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Q70E96

- AL3F1_ARATH

UniProt

Q70E96 - AL3F1_ARATH

Protein

Aldehyde dehydrogenase family 3 member F1

Gene

ALDH3F1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 2 (31 Oct 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    An aldehyde + NAD+ + H2O = a carboxylate + NADH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei119 – 1191Transition state stabilizerBy similarity
    Active sitei214 – 2141Proton acceptorBy similarity
    Active sitei252 – 2521NucleophileBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi192 – 1976NADBy similarity

    GO - Molecular functioni

    1. aldehyde dehydrogenase (NAD) activity Source: TAIR
    2. aldehyde dehydrogenase [NAD(P)+] activity Source: InterPro

    GO - Biological processi

    1. cellular aldehyde metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciARA:AT4G36250-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aldehyde dehydrogenase family 3 member F1 (EC:1.2.1.3)
    Gene namesi
    Name:ALDH3F1
    Ordered Locus Names:At4g36250
    ORF Names:F23E13.140
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 4

    Organism-specific databases

    TAIRiAT4G36250.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: TAIR
    2. membrane Source: TAIR

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 484484Aldehyde dehydrogenase family 3 member F1PRO_0000256059Add
    BLAST

    Proteomic databases

    PaxDbiQ70E96.
    PRIDEiQ70E96.

    Expressioni

    Tissue specificityi

    Constituively expressed at low levels.1 Publication

    Inductioni

    Not induced by abscisic acid (ABA), dehydration and salt stress.1 Publication

    Gene expression databases

    ArrayExpressiQ70E96.
    GenevestigatoriQ70E96.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    BioGridi15064. 2 interactions.
    IntActiQ70E96. 8 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ70E96.
    SMRiQ70E96. Positions 8-455.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG1012.
    HOGENOMiHOG000271515.
    InParanoidiQ70E96.
    KOiK00128.
    OMAiSWNFPIS.
    PhylomeDBiQ70E96.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR012394. Aldehyde_DH_NAD(P).
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036492. ALDH. 1 hit.
    SUPFAMiSSF53720. SSF53720. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q70E96-1 [UniParc]FASTAAdd to Basket

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    MEAMKETVEE SLREMRETFA SGRTRSLKWR KAQIGAIYEM VKDNEDKICN    50
    ALFQDLGKHS TEAFRDELGV VLRTATVAIN CLDKWAVPKH SKLPLLFYPA 100
    KGKVISEPYG TVLVLSSWNF PISLSLDPLI GAIAAGNTVL LKSSELSPNA 150
    SAFLAKTIPA YLDTKAIKVI EGGPDVATIL LQHQWDKIFF TGSPKIGRII 200
    MAAAAQHLTP VTLELGGKCP TIVDHHTISK NIKSVVKRIA GGKWGSCNGQ 250
    ACISVDYVLI EKSFAPTLID MLKPTIKSFF GENPKESGCL SRIANKHHVQ 300
    RLSRLLSDPR VQASIVYGGS IDEDKLYVEP TILLDPPLDS EIMNEEIFGP 350
    ILPIITVRDI QESIGIINTK PKPLAIYAFT NDENLKTRIL SETSSGSVTF 400
    NDVMIQYMCD ALPFGGVGES GIGRYHGKYS FDCFSHEKAI MEGSLGMDLE 450
    ARYPPWNNFK LTFIRLAFRE AYFKLILLML GLKR 484
    Length:484
    Mass (Da):53,615
    Last modified:October 31, 2006 - v2
    Checksum:iA243419F0C926265
    GO

    Sequence cautioni

    The sequence CAA18131.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAB80296.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti59 – 591H → L in CAE48163. (PubMed:15830124)Curated
    Sequence conflicti226 – 2261Missing in CAE48163. (PubMed:15830124)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ584644 mRNA. Translation: CAE48163.1.
    AL022141 Genomic DNA. Translation: CAA18131.1. Sequence problems.
    AL161589 Genomic DNA. Translation: CAB80296.1. Sequence problems.
    CP002687 Genomic DNA. Translation: AEE86639.1.
    PIRiT04594.
    RefSeqiNP_195348.2. NM_119793.4.
    UniGeneiAt.27542.

    Genome annotation databases

    EnsemblPlantsiAT4G36250.1; AT4G36250.1; AT4G36250.
    GeneIDi829782.
    KEGGiath:AT4G36250.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ584644 mRNA. Translation: CAE48163.1 .
    AL022141 Genomic DNA. Translation: CAA18131.1 . Sequence problems.
    AL161589 Genomic DNA. Translation: CAB80296.1 . Sequence problems.
    CP002687 Genomic DNA. Translation: AEE86639.1 .
    PIRi T04594.
    RefSeqi NP_195348.2. NM_119793.4.
    UniGenei At.27542.

    3D structure databases

    ProteinModelPortali Q70E96.
    SMRi Q70E96. Positions 8-455.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 15064. 2 interactions.
    IntActi Q70E96. 8 interactions.

    Proteomic databases

    PaxDbi Q70E96.
    PRIDEi Q70E96.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT4G36250.1 ; AT4G36250.1 ; AT4G36250 .
    GeneIDi 829782.
    KEGGi ath:AT4G36250.

    Organism-specific databases

    TAIRi AT4G36250.

    Phylogenomic databases

    eggNOGi COG1012.
    HOGENOMi HOG000271515.
    InParanoidi Q70E96.
    KOi K00128.
    OMAi SWNFPIS.
    PhylomeDBi Q70E96.

    Enzyme and pathway databases

    BioCyci ARA:AT4G36250-MONOMER.

    Gene expression databases

    ArrayExpressi Q70E96.
    Genevestigatori Q70E96.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR012394. Aldehyde_DH_NAD(P).
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036492. ALDH. 1 hit.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Detailed expression analysis of selected genes of the aldehyde dehydrogenase(ALDH) gene superfamily in Arabidopsis thaliana."
      Kirch H.-H., Schlingensiepen S., Kotchoni S., Sunkar R., Bartels D.
      Plant Mol. Biol. 57:315-332(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
    2. "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana."
      Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B.
      , Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R.
      Nature 402:769-777(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. Cited for: NOMENCLATURE.

    Entry informationi

    Entry nameiAL3F1_ARATH
    AccessioniPrimary (citable) accession number: Q70E96
    Secondary accession number(s): O65516
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: October 31, 2006
    Last modified: October 1, 2014
    This is version 81 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3