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Q70CQ4

- UBP31_HUMAN

UniProt

Q70CQ4 - UBP31_HUMAN

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Protein
Ubiquitin carboxyl-terminal hydrolase 31
Gene
USP31, KIAA1203
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei137 – 1371Nucleophile By similarity
Active sitei723 – 7231Proton acceptor By similarity

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: FlyBase

GO - Biological processi

  1. protein deubiquitination Source: FlyBase
  2. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.071.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 31 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 31
Ubiquitin thioesterase 31
Ubiquitin-specific-processing protease 31
Gene namesi
Name:USP31
Synonyms:KIAA1203
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:20060. USP31.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: FlyBase
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164742780.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13521352Ubiquitin carboxyl-terminal hydrolase 31
PRO_0000249518Add
BLAST

Proteomic databases

MaxQBiQ70CQ4.
PaxDbiQ70CQ4.
PRIDEiQ70CQ4.

PTM databases

PhosphoSiteiQ70CQ4.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

ArrayExpressiQ70CQ4.
BgeeiQ70CQ4.
CleanExiHS_USP31.
GenevestigatoriQ70CQ4.

Organism-specific databases

HPAiHPA006937.

Interactioni

Protein-protein interaction databases

BioGridi121548. 2 interactions.
STRINGi9606.ENSP00000219689.

Structurei

3D structure databases

ProteinModelPortaliQ70CQ4.
SMRiQ70CQ4. Positions 125-314, 593-765.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini128 – 765638USP
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi95 – 12531Pro-rich
Add
BLAST
Compositional biasi770 – 1221452Ser-rich
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.
Contains 1 USP domain.

Phylogenomic databases

eggNOGiCOG5560.
HOGENOMiHOG000154758.
HOVERGENiHBG094125.
InParanoidiQ70CQ4.
KOiK11852.
OMAiCHPIVER.
OrthoDBiEOG7VMP4B.
PhylomeDBiQ70CQ4.
TreeFamiTF106278.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q70CQ4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSKVTAPGSG PPAAASGKEK RSFSKRLFRS GRAGGGGAGG PGASGPAAPS     50
SPSSPSSARS VGSFMSRVLK TLSTLSHLSS EGAAPDRGGL RSCFPPGPAA 100
APTPPPCPPP PASPAPPACA AEPVPGVAGL RNHGNTCFMN ATLQCLSNTE 150
LFAEYLALGQ YRAGRPEPSP DPEQPAGRGA QGQGEVTEQL AHLVRALWTL 200
EYTPQHSRDF KTIVSKNALQ YRGNSQHDAQ EFLLWLLDRV HEDLNHSVKQ 250
SGQPPLKPPS ETDMMPEGPS FPVCSTFVQE LFQAQYRSSL TCPHCQKQSN 300
TFDPFLCISL PIPLPHTRPL YVTVVYQGKC SHCMRIGVAV PLSGTVARLR 350
EAVSMETKIP TDQIVLTEMY YDGFHRSFCD TDDLETVHES DCIFAFETPE 400
IFRPEGILSQ RGIHLNNNLN HLKFGLDYHR LSSPTQTAAK QGKMDSPTSR 450
AGSDKIVLLV CNRACTGQQG KRFGLPFVLH LEKTIAWDLL QKEILEKMKY 500
FLRPTVCIQV CPFSLRVVSV VGITYLLPQE EQPLCHPIVE RALKSCGPGG 550
TAHVKLVVEW DKETRDFLFV NTEDEYIPDA ESVRLQRERH HQPQTCTLSQ 600
CFQLYTKEER LAPDDAWRCP HCKQLQQGSI TLSLWTLPDV LIIHLKRFRQ 650
EGDRRMKLQN MVKFPLTGLD MTPHVVKRSQ SSWSLPSHWS PWRRPYGLGR 700
DPEDYIYDLY AVCNHHGTMQ GGHYTAYCKN SVDGLWYCFD DSDVQQLSED 750
EVCTQTAYIL FYQRRTAIPS WSANSSVAGS TSSSLCEHWV SRLPGSKPAS 800
VTSAASSRRT SLASLSESVE MTGERSEDDG GFSTRPFVRS VQRQSLSSRS 850
SVTSPLAVNE NCMRPSWSLS AKLQMRSNSP SRFSGDSPIH SSASTLEKIG 900
EAADDKVSIS CFGSLRNLSS SYQEPSDSHS RREHKAVGRA PLAVMEGVFK 950
DESDTRRLNS SVVDTQSKHS AQGDRLPPLS GPFDNNNQIA YVDQSDSVDS 1000
SPVKEVKAPS HPGSLAKKPE STTKRSPSSK GTSEPEKSLR KGRPALASQE 1050
SSLSSTSPSS PLPVKVSLKP SRSRSKADSS SRGSGRHSSP APAQPKKESS 1100
PKSQDSVSSP SPQKQKSASA LTYTASSTSA KKASGPATRS PFPPGKSRTS 1150
DHSLSREGSR QSLGSDRASA TSTSKPNSPR VSQARAGEGR GAGKHVRSSS 1200
MASLRSPSTS IKSGLKRDSK SEDKGLSFFK SALRQKETRR STDLGKTALL 1250
SKKAGGSSVK SVCKNTGDDE AERGHQPPAS QQPNANTTGK EQLVTKDPAS 1300
AKHSLLSARK SKSSQLDSGV PSSPGGRQSA EKSSKKLSSS MQTSARPSQK 1350
PQ 1352
Length:1,352
Mass (Da):146,651
Last modified:March 20, 2007 - v2
Checksum:iF68A90EC45D23EDF
GO
Isoform 2 (identifier: Q70CQ4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-697: Missing.
     698-725: LGRDPEDYIYDLYAVCNHHGTMQGGHYT → MSQRDGVCGSHEVAGAASPGADGGLSLA
     1095-1140: PKKESSPKSQ...KKASGPATRS → TQFPSGEPGP...QVWFEEGQQV
     1141-1352: Missing.

Note: No experimental confirmation available.

Show »
Length:443
Mass (Da):47,129
Checksum:i00B4E309593EC2E9
GO

Sequence cautioni

The sequence AK126752 differs from that shown. Reason: Frameshift at position 941.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti445 – 4451D → Y.
Corresponds to variant rs1978066 [ dbSNP | Ensembl ].
VAR_027422
Natural varianti532 – 5321Q → H.
Corresponds to variant rs4597335 [ dbSNP | Ensembl ].
VAR_027423
Natural varianti538 – 5381I → T.1 Publication
Corresponds to variant rs13339649 [ dbSNP | Ensembl ].
VAR_027424
Natural varianti552 – 5521A → T.
Corresponds to variant rs9932912 [ dbSNP | Ensembl ].
VAR_027425
Natural varianti931 – 9311R → L.
Corresponds to variant rs10083789 [ dbSNP | Ensembl ].
VAR_027426
Natural varianti1269 – 12691D → N.
Corresponds to variant rs35541113 [ dbSNP | Ensembl ].
VAR_051534
Natural varianti1309 – 13091R → C.
Corresponds to variant rs35254998 [ dbSNP | Ensembl ].
VAR_051535

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 697697Missing in isoform 2.
VSP_020459Add
BLAST
Alternative sequencei698 – 72528LGRDP…GGHYT → MSQRDGVCGSHEVAGAASPG ADGGLSLA in isoform 2.
VSP_020460Add
BLAST
Alternative sequencei1095 – 114046PKKES…PATRS → TQFPSGEPGPSRGGQGGREA RAELLHGQPALPQHKHQVWF EEGQQV in isoform 2.
VSP_020461Add
BLAST
Alternative sequencei1141 – 1352212Missing in isoform 2.
VSP_020462Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti568 – 5681L → P in CAE51935. 1 Publication
Sequence conflicti624 – 6241Q → H in AK126752. 1 Publication
Sequence conflicti1082 – 10821R → S in AK126752. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ586135 mRNA. Translation: CAE51935.2.
AK126447 mRNA. Translation: BAC86554.1.
AK126752 mRNA. No translation available.
AB033029 mRNA. Translation: BAA86517.1.
BX648357 mRNA. Translation: CAH10383.1.
CCDSiCCDS10607.1. [Q70CQ4-1]
RefSeqiNP_065769.3. NM_020718.3. [Q70CQ4-1]
UniGeneiHs.183817.

Genome annotation databases

EnsembliENST00000219689; ENSP00000219689; ENSG00000103404. [Q70CQ4-1]
GeneIDi57478.
KEGGihsa:57478.
UCSCiuc002dll.3. human. [Q70CQ4-1]

Polymorphism databases

DMDMi134047944.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ586135 mRNA. Translation: CAE51935.2 .
AK126447 mRNA. Translation: BAC86554.1 .
AK126752 mRNA. No translation available.
AB033029 mRNA. Translation: BAA86517.1 .
BX648357 mRNA. Translation: CAH10383.1 .
CCDSi CCDS10607.1. [Q70CQ4-1 ]
RefSeqi NP_065769.3. NM_020718.3. [Q70CQ4-1 ]
UniGenei Hs.183817.

3D structure databases

ProteinModelPortali Q70CQ4.
SMRi Q70CQ4. Positions 125-314, 593-765.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121548. 2 interactions.
STRINGi 9606.ENSP00000219689.

Protein family/group databases

MEROPSi C19.071.

PTM databases

PhosphoSitei Q70CQ4.

Polymorphism databases

DMDMi 134047944.

Proteomic databases

MaxQBi Q70CQ4.
PaxDbi Q70CQ4.
PRIDEi Q70CQ4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000219689 ; ENSP00000219689 ; ENSG00000103404 . [Q70CQ4-1 ]
GeneIDi 57478.
KEGGi hsa:57478.
UCSCi uc002dll.3. human. [Q70CQ4-1 ]

Organism-specific databases

CTDi 57478.
GeneCardsi GC16M022986.
H-InvDB HIX0012889.
HGNCi HGNC:20060. USP31.
HPAi HPA006937.
neXtProti NX_Q70CQ4.
PharmGKBi PA164742780.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5560.
HOGENOMi HOG000154758.
HOVERGENi HBG094125.
InParanoidi Q70CQ4.
KOi K11852.
OMAi CHPIVER.
OrthoDBi EOG7VMP4B.
PhylomeDBi Q70CQ4.
TreeFami TF106278.

Miscellaneous databases

ChiTaRSi USP31. human.
GenomeRNAii 57478.
NextBioi 63727.
PROi Q70CQ4.

Gene expression databases

ArrayExpressi Q70CQ4.
Bgeei Q70CQ4.
CleanExi HS_USP31.
Genevestigatori Q70CQ4.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases."
    Quesada V., Diaz-Perales A., Gutierrez-Fernandez A., Garabaya C., Cal S., Lopez-Otin C.
    Biochem. Biophys. Res. Commun. 314:54-62(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 110-1352 (ISOFORM 1), VARIANT THR-538.
    Tissue: Cerebellum and Uterus.
  3. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
    DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 626-1352 (ISOFORM 1).
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 539-709 (ISOFORM 1).
    Tissue: Uterine endothelium.

Entry informationi

Entry nameiUBP31_HUMAN
AccessioniPrimary (citable) accession number: Q70CQ4
Secondary accession number(s): Q6AW97
, Q6ZTC0, Q6ZTN2, Q9ULL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: March 20, 2007
Last modified: July 9, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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