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Q70D51

- SIAT9_BOVIN

UniProt

Q70D51 - SIAT9_BOVIN

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Protein

Lactosylceramide alpha-2,3-sialyltransferase

Gene

ST3GAL5

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of ganglioside GM3 (alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1, 4-beta-D-glucosylceramide).By similarity

Catalytic activityi

CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.

GO - Molecular functioni

  1. lactosylceramide alpha-2,3-sialyltransferase activity Source: UniProtKB

GO - Biological processi

  1. protein glycosylation Source: InterPro
  2. sialylation Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT29. Glycosyltransferase Family 29.

Names & Taxonomyi

Protein namesi
Recommended name:
Lactosylceramide alpha-2,3-sialyltransferase (EC:2.4.99.9)
Alternative name(s):
CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase
Ganglioside GM3 synthase
ST3Gal V
Short name:
ST3GalV
Sialyltransferase 9
Gene namesi
Name:ST3GAL5
Synonyms:SIAT9
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6767CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei68 – 8821HelicalSequence AnalysisAdd
BLAST
Topological domaini89 – 420332LumenalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of Golgi membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 420420Lactosylceramide alpha-2,3-sialyltransferasePRO_0000334617Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi197 ↔ 355By similarity
Glycosylationi238 – 2381N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ70D51.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000015414.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi20 – 267Poly-Ala

Sequence similaritiesi

Belongs to the glycosyltransferase 29 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG257001.
HOGENOMiHOG000000682.
HOVERGENiHBG056676.
InParanoidiQ70D51.
KOiK03370.

Family and domain databases

InterProiIPR001675. Glyco_trans_29.
IPR012163. Sialyl_trans.
[Graphical view]
PfamiPF00777. Glyco_transf_29. 1 hit.
[Graphical view]
PIRSFiPIRSF005557. Sialyl_trans. 1 hit.

Sequencei

Sequence statusi: Complete.

Q70D51-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRKKAAGGAE RRPLKPRTEA AAAAPAGRAM PSDHSRMKLR RDCSRPSLQW
60 70 80 90 100
YTRAQNKMRR PNLLLKDILK CTLLLFGVWI LFYILKLNHT TEECDMKRMP
110 120 130 140 150
YMDPDRIKRA QQYAQQVLQK ECRPQFAKRS MAQLFGSRYS LDLPPFVTKV
160 170 180 190 200
PAESEAEYKY DPPFGFRKFS GKVQTLLELL PEHDFPEHLR AKSCKHCVVI
210 220 230 240 250
GSGGILHGLE MGHALNQFDV VIRLNNAPVE GYSEHVGNKT TIRMTYPEGA
260 270 280 290 300
PLSDLEYYSS DLFVTVLFKS VDFNWLQAMV KNETLPFWVR LFFWKQVAEK
310 320 330 340 350
IPLQPKQFRI LNPVIIKETA FDILQYSEPQ SRFWGRDKNV PTIGVIAVVL
360 370 380 390 400
ATHLCDEVSL AGFSYALNQP RTPLHYFDNL CMAAMNFQTM HNVTTETNFL
410 420
LKLVREGVVR DLSGGIHSEF
Length:420
Mass (Da):48,263
Last modified:May 20, 2008 - v2
Checksum:iB8E51833DB069032
GO

Sequence cautioni

The sequence CAE51392.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFC03040697 Genomic DNA. No translation available.
AAFC03065753 Genomic DNA. No translation available.
AJ585768 mRNA. Translation: CAE51392.1. Different initiation.
RefSeqiNP_991376.2. NM_205807.3.
UniGeneiBt.52500.

Genome annotation databases

GeneIDi404164.
KEGGibta:404164.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFC03040697 Genomic DNA. No translation available.
AAFC03065753 Genomic DNA. No translation available.
AJ585768 mRNA. Translation: CAE51392.1 . Different initiation.
RefSeqi NP_991376.2. NM_205807.3.
UniGenei Bt.52500.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000015414.

Protein family/group databases

CAZyi GT29. Glycosyltransferase Family 29.

Proteomic databases

PRIDEi Q70D51.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 404164.
KEGGi bta:404164.

Organism-specific databases

CTDi 8869.

Phylogenomic databases

eggNOGi NOG257001.
HOGENOMi HOG000000682.
HOVERGENi HBG056676.
InParanoidi Q70D51.
KOi K03370.

Miscellaneous databases

NextBioi 20817596.

Family and domain databases

InterProi IPR001675. Glyco_trans_29.
IPR012163. Sialyl_trans.
[Graphical view ]
Pfami PF00777. Glyco_transf_29. 1 hit.
[Graphical view ]
PIRSFi PIRSF005557. Sialyl_trans. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of taurine cattle: a window to ruminant biology and evolution."
    The bovine genome sequencing and analysis consortium
    Science 324:522-528(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hereford.
  2. "The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach."
    Harduin-Lepers A., Mollicone R., Delannoy P., Oriol R.
    Glycobiology 15:805-817(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 20-420.

Entry informationi

Entry nameiSIAT9_BOVIN
AccessioniPrimary (citable) accession number: Q70D51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: October 1, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3