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Q70CQ2 (UBP34_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 34

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 34
Ubiquitin thioesterase 34
Ubiquitin-specific-processing protease 34
Gene names
Name:USP34
Synonyms:KIAA0570, KIAA0729
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length3546 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Ref.13

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). Ref.1 Ref.13

Subunit structure

Interacts with AXIN1 and AXIN2. Ref.13

Tissue specificity

Expressed in brain at low level. Ref.1

Sequence similarities

Belongs to the peptidase C19 family.

Contains 1 USP domain.

Sequence caution

The sequence AAI07762.1 differs from that shown. Reason: Frameshift at position 3200.

The sequence BAA25496.2 differs from that shown. Reason: Erroneous initiation.

The sequence BAG54261.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q70CQ2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q70CQ2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-139: Missing.
     140-162: SKSSDPFSLWSTDEKEKLLLCVA → MRRKNSYYVWQ
Isoform 3 (identifier: Q70CQ2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-139: Missing.
     140-162: SKSSDPFSLWSTDEKEKLLLCVA → MRRKNSYYVWQ
     2936-3018: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 35463546Ubiquitin carboxyl-terminal hydrolase 34
PRO_0000249519

Regions

Domain1894 – 2239346USP

Sites

Active site19031Nucleophile Probable
Active site21641Proton acceptor By similarity

Amino acid modifications

Modified residue3521Phosphoserine Ref.10
Modified residue6491Phosphoserine Ref.9
Modified residue24881Phosphoserine Ref.11
Modified residue33581Phosphoserine Ref.10
Modified residue33591Phosphoserine Ref.10
Modified residue34061Phosphoserine Ref.10

Natural variations

Alternative sequence1 – 139139Missing in isoform 2 and isoform 3.
VSP_035639
Alternative sequence140 – 16223SKSSD…LLCVA → MRRKNSYYVWQ in isoform 2 and isoform 3.
VSP_035640
Alternative sequence2936 – 301883Missing in isoform 3.
VSP_020463
Natural variant6611M → T. Ref.1 Ref.2 Ref.9
Corresponds to variant rs6722430 [ dbSNP | Ensembl ].
VAR_047106
Natural variant16631L → R.
Corresponds to variant rs6723818 [ dbSNP | Ensembl ].
VAR_047107
Natural variant23481D → N.
Corresponds to variant rs4386306 [ dbSNP | Ensembl ].
VAR_047108

Experimental info

Mutagenesis19031C → S: Loss of function. Ref.13

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 4, 2008. Version 2.
Checksum: A31851911D990044

FASTA3,546404,233
        10         20         30         40         50         60 
MCENCADLVE VLNEISDVEG GDGLQLRKEH TLKIFTYINS WTQRQCLCCF KEYKHLEIFN 

        70         80         90        100        110        120 
QVVCALINLV IAQVQVLRDQ LCKHCTTINI DSTWQDESNQ AEEPLNIDRE CNEGSTERQK 

       130        140        150        160        170        180 
SIEKKSNSTR ICNLTEEESS KSSDPFSLWS TDEKEKLLLC VAKIFQIQFP LYTAYKHNTH 

       190        200        210        220        230        240 
PTIEDISTQE SNILGAFCDM NDVEVPLHLL RYVCLFCGKN GLSLMKDCFE YGTPETLPFL 

       250        260        270        280        290        300 
IAHAFITVVS NIRIWLHIPA VMQHIIPFRT YVIRYLCKLS DQELRQSAAR NMADLMWSTV 

       310        320        330        340        350        360 
KEPLDTTLCF DKESLDLAFK YFMSPTLTMR LAGLSQITNQ LHTFNDVCNN ESLVSDTETS 

       370        380        390        400        410        420 
IAKELADWLI SNNVVEHIFG PNLHIEIIKQ CQVILNFLAA EGRLSTQHID CIWAAAQLKH 

       430        440        450        460        470        480 
CSRYIHDLFP SLIKNLDPVP LRHLLNLVSA LEPSVHTEQT LYLASMLIKA LWNNALAAKA 

       490        500        510        520        530        540 
QLSKQSSFAS LLNTNIPIGN KKEEEELRRT APSPWSPAAS PQSSDNSDTH QSGGSDIEMD 

       550        560        570        580        590        600 
EQLINRTKHV QQRLSDTEES MQGSSDETAN SGEDGSSGPG SSSGHSDGSS NEVNSSHASQ 

       610        620        630        640        650        660 
SAGSPGSEVQ SEDIADIEAL KEEDEDDDHG HNPPKSSCGT DLRNRKLESQ AGICLGDSQG 

       670        680        690        700        710        720 
MSERNGTSSG TGKDLVFNTE SLPSVDNRMR MLDACSHSED PEHDISGEMN ATHIAQGSQE 

       730        740        750        760        770        780 
SCITRTGDFL GETIGNELFN CRQFIGPQHH HHHHHHHHHH DGHMVDDMLS ADDVSCSSSQ 

       790        800        810        820        830        840 
VSAKSEKNMA DFDGEESGCE EELVQINSHA ELTSHLQQHL PNLASIYHEH LSQGPVVHKH 

       850        860        870        880        890        900 
QFNSNAVTDI NLDNVCKKGN TLLWDIVQDE DAVNLSEGLI NEAEKLLCSL VCWFTDRQIR 

       910        920        930        940        950        960 
MRFIEGCLEN LGNNRSVVIS LRLLPKLFGT FQQFGSSYDT HWITMWAEKE LNMMKLFFDN 

       970        980        990       1000       1010       1020 
LVYYIQTVRE GRQKHALYSH SAEVQVRLQF LTCVFSTLGS PDHFRLSLEQ VDILWHCLVE 

      1030       1040       1050       1060       1070       1080 
DSECYDDALH WFLNQVRSKD QHAMGMETYK HLFLEKMPQL KPETISMTGL NLFQHLCNLA 

      1090       1100       1110       1120       1130       1140 
RLATSAYDGC SNSELCGMDQ FWGIALRAQS GDVSRAAIQY INSYYINGKT GLEKEQEFIS 

      1150       1160       1170       1180       1190       1200 
KCMESLMIAS SSLEQESHSS LMVIERGLLM LKTHLEAFRR RFAYHLRQWQ IEGTGISSHL 

      1210       1220       1230       1240       1250       1260 
KALSDKQSLP LRVVCQPAGL PDKMTIEMYP SDQVADLRAE VTHWYENLQK EQINQQAQLQ 

      1270       1280       1290       1300       1310       1320 
EFGQSNRKGE FPGGLMGPVR MISSGHELTT DYDEKALHEL GFKDMQMVFV SLGAPRRERK 

      1330       1340       1350       1360       1370       1380 
GEGVQLPASC LPPPQKDNIP MLLLLQEPHL TTLFDLLEML ASFKPPSGKV AVDDSESLRC 

      1390       1400       1410       1420       1430       1440 
EELHLHAENL SRRVWELLML LPTCPNMLMA FQNISDEQSN DGFNWKELLK IKSAHKLLYA 

      1450       1460       1470       1480       1490       1500 
LEIIEALGKP NRRIRRESTG SYSDLYPDSD DSSEDQVENS KNSWSCKFVA AGGLQQLLEI 

      1510       1520       1530       1540       1550       1560 
FNSGILEPKE QESWTVWQLD CLACLLKLIC QFAVDPSDLD LAYHDVFAWS GIAESHRKRT 

      1570       1580       1590       1600       1610       1620 
WPGKSRKAAG DHAKGLHIPR LTEVFLVLVQ GTSLIQRLMS VAYTYDNLAP RVLKAQSDHR 

      1630       1640       1650       1660       1670       1680 
SRHEVSHYSM WLLVSWAHCC SLVKSSLADS DHLQDWLKKL TLLIPETAVR HESCSGLYKL 

      1690       1700       1710       1720       1730       1740 
SLSGLDGGDS INRSFLLLAA STLLKFLPDA QALKPIRIDD YEEEPILKPG CKEYFWLLCK 

      1750       1760       1770       1780       1790       1800 
LVDNIHIKDA SQTTLLDLDA LARHLADCIR SREILDHQDG NVEDDGLTGL LRLATSVVKH 

      1810       1820       1830       1840       1850       1860 
KPPFKFSREG QEFLRDIFNL LFLLPSLKDR QQPKCKSHSS RAAAYDLLVE MVKGSVENYR 

      1870       1880       1890       1900       1910       1920 
LIHNWVMAQH MQSHAPYKWD YWPHEDVRAE CRFVGLTNLG ATCYLASTIQ QLYMIPEARQ 

      1930       1940       1950       1960       1970       1980 
AVFTAKYSED MKHKTTLLEL QKMFTYLMES ECKAYNPRPF CKTYTMDKQP LNTGEQKDMT 

      1990       2000       2010       2020       2030       2040 
EFFTDLITKI EEMSPELKNT VKSLFGGVIT NNVVSLDCEH VSQTAEEFYT VRCQVADMKN 

      2050       2060       2070       2080       2090       2100 
IYESLDEVTI KDTLEGDNMY TCSHCGKKVR AEKRACFKKL PRILSFNTMR YTFNMVTMMK 

      2110       2120       2130       2140       2150       2160 
EKVNTHFSFP LRLDMTPYTE DFLMGKSERK EGFKEVSDHS KDSESYEYDL IGVTVHTGTA 

      2170       2180       2190       2200       2210       2220 
DGGHYYSFIR DIVNPHAYKN NKWYLFNDAE VKPFDSAQLA SECFGGEMTT KTYDSVTDKF 

      2230       2240       2250       2260       2270       2280 
MDFSFEKTHS AYMLFYKRME PEEENGREYK FDVSSELLEW IWHDNMQFLQ DKNIFEHTYF 

      2290       2300       2310       2320       2330       2340 
GFMWQLCSCI PSTLPDPKAV SLMTAKLSTS FVLETFIHSK EKPTMLQWIE LLTKQFNNSQ 

      2350       2360       2370       2380       2390       2400 
AACEWFLDRM ADDDWWPMQI LIKCPNQIVR QMFQRLCIHV IQRLRPVHAH LYLQPGMEDG 

      2410       2420       2430       2440       2450       2460 
SDDMDTSVED IGGRSCVTRF VRTLLLIMEH GVKPHSKHLT EYFAFLYEFA KMGEEESQFL 

      2470       2480       2490       2500       2510       2520 
LSLQAISTMV HFYMGTKGPE NPQVEVLSEE EGEEEEEEED ILSLAEEKYR PAALEKMIAL 

      2530       2540       2550       2560       2570       2580 
VALLVEQSRS ERHLTLSQTD MAALTGGKGF PFLFQHIRDG INIRQTCNLI FSLCRYNNRL 

      2590       2600       2610       2620       2630       2640 
AEHIVSMLFT SIAKLTPEAA NPFFKLLTML MEFAGGPPGM PPFASYILQR IWEVIEYNPS 

      2650       2660       2670       2680       2690       2700 
QCLDWLAVQT PRNKLAHSWV LQNMENWVER FLLAHNYPRV RTSAAYLLVS LIPSNSFRQM 

      2710       2720       2730       2740       2750       2760 
FRSTRSLHIP TRDLPLSPDT TVVLHQVYNV LLGLLSRAKL YVDAAVHGTT KLVPYFSFMT 

      2770       2780       2790       2800       2810       2820 
YCLISKTEKL MFSTYFMDLW NLFQPKLSEP AIATNHNKQA LLSFWYNVCA DCPENIRLIV 

      2830       2840       2850       2860       2870       2880 
QNPVVTKNIA FNYILADHDD QDVVLFNRGM LPAYYGILRL CCEQSPAFTR QLASHQNIQW 

      2890       2900       2910       2920       2930       2940 
AFKNLTPHAS QYPGAVEELF NLMQLFIAQR PDMREEELED IKQFKKTTIS CYLRCLDGRS 

      2950       2960       2970       2980       2990       3000 
CWTTLISAFR ILLESDEDRL LVVFNRGLIL MTESFNTLHM MYHEATACHV TGDLVELLSI 

      3010       3020       3030       3040       3050       3060 
FLSVLKSTRP YLQRKDVKQA LIQWQERIEF AHKLLTLLNS YSPPELRNAC IDVLKELVLL 

      3070       3080       3090       3100       3110       3120 
SPHDFLHTLV PFLQHNHCTY HHSNIPMSLG PYFPCRENIK LIGGKSNIRP PRPELNMCLL 

      3130       3140       3150       3160       3170       3180 
PTMVETSKGK DDVYDRMLLD YFFSYHQFIH LLCRVAINCE KFTETLVKLS VLVAYEGLPL 

      3190       3200       3210       3220       3230       3240 
HLALFPKLWT ELCQTQSAMS KNCIKLLCED PVFAEYIKCI LMDERTFLNN NIVYTFMTHF 

      3250       3260       3270       3280       3290       3300 
LLKVQSQVFS EANCANLIST LITNLISQYQ NLQSDFSNRV EISKASASLN GDLRALALLL 

      3310       3320       3330       3340       3350       3360 
SVHTPKQLNP ALIPTLQELL SKCRTCLQQR NSLQEQEAKE RKTKDDEGAT PIKRRRVSSD 

      3370       3380       3390       3400       3410       3420 
EEHTVDSCIS DMKTETREVL TPTSTSDNET RDSSIIDPGT EQDLPSPENS SVKEYRMEVP 

      3430       3440       3450       3460       3470       3480 
SSFSEDMSNI RSQHAEEQSN NGRYDDCKEF KDLHCSKDST LAEEESEFPS TSISAVLSDL 

      3490       3500       3510       3520       3530       3540 
ADLRSCDGQA LPSQDPEVAL SLSCGHSRGL FSHMQQHDIL DTLCRTIEST IHVVTRISGK 


GNQAAS 

« Hide

Isoform 2 [UniParc].

Checksum: 6171809F72C5EE8E
Show »

FASTA3,395387,154
Isoform 3 [UniParc].

Checksum: 4815E0ED77EC1C03
Show »

FASTA3,312377,599

References

« Hide 'large scale' references
[1]"Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases."
Quesada V., Diaz-Perales A., Gutierrez-Fernandez A., Garabaya C., Cal S., Lopez-Otin C.
Biochem. Biophys. Res. Commun. 314:54-62(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, ENZYME ACTIVITY, VARIANT THR-661.
[2]"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT THR-661.
Tissue: Brain.
[3]"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[4]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1723-2532 AND 2629-3546 (ISOFORM 1).
Tissue: Amygdala and Uterus.
[6]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1821-3338.
Tissue: Testis.
[7]"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2351-3546 (ISOFORM 2).
Tissue: Brain.
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2561-3546 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3024-3546 (ISOFORM 3).
Tissue: Brain, Colon and Kidney.
[9]"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.
Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-649, VARIANT [LARGE SCALE ANALYSIS] THR-661, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic kidney.
[10]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-352; SER-3358; SER-3359 AND SER-3406, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[11]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2488, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[12]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]"The Ubiquitin specific protease USP34 regulates Axin stability and Wnt/beta-catenin signaling."
Lui T.T., Lacroix C., Ahmed S.M., Goldenberg S.J., Leach C.A., Daulat A.M., Angers S.
Mol. Cell. Biol. 31:2053-2065(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, CATALYTIC ACTIVITY, INTERACTION WITH AXIN1 AND AXIN2, MUTAGENESIS OF CYS-1903.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ586138 mRNA. Translation: CAE51938.1.
AB011142 mRNA. Translation: BAA25496.2. Different initiation.
AC016747 Genomic DNA. No translation available.
AL050092 mRNA. Translation: CAB43264.1.
AL831918 mRNA. Translation: CAD38579.1.
AK125898 mRNA. Translation: BAG54261.1. Different initiation.
AB018272 mRNA. Translation: BAA34449.1.
BC022783 mRNA. Translation: AAH22783.1.
BC062325 mRNA. Translation: AAH62325.1.
BC107761 mRNA. Translation: AAI07762.1. Frameshift.
PIRT00338.
T13057.
RefSeqNP_055524.3. NM_014709.3.
UniGeneHs.644708.

3D structure databases

ProteinModelPortalQ70CQ2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115085. 40 interactions.
IntActQ70CQ2. 2 interactions.

Protein family/group databases

MEROPSC19.067.

PTM databases

PhosphoSiteQ70CQ2.

Polymorphism databases

DMDM212276488.

Proteomic databases

PaxDbQ70CQ2.
PRIDEQ70CQ2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000398571; ENSP00000381577; ENSG00000115464. [Q70CQ2-1]
ENST00000453734; ENSP00000410559; ENSG00000115464.
GeneID9736.
KEGGhsa:9736.
UCSCuc002sbe.3. human. [Q70CQ2-1]

Organism-specific databases

CTD9736.
GeneCardsGC02M061414.
H-InvDBHIX0002082.
HIX0161884.
HGNCHGNC:20066. USP34.
HPAHPA025815.
MIM615295. gene.
neXtProtNX_Q70CQ2.
PharmGKBPA134897042.
HUGESearch...
Search...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5077.
HOVERGENHBG092616.
InParanoidQ70CQ2.
KOK11853.
OMACLISKTE.
PhylomeDBQ70CQ2.
TreeFamTF323966.

Gene expression databases

ArrayExpressQ70CQ2.
BgeeQ70CQ2.
CleanExHS_USP34.
GenevestigatorQ70CQ2.

Family and domain databases

InterProIPR016024. ARM-type_fold.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF00443. UCH. 1 hit.
[Graphical view]
SUPFAMSSF48371. SSF48371. 4 hits.
PROSITEPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSUSP34. human.
GeneWikiUSP34.
GenomeRNAi9736.
NextBio36636.
PROQ70CQ2.
SOURCESearch...

Entry information

Entry nameUBP34_HUMAN
AccessionPrimary (citable) accession number: Q70CQ2
Secondary accession number(s): A8MWD0 expand/collapse secondary AC list , B3KWU9, O60316, O94834, Q3B777, Q6P6C9, Q7L8P6, Q8N3T9, Q8TBW2, Q9UGA1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: November 4, 2008
Last modified: April 16, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM