Q70CQ2 (UBP34_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ubiquitin carboxyl-terminal hydrolase 34
EC=3.4.19.12

Alternative name(s):
Deubiquitinating enzyme 34
Ubiquitin thioesterase 34
Ubiquitin-specific-processing protease 34

Gene names

Name:	USP34
Synonyms:	KIAA0570, KIAA0729

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	3546 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Ref.13
Catalytic activity	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). Ref.1 Ref.13
Subunit structure	Interacts with AXIN1 and AXIN2. Ref.13
Tissue specificity	Expressed in brain at low level. Ref.1
Sequence similarities	Belongs to the peptidase C19 family.
Sequence caution	The sequence AAI07762.1 differs from that shown. Reason: Frameshift at position 3200. The sequence BAA25496.2 differs from that shown. Reason: Erroneous initiation. The sequence BAG54261.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Ubl conjugation pathway Wnt signaling pathway
Coding sequence diversity	Alternative splicing Polymorphism
Molecular function	Hydrolase Protease Thiol protease
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Wnt receptor signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of canonical Wnt receptor signaling pathway Inferred from direct assay Ref.13. Source: UniProtKB protein K48-linked deubiquitination Inferred from direct assay Ref.13. Source: UniProtKB ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	cysteine-type endopeptidase activity Inferred from mutant phenotype Ref.13. Source: UniProtKB ubiquitin thiolesterase activity Inferred from direct assay Ref.13. Source: UniProtKB ubiquitin-specific protease activity Inferred from direct assay Ref.13. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q70CQ2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q70CQ2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-139: Missing.
     140-162: SKSSDPFSLWSTDEKEKLLLCVA → MRRKNSYYVWQ

Isoform 3 (identifier: Q70CQ2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-139: Missing.
     140-162: SKSSDPFSLWSTDEKEKLLLCVA → MRRKNSYYVWQ
     2936-3018: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 3546	3546	Ubiquitin carboxyl-terminal hydrolase 34		PRO_0000249519
Sites
	Active site	1903	1	Nucleophile Probable
	Active site	2164	1	Proton acceptor By similarity
Amino acid modifications
	Modified residue	352	1	Phosphoserine Ref.10
	Modified residue	649	1	Phosphoserine Ref.9
	Modified residue	2488	1	Phosphoserine Ref.11
	Modified residue	2545	1	Phosphothreonine By similarity
	Modified residue	3358	1	Phosphoserine Ref.10
	Modified residue	3359	1	Phosphoserine Ref.10
	Modified residue	3406	1	Phosphoserine Ref.10
Natural variations
	Alternative sequence	1 – 139	139	Missing in isoform 2 and isoform 3.		VSP_035639
	Alternative sequence	140 – 162	23	SKSSD…LLCVA → MRRKNSYYVWQ in isoform 2 and isoform 3.		VSP_035640
	Alternative sequence	2936 – 3018	83	Missing in isoform 3.		VSP_020463
	Natural variant	661	1	M → T. Ref.1 Ref.2 Ref.9 Corresponds to variant rs6722430 [ dbSNP | Ensembl ].		VAR_047106
	Natural variant	1663	1	L → R. Corresponds to variant rs6723818 [ dbSNP | Ensembl ].		VAR_047107
	Natural variant	2348	1	D → N. Corresponds to variant rs4386306 [ dbSNP | Ensembl ].		VAR_047108
Experimental info
	Mutagenesis	1903	1	C → S: Loss of function. Ref.13

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 4, 2008. Version 2. Checksum: A31851911D990044	FASTA	3,546	404,233
	10 20 30 40 50 60 MCENCADLVE VLNEISDVEG GDGLQLRKEH TLKIFTYINS WTQRQCLCCF KEYKHLEIFN 70 80 90 100 110 120 QVVCALINLV IAQVQVLRDQ LCKHCTTINI DSTWQDESNQ AEEPLNIDRE CNEGSTERQK 130 140 150 160 170 180 SIEKKSNSTR ICNLTEEESS KSSDPFSLWS TDEKEKLLLC VAKIFQIQFP LYTAYKHNTH 190 200 210 220 230 240 PTIEDISTQE SNILGAFCDM NDVEVPLHLL RYVCLFCGKN GLSLMKDCFE YGTPETLPFL 250 260 270 280 290 300 IAHAFITVVS NIRIWLHIPA VMQHIIPFRT YVIRYLCKLS DQELRQSAAR NMADLMWSTV 310 320 330 340 350 360 KEPLDTTLCF DKESLDLAFK YFMSPTLTMR LAGLSQITNQ LHTFNDVCNN ESLVSDTETS 370 380 390 400 410 420 IAKELADWLI SNNVVEHIFG PNLHIEIIKQ CQVILNFLAA EGRLSTQHID CIWAAAQLKH 430 440 450 460 470 480 CSRYIHDLFP SLIKNLDPVP LRHLLNLVSA LEPSVHTEQT LYLASMLIKA LWNNALAAKA 490 500 510 520 530 540 QLSKQSSFAS LLNTNIPIGN KKEEEELRRT APSPWSPAAS PQSSDNSDTH QSGGSDIEMD 550 560 570 580 590 600 EQLINRTKHV QQRLSDTEES MQGSSDETAN SGEDGSSGPG SSSGHSDGSS NEVNSSHASQ 610 620 630 640 650 660 SAGSPGSEVQ SEDIADIEAL KEEDEDDDHG HNPPKSSCGT DLRNRKLESQ AGICLGDSQG 670 680 690 700 710 720 MSERNGTSSG TGKDLVFNTE SLPSVDNRMR MLDACSHSED PEHDISGEMN ATHIAQGSQE 730 740 750 760 770 780 SCITRTGDFL GETIGNELFN CRQFIGPQHH HHHHHHHHHH DGHMVDDMLS ADDVSCSSSQ 790 800 810 820 830 840 VSAKSEKNMA DFDGEESGCE EELVQINSHA ELTSHLQQHL PNLASIYHEH LSQGPVVHKH 850 860 870 880 890 900 QFNSNAVTDI NLDNVCKKGN TLLWDIVQDE DAVNLSEGLI NEAEKLLCSL VCWFTDRQIR 910 920 930 940 950 960 MRFIEGCLEN LGNNRSVVIS LRLLPKLFGT FQQFGSSYDT HWITMWAEKE LNMMKLFFDN 970 980 990 1000 1010 1020 LVYYIQTVRE GRQKHALYSH SAEVQVRLQF LTCVFSTLGS PDHFRLSLEQ VDILWHCLVE 1030 1040 1050 1060 1070 1080 DSECYDDALH WFLNQVRSKD QHAMGMETYK HLFLEKMPQL KPETISMTGL NLFQHLCNLA 1090 1100 1110 1120 1130 1140 RLATSAYDGC SNSELCGMDQ FWGIALRAQS GDVSRAAIQY INSYYINGKT GLEKEQEFIS 1150 1160 1170 1180 1190 1200 KCMESLMIAS SSLEQESHSS LMVIERGLLM LKTHLEAFRR RFAYHLRQWQ IEGTGISSHL 1210 1220 1230 1240 1250 1260 KALSDKQSLP LRVVCQPAGL PDKMTIEMYP SDQVADLRAE VTHWYENLQK EQINQQAQLQ 1270 1280 1290 1300 1310 1320 EFGQSNRKGE FPGGLMGPVR MISSGHELTT DYDEKALHEL GFKDMQMVFV SLGAPRRERK 1330 1340 1350 1360 1370 1380 GEGVQLPASC LPPPQKDNIP MLLLLQEPHL TTLFDLLEML ASFKPPSGKV AVDDSESLRC 1390 1400 1410 1420 1430 1440 EELHLHAENL SRRVWELLML LPTCPNMLMA FQNISDEQSN DGFNWKELLK IKSAHKLLYA 1450 1460 1470 1480 1490 1500 LEIIEALGKP NRRIRRESTG SYSDLYPDSD DSSEDQVENS KNSWSCKFVA AGGLQQLLEI 1510 1520 1530 1540 1550 1560 FNSGILEPKE QESWTVWQLD CLACLLKLIC QFAVDPSDLD LAYHDVFAWS GIAESHRKRT 1570 1580 1590 1600 1610 1620 WPGKSRKAAG DHAKGLHIPR LTEVFLVLVQ GTSLIQRLMS VAYTYDNLAP RVLKAQSDHR 1630 1640 1650 1660 1670 1680 SRHEVSHYSM WLLVSWAHCC SLVKSSLADS DHLQDWLKKL TLLIPETAVR HESCSGLYKL 1690 1700 1710 1720 1730 1740 SLSGLDGGDS INRSFLLLAA STLLKFLPDA QALKPIRIDD YEEEPILKPG CKEYFWLLCK 1750 1760 1770 1780 1790 1800 LVDNIHIKDA SQTTLLDLDA LARHLADCIR SREILDHQDG NVEDDGLTGL LRLATSVVKH 1810 1820 1830 1840 1850 1860 KPPFKFSREG QEFLRDIFNL LFLLPSLKDR QQPKCKSHSS RAAAYDLLVE MVKGSVENYR 1870 1880 1890 1900 1910 1920 LIHNWVMAQH MQSHAPYKWD YWPHEDVRAE CRFVGLTNLG ATCYLASTIQ QLYMIPEARQ 1930 1940 1950 1960 1970 1980 AVFTAKYSED MKHKTTLLEL QKMFTYLMES ECKAYNPRPF CKTYTMDKQP LNTGEQKDMT 1990 2000 2010 2020 2030 2040 EFFTDLITKI EEMSPELKNT VKSLFGGVIT NNVVSLDCEH VSQTAEEFYT VRCQVADMKN 2050 2060 2070 2080 2090 2100 IYESLDEVTI KDTLEGDNMY TCSHCGKKVR AEKRACFKKL PRILSFNTMR YTFNMVTMMK 2110 2120 2130 2140 2150 2160 EKVNTHFSFP LRLDMTPYTE DFLMGKSERK EGFKEVSDHS KDSESYEYDL IGVTVHTGTA 2170 2180 2190 2200 2210 2220 DGGHYYSFIR DIVNPHAYKN NKWYLFNDAE VKPFDSAQLA SECFGGEMTT KTYDSVTDKF 2230 2240 2250 2260 2270 2280 MDFSFEKTHS AYMLFYKRME PEEENGREYK FDVSSELLEW IWHDNMQFLQ DKNIFEHTYF 2290 2300 2310 2320 2330 2340 GFMWQLCSCI PSTLPDPKAV SLMTAKLSTS FVLETFIHSK EKPTMLQWIE LLTKQFNNSQ 2350 2360 2370 2380 2390 2400 AACEWFLDRM ADDDWWPMQI LIKCPNQIVR QMFQRLCIHV IQRLRPVHAH LYLQPGMEDG 2410 2420 2430 2440 2450 2460 SDDMDTSVED IGGRSCVTRF VRTLLLIMEH GVKPHSKHLT EYFAFLYEFA KMGEEESQFL 2470 2480 2490 2500 2510 2520 LSLQAISTMV HFYMGTKGPE NPQVEVLSEE EGEEEEEEED ILSLAEEKYR PAALEKMIAL 2530 2540 2550 2560 2570 2580 VALLVEQSRS ERHLTLSQTD MAALTGGKGF PFLFQHIRDG INIRQTCNLI FSLCRYNNRL 2590 2600 2610 2620 2630 2640 AEHIVSMLFT SIAKLTPEAA NPFFKLLTML MEFAGGPPGM PPFASYILQR IWEVIEYNPS 2650 2660 2670 2680 2690 2700 QCLDWLAVQT PRNKLAHSWV LQNMENWVER FLLAHNYPRV RTSAAYLLVS LIPSNSFRQM 2710 2720 2730 2740 2750 2760 FRSTRSLHIP TRDLPLSPDT TVVLHQVYNV LLGLLSRAKL YVDAAVHGTT KLVPYFSFMT 2770 2780 2790 2800 2810 2820 YCLISKTEKL MFSTYFMDLW NLFQPKLSEP AIATNHNKQA LLSFWYNVCA DCPENIRLIV 2830 2840 2850 2860 2870 2880 QNPVVTKNIA FNYILADHDD QDVVLFNRGM LPAYYGILRL CCEQSPAFTR QLASHQNIQW 2890 2900 2910 2920 2930 2940 AFKNLTPHAS QYPGAVEELF NLMQLFIAQR PDMREEELED IKQFKKTTIS CYLRCLDGRS 2950 2960 2970 2980 2990 3000 CWTTLISAFR ILLESDEDRL LVVFNRGLIL MTESFNTLHM MYHEATACHV TGDLVELLSI 3010 3020 3030 3040 3050 3060 FLSVLKSTRP YLQRKDVKQA LIQWQERIEF AHKLLTLLNS YSPPELRNAC IDVLKELVLL 3070 3080 3090 3100 3110 3120 SPHDFLHTLV PFLQHNHCTY HHSNIPMSLG PYFPCRENIK LIGGKSNIRP PRPELNMCLL 3130 3140 3150 3160 3170 3180 PTMVETSKGK DDVYDRMLLD YFFSYHQFIH LLCRVAINCE KFTETLVKLS VLVAYEGLPL 3190 3200 3210 3220 3230 3240 HLALFPKLWT ELCQTQSAMS KNCIKLLCED PVFAEYIKCI LMDERTFLNN NIVYTFMTHF 3250 3260 3270 3280 3290 3300 LLKVQSQVFS EANCANLIST LITNLISQYQ NLQSDFSNRV EISKASASLN GDLRALALLL 3310 3320 3330 3340 3350 3360 SVHTPKQLNP ALIPTLQELL SKCRTCLQQR NSLQEQEAKE RKTKDDEGAT PIKRRRVSSD 3370 3380 3390 3400 3410 3420 EEHTVDSCIS DMKTETREVL TPTSTSDNET RDSSIIDPGT EQDLPSPENS SVKEYRMEVP 3430 3440 3450 3460 3470 3480 SSFSEDMSNI RSQHAEEQSN NGRYDDCKEF KDLHCSKDST LAEEESEFPS TSISAVLSDL 3490 3500 3510 3520 3530 3540 ADLRSCDGQA LPSQDPEVAL SLSCGHSRGL FSHMQQHDIL DTLCRTIEST IHVVTRISGK GNQAAS
	Isoform 2 [UniParc]. Checksum: 6171809F72C5EE8E	FASTA	3,395	387,154
	10 20 30 40 50 60 MRRKNSYYVW QKIFQIQFPL YTAYKHNTHP TIEDISTQES NILGAFCDMN DVEVPLHLLR 70 80 90 100 110 120 YVCLFCGKNG LSLMKDCFEY GTPETLPFLI AHAFITVVSN IRIWLHIPAV MQHIIPFRTY 130 140 150 160 170 180 VIRYLCKLSD QELRQSAARN MADLMWSTVK EPLDTTLCFD KESLDLAFKY FMSPTLTMRL 190 200 210 220 230 240 AGLSQITNQL HTFNDVCNNE SLVSDTETSI AKELADWLIS NNVVEHIFGP NLHIEIIKQC 250 260 270 280 290 300 QVILNFLAAE GRLSTQHIDC IWAAAQLKHC SRYIHDLFPS LIKNLDPVPL RHLLNLVSAL 310 320 330 340 350 360 EPSVHTEQTL YLASMLIKAL WNNALAAKAQ LSKQSSFASL LNTNIPIGNK KEEEELRRTA 370 380 390 400 410 420 PSPWSPAASP QSSDNSDTHQ SGGSDIEMDE QLINRTKHVQ QRLSDTEESM QGSSDETANS 430 440 450 460 470 480 GEDGSSGPGS SSGHSDGSSN EVNSSHASQS AGSPGSEVQS EDIADIEALK EEDEDDDHGH 490 500 510 520 530 540 NPPKSSCGTD LRNRKLESQA GICLGDSQGM SERNGTSSGT GKDLVFNTES LPSVDNRMRM 550 560 570 580 590 600 LDACSHSEDP EHDISGEMNA THIAQGSQES CITRTGDFLG ETIGNELFNC RQFIGPQHHH 610 620 630 640 650 660 HHHHHHHHHD GHMVDDMLSA DDVSCSSSQV SAKSEKNMAD FDGEESGCEE ELVQINSHAE 670 680 690 700 710 720 LTSHLQQHLP NLASIYHEHL SQGPVVHKHQ FNSNAVTDIN LDNVCKKGNT LLWDIVQDED 730 740 750 760 770 780 AVNLSEGLIN EAEKLLCSLV CWFTDRQIRM RFIEGCLENL GNNRSVVISL RLLPKLFGTF 790 800 810 820 830 840 QQFGSSYDTH WITMWAEKEL NMMKLFFDNL VYYIQTVREG RQKHALYSHS AEVQVRLQFL 850 860 870 880 890 900 TCVFSTLGSP DHFRLSLEQV DILWHCLVED SECYDDALHW FLNQVRSKDQ HAMGMETYKH 910 920 930 940 950 960 LFLEKMPQLK PETISMTGLN LFQHLCNLAR LATSAYDGCS NSELCGMDQF WGIALRAQSG 970 980 990 1000 1010 1020 DVSRAAIQYI NSYYINGKTG LEKEQEFISK CMESLMIASS SLEQESHSSL MVIERGLLML 1030 1040 1050 1060 1070 1080 KTHLEAFRRR FAYHLRQWQI EGTGISSHLK ALSDKQSLPL RVVCQPAGLP DKMTIEMYPS 1090 1100 1110 1120 1130 1140 DQVADLRAEV THWYENLQKE QINQQAQLQE FGQSNRKGEF PGGLMGPVRM ISSGHELTTD 1150 1160 1170 1180 1190 1200 YDEKALHELG FKDMQMVFVS LGAPRRERKG EGVQLPASCL PPPQKDNIPM LLLLQEPHLT 1210 1220 1230 1240 1250 1260 TLFDLLEMLA SFKPPSGKVA VDDSESLRCE ELHLHAENLS RRVWELLMLL PTCPNMLMAF 1270 1280 1290 1300 1310 1320 QNISDEQSND GFNWKELLKI KSAHKLLYAL EIIEALGKPN RRIRRESTGS YSDLYPDSDD 1330 1340 1350 1360 1370 1380 SSEDQVENSK NSWSCKFVAA GGLQQLLEIF NSGILEPKEQ ESWTVWQLDC LACLLKLICQ 1390 1400 1410 1420 1430 1440 FAVDPSDLDL AYHDVFAWSG IAESHRKRTW PGKSRKAAGD HAKGLHIPRL TEVFLVLVQG 1450 1460 1470 1480 1490 1500 TSLIQRLMSV AYTYDNLAPR VLKAQSDHRS RHEVSHYSMW LLVSWAHCCS LVKSSLADSD 1510 1520 1530 1540 1550 1560 HLQDWLKKLT LLIPETAVRH ESCSGLYKLS LSGLDGGDSI NRSFLLLAAS TLLKFLPDAQ 1570 1580 1590 1600 1610 1620 ALKPIRIDDY EEEPILKPGC KEYFWLLCKL VDNIHIKDAS QTTLLDLDAL ARHLADCIRS 1630 1640 1650 1660 1670 1680 REILDHQDGN VEDDGLTGLL RLATSVVKHK PPFKFSREGQ EFLRDIFNLL FLLPSLKDRQ 1690 1700 1710 1720 1730 1740 QPKCKSHSSR AAAYDLLVEM VKGSVENYRL IHNWVMAQHM QSHAPYKWDY WPHEDVRAEC 1750 1760 1770 1780 1790 1800 RFVGLTNLGA TCYLASTIQQ LYMIPEARQA VFTAKYSEDM KHKTTLLELQ KMFTYLMESE 1810 1820 1830 1840 1850 1860 CKAYNPRPFC KTYTMDKQPL NTGEQKDMTE FFTDLITKIE EMSPELKNTV KSLFGGVITN 1870 1880 1890 1900 1910 1920 NVVSLDCEHV SQTAEEFYTV RCQVADMKNI YESLDEVTIK DTLEGDNMYT CSHCGKKVRA 1930 1940 1950 1960 1970 1980 EKRACFKKLP RILSFNTMRY TFNMVTMMKE KVNTHFSFPL RLDMTPYTED FLMGKSERKE 1990 2000 2010 2020 2030 2040 GFKEVSDHSK DSESYEYDLI GVTVHTGTAD GGHYYSFIRD IVNPHAYKNN KWYLFNDAEV 2050 2060 2070 2080 2090 2100 KPFDSAQLAS ECFGGEMTTK TYDSVTDKFM DFSFEKTHSA YMLFYKRMEP EEENGREYKF 2110 2120 2130 2140 2150 2160 DVSSELLEWI WHDNMQFLQD KNIFEHTYFG FMWQLCSCIP STLPDPKAVS LMTAKLSTSF 2170 2180 2190 2200 2210 2220 VLETFIHSKE KPTMLQWIEL LTKQFNNSQA ACEWFLDRMA DDDWWPMQIL IKCPNQIVRQ 2230 2240 2250 2260 2270 2280 MFQRLCIHVI QRLRPVHAHL YLQPGMEDGS DDMDTSVEDI GGRSCVTRFV RTLLLIMEHG 2290 2300 2310 2320 2330 2340 VKPHSKHLTE YFAFLYEFAK MGEEESQFLL SLQAISTMVH FYMGTKGPEN PQVEVLSEEE 2350 2360 2370 2380 2390 2400 GEEEEEEEDI LSLAEEKYRP AALEKMIALV ALLVEQSRSE RHLTLSQTDM AALTGGKGFP 2410 2420 2430 2440 2450 2460 FLFQHIRDGI NIRQTCNLIF SLCRYNNRLA EHIVSMLFTS IAKLTPEAAN PFFKLLTMLM 2470 2480 2490 2500 2510 2520 EFAGGPPGMP PFASYILQRI WEVIEYNPSQ CLDWLAVQTP RNKLAHSWVL QNMENWVERF 2530 2540 2550 2560 2570 2580 LLAHNYPRVR TSAAYLLVSL IPSNSFRQMF RSTRSLHIPT RDLPLSPDTT VVLHQVYNVL 2590 2600 2610 2620 2630 2640 LGLLSRAKLY VDAAVHGTTK LVPYFSFMTY CLISKTEKLM FSTYFMDLWN LFQPKLSEPA 2650 2660 2670 2680 2690 2700 IATNHNKQAL LSFWYNVCAD CPENIRLIVQ NPVVTKNIAF NYILADHDDQ DVVLFNRGML 2710 2720 2730 2740 2750 2760 PAYYGILRLC CEQSPAFTRQ LASHQNIQWA FKNLTPHASQ YPGAVEELFN LMQLFIAQRP 2770 2780 2790 2800 2810 2820 DMREEELEDI KQFKKTTISC YLRCLDGRSC WTTLISAFRI LLESDEDRLL VVFNRGLILM 2830 2840 2850 2860 2870 2880 TESFNTLHMM YHEATACHVT GDLVELLSIF LSVLKSTRPY LQRKDVKQAL IQWQERIEFA 2890 2900 2910 2920 2930 2940 HKLLTLLNSY SPPELRNACI DVLKELVLLS PHDFLHTLVP FLQHNHCTYH HSNIPMSLGP 2950 2960 2970 2980 2990 3000 YFPCRENIKL IGGKSNIRPP RPELNMCLLP TMVETSKGKD DVYDRMLLDY FFSYHQFIHL 3010 3020 3030 3040 3050 3060 LCRVAINCEK FTETLVKLSV LVAYEGLPLH LALFPKLWTE LCQTQSAMSK NCIKLLCEDP 3070 3080 3090 3100 3110 3120 VFAEYIKCIL MDERTFLNNN IVYTFMTHFL LKVQSQVFSE ANCANLISTL ITNLISQYQN 3130 3140 3150 3160 3170 3180 LQSDFSNRVE ISKASASLNG DLRALALLLS VHTPKQLNPA LIPTLQELLS KCRTCLQQRN 3190 3200 3210 3220 3230 3240 SLQEQEAKER KTKDDEGATP IKRRRVSSDE EHTVDSCISD MKTETREVLT PTSTSDNETR 3250 3260 3270 3280 3290 3300 DSSIIDPGTE QDLPSPENSS VKEYRMEVPS SFSEDMSNIR SQHAEEQSNN GRYDDCKEFK 3310 3320 3330 3340 3350 3360 DLHCSKDSTL AEEESEFPST SISAVLSDLA DLRSCDGQAL PSQDPEVALS LSCGHSRGLF 3370 3380 3390 SHMQQHDILD TLCRTIESTI HVVTRISGKG NQAAS
	Isoform 3 [UniParc]. Checksum: 4815E0ED77EC1C03	FASTA	3,312	377,599
	10 20 30 40 50 60 MRRKNSYYVW QKIFQIQFPL YTAYKHNTHP TIEDISTQES NILGAFCDMN DVEVPLHLLR 70 80 90 100 110 120 YVCLFCGKNG LSLMKDCFEY GTPETLPFLI AHAFITVVSN IRIWLHIPAV MQHIIPFRTY 130 140 150 160 170 180 VIRYLCKLSD QELRQSAARN MADLMWSTVK EPLDTTLCFD KESLDLAFKY FMSPTLTMRL 190 200 210 220 230 240 AGLSQITNQL HTFNDVCNNE SLVSDTETSI AKELADWLIS NNVVEHIFGP NLHIEIIKQC 250 260 270 280 290 300 QVILNFLAAE GRLSTQHIDC IWAAAQLKHC SRYIHDLFPS LIKNLDPVPL RHLLNLVSAL 310 320 330 340 350 360 EPSVHTEQTL YLASMLIKAL WNNALAAKAQ LSKQSSFASL LNTNIPIGNK KEEEELRRTA 370 380 390 400 410 420 PSPWSPAASP QSSDNSDTHQ SGGSDIEMDE QLINRTKHVQ QRLSDTEESM QGSSDETANS 430 440 450 460 470 480 GEDGSSGPGS SSGHSDGSSN EVNSSHASQS AGSPGSEVQS EDIADIEALK EEDEDDDHGH 490 500 510 520 530 540 NPPKSSCGTD LRNRKLESQA GICLGDSQGM SERNGTSSGT GKDLVFNTES LPSVDNRMRM 550 560 570 580 590 600 LDACSHSEDP EHDISGEMNA THIAQGSQES CITRTGDFLG ETIGNELFNC RQFIGPQHHH 610 620 630 640 650 660 HHHHHHHHHD GHMVDDMLSA DDVSCSSSQV SAKSEKNMAD FDGEESGCEE ELVQINSHAE 670 680 690 700 710 720 LTSHLQQHLP NLASIYHEHL SQGPVVHKHQ FNSNAVTDIN LDNVCKKGNT LLWDIVQDED 730 740 750 760 770 780 AVNLSEGLIN EAEKLLCSLV CWFTDRQIRM RFIEGCLENL GNNRSVVISL RLLPKLFGTF 790 800 810 820 830 840 QQFGSSYDTH WITMWAEKEL NMMKLFFDNL VYYIQTVREG RQKHALYSHS AEVQVRLQFL 850 860 870 880 890 900 TCVFSTLGSP DHFRLSLEQV DILWHCLVED SECYDDALHW FLNQVRSKDQ HAMGMETYKH 910 920 930 940 950 960 LFLEKMPQLK PETISMTGLN LFQHLCNLAR LATSAYDGCS NSELCGMDQF WGIALRAQSG 970 980 990 1000 1010 1020 DVSRAAIQYI NSYYINGKTG LEKEQEFISK CMESLMIASS SLEQESHSSL MVIERGLLML 1030 1040 1050 1060 1070 1080 KTHLEAFRRR FAYHLRQWQI EGTGISSHLK ALSDKQSLPL RVVCQPAGLP DKMTIEMYPS 1090 1100 1110 1120 1130 1140 DQVADLRAEV THWYENLQKE QINQQAQLQE FGQSNRKGEF PGGLMGPVRM ISSGHELTTD 1150 1160 1170 1180 1190 1200 YDEKALHELG FKDMQMVFVS LGAPRRERKG EGVQLPASCL PPPQKDNIPM LLLLQEPHLT 1210 1220 1230 1240 1250 1260 TLFDLLEMLA SFKPPSGKVA VDDSESLRCE ELHLHAENLS RRVWELLMLL PTCPNMLMAF 1270 1280 1290 1300 1310 1320 QNISDEQSND GFNWKELLKI KSAHKLLYAL EIIEALGKPN RRIRRESTGS YSDLYPDSDD 1330 1340 1350 1360 1370 1380 SSEDQVENSK NSWSCKFVAA GGLQQLLEIF NSGILEPKEQ ESWTVWQLDC LACLLKLICQ 1390 1400 1410 1420 1430 1440 FAVDPSDLDL AYHDVFAWSG IAESHRKRTW PGKSRKAAGD HAKGLHIPRL TEVFLVLVQG 1450 1460 1470 1480 1490 1500 TSLIQRLMSV AYTYDNLAPR VLKAQSDHRS RHEVSHYSMW LLVSWAHCCS LVKSSLADSD 1510 1520 1530 1540 1550 1560 HLQDWLKKLT LLIPETAVRH ESCSGLYKLS LSGLDGGDSI NRSFLLLAAS TLLKFLPDAQ 1570 1580 1590 1600 1610 1620 ALKPIRIDDY EEEPILKPGC KEYFWLLCKL VDNIHIKDAS QTTLLDLDAL ARHLADCIRS 1630 1640 1650 1660 1670 1680 REILDHQDGN VEDDGLTGLL RLATSVVKHK PPFKFSREGQ EFLRDIFNLL FLLPSLKDRQ 1690 1700 1710 1720 1730 1740 QPKCKSHSSR AAAYDLLVEM VKGSVENYRL IHNWVMAQHM QSHAPYKWDY WPHEDVRAEC 1750 1760 1770 1780 1790 1800 RFVGLTNLGA TCYLASTIQQ LYMIPEARQA VFTAKYSEDM KHKTTLLELQ KMFTYLMESE 1810 1820 1830 1840 1850 1860 CKAYNPRPFC KTYTMDKQPL NTGEQKDMTE FFTDLITKIE EMSPELKNTV KSLFGGVITN 1870 1880 1890 1900 1910 1920 NVVSLDCEHV SQTAEEFYTV RCQVADMKNI YESLDEVTIK DTLEGDNMYT CSHCGKKVRA 1930 1940 1950 1960 1970 1980 EKRACFKKLP RILSFNTMRY TFNMVTMMKE KVNTHFSFPL RLDMTPYTED FLMGKSERKE 1990 2000 2010 2020 2030 2040 GFKEVSDHSK DSESYEYDLI GVTVHTGTAD GGHYYSFIRD IVNPHAYKNN KWYLFNDAEV 2050 2060 2070 2080 2090 2100 KPFDSAQLAS ECFGGEMTTK TYDSVTDKFM DFSFEKTHSA YMLFYKRMEP EEENGREYKF 2110 2120 2130 2140 2150 2160 DVSSELLEWI WHDNMQFLQD KNIFEHTYFG FMWQLCSCIP STLPDPKAVS LMTAKLSTSF 2170 2180 2190 2200 2210 2220 VLETFIHSKE KPTMLQWIEL LTKQFNNSQA ACEWFLDRMA DDDWWPMQIL IKCPNQIVRQ 2230 2240 2250 2260 2270 2280 MFQRLCIHVI QRLRPVHAHL YLQPGMEDGS DDMDTSVEDI GGRSCVTRFV RTLLLIMEHG 2290 2300 2310 2320 2330 2340 VKPHSKHLTE YFAFLYEFAK MGEEESQFLL SLQAISTMVH FYMGTKGPEN PQVEVLSEEE 2350 2360 2370 2380 2390 2400 GEEEEEEEDI LSLAEEKYRP AALEKMIALV ALLVEQSRSE RHLTLSQTDM AALTGGKGFP 2410 2420 2430 2440 2450 2460 FLFQHIRDGI NIRQTCNLIF SLCRYNNRLA EHIVSMLFTS IAKLTPEAAN PFFKLLTMLM 2470 2480 2490 2500 2510 2520 EFAGGPPGMP PFASYILQRI WEVIEYNPSQ CLDWLAVQTP RNKLAHSWVL QNMENWVERF 2530 2540 2550 2560 2570 2580 LLAHNYPRVR TSAAYLLVSL IPSNSFRQMF RSTRSLHIPT RDLPLSPDTT VVLHQVYNVL 2590 2600 2610 2620 2630 2640 LGLLSRAKLY VDAAVHGTTK LVPYFSFMTY CLISKTEKLM FSTYFMDLWN LFQPKLSEPA 2650 2660 2670 2680 2690 2700 IATNHNKQAL LSFWYNVCAD CPENIRLIVQ NPVVTKNIAF NYILADHDDQ DVVLFNRGML 2710 2720 2730 2740 2750 2760 PAYYGILRLC CEQSPAFTRQ LASHQNIQWA FKNLTPHASQ YPGAVEELFN LMQLFIAQRP 2770 2780 2790 2800 2810 2820 DMREEELEDI KQFKKTTISC YLRCQALIQW QERIEFAHKL LTLLNSYSPP ELRNACIDVL 2830 2840 2850 2860 2870 2880 KELVLLSPHD FLHTLVPFLQ HNHCTYHHSN IPMSLGPYFP CRENIKLIGG KSNIRPPRPE 2890 2900 2910 2920 2930 2940 LNMCLLPTMV ETSKGKDDVY DRMLLDYFFS YHQFIHLLCR VAINCEKFTE TLVKLSVLVA 2950 2960 2970 2980 2990 3000 YEGLPLHLAL FPKLWTELCQ TQSAMSKNCI KLLCEDPVFA EYIKCILMDE RTFLNNNIVY 3010 3020 3030 3040 3050 3060 TFMTHFLLKV QSQVFSEANC ANLISTLITN LISQYQNLQS DFSNRVEISK ASASLNGDLR 3070 3080 3090 3100 3110 3120 ALALLLSVHT PKQLNPALIP TLQELLSKCR TCLQQRNSLQ EQEAKERKTK DDEGATPIKR 3130 3140 3150 3160 3170 3180 RRVSSDEEHT VDSCISDMKT ETREVLTPTS TSDNETRDSS IIDPGTEQDL PSPENSSVKE 3190 3200 3210 3220 3230 3240 YRMEVPSSFS EDMSNIRSQH AEEQSNNGRY DDCKEFKDLH CSKDSTLAEE ESEFPSTSIS 3250 3260 3270 3280 3290 3300 AVLSDLADLR SCDGQALPSQ DPEVALSLSC GHSRGLFSHM QQHDILDTLC RTIESTIHVV 3310 TRISGKGNQA AS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases." Quesada V., Diaz-Perales A., Gutierrez-Fernandez A., Garabaya C., Cal S., Lopez-Otin C. Biochem. Biophys. Res. Commun. 314:54-62(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, ENZYME ACTIVITY, VARIANT THR-661.
[2]	"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT THR-661. Tissue: Brain.
[3]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[4]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1723-2532 AND 2629-3546 (ISOFORM 1). Tissue: Amygdala and Uterus.
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1821-3338. Tissue: Testis.
[7]	"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2351-3546 (ISOFORM 2). Tissue: Brain.
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2561-3546 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3024-3546 (ISOFORM 3). Tissue: Brain, Colon and Kidney.
[9]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-649, VARIANT [LARGE SCALE ANALYSIS] THR-661, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[10]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-352; SER-3358; SER-3359 AND SER-3406, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2488, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[12]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]	"The Ubiquitin specific protease USP34 regulates Axin stability and Wnt/beta-catenin signaling." Lui T.T., Lacroix C., Ahmed S.M., Goldenberg S.J., Leach C.A., Daulat A.M., Angers S. Mol. Cell. Biol. 31:2053-2065(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, CATALYTIC ACTIVITY, INTERACTION WITH AXIN1 AND AXIN2, MUTAGENESIS OF CYS-1903.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ586138 mRNA. Translation: CAE51938.1. AB011142 mRNA. Translation: BAA25496.2. Different initiation. AC016747 Genomic DNA. No translation available. AL050092 mRNA. Translation: CAB43264.1. AL831918 mRNA. Translation: CAD38579.1. AK125898 mRNA. Translation: BAG54261.1. Different initiation. AB018272 mRNA. Translation: BAA34449.1. BC022783 mRNA. Translation: AAH22783.1. BC062325 mRNA. Translation: AAH62325.1. BC107761 mRNA. Translation: AAI07762.1. Frameshift.
IPI	IPI00297593. IPI00787401. IPI00894492.
PIR	T00338. T13057.
RefSeq	NP_055524.3. NM_014709.3.
UniGene	Hs.644708.
3D structure databases
HSSP	HSSP built from PDB template 2AYN based on UniProtKB P54578.
ProteinModelPortal	Q70CQ2.
SMR	Q70CQ2. Positions 1877-2266.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q70CQ2. 1 interaction.
Protein family/group databases
MEROPS	C19.067.
PTM databases
PhosphoSite	Q70CQ2.
Polymorphism databases
DMDM	212276488.
Proteomic databases
PaxDb	Q70CQ2.
PRIDE	Q70CQ2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000398571; ENSP00000381577; ENSG00000115464. ENST00000453734; ENSP00000410559; ENSG00000115464.
GeneID	9736.
KEGG	hsa:9736.
UCSC	uc002sbe.3. human.
Organism-specific databases
CTD	9736.
GeneCards	GC02M061414.
H-InvDB	HIX0002082. HIX0161884.
HGNC	HGNC:20066. USP34.
HPA	HPA025815.
neXtProt	NX_Q70CQ2.
PharmGKB	PA134897042.
HUGE	Search... Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5077.
HOVERGEN	HBG092616.
InParanoid	Q70CQ2.
KO	K11853.
OMA	ASQYPGA.
OrthoDB	EOG47M1WX.
Gene expression databases
ArrayExpress	Q70CQ2.
Bgee	Q70CQ2.
CleanEx	HS_USP34.
Genevestigator	Q70CQ2.
GermOnline	ENSG00000115464. Homo sapiens.
Family and domain databases
InterPro	IPR016024. ARM-type_fold. IPR018200. Pept_C19ubi-hydrolase_C_CS. IPR001394. Peptidase_C19. [Graphical view]
Pfam	PF00443. UCH. 1 hit. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit.
PROSITE	PS00972. UCH_2_1. 1 hit. PS00973. UCH_2_2. 1 hit. PS50235. UCH_2_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	USP34. human.
GenomeRNAi	9736.
NextBio	36636.

Entry information

Entry name

UBP34_HUMAN

Accession

Primary (citable) accession number: Q70CQ2
Secondary accession number(s): A8MWD0 , B3KWU9, O60316, O94834, Q3B777, Q6P6C9, Q7L8P6, Q8N3T9, Q8TBW2, Q9UGA1

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2006
Last sequence update:	November 4, 2008
Last modified:	May 1, 2013
This is version 80 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.