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Q70CQ4

- UBP31_HUMAN

UniProt

Q70CQ4 - UBP31_HUMAN

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Protein

Ubiquitin carboxyl-terminal hydrolase 31

Gene

USP31

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei137 – 1371NucleophilePROSITE-ProRule annotation
Active sitei723 – 7231Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: FlyBase

GO - Biological processi

  1. protein deubiquitination Source: FlyBase
  2. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.071.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 31 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 31
Ubiquitin thioesterase 31
Ubiquitin-specific-processing protease 31
Gene namesi
Name:USP31
Synonyms:KIAA1203
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:20060. USP31.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: FlyBase
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164742780.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13521352Ubiquitin carboxyl-terminal hydrolase 31PRO_0000249518Add
BLAST

Proteomic databases

MaxQBiQ70CQ4.
PaxDbiQ70CQ4.
PRIDEiQ70CQ4.

PTM databases

PhosphoSiteiQ70CQ4.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiQ70CQ4.
CleanExiHS_USP31.
ExpressionAtlasiQ70CQ4. baseline and differential.
GenevestigatoriQ70CQ4.

Organism-specific databases

HPAiHPA006937.

Interactioni

Protein-protein interaction databases

BioGridi121548. 2 interactions.
STRINGi9606.ENSP00000219689.

Structurei

3D structure databases

ProteinModelPortaliQ70CQ4.
SMRiQ70CQ4. Positions 125-314, 593-765.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini128 – 765638USPAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi95 – 12531Pro-richAdd
BLAST
Compositional biasi770 – 1221452Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 USP domain.Curated

Phylogenomic databases

eggNOGiCOG5560.
GeneTreeiENSGT00670000097750.
HOGENOMiHOG000154758.
HOVERGENiHBG094125.
InParanoidiQ70CQ4.
KOiK11852.
OMAiCHPIVER.
OrthoDBiEOG7VMP4B.
PhylomeDBiQ70CQ4.
TreeFamiTF106278.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q70CQ4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKVTAPGSG PPAAASGKEK RSFSKRLFRS GRAGGGGAGG PGASGPAAPS
60 70 80 90 100
SPSSPSSARS VGSFMSRVLK TLSTLSHLSS EGAAPDRGGL RSCFPPGPAA
110 120 130 140 150
APTPPPCPPP PASPAPPACA AEPVPGVAGL RNHGNTCFMN ATLQCLSNTE
160 170 180 190 200
LFAEYLALGQ YRAGRPEPSP DPEQPAGRGA QGQGEVTEQL AHLVRALWTL
210 220 230 240 250
EYTPQHSRDF KTIVSKNALQ YRGNSQHDAQ EFLLWLLDRV HEDLNHSVKQ
260 270 280 290 300
SGQPPLKPPS ETDMMPEGPS FPVCSTFVQE LFQAQYRSSL TCPHCQKQSN
310 320 330 340 350
TFDPFLCISL PIPLPHTRPL YVTVVYQGKC SHCMRIGVAV PLSGTVARLR
360 370 380 390 400
EAVSMETKIP TDQIVLTEMY YDGFHRSFCD TDDLETVHES DCIFAFETPE
410 420 430 440 450
IFRPEGILSQ RGIHLNNNLN HLKFGLDYHR LSSPTQTAAK QGKMDSPTSR
460 470 480 490 500
AGSDKIVLLV CNRACTGQQG KRFGLPFVLH LEKTIAWDLL QKEILEKMKY
510 520 530 540 550
FLRPTVCIQV CPFSLRVVSV VGITYLLPQE EQPLCHPIVE RALKSCGPGG
560 570 580 590 600
TAHVKLVVEW DKETRDFLFV NTEDEYIPDA ESVRLQRERH HQPQTCTLSQ
610 620 630 640 650
CFQLYTKEER LAPDDAWRCP HCKQLQQGSI TLSLWTLPDV LIIHLKRFRQ
660 670 680 690 700
EGDRRMKLQN MVKFPLTGLD MTPHVVKRSQ SSWSLPSHWS PWRRPYGLGR
710 720 730 740 750
DPEDYIYDLY AVCNHHGTMQ GGHYTAYCKN SVDGLWYCFD DSDVQQLSED
760 770 780 790 800
EVCTQTAYIL FYQRRTAIPS WSANSSVAGS TSSSLCEHWV SRLPGSKPAS
810 820 830 840 850
VTSAASSRRT SLASLSESVE MTGERSEDDG GFSTRPFVRS VQRQSLSSRS
860 870 880 890 900
SVTSPLAVNE NCMRPSWSLS AKLQMRSNSP SRFSGDSPIH SSASTLEKIG
910 920 930 940 950
EAADDKVSIS CFGSLRNLSS SYQEPSDSHS RREHKAVGRA PLAVMEGVFK
960 970 980 990 1000
DESDTRRLNS SVVDTQSKHS AQGDRLPPLS GPFDNNNQIA YVDQSDSVDS
1010 1020 1030 1040 1050
SPVKEVKAPS HPGSLAKKPE STTKRSPSSK GTSEPEKSLR KGRPALASQE
1060 1070 1080 1090 1100
SSLSSTSPSS PLPVKVSLKP SRSRSKADSS SRGSGRHSSP APAQPKKESS
1110 1120 1130 1140 1150
PKSQDSVSSP SPQKQKSASA LTYTASSTSA KKASGPATRS PFPPGKSRTS
1160 1170 1180 1190 1200
DHSLSREGSR QSLGSDRASA TSTSKPNSPR VSQARAGEGR GAGKHVRSSS
1210 1220 1230 1240 1250
MASLRSPSTS IKSGLKRDSK SEDKGLSFFK SALRQKETRR STDLGKTALL
1260 1270 1280 1290 1300
SKKAGGSSVK SVCKNTGDDE AERGHQPPAS QQPNANTTGK EQLVTKDPAS
1310 1320 1330 1340 1350
AKHSLLSARK SKSSQLDSGV PSSPGGRQSA EKSSKKLSSS MQTSARPSQK

PQ
Length:1,352
Mass (Da):146,651
Last modified:March 20, 2007 - v2
Checksum:iF68A90EC45D23EDF
GO
Isoform 2 (identifier: Q70CQ4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-697: Missing.
     698-725: LGRDPEDYIYDLYAVCNHHGTMQGGHYT → MSQRDGVCGSHEVAGAASPGADGGLSLA
     1095-1140: PKKESSPKSQ...KKASGPATRS → TQFPSGEPGP...QVWFEEGQQV
     1141-1352: Missing.

Note: No experimental confirmation available.

Show »
Length:443
Mass (Da):47,129
Checksum:i00B4E309593EC2E9
GO

Sequence cautioni

The sequence AK126752 differs from that shown. Reason: Frameshift at position 941. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti568 – 5681L → P in CAE51935. (PubMed:14715245)Curated
Sequence conflicti624 – 6241Q → H in AK126752. (PubMed:14702039)Curated
Sequence conflicti1082 – 10821R → S in AK126752. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti445 – 4451D → Y.
Corresponds to variant rs1978066 [ dbSNP | Ensembl ].
VAR_027422
Natural varianti532 – 5321Q → H.
Corresponds to variant rs4597335 [ dbSNP | Ensembl ].
VAR_027423
Natural varianti538 – 5381I → T.1 Publication
Corresponds to variant rs13339649 [ dbSNP | Ensembl ].
VAR_027424
Natural varianti552 – 5521A → T.
Corresponds to variant rs9932912 [ dbSNP | Ensembl ].
VAR_027425
Natural varianti931 – 9311R → L.
Corresponds to variant rs10083789 [ dbSNP | Ensembl ].
VAR_027426
Natural varianti1269 – 12691D → N.
Corresponds to variant rs35541113 [ dbSNP | Ensembl ].
VAR_051534
Natural varianti1309 – 13091R → C.
Corresponds to variant rs35254998 [ dbSNP | Ensembl ].
VAR_051535

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 697697Missing in isoform 2. 1 PublicationVSP_020459Add
BLAST
Alternative sequencei698 – 72528LGRDP…GGHYT → MSQRDGVCGSHEVAGAASPG ADGGLSLA in isoform 2. 1 PublicationVSP_020460Add
BLAST
Alternative sequencei1095 – 114046PKKES…PATRS → TQFPSGEPGPSRGGQGGREA RAELLHGQPALPQHKHQVWF EEGQQV in isoform 2. 1 PublicationVSP_020461Add
BLAST
Alternative sequencei1141 – 1352212Missing in isoform 2. 1 PublicationVSP_020462Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ586135 mRNA. Translation: CAE51935.2.
AK126447 mRNA. Translation: BAC86554.1.
AK126752 mRNA. No translation available.
AB033029 mRNA. Translation: BAA86517.1.
BX648357 mRNA. Translation: CAH10383.1.
CCDSiCCDS10607.1. [Q70CQ4-1]
RefSeqiNP_065769.3. NM_020718.3. [Q70CQ4-1]
UniGeneiHs.183817.

Genome annotation databases

EnsembliENST00000219689; ENSP00000219689; ENSG00000103404. [Q70CQ4-1]
GeneIDi57478.
KEGGihsa:57478.
UCSCiuc002dll.3. human. [Q70CQ4-1]

Polymorphism databases

DMDMi134047944.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ586135 mRNA. Translation: CAE51935.2 .
AK126447 mRNA. Translation: BAC86554.1 .
AK126752 mRNA. No translation available.
AB033029 mRNA. Translation: BAA86517.1 .
BX648357 mRNA. Translation: CAH10383.1 .
CCDSi CCDS10607.1. [Q70CQ4-1 ]
RefSeqi NP_065769.3. NM_020718.3. [Q70CQ4-1 ]
UniGenei Hs.183817.

3D structure databases

ProteinModelPortali Q70CQ4.
SMRi Q70CQ4. Positions 125-314, 593-765.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121548. 2 interactions.
STRINGi 9606.ENSP00000219689.

Protein family/group databases

MEROPSi C19.071.

PTM databases

PhosphoSitei Q70CQ4.

Polymorphism databases

DMDMi 134047944.

Proteomic databases

MaxQBi Q70CQ4.
PaxDbi Q70CQ4.
PRIDEi Q70CQ4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000219689 ; ENSP00000219689 ; ENSG00000103404 . [Q70CQ4-1 ]
GeneIDi 57478.
KEGGi hsa:57478.
UCSCi uc002dll.3. human. [Q70CQ4-1 ]

Organism-specific databases

CTDi 57478.
GeneCardsi GC16M022986.
H-InvDB HIX0012889.
HGNCi HGNC:20060. USP31.
HPAi HPA006937.
neXtProti NX_Q70CQ4.
PharmGKBi PA164742780.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5560.
GeneTreei ENSGT00670000097750.
HOGENOMi HOG000154758.
HOVERGENi HBG094125.
InParanoidi Q70CQ4.
KOi K11852.
OMAi CHPIVER.
OrthoDBi EOG7VMP4B.
PhylomeDBi Q70CQ4.
TreeFami TF106278.

Miscellaneous databases

ChiTaRSi USP31. human.
GenomeRNAii 57478.
NextBioi 63727.
PROi Q70CQ4.

Gene expression databases

Bgeei Q70CQ4.
CleanExi HS_USP31.
ExpressionAtlasi Q70CQ4. baseline and differential.
Genevestigatori Q70CQ4.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases."
    Quesada V., Diaz-Perales A., Gutierrez-Fernandez A., Garabaya C., Cal S., Lopez-Otin C.
    Biochem. Biophys. Res. Commun. 314:54-62(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 110-1352 (ISOFORM 1), VARIANT THR-538.
    Tissue: Cerebellum and Uterus.
  3. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
    DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 626-1352 (ISOFORM 1).
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 539-709 (ISOFORM 1).
    Tissue: Uterine endothelium.

Entry informationi

Entry nameiUBP31_HUMAN
AccessioniPrimary (citable) accession number: Q70CQ4
Secondary accession number(s): Q6AW97
, Q6ZTC0, Q6ZTN2, Q9ULL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: March 20, 2007
Last modified: October 29, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3