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Protein

Aldehyde dehydrogenase family 3 member F1

Gene

ALDH3F1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei119Transition state stabilizerBy similarity1
Active sitei214Proton acceptorBy similarity1
Active sitei252NucleophileBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi192 – 197NADBy similarity6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciARA:AT4G36250-MONOMER.
ReactomeiR-ATH-1660661. Sphingolipid de novo biosynthesis.
R-ATH-211945. Phase 1 - Functionalization of compounds.
R-ATH-389599. Alpha-oxidation of phytanate.
R-ATH-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase family 3 member F1 (EC:1.2.1.3)
Gene namesi
Name:ALDH3F1
Ordered Locus Names:At4g36250
ORF Names:F23E13.140
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G36250.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum Source: TAIR
  • membrane Source: TAIR
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002560591 – 484Aldehyde dehydrogenase family 3 member F1Add BLAST484

Proteomic databases

PaxDbiQ70E96.
PRIDEiQ70E96.

PTM databases

iPTMnetiQ70E96.

Expressioni

Tissue specificityi

Constituively expressed at low levels.1 Publication

Inductioni

Not induced by abscisic acid (ABA), dehydration and salt stress.1 Publication

Gene expression databases

ExpressionAtlasiQ70E96. baseline and differential.
GenevisibleiQ70E96. AT.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

BioGridi15064. 2 interactors.
IntActiQ70E96. 8 interactors.
STRINGi3702.AT4G36250.1.

Structurei

3D structure databases

ProteinModelPortaliQ70E96.
SMRiQ70E96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiKOG2456. Eukaryota.
COG1012. LUCA.
HOGENOMiHOG000271515.
InParanoidiQ70E96.
KOiK00128.
OMAiKCPTILD.
OrthoDBiEOG09360B56.
PhylomeDBiQ70E96.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR012394. Aldehyde_DH_NAD(P).
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFiPIRSF036492. ALDH. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.

Sequencei

Sequence statusi: Complete.

Q70E96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAMKETVEE SLREMRETFA SGRTRSLKWR KAQIGAIYEM VKDNEDKICN
60 70 80 90 100
ALFQDLGKHS TEAFRDELGV VLRTATVAIN CLDKWAVPKH SKLPLLFYPA
110 120 130 140 150
KGKVISEPYG TVLVLSSWNF PISLSLDPLI GAIAAGNTVL LKSSELSPNA
160 170 180 190 200
SAFLAKTIPA YLDTKAIKVI EGGPDVATIL LQHQWDKIFF TGSPKIGRII
210 220 230 240 250
MAAAAQHLTP VTLELGGKCP TIVDHHTISK NIKSVVKRIA GGKWGSCNGQ
260 270 280 290 300
ACISVDYVLI EKSFAPTLID MLKPTIKSFF GENPKESGCL SRIANKHHVQ
310 320 330 340 350
RLSRLLSDPR VQASIVYGGS IDEDKLYVEP TILLDPPLDS EIMNEEIFGP
360 370 380 390 400
ILPIITVRDI QESIGIINTK PKPLAIYAFT NDENLKTRIL SETSSGSVTF
410 420 430 440 450
NDVMIQYMCD ALPFGGVGES GIGRYHGKYS FDCFSHEKAI MEGSLGMDLE
460 470 480
ARYPPWNNFK LTFIRLAFRE AYFKLILLML GLKR
Length:484
Mass (Da):53,615
Last modified:October 31, 2006 - v2
Checksum:iA243419F0C926265
GO

Sequence cautioni

The sequence CAA18131 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB80296 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti59H → L in CAE48163 (PubMed:15830124).Curated1
Sequence conflicti226Missing in CAE48163 (PubMed:15830124).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ584644 mRNA. Translation: CAE48163.1.
AL022141 Genomic DNA. Translation: CAA18131.1. Sequence problems.
AL161589 Genomic DNA. Translation: CAB80296.1. Sequence problems.
CP002687 Genomic DNA. Translation: AEE86639.1.
PIRiT04594.
RefSeqiNP_195348.2. NM_119793.5.
UniGeneiAt.27542.

Genome annotation databases

EnsemblPlantsiAT4G36250.1; AT4G36250.1; AT4G36250.
GeneIDi829782.
GrameneiAT4G36250.1; AT4G36250.1; AT4G36250.
KEGGiath:AT4G36250.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ584644 mRNA. Translation: CAE48163.1.
AL022141 Genomic DNA. Translation: CAA18131.1. Sequence problems.
AL161589 Genomic DNA. Translation: CAB80296.1. Sequence problems.
CP002687 Genomic DNA. Translation: AEE86639.1.
PIRiT04594.
RefSeqiNP_195348.2. NM_119793.5.
UniGeneiAt.27542.

3D structure databases

ProteinModelPortaliQ70E96.
SMRiQ70E96.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi15064. 2 interactors.
IntActiQ70E96. 8 interactors.
STRINGi3702.AT4G36250.1.

PTM databases

iPTMnetiQ70E96.

Proteomic databases

PaxDbiQ70E96.
PRIDEiQ70E96.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G36250.1; AT4G36250.1; AT4G36250.
GeneIDi829782.
GrameneiAT4G36250.1; AT4G36250.1; AT4G36250.
KEGGiath:AT4G36250.

Organism-specific databases

TAIRiAT4G36250.

Phylogenomic databases

eggNOGiKOG2456. Eukaryota.
COG1012. LUCA.
HOGENOMiHOG000271515.
InParanoidiQ70E96.
KOiK00128.
OMAiKCPTILD.
OrthoDBiEOG09360B56.
PhylomeDBiQ70E96.

Enzyme and pathway databases

BioCyciARA:AT4G36250-MONOMER.
ReactomeiR-ATH-1660661. Sphingolipid de novo biosynthesis.
R-ATH-211945. Phase 1 - Functionalization of compounds.
R-ATH-389599. Alpha-oxidation of phytanate.
R-ATH-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiQ70E96.

Gene expression databases

ExpressionAtlasiQ70E96. baseline and differential.
GenevisibleiQ70E96. AT.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR012394. Aldehyde_DH_NAD(P).
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFiPIRSF036492. ALDH. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAL3F1_ARATH
AccessioniPrimary (citable) accession number: Q70E96
Secondary accession number(s): O65516
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: November 30, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.