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Q70CQ2

- UBP34_HUMAN

UniProt

Q70CQ2 - UBP34_HUMAN

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Protein
Ubiquitin carboxyl-terminal hydrolase 34
Gene
USP34, KIAA0570, KIAA0729
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.1 Publication

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1903 – 19031Nucleophile Inferred
Active sitei2164 – 21641Proton acceptor By similarity

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: UniProtKB
  2. protein binding Source: UniProtKB
  3. ubiquitin thiolesterase activity Source: UniProtKB
  4. ubiquitin-specific protease activity Source: UniProtKB

GO - Biological processi

  1. Wnt signaling pathway Source: UniProtKB-KW
  2. positive regulation of canonical Wnt signaling pathway Source: UniProtKB
  3. protein K48-linked deubiquitination Source: UniProtKB
  4. protein deubiquitination Source: FlyBase
  5. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway, Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_200777. TCF dependent signaling in response to WNT.

Protein family/group databases

MEROPSiC19.067.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 34 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 34
Ubiquitin thioesterase 34
Ubiquitin-specific-processing protease 34
Gene namesi
Name:USP34
Synonyms:KIAA0570, KIAA0729
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:20066. USP34.

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi1903 – 19031C → S: Loss of function. 1 Publication

Organism-specific databases

PharmGKBiPA134897042.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 35463546Ubiquitin carboxyl-terminal hydrolase 34
PRO_0000249519Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei352 – 3521Phosphoserine1 Publication
Modified residuei649 – 6491Phosphoserine1 Publication
Modified residuei2488 – 24881Phosphoserine1 Publication
Modified residuei3358 – 33581Phosphoserine1 Publication
Modified residuei3359 – 33591Phosphoserine1 Publication
Modified residuei3406 – 34061Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ70CQ2.
PaxDbiQ70CQ2.
PRIDEiQ70CQ2.

PTM databases

PhosphoSiteiQ70CQ2.

Expressioni

Tissue specificityi

Expressed in brain at low level.1 Publication

Gene expression databases

ArrayExpressiQ70CQ2.
BgeeiQ70CQ2.
CleanExiHS_USP34.
GenevestigatoriQ70CQ2.

Organism-specific databases

HPAiHPA025815.

Interactioni

Subunit structurei

Interacts with AXIN1 and AXIN2.1 Publication

Protein-protein interaction databases

BioGridi115085. 39 interactions.
IntActiQ70CQ2. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ70CQ2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1894 – 2239346USP
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.
Contains 1 USP domain.

Phylogenomic databases

eggNOGiCOG5077.
HOVERGENiHBG092616.
InParanoidiQ70CQ2.
KOiK11853.
OMAiCLISKTE.
PhylomeDBiQ70CQ2.
TreeFamiTF323966.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 4 hits.
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q70CQ2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MCENCADLVE VLNEISDVEG GDGLQLRKEH TLKIFTYINS WTQRQCLCCF     50
KEYKHLEIFN QVVCALINLV IAQVQVLRDQ LCKHCTTINI DSTWQDESNQ 100
AEEPLNIDRE CNEGSTERQK SIEKKSNSTR ICNLTEEESS KSSDPFSLWS 150
TDEKEKLLLC VAKIFQIQFP LYTAYKHNTH PTIEDISTQE SNILGAFCDM 200
NDVEVPLHLL RYVCLFCGKN GLSLMKDCFE YGTPETLPFL IAHAFITVVS 250
NIRIWLHIPA VMQHIIPFRT YVIRYLCKLS DQELRQSAAR NMADLMWSTV 300
KEPLDTTLCF DKESLDLAFK YFMSPTLTMR LAGLSQITNQ LHTFNDVCNN 350
ESLVSDTETS IAKELADWLI SNNVVEHIFG PNLHIEIIKQ CQVILNFLAA 400
EGRLSTQHID CIWAAAQLKH CSRYIHDLFP SLIKNLDPVP LRHLLNLVSA 450
LEPSVHTEQT LYLASMLIKA LWNNALAAKA QLSKQSSFAS LLNTNIPIGN 500
KKEEEELRRT APSPWSPAAS PQSSDNSDTH QSGGSDIEMD EQLINRTKHV 550
QQRLSDTEES MQGSSDETAN SGEDGSSGPG SSSGHSDGSS NEVNSSHASQ 600
SAGSPGSEVQ SEDIADIEAL KEEDEDDDHG HNPPKSSCGT DLRNRKLESQ 650
AGICLGDSQG MSERNGTSSG TGKDLVFNTE SLPSVDNRMR MLDACSHSED 700
PEHDISGEMN ATHIAQGSQE SCITRTGDFL GETIGNELFN CRQFIGPQHH 750
HHHHHHHHHH DGHMVDDMLS ADDVSCSSSQ VSAKSEKNMA DFDGEESGCE 800
EELVQINSHA ELTSHLQQHL PNLASIYHEH LSQGPVVHKH QFNSNAVTDI 850
NLDNVCKKGN TLLWDIVQDE DAVNLSEGLI NEAEKLLCSL VCWFTDRQIR 900
MRFIEGCLEN LGNNRSVVIS LRLLPKLFGT FQQFGSSYDT HWITMWAEKE 950
LNMMKLFFDN LVYYIQTVRE GRQKHALYSH SAEVQVRLQF LTCVFSTLGS 1000
PDHFRLSLEQ VDILWHCLVE DSECYDDALH WFLNQVRSKD QHAMGMETYK 1050
HLFLEKMPQL KPETISMTGL NLFQHLCNLA RLATSAYDGC SNSELCGMDQ 1100
FWGIALRAQS GDVSRAAIQY INSYYINGKT GLEKEQEFIS KCMESLMIAS 1150
SSLEQESHSS LMVIERGLLM LKTHLEAFRR RFAYHLRQWQ IEGTGISSHL 1200
KALSDKQSLP LRVVCQPAGL PDKMTIEMYP SDQVADLRAE VTHWYENLQK 1250
EQINQQAQLQ EFGQSNRKGE FPGGLMGPVR MISSGHELTT DYDEKALHEL 1300
GFKDMQMVFV SLGAPRRERK GEGVQLPASC LPPPQKDNIP MLLLLQEPHL 1350
TTLFDLLEML ASFKPPSGKV AVDDSESLRC EELHLHAENL SRRVWELLML 1400
LPTCPNMLMA FQNISDEQSN DGFNWKELLK IKSAHKLLYA LEIIEALGKP 1450
NRRIRRESTG SYSDLYPDSD DSSEDQVENS KNSWSCKFVA AGGLQQLLEI 1500
FNSGILEPKE QESWTVWQLD CLACLLKLIC QFAVDPSDLD LAYHDVFAWS 1550
GIAESHRKRT WPGKSRKAAG DHAKGLHIPR LTEVFLVLVQ GTSLIQRLMS 1600
VAYTYDNLAP RVLKAQSDHR SRHEVSHYSM WLLVSWAHCC SLVKSSLADS 1650
DHLQDWLKKL TLLIPETAVR HESCSGLYKL SLSGLDGGDS INRSFLLLAA 1700
STLLKFLPDA QALKPIRIDD YEEEPILKPG CKEYFWLLCK LVDNIHIKDA 1750
SQTTLLDLDA LARHLADCIR SREILDHQDG NVEDDGLTGL LRLATSVVKH 1800
KPPFKFSREG QEFLRDIFNL LFLLPSLKDR QQPKCKSHSS RAAAYDLLVE 1850
MVKGSVENYR LIHNWVMAQH MQSHAPYKWD YWPHEDVRAE CRFVGLTNLG 1900
ATCYLASTIQ QLYMIPEARQ AVFTAKYSED MKHKTTLLEL QKMFTYLMES 1950
ECKAYNPRPF CKTYTMDKQP LNTGEQKDMT EFFTDLITKI EEMSPELKNT 2000
VKSLFGGVIT NNVVSLDCEH VSQTAEEFYT VRCQVADMKN IYESLDEVTI 2050
KDTLEGDNMY TCSHCGKKVR AEKRACFKKL PRILSFNTMR YTFNMVTMMK 2100
EKVNTHFSFP LRLDMTPYTE DFLMGKSERK EGFKEVSDHS KDSESYEYDL 2150
IGVTVHTGTA DGGHYYSFIR DIVNPHAYKN NKWYLFNDAE VKPFDSAQLA 2200
SECFGGEMTT KTYDSVTDKF MDFSFEKTHS AYMLFYKRME PEEENGREYK 2250
FDVSSELLEW IWHDNMQFLQ DKNIFEHTYF GFMWQLCSCI PSTLPDPKAV 2300
SLMTAKLSTS FVLETFIHSK EKPTMLQWIE LLTKQFNNSQ AACEWFLDRM 2350
ADDDWWPMQI LIKCPNQIVR QMFQRLCIHV IQRLRPVHAH LYLQPGMEDG 2400
SDDMDTSVED IGGRSCVTRF VRTLLLIMEH GVKPHSKHLT EYFAFLYEFA 2450
KMGEEESQFL LSLQAISTMV HFYMGTKGPE NPQVEVLSEE EGEEEEEEED 2500
ILSLAEEKYR PAALEKMIAL VALLVEQSRS ERHLTLSQTD MAALTGGKGF 2550
PFLFQHIRDG INIRQTCNLI FSLCRYNNRL AEHIVSMLFT SIAKLTPEAA 2600
NPFFKLLTML MEFAGGPPGM PPFASYILQR IWEVIEYNPS QCLDWLAVQT 2650
PRNKLAHSWV LQNMENWVER FLLAHNYPRV RTSAAYLLVS LIPSNSFRQM 2700
FRSTRSLHIP TRDLPLSPDT TVVLHQVYNV LLGLLSRAKL YVDAAVHGTT 2750
KLVPYFSFMT YCLISKTEKL MFSTYFMDLW NLFQPKLSEP AIATNHNKQA 2800
LLSFWYNVCA DCPENIRLIV QNPVVTKNIA FNYILADHDD QDVVLFNRGM 2850
LPAYYGILRL CCEQSPAFTR QLASHQNIQW AFKNLTPHAS QYPGAVEELF 2900
NLMQLFIAQR PDMREEELED IKQFKKTTIS CYLRCLDGRS CWTTLISAFR 2950
ILLESDEDRL LVVFNRGLIL MTESFNTLHM MYHEATACHV TGDLVELLSI 3000
FLSVLKSTRP YLQRKDVKQA LIQWQERIEF AHKLLTLLNS YSPPELRNAC 3050
IDVLKELVLL SPHDFLHTLV PFLQHNHCTY HHSNIPMSLG PYFPCRENIK 3100
LIGGKSNIRP PRPELNMCLL PTMVETSKGK DDVYDRMLLD YFFSYHQFIH 3150
LLCRVAINCE KFTETLVKLS VLVAYEGLPL HLALFPKLWT ELCQTQSAMS 3200
KNCIKLLCED PVFAEYIKCI LMDERTFLNN NIVYTFMTHF LLKVQSQVFS 3250
EANCANLIST LITNLISQYQ NLQSDFSNRV EISKASASLN GDLRALALLL 3300
SVHTPKQLNP ALIPTLQELL SKCRTCLQQR NSLQEQEAKE RKTKDDEGAT 3350
PIKRRRVSSD EEHTVDSCIS DMKTETREVL TPTSTSDNET RDSSIIDPGT 3400
EQDLPSPENS SVKEYRMEVP SSFSEDMSNI RSQHAEEQSN NGRYDDCKEF 3450
KDLHCSKDST LAEEESEFPS TSISAVLSDL ADLRSCDGQA LPSQDPEVAL 3500
SLSCGHSRGL FSHMQQHDIL DTLCRTIEST IHVVTRISGK GNQAAS 3546
Length:3,546
Mass (Da):404,233
Last modified:November 4, 2008 - v2
Checksum:iA31851911D990044
GO
Isoform 2 (identifier: Q70CQ2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-139: Missing.
     140-162: SKSSDPFSLWSTDEKEKLLLCVA → MRRKNSYYVWQ

Show »
Length:3,395
Mass (Da):387,154
Checksum:i6171809F72C5EE8E
GO
Isoform 3 (identifier: Q70CQ2-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-139: Missing.
     140-162: SKSSDPFSLWSTDEKEKLLLCVA → MRRKNSYYVWQ
     2936-3018: Missing.

Note: No experimental confirmation available.

Show »
Length:3,312
Mass (Da):377,599
Checksum:i4815E0ED77EC1C03
GO

Sequence cautioni

The sequence AAI07762.1 differs from that shown. Reason: Frameshift at position 3200.
The sequence BAA25496.2 differs from that shown. Reason: Erroneous initiation.
The sequence BAG54261.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti661 – 6611M → T.3 Publications
Corresponds to variant rs6722430 [ dbSNP | Ensembl ].
VAR_047106
Natural varianti1663 – 16631L → R.
Corresponds to variant rs6723818 [ dbSNP | Ensembl ].
VAR_047107
Natural varianti2348 – 23481D → N.
Corresponds to variant rs4386306 [ dbSNP | Ensembl ].
VAR_047108

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 139139Missing in isoform 2 and isoform 3.
VSP_035639Add
BLAST
Alternative sequencei140 – 16223SKSSD…LLCVA → MRRKNSYYVWQ in isoform 2 and isoform 3.
VSP_035640Add
BLAST
Alternative sequencei2936 – 301883Missing in isoform 3.
VSP_020463Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ586138 mRNA. Translation: CAE51938.1.
AB011142 mRNA. Translation: BAA25496.2. Different initiation.
AC016747 Genomic DNA. No translation available.
AL050092 mRNA. Translation: CAB43264.1.
AL831918 mRNA. Translation: CAD38579.1.
AK125898 mRNA. Translation: BAG54261.1. Different initiation.
AB018272 mRNA. Translation: BAA34449.1.
BC022783 mRNA. Translation: AAH22783.1.
BC062325 mRNA. Translation: AAH62325.1.
BC107761 mRNA. Translation: AAI07762.1. Frameshift.
CCDSiCCDS42686.1. [Q70CQ2-1]
PIRiT00338.
T13057.
RefSeqiNP_055524.3. NM_014709.3. [Q70CQ2-1]
UniGeneiHs.644708.

Genome annotation databases

EnsembliENST00000398571; ENSP00000381577; ENSG00000115464. [Q70CQ2-1]
ENST00000453734; ENSP00000410559; ENSG00000115464.
GeneIDi9736.
KEGGihsa:9736.
UCSCiuc002sbe.3. human. [Q70CQ2-1]

Polymorphism databases

DMDMi212276488.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ586138 mRNA. Translation: CAE51938.1 .
AB011142 mRNA. Translation: BAA25496.2 . Different initiation.
AC016747 Genomic DNA. No translation available.
AL050092 mRNA. Translation: CAB43264.1 .
AL831918 mRNA. Translation: CAD38579.1 .
AK125898 mRNA. Translation: BAG54261.1 . Different initiation.
AB018272 mRNA. Translation: BAA34449.1 .
BC022783 mRNA. Translation: AAH22783.1 .
BC062325 mRNA. Translation: AAH62325.1 .
BC107761 mRNA. Translation: AAI07762.1 . Frameshift.
CCDSi CCDS42686.1. [Q70CQ2-1 ]
PIRi T00338.
T13057.
RefSeqi NP_055524.3. NM_014709.3. [Q70CQ2-1 ]
UniGenei Hs.644708.

3D structure databases

ProteinModelPortali Q70CQ2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115085. 39 interactions.
IntActi Q70CQ2. 2 interactions.

Protein family/group databases

MEROPSi C19.067.

PTM databases

PhosphoSitei Q70CQ2.

Polymorphism databases

DMDMi 212276488.

Proteomic databases

MaxQBi Q70CQ2.
PaxDbi Q70CQ2.
PRIDEi Q70CQ2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000398571 ; ENSP00000381577 ; ENSG00000115464 . [Q70CQ2-1 ]
ENST00000453734 ; ENSP00000410559 ; ENSG00000115464 .
GeneIDi 9736.
KEGGi hsa:9736.
UCSCi uc002sbe.3. human. [Q70CQ2-1 ]

Organism-specific databases

CTDi 9736.
GeneCardsi GC02M061414.
H-InvDB HIX0002082.
HIX0161884.
HGNCi HGNC:20066. USP34.
HPAi HPA025815.
MIMi 615295. gene.
neXtProti NX_Q70CQ2.
PharmGKBi PA134897042.
HUGEi Search...
Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5077.
HOVERGENi HBG092616.
InParanoidi Q70CQ2.
KOi K11853.
OMAi CLISKTE.
PhylomeDBi Q70CQ2.
TreeFami TF323966.

Enzyme and pathway databases

Reactomei REACT_200777. TCF dependent signaling in response to WNT.

Miscellaneous databases

ChiTaRSi USP34. human.
GeneWikii USP34.
GenomeRNAii 9736.
NextBioi 36636.
PROi Q70CQ2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q70CQ2.
Bgeei Q70CQ2.
CleanExi HS_USP34.
Genevestigatori Q70CQ2.

Family and domain databases

InterProi IPR016024. ARM-type_fold.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 4 hits.
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases."
    Quesada V., Diaz-Perales A., Gutierrez-Fernandez A., Garabaya C., Cal S., Lopez-Otin C.
    Biochem. Biophys. Res. Commun. 314:54-62(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, ENZYME ACTIVITY, VARIANT THR-661.
  2. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT THR-661.
    Tissue: Brain.
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1723-2532 AND 2629-3546 (ISOFORM 1).
    Tissue: Amygdala and Uterus.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1821-3338.
    Tissue: Testis.
  7. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2351-3546 (ISOFORM 2).
    Tissue: Brain.
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2561-3546 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3024-3546 (ISOFORM 3).
    Tissue: Brain, Colon and Kidney.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-649, VARIANT [LARGE SCALE ANALYSIS] THR-661, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-352; SER-3358; SER-3359 AND SER-3406, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2488, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "The Ubiquitin specific protease USP34 regulates Axin stability and Wnt/beta-catenin signaling."
    Lui T.T., Lacroix C., Ahmed S.M., Goldenberg S.J., Leach C.A., Daulat A.M., Angers S.
    Mol. Cell. Biol. 31:2053-2065(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY, INTERACTION WITH AXIN1 AND AXIN2, MUTAGENESIS OF CYS-1903.

Entry informationi

Entry nameiUBP34_HUMAN
AccessioniPrimary (citable) accession number: Q70CQ2
Secondary accession number(s): A8MWD0
, B3KWU9, O60316, O94834, Q3B777, Q6P6C9, Q7L8P6, Q8N3T9, Q8TBW2, Q9UGA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: November 4, 2008
Last modified: September 3, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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