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Protein

Aldehyde dehydrogenase family 3 member F1

Gene

ALDH3F1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei119Transition state stabilizerBy similarity1
Active sitei214Proton acceptorBy similarity1
Active sitei252NucleophileBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi192 – 197NADBy similarity6

GO - Molecular functioni

  • aldehyde dehydrogenase (NAD) activity Source: TAIR
  • aldehyde dehydrogenase [NAD(P)+] activity Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

BioCyciARA:AT4G36250-MONOMER
ReactomeiR-ATH-1660661 Sphingolipid de novo biosynthesis
R-ATH-211945 Phase I - Functionalization of compounds
R-ATH-389599 Alpha-oxidation of phytanate
R-ATH-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase family 3 member F1 (EC:1.2.1.3)
Gene namesi
Name:ALDH3F1
Ordered Locus Names:At4g36250
ORF Names:F23E13.140
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G36250
TAIRilocus:2122224 AT4G36250

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002560591 – 484Aldehyde dehydrogenase family 3 member F1Add BLAST484

Proteomic databases

PaxDbiQ70E96
PRIDEiQ70E96

PTM databases

iPTMnetiQ70E96

Expressioni

Tissue specificityi

Constituively expressed at low levels.1 Publication

Inductioni

Not induced by abscisic acid (ABA), dehydration and salt stress.1 Publication

Gene expression databases

ExpressionAtlasiQ70E96 differential
GenevisibleiQ70E96 AT

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

BioGridi15064, 2 interactors
IntActiQ70E96, 8 interactors
STRINGi3702.AT4G36250.1

Structurei

3D structure databases

ProteinModelPortaliQ70E96
SMRiQ70E96
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiKOG2456 Eukaryota
COG1012 LUCA
HOGENOMiHOG000271515
InParanoidiQ70E96
KOiK00128
OMAiQKLPEWA
OrthoDBiEOG09360B56
PhylomeDBiQ70E96

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 2 hits
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR012394 Aldehyde_DH_NAD(P)
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
PIRSFiPIRSF036492 ALDH, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit

Sequencei

Sequence statusi: Complete.

Q70E96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAMKETVEE SLREMRETFA SGRTRSLKWR KAQIGAIYEM VKDNEDKICN
60 70 80 90 100
ALFQDLGKHS TEAFRDELGV VLRTATVAIN CLDKWAVPKH SKLPLLFYPA
110 120 130 140 150
KGKVISEPYG TVLVLSSWNF PISLSLDPLI GAIAAGNTVL LKSSELSPNA
160 170 180 190 200
SAFLAKTIPA YLDTKAIKVI EGGPDVATIL LQHQWDKIFF TGSPKIGRII
210 220 230 240 250
MAAAAQHLTP VTLELGGKCP TIVDHHTISK NIKSVVKRIA GGKWGSCNGQ
260 270 280 290 300
ACISVDYVLI EKSFAPTLID MLKPTIKSFF GENPKESGCL SRIANKHHVQ
310 320 330 340 350
RLSRLLSDPR VQASIVYGGS IDEDKLYVEP TILLDPPLDS EIMNEEIFGP
360 370 380 390 400
ILPIITVRDI QESIGIINTK PKPLAIYAFT NDENLKTRIL SETSSGSVTF
410 420 430 440 450
NDVMIQYMCD ALPFGGVGES GIGRYHGKYS FDCFSHEKAI MEGSLGMDLE
460 470 480
ARYPPWNNFK LTFIRLAFRE AYFKLILLML GLKR
Length:484
Mass (Da):53,615
Last modified:October 31, 2006 - v2
Checksum:iA243419F0C926265
GO

Sequence cautioni

The sequence CAA18131 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB80296 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti59H → L in CAE48163 (PubMed:15830124).Curated1
Sequence conflicti226Missing in CAE48163 (PubMed:15830124).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ584644 mRNA Translation: CAE48163.1
AL022141 Genomic DNA Translation: CAA18131.1 Sequence problems.
AL161589 Genomic DNA Translation: CAB80296.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE86639.1
PIRiT04594
RefSeqiNP_195348.2, NM_119793.5
UniGeneiAt.27542

Genome annotation databases

EnsemblPlantsiAT4G36250.1; AT4G36250.1; AT4G36250
GeneIDi829782
GrameneiAT4G36250.1; AT4G36250.1; AT4G36250
KEGGiath:AT4G36250

Similar proteinsi

Entry informationi

Entry nameiAL3F1_ARATH
AccessioniPrimary (citable) accession number: Q70E96
Secondary accession number(s): O65516
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: May 23, 2018
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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