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Q70D51 (SIAT9_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lactosylceramide alpha-2,3-sialyltransferase

EC=2.4.99.9
Alternative name(s):
CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase
Ganglioside GM3 synthase
ST3Gal V
Short name=ST3GalV
Sialyltransferase 9
Gene names
Name:ST3GAL5
Synonyms:SIAT9
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length420 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the formation of ganglioside GM3 (alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1, 4-beta-D-glucosylceramide) By similarity.

Catalytic activity

CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.

Subcellular location

Golgi apparatus membrane; Single-pass type II membrane protein Potential.

Sequence similarities

Belongs to the glycosyltransferase 29 family.

Sequence caution

The sequence CAE51392.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 420420Lactosylceramide alpha-2,3-sialyltransferase
PRO_0000334617

Regions

Topological domain1 – 6767Cytoplasmic Potential
Transmembrane68 – 8821Helical; Potential
Topological domain89 – 420332Lumenal Potential
Compositional bias20 – 267Poly-Ala

Amino acid modifications

Glycosylation2381N-linked (GlcNAc...) Potential
Disulfide bond197 ↔ 355 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q70D51 [UniParc].

Last modified May 20, 2008. Version 2.
Checksum: B8E51833DB069032

FASTA42048,263
        10         20         30         40         50         60 
MRKKAAGGAE RRPLKPRTEA AAAAPAGRAM PSDHSRMKLR RDCSRPSLQW YTRAQNKMRR 

        70         80         90        100        110        120 
PNLLLKDILK CTLLLFGVWI LFYILKLNHT TEECDMKRMP YMDPDRIKRA QQYAQQVLQK 

       130        140        150        160        170        180 
ECRPQFAKRS MAQLFGSRYS LDLPPFVTKV PAESEAEYKY DPPFGFRKFS GKVQTLLELL 

       190        200        210        220        230        240 
PEHDFPEHLR AKSCKHCVVI GSGGILHGLE MGHALNQFDV VIRLNNAPVE GYSEHVGNKT 

       250        260        270        280        290        300 
TIRMTYPEGA PLSDLEYYSS DLFVTVLFKS VDFNWLQAMV KNETLPFWVR LFFWKQVAEK 

       310        320        330        340        350        360 
IPLQPKQFRI LNPVIIKETA FDILQYSEPQ SRFWGRDKNV PTIGVIAVVL ATHLCDEVSL 

       370        380        390        400        410        420 
AGFSYALNQP RTPLHYFDNL CMAAMNFQTM HNVTTETNFL LKLVREGVVR DLSGGIHSEF 

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of taurine cattle: a window to ruminant biology and evolution."
The bovine genome sequencing and analysis consortium
Science 324:522-528(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Hereford.
[2]"The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach."
Harduin-Lepers A., Mollicone R., Delannoy P., Oriol R.
Glycobiology 15:805-817(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 20-420.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFC03040697 Genomic DNA. No translation available.
AAFC03065753 Genomic DNA. No translation available.
AJ585768 mRNA. Translation: CAE51392.1. Different initiation.
RefSeqNP_991376.2. NM_205807.3.
UniGeneBt.52500.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000015414.

Protein family/group databases

CAZyGT29. Glycosyltransferase Family 29.

Proteomic databases

PRIDEQ70D51.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID404164.
KEGGbta:404164.

Organism-specific databases

CTD8869.

Phylogenomic databases

eggNOGNOG257001.
HOGENOMHOG000000682.
HOVERGENHBG056676.
InParanoidQ70D51.
KOK03370.

Family and domain databases

InterProIPR001675. Glyco_trans_29.
IPR012163. Sialyl_trans.
[Graphical view]
PfamPF00777. Glyco_transf_29. 1 hit.
[Graphical view]
PIRSFPIRSF005557. Sialyl_trans. 1 hit.
ProtoNetSearch...

Other

NextBio20817596.

Entry information

Entry nameSIAT9_BOVIN
AccessionPrimary (citable) accession number: Q70D51
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: April 16, 2014
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families