf_RING/FYVE/PHD
IPR001607 Znf_UBP
PANTHERiPTHR43961:SF4 PTHR43961:SF4, 1 hit
PfamiView protein in Pfam
PF00443 UCH, 1 hit
PF02148 zf-UBP, 1 hit
PROSITEiView protein in PROSITE
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit
PS50271 ZF_UBP, 1 hit

Sequencei

Sequence statusi: Complete.

Q70EK9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQVRETSLP SGSGVRWISG GGGGASPEEA VEKAGKMEEA AAGATKASSR
60 70 80 90 100
REAEEMKLEP LQEREPAPEE NLTWSSSGGD EKVLPSIPLR CHSSSSPVCP
110 120 130 140 150
RRKPRPRPQP RARSRSQPGL SAPPPPPARP PPPPPPPPPP APRPRAWRGS
160 170 180 190 200
RRRSRPGSRP QTRRSCSGDL DGSGDPGGLG DWLLEVEFGQ GPTGCSHVES
210 220 230 240 250
FKVGKNWQKN LRLIYQRFVW SGTPETRKRK AKSCICHVCS THMNRLHSCL
260 270 280 290 300
SCVFFGCFTE KHIHKHAETK QHHLAVDLYH GVIYCFMCKD YVYDKDIEQI
310 320 330 340 350
AKETKEKILR LLTSTSTDVS HQQFMTSGFE DKQSTCETKE QEPKLVKPKK
360 370 380 390 400
KRRKKSVYTV GLRGLINLGN TCFMNCIVQA LTHIPLLKDF FLSDKHKCIM
410 420 430 440 450
TSPSLCLVCE MSSLFHAMYS GSRTPHIPYK LLHLIWIHAE HLAGYRQQDA
460 470 480 490 500
HEFLIAILDV LHRHSKDDSG GQEANNPNCC NCIIDQIFTG GLQSDVTCQA
510 520 530 540 550
CHSVSTTIDP CWDISLDLPG SCATFDSQNP ERADSTVSRD DHIPGIPSLT
560 570 580 590 600
DCLQWFTRPE HLGSSAKIKC NSCQSYQEST KQLTMKKLPI VACFHLKRFE
610 620 630 640 650
HVGKQRRKIN TFISFPLELD MTPFLASTKE SRMKEGQPPT DCVPNENKYS
660 670 680 690 700
LFAVINHHGT LESGHYTSFI RQQKDQWFSC DDAIITKATI EDLLYSEGYL
710
LFYHKQGLEK D
Length:711
Mass (Da):79,756
Last modified:July 5, 2004 - v1
Checksum:iB721E620AE7ACE86
GO

Sequence cautioni

The sequence AAH35907 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ583823 mRNA Translation: CAE47750.2
AL732358 Genomic DNA No translation available.
BC035907 mRNA Translation: AAH35907.1 Sequence problems.
BN000340 mRNA Translation: CAE48396.2
CCDSiCCDS14370.1
RefSeqiNP_958443.1, NM_201286.3
XP_016884788.1, XM_017029299.1
XP_016884789.1, XM_017029300.1
XP_016884790.1, XM_017029301.1
UniGeneiHs.40061
Hs.607524

Genome annotation databases

EnsembliENST00000500968; ENSP00000423333; ENSG00000247746
GeneIDi158880
KEGGihsa:158880
UCSCiuc004dun.3 human

Similar proteinsi

Entry informationi

Entry nameiUBP51_HUMAN
AccessioniPrimary (citable) accession number: Q70EK9
Secondary accession number(s): Q8IWJ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health