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Q70D51

- SIAT9_BOVIN

UniProt

Q70D51 - SIAT9_BOVIN

Protein

Lactosylceramide alpha-2,3-sialyltransferase

Gene

ST3GAL5

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 2 (20 May 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of ganglioside GM3 (alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1, 4-beta-D-glucosylceramide).By similarity

    Catalytic activityi

    CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.

    GO - Molecular functioni

    1. lactosylceramide alpha-2,3-sialyltransferase activity Source: UniProtKB

    GO - Biological processi

    1. protein glycosylation Source: InterPro
    2. sialylation Source: GOC

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Protein family/group databases

    CAZyiGT29. Glycosyltransferase Family 29.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lactosylceramide alpha-2,3-sialyltransferase (EC:2.4.99.9)
    Alternative name(s):
    CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase
    Ganglioside GM3 synthase
    ST3Gal V
    Short name:
    ST3GalV
    Sialyltransferase 9
    Gene namesi
    Name:ST3GAL5
    Synonyms:SIAT9
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of Golgi membrane Source: InterPro

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 420420Lactosylceramide alpha-2,3-sialyltransferasePRO_0000334617Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi197 ↔ 355By similarity
    Glycosylationi238 – 2381N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ70D51.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000015414.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6767CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini89 – 420332LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei68 – 8821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi20 – 267Poly-Ala

    Sequence similaritiesi

    Belongs to the glycosyltransferase 29 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG257001.
    HOGENOMiHOG000000682.
    HOVERGENiHBG056676.
    InParanoidiQ70D51.
    KOiK03370.

    Family and domain databases

    InterProiIPR001675. Glyco_trans_29.
    IPR012163. Sialyl_trans.
    [Graphical view]
    PfamiPF00777. Glyco_transf_29. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005557. Sialyl_trans. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q70D51-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRKKAAGGAE RRPLKPRTEA AAAAPAGRAM PSDHSRMKLR RDCSRPSLQW    50
    YTRAQNKMRR PNLLLKDILK CTLLLFGVWI LFYILKLNHT TEECDMKRMP 100
    YMDPDRIKRA QQYAQQVLQK ECRPQFAKRS MAQLFGSRYS LDLPPFVTKV 150
    PAESEAEYKY DPPFGFRKFS GKVQTLLELL PEHDFPEHLR AKSCKHCVVI 200
    GSGGILHGLE MGHALNQFDV VIRLNNAPVE GYSEHVGNKT TIRMTYPEGA 250
    PLSDLEYYSS DLFVTVLFKS VDFNWLQAMV KNETLPFWVR LFFWKQVAEK 300
    IPLQPKQFRI LNPVIIKETA FDILQYSEPQ SRFWGRDKNV PTIGVIAVVL 350
    ATHLCDEVSL AGFSYALNQP RTPLHYFDNL CMAAMNFQTM HNVTTETNFL 400
    LKLVREGVVR DLSGGIHSEF 420
    Length:420
    Mass (Da):48,263
    Last modified:May 20, 2008 - v2
    Checksum:iB8E51833DB069032
    GO

    Sequence cautioni

    The sequence CAE51392.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFC03040697 Genomic DNA. No translation available.
    AAFC03065753 Genomic DNA. No translation available.
    AJ585768 mRNA. Translation: CAE51392.1. Different initiation.
    RefSeqiNP_991376.2. NM_205807.3.
    UniGeneiBt.52500.

    Genome annotation databases

    GeneIDi404164.
    KEGGibta:404164.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFC03040697 Genomic DNA. No translation available.
    AAFC03065753 Genomic DNA. No translation available.
    AJ585768 mRNA. Translation: CAE51392.1 . Different initiation.
    RefSeqi NP_991376.2. NM_205807.3.
    UniGenei Bt.52500.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000015414.

    Protein family/group databases

    CAZyi GT29. Glycosyltransferase Family 29.

    Proteomic databases

    PRIDEi Q70D51.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 404164.
    KEGGi bta:404164.

    Organism-specific databases

    CTDi 8869.

    Phylogenomic databases

    eggNOGi NOG257001.
    HOGENOMi HOG000000682.
    HOVERGENi HBG056676.
    InParanoidi Q70D51.
    KOi K03370.

    Miscellaneous databases

    NextBioi 20817596.

    Family and domain databases

    InterProi IPR001675. Glyco_trans_29.
    IPR012163. Sialyl_trans.
    [Graphical view ]
    Pfami PF00777. Glyco_transf_29. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005557. Sialyl_trans. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of taurine cattle: a window to ruminant biology and evolution."
      The bovine genome sequencing and analysis consortium
      Science 324:522-528(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Hereford.
    2. "The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach."
      Harduin-Lepers A., Mollicone R., Delannoy P., Oriol R.
      Glycobiology 15:805-817(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 20-420.

    Entry informationi

    Entry nameiSIAT9_BOVIN
    AccessioniPrimary (citable) accession number: Q70D51
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 66 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3