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Q70E96

- AL3F1_ARATH

UniProt

Q70E96 - AL3F1_ARATH

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Protein
Aldehyde dehydrogenase family 3 member F1
Gene
ALDH3F1, At4g36250, F23E13.140
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei119 – 1191Transition state stabilizer By similarity
Active sitei214 – 2141Proton acceptor By similarity
Active sitei252 – 2521Nucleophile By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi192 – 1976NAD By similarity

GO - Molecular functioni

  1. aldehyde dehydrogenase (NAD) activity Source: TAIR
  2. aldehyde dehydrogenase [NAD(P)+] activity Source: InterPro

GO - Biological processi

  1. cellular aldehyde metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciARA:AT4G36250-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase family 3 member F1 (EC:1.2.1.3)
Gene namesi
Name:ALDH3F1
Ordered Locus Names:At4g36250
ORF Names:F23E13.140
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 4

Organism-specific databases

TAIRiAT4G36250.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: TAIR
  2. membrane Source: TAIR
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 484484Aldehyde dehydrogenase family 3 member F1
PRO_0000256059Add
BLAST

Proteomic databases

PaxDbiQ70E96.
PRIDEiQ70E96.

Expressioni

Tissue specificityi

Constituively expressed at low levels.1 Publication

Inductioni

Not induced by abscisic acid (ABA), dehydration and salt stress.1 Publication

Gene expression databases

ArrayExpressiQ70E96.
GenevestigatoriQ70E96.

Interactioni

Subunit structurei

Homotetramer By similarity.

Protein-protein interaction databases

BioGridi15064. 2 interactions.
IntActiQ70E96. 8 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ70E96.
SMRiQ70E96. Positions 8-455.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271515.
InParanoidiQ70E96.
KOiK00128.
OMAiSWNFPIS.
PhylomeDBiQ70E96.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR012394. Aldehyde_DH_NAD(P).
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFiPIRSF036492. ALDH. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.

Sequencei

Sequence statusi: Complete.

Q70E96-1 [UniParc]FASTAAdd to Basket

« Hide

MEAMKETVEE SLREMRETFA SGRTRSLKWR KAQIGAIYEM VKDNEDKICN    50
ALFQDLGKHS TEAFRDELGV VLRTATVAIN CLDKWAVPKH SKLPLLFYPA 100
KGKVISEPYG TVLVLSSWNF PISLSLDPLI GAIAAGNTVL LKSSELSPNA 150
SAFLAKTIPA YLDTKAIKVI EGGPDVATIL LQHQWDKIFF TGSPKIGRII 200
MAAAAQHLTP VTLELGGKCP TIVDHHTISK NIKSVVKRIA GGKWGSCNGQ 250
ACISVDYVLI EKSFAPTLID MLKPTIKSFF GENPKESGCL SRIANKHHVQ 300
RLSRLLSDPR VQASIVYGGS IDEDKLYVEP TILLDPPLDS EIMNEEIFGP 350
ILPIITVRDI QESIGIINTK PKPLAIYAFT NDENLKTRIL SETSSGSVTF 400
NDVMIQYMCD ALPFGGVGES GIGRYHGKYS FDCFSHEKAI MEGSLGMDLE 450
ARYPPWNNFK LTFIRLAFRE AYFKLILLML GLKR 484
Length:484
Mass (Da):53,615
Last modified:October 31, 2006 - v2
Checksum:iA243419F0C926265
GO

Sequence cautioni

The sequence CAA18131.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAB80296.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti59 – 591H → L in CAE48163. 1 Publication
Sequence conflicti226 – 2261Missing in CAE48163. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ584644 mRNA. Translation: CAE48163.1.
AL022141 Genomic DNA. Translation: CAA18131.1. Sequence problems.
AL161589 Genomic DNA. Translation: CAB80296.1. Sequence problems.
CP002687 Genomic DNA. Translation: AEE86639.1.
PIRiT04594.
RefSeqiNP_195348.2. NM_119793.4.
UniGeneiAt.27542.

Genome annotation databases

EnsemblPlantsiAT4G36250.1; AT4G36250.1; AT4G36250.
GeneIDi829782.
KEGGiath:AT4G36250.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ584644 mRNA. Translation: CAE48163.1 .
AL022141 Genomic DNA. Translation: CAA18131.1 . Sequence problems.
AL161589 Genomic DNA. Translation: CAB80296.1 . Sequence problems.
CP002687 Genomic DNA. Translation: AEE86639.1 .
PIRi T04594.
RefSeqi NP_195348.2. NM_119793.4.
UniGenei At.27542.

3D structure databases

ProteinModelPortali Q70E96.
SMRi Q70E96. Positions 8-455.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 15064. 2 interactions.
IntActi Q70E96. 8 interactions.

Proteomic databases

PaxDbi Q70E96.
PRIDEi Q70E96.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT4G36250.1 ; AT4G36250.1 ; AT4G36250 .
GeneIDi 829782.
KEGGi ath:AT4G36250.

Organism-specific databases

TAIRi AT4G36250.

Phylogenomic databases

eggNOGi COG1012.
HOGENOMi HOG000271515.
InParanoidi Q70E96.
KOi K00128.
OMAi SWNFPIS.
PhylomeDBi Q70E96.

Enzyme and pathway databases

BioCyci ARA:AT4G36250-MONOMER.

Gene expression databases

ArrayExpressi Q70E96.
Genevestigatori Q70E96.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR012394. Aldehyde_DH_NAD(P).
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
PIRSFi PIRSF036492. ALDH. 1 hit.
SUPFAMi SSF53720. SSF53720. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Detailed expression analysis of selected genes of the aldehyde dehydrogenase(ALDH) gene superfamily in Arabidopsis thaliana."
    Kirch H.-H., Schlingensiepen S., Kotchoni S., Sunkar R., Bartels D.
    Plant Mol. Biol. 57:315-332(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
  2. "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana."
    Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B.
    , Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R.
    Nature 402:769-777(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. Cited for: NOMENCLATURE.

Entry informationi

Entry nameiAL3F1_ARATH
AccessioniPrimary (citable) accession number: Q70E96
Secondary accession number(s): O65516
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: June 11, 2014
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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