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Protein

Inactive ubiquitin carboxyl-terminal hydrolase 53

Gene

USP53

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Tight junction-associated protein that is involved in the survival of auditory hair cells and hearing. Maybe by modulating the barrier properties and mechanical stability of tight junctions (By similarity). Has no peptidase activity (PubMed:14715245).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Protein family/group databases

MEROPSiC19.081.

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive ubiquitin carboxyl-terminal hydrolase 53
Alternative name(s):
Inactive ubiquitin-specific peptidase 53
Gene namesi
Name:USP53Imported
Synonyms:KIAA1350Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:29255. USP53.

Subcellular locationi

  • Cell junctiontight junction By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Tight junction

Pathology & Biotechi

Organism-specific databases

DisGeNETi54532.
OpenTargetsiENSG00000145390.
PharmGKBiPA134940368.

Polymorphism and mutation databases

BioMutaiUSP53.
DMDMi88943889.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000806811 – 1073Inactive ubiquitin carboxyl-terminal hydrolase 53Add BLAST1073

Proteomic databases

EPDiQ70EK8.
MaxQBiQ70EK8.
PaxDbiQ70EK8.
PeptideAtlasiQ70EK8.
PRIDEiQ70EK8.

PTM databases

iPTMnetiQ70EK8.
PhosphoSitePlusiQ70EK8.

Expressioni

Tissue specificityi

Expressed predominantly in skeletal muscle and heart.1 Publication

Gene expression databases

BgeeiENSG00000145390.
CleanExiHS_USP53.
ExpressionAtlasiQ70EK8. baseline and differential.
GenevisibleiQ70EK8. HS.

Organism-specific databases

HPAiHPA035844.
HPA035845.

Interactioni

Subunit structurei

Interacts (via the C-terminal region) with the heterodimer TJP1:TJP2.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CRKP461084EBI-742050,EBI-886
TRAF2Q129333EBI-742050,EBI-355744

Protein-protein interaction databases

BioGridi120020. 24 interactors.
IntActiQ70EK8. 25 interactors.
MINTiMINT-1452598.
STRINGi9606.ENSP00000274030.

Structurei

3D structure databases

ProteinModelPortaliQ70EK8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 351USPAdd BLAST322

Sequence similaritiesi

Belongs to the peptidase C19 family.Sequence analysis
Contains 1 USP domain.Curated

Phylogenomic databases

eggNOGiKOG1887. Eukaryota.
ENOG410XSNE. LUCA.
GeneTreeiENSGT00440000033513.
HOGENOMiHOG000236318.
HOVERGENiHBG080701.
InParanoidiQ70EK8.
OMAiQRENQKF.
OrthoDBiEOG091G00Q6.
PhylomeDBiQ70EK8.
TreeFamiTF323194.

Family and domain databases

InterProiIPR001394. Peptidase_C19_UCH.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q70EK8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWVKFLRKP GGNLGKVYQP GSMLSLAPTK GLLNEPGQNS CFLNSAVQVL
60 70 80 90 100
WQLDIFRRSL RVLTGHVCQG DACIFCALKT IFAQFQHSRE KALPSDNIRH
110 120 130 140 150
ALAESFKDEQ RFQLGLMDDA AECFENMLER IHFHIVPSRD ADMCTSKSCI
160 170 180 190 200
THQKFAMTLY EQCVCRSCGA SSDPLPFTEF VRYISTTALC NEVERMLERH
210 220 230 240 250
ERFKPEMFAE LLQAANTTDD YRKCPSNCGQ KIKIRRVLMN CPEIVTIGLV
260 270 280 290 300
WDSEHSDLTE AVVRNLATHL YLPGLFYRVT DENAKNSELN LVGMICYTSQ
310 320 330 340 350
HYCAFAFHTK SSKWVFFDDA NVKEIGTRWK DVVSKCIRCH FQPLLLFYAN
360 370 380 390 400
PDGTAVSTED ALRQVISWSH YKSVAENMGC EKPVIHKSDN LKENGFGDQA
410 420 430 440 450
KQRENQKFPT DNISSSNRSH SHTGVGKGPA KLSHIDQREK IKDISRECAL
460 470 480 490 500
KAIEQKNLLS SQRKDLEKGQ RKDLGRHRDL VDEDLSHFQS GSPPAPNGFK
510 520 530 540 550
QHGNPHLYHS QGKGSYKHDR VVPQSRASAQ IISSSKSQIL APGEKITGKV
560 570 580 590 600
KSDNGTGYDT DSSQDSRDRG NSCDSSSKSR NRGWKPMRET LNVDSIFSES
610 620 630 640 650
EKRQHSPRHK PNISNKPKSS KDPSFSNWPK ENPKQKGLMT IYEDEMKQEI
660 670 680 690 700
GSRSSLESNG KGAEKNKGLV EGKVHGDNWQ MQRTESGYES SDHISNGSTN
710 720 730 740 750
LDSPVIDGNG TVMDISGVKE TVCFSDQITT SNLNKERGDC TSLQSQHHLE
760 770 780 790 800
GFRKELRNLE AGYKSHEFHP ESHLQIKNHL IKRSHVHEDN GKLFPSSSLQ
810 820 830 840 850
IPKDHNAREH IHQSDEQKLE KPNECKFSEW LNIENSERTG LPFHVDNSAS
860 870 880 890 900
GKRVNSNEPS SLWSSHLRTV GLKPETAPLI QQQNIMDQCY FENSLSTECI
910 920 930 940 950
IRSASRSDGC QMPKLFCQNL PPPLPPKKYA ITSVPQSEKS ESTPDVKLTE
960 970 980 990 1000
VFKATSHLPK HSLSTASEPS LEVSTHMNDE RHKETFQVRE CFGNTPNCPS
1010 1020 1030 1040 1050
SSSTNDFQAN SGAIDAFCQP ELDSISTCPN ETVSLTTYFS VDSCMTDTYR
1060 1070
LKYHQRPKLS FPESSGFCNN SLS
Length:1,073
Mass (Da):120,806
Last modified:February 7, 2006 - v2
Checksum:i2A5E8B0AB4158878
GO

Sequence cautioni

The sequence AAH17382 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti190Missing in CAE47751 (PubMed:14715245).Curated1
Sequence conflicti209A → V in CAH18315 (PubMed:17974005).Curated1
Sequence conflicti276F → FF in CAH18315 (PubMed:17974005).Curated1
Sequence conflicti611P → A in CAH18315 (PubMed:17974005).Curated1
Sequence conflicti869T → G in AAH17382 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051541962S → R.1 PublicationCorresponds to variant rs3749591dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ583824 mRNA. Translation: CAE47751.1.
CR749490 mRNA. Translation: CAH18315.1.
AB037771 mRNA. Translation: BAA92588.1.
BC017382 mRNA. Translation: AAH17382.1. Different initiation.
CCDSiCCDS43265.1.
RefSeqiNP_061923.2. NM_019050.2.
XP_005263130.1. XM_005263073.3.
XP_011530339.1. XM_011532037.2.
XP_016863801.1. XM_017008312.1.
XP_016863802.1. XM_017008313.1.
XP_016863803.1. XM_017008314.1.
XP_016863804.1. XM_017008315.1.
UniGeneiHs.431081.
Hs.595368.

Genome annotation databases

EnsembliENST00000274030; ENSP00000274030; ENSG00000145390.
ENST00000450251; ENSP00000409906; ENSG00000145390.
GeneIDi54532.
KEGGihsa:54532.
UCSCiuc003icr.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ583824 mRNA. Translation: CAE47751.1.
CR749490 mRNA. Translation: CAH18315.1.
AB037771 mRNA. Translation: BAA92588.1.
BC017382 mRNA. Translation: AAH17382.1. Different initiation.
CCDSiCCDS43265.1.
RefSeqiNP_061923.2. NM_019050.2.
XP_005263130.1. XM_005263073.3.
XP_011530339.1. XM_011532037.2.
XP_016863801.1. XM_017008312.1.
XP_016863802.1. XM_017008313.1.
XP_016863803.1. XM_017008314.1.
XP_016863804.1. XM_017008315.1.
UniGeneiHs.431081.
Hs.595368.

3D structure databases

ProteinModelPortaliQ70EK8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120020. 24 interactors.
IntActiQ70EK8. 25 interactors.
MINTiMINT-1452598.
STRINGi9606.ENSP00000274030.

Protein family/group databases

MEROPSiC19.081.

PTM databases

iPTMnetiQ70EK8.
PhosphoSitePlusiQ70EK8.

Polymorphism and mutation databases

BioMutaiUSP53.
DMDMi88943889.

Proteomic databases

EPDiQ70EK8.
MaxQBiQ70EK8.
PaxDbiQ70EK8.
PeptideAtlasiQ70EK8.
PRIDEiQ70EK8.

Protocols and materials databases

DNASUi54532.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274030; ENSP00000274030; ENSG00000145390.
ENST00000450251; ENSP00000409906; ENSG00000145390.
GeneIDi54532.
KEGGihsa:54532.
UCSCiuc003icr.5. human.

Organism-specific databases

CTDi54532.
DisGeNETi54532.
GeneCardsiUSP53.
H-InvDBHIX0004467.
HGNCiHGNC:29255. USP53.
HPAiHPA035844.
HPA035845.
neXtProtiNX_Q70EK8.
OpenTargetsiENSG00000145390.
PharmGKBiPA134940368.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1887. Eukaryota.
ENOG410XSNE. LUCA.
GeneTreeiENSGT00440000033513.
HOGENOMiHOG000236318.
HOVERGENiHBG080701.
InParanoidiQ70EK8.
OMAiQRENQKF.
OrthoDBiEOG091G00Q6.
PhylomeDBiQ70EK8.
TreeFamiTF323194.

Miscellaneous databases

GeneWikiiUSP53.
GenomeRNAii54532.
PROiQ70EK8.

Gene expression databases

BgeeiENSG00000145390.
CleanExiHS_USP53.
ExpressionAtlasiQ70EK8. baseline and differential.
GenevisibleiQ70EK8. HS.

Family and domain databases

InterProiIPR001394. Peptidase_C19_UCH.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUBP53_HUMAN
AccessioniPrimary (citable) accession number: Q70EK8
Secondary accession number(s): Q68DA5, Q8WVQ5, Q9P2J7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: February 7, 2006
Last modified: November 30, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Although the active site residues are conserved, lacks the conserved His residue which is normally found 9 residues before the catalytic His.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.