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Protein

Sushi, nidogen and EGF-like domain-containing protein 1

Gene

Sned1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Sushi, nidogen and EGF-like domain-containing protein 1
Alternative name(s):
Secreted protein SST-3
Stromal nidogen extracellular matrix protein
Gene namesi
Name:Sned1
Synonyms:Snep
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:3045960. Sned1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 14031379Sushi, nidogen and EGF-like domain-containing protein 1PRO_5000072108Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi272 ↔ 284By similarity
Disulfide bondi278 ↔ 297By similarity
Disulfide bondi299 ↔ 308By similarity
Disulfide bondi315 ↔ 326By similarity
Disulfide bondi320 ↔ 335By similarity
Disulfide bondi337 ↔ 346By similarity
Disulfide bondi353 ↔ 364By similarity
Disulfide bondi358 ↔ 373By similarity
Disulfide bondi375 ↔ 384By similarity
Disulfide bondi391 ↔ 402By similarity
Disulfide bondi396 ↔ 411By similarity
Glycosylationi408 – 4081N-linked (GlcNAc...)Sequence analysis
Disulfide bondi413 ↔ 422By similarity
Disulfide bondi433 ↔ 444By similarity
Disulfide bondi438 ↔ 453By similarity
Disulfide bondi455 ↔ 464By similarity
Disulfide bondi472 ↔ 480By similarity
Disulfide bondi474 ↔ 488By similarity
Disulfide bondi490 ↔ 499By similarity
Disulfide bondi545 ↔ 556By similarity
Disulfide bondi550 ↔ 565By similarity
Disulfide bondi567 ↔ 576By similarity
Disulfide bondi584 ↔ 595By similarity
Disulfide bondi589 ↔ 604By similarity
Disulfide bondi606 ↔ 615By similarity
Disulfide bondi623 ↔ 634By similarity
Disulfide bondi628 ↔ 643By similarity
Disulfide bondi645 ↔ 654By similarity
Disulfide bondi661 ↔ 672By similarity
Disulfide bondi666 ↔ 681By similarity
Disulfide bondi683 ↔ 692By similarity
Disulfide bondi698 ↔ 739By similarity
Glycosylationi712 – 7121N-linked (GlcNAc...)Sequence analysis
Disulfide bondi724 ↔ 751By similarity
Disulfide bondi757 ↔ 768By similarity
Disulfide bondi762 ↔ 777By similarity
Disulfide bondi779 ↔ 788By similarity
Disulfide bondi795 ↔ 806By similarity
Disulfide bondi800 ↔ 815By similarity
Disulfide bondi817 ↔ 826By similarity
Disulfide bondi833 ↔ 844By similarity
Disulfide bondi838 ↔ 853By similarity
Disulfide bondi855 ↔ 864By similarity
Disulfide bondi871 ↔ 882By similarity
Disulfide bondi876 ↔ 891By similarity
Disulfide bondi893 ↔ 902By similarity
Glycosylationi977 – 9771N-linked (GlcNAc...)Sequence analysis
Disulfide bondi1310 ↔ 1321By similarity
Disulfide bondi1315 ↔ 1330By similarity
Disulfide bondi1332 ↔ 1341By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ70E20.
PaxDbiQ70E20.
PRIDEiQ70E20.

PTM databases

iPTMnetiQ70E20.
PhosphoSiteiQ70E20.

Expressioni

Tissue specificityi

Expressed in lung.1 Publication

Developmental stagei

Expressed in mesenchymal cells or stromal cell from E10.5 to E17.5.1 Publication

Gene expression databases

BgeeiENSMUSG00000047793.
CleanExiMM_SNED1.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050832.

Structurei

3D structure databases

ProteinModelPortaliQ70E20.
SMRiQ70E20. Positions 257-893, 905-1185.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini103 – 258156NIDOPROSITE-ProRule annotationAdd
BLAST
Domaini268 – 30942EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini311 – 34737EGF-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini349 – 38537EGF-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini387 – 42337EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini429 – 46537EGF-like 5PROSITE-ProRule annotationAdd
BLAST
Domaini468 – 50033EGF-like 6PROSITE-ProRule annotationAdd
BLAST
Domaini541 – 57737EGF-like 7PROSITE-ProRule annotationAdd
BLAST
Domaini580 – 61637EGF-like 8PROSITE-ProRule annotationAdd
BLAST
Domaini619 – 65537EGF-like 9PROSITE-ProRule annotationAdd
BLAST
Domaini657 – 69337EGF-like 10PROSITE-ProRule annotationAdd
BLAST
Domaini696 – 75358SushiPROSITE-ProRule annotationAdd
BLAST
Domaini753 – 78937EGF-like 11; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini791 – 82737EGF-like 12; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini829 – 86537EGF-like 13PROSITE-ProRule annotationAdd
BLAST
Domaini867 – 90337EGF-like 14PROSITE-ProRule annotationAdd
BLAST
Domaini908 – 100699Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini1007 – 110599Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini1106 – 120095Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini1306 – 134237EGF-like 15PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 15 EGF-like domains.PROSITE-ProRule annotation
Contains 3 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 1 NIDO domain.PROSITE-ProRule annotation
Contains 1 Sushi (CCP/SCR) domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiKOG1217. Eukaryota.
KOG4291. Eukaryota.
ENOG410ZK2K. LUCA.
HOGENOMiHOG000081748.
HOVERGENiHBG108495.
InParanoidiQ70E20.
PhylomeDBiQ70E20.
TreeFamiTF335195.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR003961. FN3_dom.
IPR009030. Growth_fac_rcpt_.
IPR013783. Ig-like_fold.
IPR003886. NIDO_dom.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00008. EGF. 13 hits.
PF00041. fn3. 3 hits.
PF12661. hEGF. 2 hits.
PF06119. NIDO. 1 hit.
[Graphical view]
SMARTiSM00032. CCP. 1 hit.
SM00181. EGF. 15 hits.
SM00179. EGF_CA. 14 hits.
SM00060. FN3. 3 hits.
SM00539. NIDO. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
SSF57184. SSF57184. 1 hit.
SSF57535. SSF57535. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 6 hits.
PS00022. EGF_1. 15 hits.
PS01186. EGF_2. 14 hits.
PS50026. EGF_3. 15 hits.
PS01187. EGF_CA. 3 hits.
PS50853. FN3. 3 hits.
PS51220. NIDO. 1 hit.
PS50923. SUSHI. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q70E20-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLGAAWALL LAAALGLGTR GVRAAVALAD FYPFGTKRGD TVTPKQDDGG
60 70 80 90 100
SGLQPLSVPF PFFGAEHSGL YVNNNGIISF LKEVSQFTPV AFPIAKDRCV
110 120 130 140 150
VAAFWADVDN RRAGDVYYRE ATDPAMLNRA TEDIRRYFPE LPDFSATWVF
160 170 180 190 200
VATWYRVTFF GGSSSSPVNT FQTVLITDGR FSFTIFNYES ILWTTGTHAS
210 220 230 240 250
SGGDTDGLGG IAAQAGFNAG DGHRYFNIPG SRTADMAEVE TTTNVGVPGR
260 270 280 290 300
WAFRIDDAQV RVGGCGHTTS VCLVLRPCLN GGKCIDDCVT GNPSYTCSCL
310 320 330 340 350
AGFTGRRCHL DVNECASHPC QNGGTCTHGV NSFSCQCPAG FKGPTCESAQ
360 370 380 390 400
SPCDNKVCQN GGQCQAESSS AVCVCQAGYT GATCETDVDE CSSDPCQNGG
410 420 430 440 450
SCVDLVGNYS CICVEPFEGP QCETGSYLVP SPCLSNPCQN GGTCVDADEG
460 470 480 490 500
YVCECPEGFM GLDCRERILN DCDCRNGGRC LGANTTLCQC PPGFFGLLCE
510 520 530 540 550
FEVTATPCNM NTQCPDGGYC MEYGGSYLCV CHTDHNISHS LPSPCDSDPC
560 570 580 590 600
FNGGSCDAHE DSYTCECPRG FHGRHCEKAR PHLCSSGPCR NGGTCKEMGD
610 620 630 640 650
EYRCTCPYRF TGRHCEIGKP DSCASGPCHN GGTCFHYIGK YKCDCPPGFS
660 670 680 690 700
GRHCEIAPSP CFRSPCMNGG TCEDLGTDFS CYCQPGYTGH RCQAEVDCGH
710 720 730 740 750
PEEVEHATMR FNGTHVGSVA LYTCEPGFSL SALSHIRVCQ PQGVWSQPPQ
760 770 780 790 800
CIEVDECRSQ PCLHGGSCQD LIADYQCLCS PGYEGVHCEL ETDECQAQPC
810 820 830 840 850
RNGGSCRDLP RAFICQCPEG FVGIHCETEV DACASSPCQH GGRCEDGGGA
860 870 880 890 900
YLCVCPEGFF GYNCETVSDP CFSSPCGSRG YCLASNGSHS CTCKVGYTGK
910 920 930 940 950
DCTKELLPPT ALRVERVEES GVSISWSPPE GTTARQVLDG YAVTYASSDG
960 970 980 990 1000
SSRRTDFVDR SRSSHQLRAL AAGRAYNISV FSVKRNTNNK NDISRPAALL
1010 1020 1030 1040 1050
TRTRPRPIED FEVTNISANA ISVQWALHRI QHATVSRVRV SILYPEASAV
1060 1070 1080 1090 1100
QSTEVDRSVD RLTFGDLLPG RRYTVRLTTL SGPGGAEYPT ESLASAPLNV
1110 1120 1130 1140 1150
WTRPLPPANL TASRVTATSA HMIWDTPAPG ISLEAYVINV TTSQSTKSRY
1160 1170 1180 1190 1200
IPNGKLVSYT VRDLMPGRRY QLSVTAVQST EQGQLHSEPA HLYIITSPRD
1210 1220 1230 1240 1250
GTDRRWHHGG HHSRMLRNRP APVRLPELRL LNDHSAPETP TQSSRFSELV
1260 1270 1280 1290 1300
DGRGRVSARF GGLPSRAVTV RSQPTTPVPL KNTEAPEQVH LALQLPKNSS
1310 1320 1330 1340 1350
KDTESTPGSC SEDACQNGGT CVPGADAHSC DCRPGFKGRH CELACEKVPR
1360 1370 1380 1390 1400
PCTRLFSETK SFPVWEGDIC HHVYKKVYKV HQDVCFKERC QSTSLRKPKQ

ETK
Length:1,403
Mass (Da):151,581
Last modified:September 11, 2007 - v2
Checksum:i869F84724E44D8CE
GO
Isoform 2 (identifier: Q70E20-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1066-1403: Missing.

Show »
Length:1,065
Mass (Da):114,252
Checksum:iF2390427F60E2373
GO

Sequence cautioni

The sequence BAC28030 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti288 – 2881C → W in CAE48492 (PubMed:15162516).Curated
Sequence conflicti867 – 8671V → M in AAO41836 (PubMed:12665856).Curated
Sequence conflicti1084 – 10841Missing in BAC28030 (PubMed:16141072).Curated
Sequence conflicti1123 – 11231I → V in AAI45887 (PubMed:15489334).Curated
Sequence conflicti1123 – 11231I → V in BAC28030 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1066 – 1403338Missing in isoform 2. 1 PublicationVSP_027755Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY169783 mRNA. Translation: AAO41836.1.
AJ584850 mRNA. Translation: CAE48492.1.
BC145886 mRNA. Translation: AAI45887.1.
AK032805 mRNA. Translation: BAC28030.1. Different initiation.
CCDSiCCDS35670.1. [Q70E20-1]
RefSeqiNP_766051.4. NM_172463.4.
UniGeneiMm.271897.

Genome annotation databases

GeneIDi208777.
KEGGimmu:208777.
UCSCiuc007cdm.1. mouse. [Q70E20-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY169783 mRNA. Translation: AAO41836.1.
AJ584850 mRNA. Translation: CAE48492.1.
BC145886 mRNA. Translation: AAI45887.1.
AK032805 mRNA. Translation: BAC28030.1. Different initiation.
CCDSiCCDS35670.1. [Q70E20-1]
RefSeqiNP_766051.4. NM_172463.4.
UniGeneiMm.271897.

3D structure databases

ProteinModelPortaliQ70E20.
SMRiQ70E20. Positions 257-893, 905-1185.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050832.

PTM databases

iPTMnetiQ70E20.
PhosphoSiteiQ70E20.

Proteomic databases

MaxQBiQ70E20.
PaxDbiQ70E20.
PRIDEiQ70E20.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi208777.
KEGGimmu:208777.
UCSCiuc007cdm.1. mouse. [Q70E20-1]

Organism-specific databases

CTDi25992.
MGIiMGI:3045960. Sned1.

Phylogenomic databases

eggNOGiKOG1217. Eukaryota.
KOG4291. Eukaryota.
ENOG410ZK2K. LUCA.
HOGENOMiHOG000081748.
HOVERGENiHBG108495.
InParanoidiQ70E20.
PhylomeDBiQ70E20.
TreeFamiTF335195.

Miscellaneous databases

PROiQ70E20.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000047793.
CleanExiMM_SNED1.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR003961. FN3_dom.
IPR009030. Growth_fac_rcpt_.
IPR013783. Ig-like_fold.
IPR003886. NIDO_dom.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00008. EGF. 13 hits.
PF00041. fn3. 3 hits.
PF12661. hEGF. 2 hits.
PF06119. NIDO. 1 hit.
[Graphical view]
SMARTiSM00032. CCP. 1 hit.
SM00181. EGF. 15 hits.
SM00179. EGF_CA. 14 hits.
SM00060. FN3. 3 hits.
SM00539. NIDO. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
SSF57184. SSF57184. 1 hit.
SSF57535. SSF57535. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 6 hits.
PS00022. EGF_1. 15 hits.
PS01186. EGF_2. 14 hits.
PS50026. EGF_3. 15 hits.
PS01187. EGF_CA. 3 hits.
PS50853. FN3. 3 hits.
PS51220. NIDO. 1 hit.
PS50923. SUSHI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSNED1_MOUSE
AccessioniPrimary (citable) accession number: Q70E20
Secondary accession number(s): A6H6I3, Q810H2, Q8BMD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: September 7, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.