Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q70CQ4

- UBP31_HUMAN

UniProt

Q70CQ4 - UBP31_HUMAN

Protein

Ubiquitin carboxyl-terminal hydrolase 31

Gene

USP31

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 2 (20 Mar 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei137 – 1371NucleophilePROSITE-ProRule annotation
    Active sitei723 – 7231Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ubiquitin-specific protease activity Source: FlyBase

    GO - Biological processi

    1. protein deubiquitination Source: FlyBase
    2. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC19.071.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 31 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 31
    Ubiquitin thioesterase 31
    Ubiquitin-specific-processing protease 31
    Gene namesi
    Name:USP31
    Synonyms:KIAA1203
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:20060. USP31.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: FlyBase

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164742780.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13521352Ubiquitin carboxyl-terminal hydrolase 31PRO_0000249518Add
    BLAST

    Proteomic databases

    MaxQBiQ70CQ4.
    PaxDbiQ70CQ4.
    PRIDEiQ70CQ4.

    PTM databases

    PhosphoSiteiQ70CQ4.

    Expressioni

    Tissue specificityi

    Widely expressed.1 Publication

    Gene expression databases

    ArrayExpressiQ70CQ4.
    BgeeiQ70CQ4.
    CleanExiHS_USP31.
    GenevestigatoriQ70CQ4.

    Organism-specific databases

    HPAiHPA006937.

    Interactioni

    Protein-protein interaction databases

    BioGridi121548. 2 interactions.
    STRINGi9606.ENSP00000219689.

    Structurei

    3D structure databases

    ProteinModelPortaliQ70CQ4.
    SMRiQ70CQ4. Positions 125-314, 593-765.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini128 – 765638USPAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi95 – 12531Pro-richAdd
    BLAST
    Compositional biasi770 – 1221452Ser-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiCOG5560.
    HOGENOMiHOG000154758.
    HOVERGENiHBG094125.
    InParanoidiQ70CQ4.
    KOiK11852.
    OMAiCHPIVER.
    OrthoDBiEOG7VMP4B.
    PhylomeDBiQ70CQ4.
    TreeFamiTF106278.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q70CQ4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSKVTAPGSG PPAAASGKEK RSFSKRLFRS GRAGGGGAGG PGASGPAAPS     50
    SPSSPSSARS VGSFMSRVLK TLSTLSHLSS EGAAPDRGGL RSCFPPGPAA 100
    APTPPPCPPP PASPAPPACA AEPVPGVAGL RNHGNTCFMN ATLQCLSNTE 150
    LFAEYLALGQ YRAGRPEPSP DPEQPAGRGA QGQGEVTEQL AHLVRALWTL 200
    EYTPQHSRDF KTIVSKNALQ YRGNSQHDAQ EFLLWLLDRV HEDLNHSVKQ 250
    SGQPPLKPPS ETDMMPEGPS FPVCSTFVQE LFQAQYRSSL TCPHCQKQSN 300
    TFDPFLCISL PIPLPHTRPL YVTVVYQGKC SHCMRIGVAV PLSGTVARLR 350
    EAVSMETKIP TDQIVLTEMY YDGFHRSFCD TDDLETVHES DCIFAFETPE 400
    IFRPEGILSQ RGIHLNNNLN HLKFGLDYHR LSSPTQTAAK QGKMDSPTSR 450
    AGSDKIVLLV CNRACTGQQG KRFGLPFVLH LEKTIAWDLL QKEILEKMKY 500
    FLRPTVCIQV CPFSLRVVSV VGITYLLPQE EQPLCHPIVE RALKSCGPGG 550
    TAHVKLVVEW DKETRDFLFV NTEDEYIPDA ESVRLQRERH HQPQTCTLSQ 600
    CFQLYTKEER LAPDDAWRCP HCKQLQQGSI TLSLWTLPDV LIIHLKRFRQ 650
    EGDRRMKLQN MVKFPLTGLD MTPHVVKRSQ SSWSLPSHWS PWRRPYGLGR 700
    DPEDYIYDLY AVCNHHGTMQ GGHYTAYCKN SVDGLWYCFD DSDVQQLSED 750
    EVCTQTAYIL FYQRRTAIPS WSANSSVAGS TSSSLCEHWV SRLPGSKPAS 800
    VTSAASSRRT SLASLSESVE MTGERSEDDG GFSTRPFVRS VQRQSLSSRS 850
    SVTSPLAVNE NCMRPSWSLS AKLQMRSNSP SRFSGDSPIH SSASTLEKIG 900
    EAADDKVSIS CFGSLRNLSS SYQEPSDSHS RREHKAVGRA PLAVMEGVFK 950
    DESDTRRLNS SVVDTQSKHS AQGDRLPPLS GPFDNNNQIA YVDQSDSVDS 1000
    SPVKEVKAPS HPGSLAKKPE STTKRSPSSK GTSEPEKSLR KGRPALASQE 1050
    SSLSSTSPSS PLPVKVSLKP SRSRSKADSS SRGSGRHSSP APAQPKKESS 1100
    PKSQDSVSSP SPQKQKSASA LTYTASSTSA KKASGPATRS PFPPGKSRTS 1150
    DHSLSREGSR QSLGSDRASA TSTSKPNSPR VSQARAGEGR GAGKHVRSSS 1200
    MASLRSPSTS IKSGLKRDSK SEDKGLSFFK SALRQKETRR STDLGKTALL 1250
    SKKAGGSSVK SVCKNTGDDE AERGHQPPAS QQPNANTTGK EQLVTKDPAS 1300
    AKHSLLSARK SKSSQLDSGV PSSPGGRQSA EKSSKKLSSS MQTSARPSQK 1350
    PQ 1352
    Length:1,352
    Mass (Da):146,651
    Last modified:March 20, 2007 - v2
    Checksum:iF68A90EC45D23EDF
    GO
    Isoform 2 (identifier: Q70CQ4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-697: Missing.
         698-725: LGRDPEDYIYDLYAVCNHHGTMQGGHYT → MSQRDGVCGSHEVAGAASPGADGGLSLA
         1095-1140: PKKESSPKSQ...KKASGPATRS → TQFPSGEPGP...QVWFEEGQQV
         1141-1352: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:443
    Mass (Da):47,129
    Checksum:i00B4E309593EC2E9
    GO

    Sequence cautioni

    The sequence AK126752 differs from that shown. Reason: Frameshift at position 941.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti568 – 5681L → P in CAE51935. (PubMed:14715245)Curated
    Sequence conflicti624 – 6241Q → H in AK126752. (PubMed:14702039)Curated
    Sequence conflicti1082 – 10821R → S in AK126752. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti445 – 4451D → Y.
    Corresponds to variant rs1978066 [ dbSNP | Ensembl ].
    VAR_027422
    Natural varianti532 – 5321Q → H.
    Corresponds to variant rs4597335 [ dbSNP | Ensembl ].
    VAR_027423
    Natural varianti538 – 5381I → T.1 Publication
    Corresponds to variant rs13339649 [ dbSNP | Ensembl ].
    VAR_027424
    Natural varianti552 – 5521A → T.
    Corresponds to variant rs9932912 [ dbSNP | Ensembl ].
    VAR_027425
    Natural varianti931 – 9311R → L.
    Corresponds to variant rs10083789 [ dbSNP | Ensembl ].
    VAR_027426
    Natural varianti1269 – 12691D → N.
    Corresponds to variant rs35541113 [ dbSNP | Ensembl ].
    VAR_051534
    Natural varianti1309 – 13091R → C.
    Corresponds to variant rs35254998 [ dbSNP | Ensembl ].
    VAR_051535

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 697697Missing in isoform 2. 1 PublicationVSP_020459Add
    BLAST
    Alternative sequencei698 – 72528LGRDP…GGHYT → MSQRDGVCGSHEVAGAASPG ADGGLSLA in isoform 2. 1 PublicationVSP_020460Add
    BLAST
    Alternative sequencei1095 – 114046PKKES…PATRS → TQFPSGEPGPSRGGQGGREA RAELLHGQPALPQHKHQVWF EEGQQV in isoform 2. 1 PublicationVSP_020461Add
    BLAST
    Alternative sequencei1141 – 1352212Missing in isoform 2. 1 PublicationVSP_020462Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ586135 mRNA. Translation: CAE51935.2.
    AK126447 mRNA. Translation: BAC86554.1.
    AK126752 mRNA. No translation available.
    AB033029 mRNA. Translation: BAA86517.1.
    BX648357 mRNA. Translation: CAH10383.1.
    CCDSiCCDS10607.1. [Q70CQ4-1]
    RefSeqiNP_065769.3. NM_020718.3. [Q70CQ4-1]
    UniGeneiHs.183817.

    Genome annotation databases

    EnsembliENST00000219689; ENSP00000219689; ENSG00000103404. [Q70CQ4-1]
    GeneIDi57478.
    KEGGihsa:57478.
    UCSCiuc002dll.3. human. [Q70CQ4-1]

    Polymorphism databases

    DMDMi134047944.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ586135 mRNA. Translation: CAE51935.2 .
    AK126447 mRNA. Translation: BAC86554.1 .
    AK126752 mRNA. No translation available.
    AB033029 mRNA. Translation: BAA86517.1 .
    BX648357 mRNA. Translation: CAH10383.1 .
    CCDSi CCDS10607.1. [Q70CQ4-1 ]
    RefSeqi NP_065769.3. NM_020718.3. [Q70CQ4-1 ]
    UniGenei Hs.183817.

    3D structure databases

    ProteinModelPortali Q70CQ4.
    SMRi Q70CQ4. Positions 125-314, 593-765.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121548. 2 interactions.
    STRINGi 9606.ENSP00000219689.

    Protein family/group databases

    MEROPSi C19.071.

    PTM databases

    PhosphoSitei Q70CQ4.

    Polymorphism databases

    DMDMi 134047944.

    Proteomic databases

    MaxQBi Q70CQ4.
    PaxDbi Q70CQ4.
    PRIDEi Q70CQ4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000219689 ; ENSP00000219689 ; ENSG00000103404 . [Q70CQ4-1 ]
    GeneIDi 57478.
    KEGGi hsa:57478.
    UCSCi uc002dll.3. human. [Q70CQ4-1 ]

    Organism-specific databases

    CTDi 57478.
    GeneCardsi GC16M022986.
    H-InvDB HIX0012889.
    HGNCi HGNC:20060. USP31.
    HPAi HPA006937.
    neXtProti NX_Q70CQ4.
    PharmGKBi PA164742780.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5560.
    HOGENOMi HOG000154758.
    HOVERGENi HBG094125.
    InParanoidi Q70CQ4.
    KOi K11852.
    OMAi CHPIVER.
    OrthoDBi EOG7VMP4B.
    PhylomeDBi Q70CQ4.
    TreeFami TF106278.

    Miscellaneous databases

    ChiTaRSi USP31. human.
    GenomeRNAii 57478.
    NextBioi 63727.
    PROi Q70CQ4.

    Gene expression databases

    ArrayExpressi Q70CQ4.
    Bgeei Q70CQ4.
    CleanExi HS_USP31.
    Genevestigatori Q70CQ4.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases."
      Quesada V., Diaz-Perales A., Gutierrez-Fernandez A., Garabaya C., Cal S., Lopez-Otin C.
      Biochem. Biophys. Res. Commun. 314:54-62(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 110-1352 (ISOFORM 1), VARIANT THR-538.
      Tissue: Cerebellum and Uterus.
    3. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
      DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 626-1352 (ISOFORM 1).
      Tissue: Brain.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 539-709 (ISOFORM 1).
      Tissue: Uterine endothelium.

    Entry informationi

    Entry nameiUBP31_HUMAN
    AccessioniPrimary (citable) accession number: Q70CQ4
    Secondary accession number(s): Q6AW97
    , Q6ZTC0, Q6ZTN2, Q9ULL7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2006
    Last sequence update: March 20, 2007
    Last modified: October 1, 2014
    This is version 92 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. Peptidase families
      Classification of peptidase families and list of entries
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3