Reviewed,
UniProtKB/Swiss-Prot Q70DU8 (AL3H1_ARATH)
Last modified
November 25, 2008.
Version 32.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Aldehyde dehydrogenase family 3 member H1 Short name=AtALDH4 EC=1.2.1.3 | ||||||
| Gene names |
| ||||||
| Organism | Arabidopsis thaliana (Mouse-ear cress) [Complete proteome] | ||||||
| Taxonomic identifier | 3702 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis |
Protein attributes
| Sequence length | 484 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | An aldehyde + NAD(+) + H(2)O = an acid + NADH. |
| Subunit structure | Homotetramer By similarity. |
| Induction | By abscisic acid (ABA), dehydration and salt stress in roots. |
| Sequence similarities | Belongs to the aldehyde dehydrogenase family. |
Ontologies
Keywords | |
|---|---|
| Biological process | Stress response |
| Coding sequence diversity | Alternative splicing |
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
Gene Ontology (GO) | |
| Biological process | cellular aldehyde metabolic process Inferred from electronic annotation. Source: InterPro oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW response to stressInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | aldehyde dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC aldehyde dehydrogenase [NAD(P)+] activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Alternative products
| This entry describes 1 isoform produced by alternative splicing. [Select] Notes: A number of isoforms are produced. According to EST sequences. | ||||||
| Isoform 1 (identifier: Q70DU8-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 484 | 484 | Aldehyde dehydrogenase family 3 member H1 | PRO_0000256060 | |||||
Regions | |||||||||
| Nucleotide binding | 196 – 201 | 6 | NAD By similarity | ||||||
Sites | |||||||||
| Active site | 218 | 1 | Proton acceptor By similarity | ||||||
| Active site | 253 | 1 | Nucleophile By similarity | ||||||
| Site | 123 | 1 | Transition state stabilizer By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 200 | 1 | I → V in CAE51203. Ref.4 | ||||||
| Sequence conflict | 272 | 1 | A → D in CAE51203. Ref.4 | ||||||
| Sequence conflict | 300 | 1 | F → L in CAE51203. Ref.4 | ||||||
| Sequence conflict | 391 | 1 | A → T in AAM61211. Ref.3 | ||||||
| Sequence conflict | 435 | 1 | F → S in CAE51203. Ref.4 | ||||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana." Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. Davis R.W.Nature 408:816-820(2000) [PubMed: 11130712] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia. |
| [2] | "Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. Ecker J.R.Science 302:842-846(2003) [PubMed: 14593172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia. |
| [3] | "Full-length cDNA from Arabidopsis thaliana." Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [4] | "Detailed expression analysis of selected genes of the aldehyde dehydrogenase(ALDH) gene superfamily in Arabidopsis thaliana." Kirch H.-H., Schlingensiepen S., Kotchoni S., Sunkar R., Bartels D. Plant Mol. Biol. 57:315-322(2005) [PubMed: 15830124] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-484, INDUCTION. |
| [5] | "The ALDH gene superfamily of Arabidopsis." Kirch H.-H., Bartels D., Wei Y., Schnable P.S., Wood A.J. Trends Plant Sci. 9:371-377(2004) [PubMed: 15358267] [Abstract] Cited for: NOMENCLATURE. |
Cross-references
Sequence databases | |
|---|---|
| AC074228 Genomic DNA. Translation: AAG50550.1. AY072122 mRNA. Translation: AAL59944.1. AY084648 mRNA. Translation: AAM61211.1. AJ585241 mRNA. Translation: CAE51203.1. | |
| PIR | H96505. |
| RefSeq | NP_175081.1. NP_849770.1. |
| UniGene | At.17189 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1AD3 based on UniProtKB P11883. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 841020. |
| GenomeReviews | Gene locus AT1G44170 in contig CT485782_GR. |
| NMPDR | fig|3702.1.peg.4090. |
Organism-specific databases | |
| TAIR | At1g44170. |
Family and domain databases | |
| InterPro | IPR016160. Ald_DHase_CS. IPR016162. Ald_DHase_N. IPR012394. Ald_DHase_NAD(P). IPR015590. Aldehyde_DHase. [Graphical view] |
| Gene3D | G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit. |
| PANTHER | PTHR11699. Aldehyde_dehyd. 1 hit. PTHR11699:SF15. ALDH. 1 hit. |
| Pfam | PF00171. Aldedh. 1 hit. [Graphical view] |
| PIRSF | PIRSF036492. ALDH. 1 hit. |
| PROSITE | PS00070. ALDEHYDE_DEHYDR_CYS. False negative. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | AL3H1_ARATH | ||||||||
| Accession | Primary (citable) accession number: Q70DU8 Secondary accession number(s): Q8LFT7, Q9C6Y7 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | PPAP (Plant Proteome Annotation Project) | ||||||||
Relevant documents
| Arabidopsis thaliana Arabidopsis thaliana: entries and gene names |
| UniProtKB secondary accession numbers Index of UniProtKB secondary accession numbers |
| SIMILARITY comments Index of protein domains and families |

Clusters with


