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Q70CQ2

- UBP34_HUMAN

UniProt

Q70CQ2 - UBP34_HUMAN

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Protein

Ubiquitin carboxyl-terminal hydrolase 34

Gene

USP34

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.1 Publication

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1903 – 19031NucleophileCurated
Active sitei2164 – 21641Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: UniProtKB
  2. ubiquitin-specific protease activity Source: UniProtKB
  3. ubiquitin thiolesterase activity Source: UniProtKB

GO - Biological processi

  1. positive regulation of canonical Wnt signaling pathway Source: UniProtKB
  2. protein deubiquitination Source: FlyBase
  3. protein K48-linked deubiquitination Source: UniProtKB
  4. ubiquitin-dependent protein catabolic process Source: InterPro
  5. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway, Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_200777. TCF dependent signaling in response to WNT.

Protein family/group databases

MEROPSiC19.067.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 34 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 34
Ubiquitin thioesterase 34
Ubiquitin-specific-processing protease 34
Gene namesi
Name:USP34
Synonyms:KIAA0570, KIAA0729
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:20066. USP34.

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi1903 – 19031C → S: Loss of function. 1 Publication

Organism-specific databases

PharmGKBiPA134897042.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 35463546Ubiquitin carboxyl-terminal hydrolase 34PRO_0000249519Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei352 – 3521Phosphoserine1 Publication
Modified residuei649 – 6491Phosphoserine1 Publication
Modified residuei2488 – 24881Phosphoserine1 Publication
Modified residuei3358 – 33581Phosphoserine1 Publication
Modified residuei3359 – 33591Phosphoserine1 Publication
Modified residuei3406 – 34061Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ70CQ2.
PaxDbiQ70CQ2.
PRIDEiQ70CQ2.

PTM databases

PhosphoSiteiQ70CQ2.

Expressioni

Tissue specificityi

Expressed in brain at low level.1 Publication

Gene expression databases

BgeeiQ70CQ2.
CleanExiHS_USP34.
ExpressionAtlasiQ70CQ2. baseline and differential.
GenevestigatoriQ70CQ2.

Organism-specific databases

HPAiHPA025815.

Interactioni

Subunit structurei

Interacts with AXIN1 and AXIN2.1 Publication

Protein-protein interaction databases

BioGridi115085. 41 interactions.
IntActiQ70CQ2. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ70CQ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1894 – 2239346USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 USP domain.Curated

Phylogenomic databases

eggNOGiCOG5077.
GeneTreeiENSGT00760000119158.
HOVERGENiHBG092616.
InParanoidiQ70CQ2.
KOiK11853.
OMAiCLISKTE.
PhylomeDBiQ70CQ2.
TreeFamiTF323966.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 4 hits.
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q70CQ2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCENCADLVE VLNEISDVEG GDGLQLRKEH TLKIFTYINS WTQRQCLCCF
60 70 80 90 100
KEYKHLEIFN QVVCALINLV IAQVQVLRDQ LCKHCTTINI DSTWQDESNQ
110 120 130 140 150
AEEPLNIDRE CNEGSTERQK SIEKKSNSTR ICNLTEEESS KSSDPFSLWS
160 170 180 190 200
TDEKEKLLLC VAKIFQIQFP LYTAYKHNTH PTIEDISTQE SNILGAFCDM
210 220 230 240 250
NDVEVPLHLL RYVCLFCGKN GLSLMKDCFE YGTPETLPFL IAHAFITVVS
260 270 280 290 300
NIRIWLHIPA VMQHIIPFRT YVIRYLCKLS DQELRQSAAR NMADLMWSTV
310 320 330 340 350
KEPLDTTLCF DKESLDLAFK YFMSPTLTMR LAGLSQITNQ LHTFNDVCNN
360 370 380 390 400
ESLVSDTETS IAKELADWLI SNNVVEHIFG PNLHIEIIKQ CQVILNFLAA
410 420 430 440 450
EGRLSTQHID CIWAAAQLKH CSRYIHDLFP SLIKNLDPVP LRHLLNLVSA
460 470 480 490 500
LEPSVHTEQT LYLASMLIKA LWNNALAAKA QLSKQSSFAS LLNTNIPIGN
510 520 530 540 550
KKEEEELRRT APSPWSPAAS PQSSDNSDTH QSGGSDIEMD EQLINRTKHV
560 570 580 590 600
QQRLSDTEES MQGSSDETAN SGEDGSSGPG SSSGHSDGSS NEVNSSHASQ
610 620 630 640 650
SAGSPGSEVQ SEDIADIEAL KEEDEDDDHG HNPPKSSCGT DLRNRKLESQ
660 670 680 690 700
AGICLGDSQG MSERNGTSSG TGKDLVFNTE SLPSVDNRMR MLDACSHSED
710 720 730 740 750
PEHDISGEMN ATHIAQGSQE SCITRTGDFL GETIGNELFN CRQFIGPQHH
760 770 780 790 800
HHHHHHHHHH DGHMVDDMLS ADDVSCSSSQ VSAKSEKNMA DFDGEESGCE
810 820 830 840 850
EELVQINSHA ELTSHLQQHL PNLASIYHEH LSQGPVVHKH QFNSNAVTDI
860 870 880 890 900
NLDNVCKKGN TLLWDIVQDE DAVNLSEGLI NEAEKLLCSL VCWFTDRQIR
910 920 930 940 950
MRFIEGCLEN LGNNRSVVIS LRLLPKLFGT FQQFGSSYDT HWITMWAEKE
960 970 980 990 1000
LNMMKLFFDN LVYYIQTVRE GRQKHALYSH SAEVQVRLQF LTCVFSTLGS
1010 1020 1030 1040 1050
PDHFRLSLEQ VDILWHCLVE DSECYDDALH WFLNQVRSKD QHAMGMETYK
1060 1070 1080 1090 1100
HLFLEKMPQL KPETISMTGL NLFQHLCNLA RLATSAYDGC SNSELCGMDQ
1110 1120 1130 1140 1150
FWGIALRAQS GDVSRAAIQY INSYYINGKT GLEKEQEFIS KCMESLMIAS
1160 1170 1180 1190 1200
SSLEQESHSS LMVIERGLLM LKTHLEAFRR RFAYHLRQWQ IEGTGISSHL
1210 1220 1230 1240 1250
KALSDKQSLP LRVVCQPAGL PDKMTIEMYP SDQVADLRAE VTHWYENLQK
1260 1270 1280 1290 1300
EQINQQAQLQ EFGQSNRKGE FPGGLMGPVR MISSGHELTT DYDEKALHEL
1310 1320 1330 1340 1350
GFKDMQMVFV SLGAPRRERK GEGVQLPASC LPPPQKDNIP MLLLLQEPHL
1360 1370 1380 1390 1400
TTLFDLLEML ASFKPPSGKV AVDDSESLRC EELHLHAENL SRRVWELLML
1410 1420 1430 1440 1450
LPTCPNMLMA FQNISDEQSN DGFNWKELLK IKSAHKLLYA LEIIEALGKP
1460 1470 1480 1490 1500
NRRIRRESTG SYSDLYPDSD DSSEDQVENS KNSWSCKFVA AGGLQQLLEI
1510 1520 1530 1540 1550
FNSGILEPKE QESWTVWQLD CLACLLKLIC QFAVDPSDLD LAYHDVFAWS
1560 1570 1580 1590 1600
GIAESHRKRT WPGKSRKAAG DHAKGLHIPR LTEVFLVLVQ GTSLIQRLMS
1610 1620 1630 1640 1650
VAYTYDNLAP RVLKAQSDHR SRHEVSHYSM WLLVSWAHCC SLVKSSLADS
1660 1670 1680 1690 1700
DHLQDWLKKL TLLIPETAVR HESCSGLYKL SLSGLDGGDS INRSFLLLAA
1710 1720 1730 1740 1750
STLLKFLPDA QALKPIRIDD YEEEPILKPG CKEYFWLLCK LVDNIHIKDA
1760 1770 1780 1790 1800
SQTTLLDLDA LARHLADCIR SREILDHQDG NVEDDGLTGL LRLATSVVKH
1810 1820 1830 1840 1850
KPPFKFSREG QEFLRDIFNL LFLLPSLKDR QQPKCKSHSS RAAAYDLLVE
1860 1870 1880 1890 1900
MVKGSVENYR LIHNWVMAQH MQSHAPYKWD YWPHEDVRAE CRFVGLTNLG
1910 1920 1930 1940 1950
ATCYLASTIQ QLYMIPEARQ AVFTAKYSED MKHKTTLLEL QKMFTYLMES
1960 1970 1980 1990 2000
ECKAYNPRPF CKTYTMDKQP LNTGEQKDMT EFFTDLITKI EEMSPELKNT
2010 2020 2030 2040 2050
VKSLFGGVIT NNVVSLDCEH VSQTAEEFYT VRCQVADMKN IYESLDEVTI
2060 2070 2080 2090 2100
KDTLEGDNMY TCSHCGKKVR AEKRACFKKL PRILSFNTMR YTFNMVTMMK
2110 2120 2130 2140 2150
EKVNTHFSFP LRLDMTPYTE DFLMGKSERK EGFKEVSDHS KDSESYEYDL
2160 2170 2180 2190 2200
IGVTVHTGTA DGGHYYSFIR DIVNPHAYKN NKWYLFNDAE VKPFDSAQLA
2210 2220 2230 2240 2250
SECFGGEMTT KTYDSVTDKF MDFSFEKTHS AYMLFYKRME PEEENGREYK
2260 2270 2280 2290 2300
FDVSSELLEW IWHDNMQFLQ DKNIFEHTYF GFMWQLCSCI PSTLPDPKAV
2310 2320 2330 2340 2350
SLMTAKLSTS FVLETFIHSK EKPTMLQWIE LLTKQFNNSQ AACEWFLDRM
2360 2370 2380 2390 2400
ADDDWWPMQI LIKCPNQIVR QMFQRLCIHV IQRLRPVHAH LYLQPGMEDG
2410 2420 2430 2440 2450
SDDMDTSVED IGGRSCVTRF VRTLLLIMEH GVKPHSKHLT EYFAFLYEFA
2460 2470 2480 2490 2500
KMGEEESQFL LSLQAISTMV HFYMGTKGPE NPQVEVLSEE EGEEEEEEED
2510 2520 2530 2540 2550
ILSLAEEKYR PAALEKMIAL VALLVEQSRS ERHLTLSQTD MAALTGGKGF
2560 2570 2580 2590 2600
PFLFQHIRDG INIRQTCNLI FSLCRYNNRL AEHIVSMLFT SIAKLTPEAA
2610 2620 2630 2640 2650
NPFFKLLTML MEFAGGPPGM PPFASYILQR IWEVIEYNPS QCLDWLAVQT
2660 2670 2680 2690 2700
PRNKLAHSWV LQNMENWVER FLLAHNYPRV RTSAAYLLVS LIPSNSFRQM
2710 2720 2730 2740 2750
FRSTRSLHIP TRDLPLSPDT TVVLHQVYNV LLGLLSRAKL YVDAAVHGTT
2760 2770 2780 2790 2800
KLVPYFSFMT YCLISKTEKL MFSTYFMDLW NLFQPKLSEP AIATNHNKQA
2810 2820 2830 2840 2850
LLSFWYNVCA DCPENIRLIV QNPVVTKNIA FNYILADHDD QDVVLFNRGM
2860 2870 2880 2890 2900
LPAYYGILRL CCEQSPAFTR QLASHQNIQW AFKNLTPHAS QYPGAVEELF
2910 2920 2930 2940 2950
NLMQLFIAQR PDMREEELED IKQFKKTTIS CYLRCLDGRS CWTTLISAFR
2960 2970 2980 2990 3000
ILLESDEDRL LVVFNRGLIL MTESFNTLHM MYHEATACHV TGDLVELLSI
3010 3020 3030 3040 3050
FLSVLKSTRP YLQRKDVKQA LIQWQERIEF AHKLLTLLNS YSPPELRNAC
3060 3070 3080 3090 3100
IDVLKELVLL SPHDFLHTLV PFLQHNHCTY HHSNIPMSLG PYFPCRENIK
3110 3120 3130 3140 3150
LIGGKSNIRP PRPELNMCLL PTMVETSKGK DDVYDRMLLD YFFSYHQFIH
3160 3170 3180 3190 3200
LLCRVAINCE KFTETLVKLS VLVAYEGLPL HLALFPKLWT ELCQTQSAMS
3210 3220 3230 3240 3250
KNCIKLLCED PVFAEYIKCI LMDERTFLNN NIVYTFMTHF LLKVQSQVFS
3260 3270 3280 3290 3300
EANCANLIST LITNLISQYQ NLQSDFSNRV EISKASASLN GDLRALALLL
3310 3320 3330 3340 3350
SVHTPKQLNP ALIPTLQELL SKCRTCLQQR NSLQEQEAKE RKTKDDEGAT
3360 3370 3380 3390 3400
PIKRRRVSSD EEHTVDSCIS DMKTETREVL TPTSTSDNET RDSSIIDPGT
3410 3420 3430 3440 3450
EQDLPSPENS SVKEYRMEVP SSFSEDMSNI RSQHAEEQSN NGRYDDCKEF
3460 3470 3480 3490 3500
KDLHCSKDST LAEEESEFPS TSISAVLSDL ADLRSCDGQA LPSQDPEVAL
3510 3520 3530 3540
SLSCGHSRGL FSHMQQHDIL DTLCRTIEST IHVVTRISGK GNQAAS
Length:3,546
Mass (Da):404,233
Last modified:November 4, 2008 - v2
Checksum:iA31851911D990044
GO
Isoform 2 (identifier: Q70CQ2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-139: Missing.
     140-162: SKSSDPFSLWSTDEKEKLLLCVA → MRRKNSYYVWQ

Show »
Length:3,395
Mass (Da):387,154
Checksum:i6171809F72C5EE8E
GO
Isoform 3 (identifier: Q70CQ2-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-139: Missing.
     140-162: SKSSDPFSLWSTDEKEKLLLCVA → MRRKNSYYVWQ
     2936-3018: Missing.

Note: No experimental confirmation available.

Show »
Length:3,312
Mass (Da):377,599
Checksum:i4815E0ED77EC1C03
GO

Sequence cautioni

The sequence AAI07762.1 differs from that shown. Reason: Frameshift at position 3200.
The sequence BAA25496.2 differs from that shown. Reason: Erroneous initiation.
The sequence BAG54261.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti661 – 6611M → T.3 Publications
Corresponds to variant rs6722430 [ dbSNP | Ensembl ].
VAR_047106
Natural varianti1663 – 16631L → R.
Corresponds to variant rs6723818 [ dbSNP | Ensembl ].
VAR_047107
Natural varianti2348 – 23481D → N.
Corresponds to variant rs4386306 [ dbSNP | Ensembl ].
VAR_047108

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 139139Missing in isoform 2 and isoform 3. 4 PublicationsVSP_035639Add
BLAST
Alternative sequencei140 – 16223SKSSD…LLCVA → MRRKNSYYVWQ in isoform 2 and isoform 3. 4 PublicationsVSP_035640Add
BLAST
Alternative sequencei2936 – 301883Missing in isoform 3. 1 PublicationVSP_020463Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ586138 mRNA. Translation: CAE51938.1.
AB011142 mRNA. Translation: BAA25496.2. Different initiation.
AC016747 Genomic DNA. No translation available.
AL050092 mRNA. Translation: CAB43264.1.
AL831918 mRNA. Translation: CAD38579.1.
AK125898 mRNA. Translation: BAG54261.1. Different initiation.
AB018272 mRNA. Translation: BAA34449.1.
BC022783 mRNA. Translation: AAH22783.1.
BC062325 mRNA. Translation: AAH62325.1.
BC107761 mRNA. Translation: AAI07762.1. Frameshift.
CCDSiCCDS42686.1. [Q70CQ2-1]
PIRiT00338.
T13057.
RefSeqiNP_055524.3. NM_014709.3. [Q70CQ2-1]
UniGeneiHs.644708.

Genome annotation databases

EnsembliENST00000398571; ENSP00000381577; ENSG00000115464. [Q70CQ2-1]
ENST00000453734; ENSP00000410559; ENSG00000115464.
GeneIDi9736.
KEGGihsa:9736.
UCSCiuc002sbe.3. human. [Q70CQ2-1]

Polymorphism databases

DMDMi212276488.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ586138 mRNA. Translation: CAE51938.1 .
AB011142 mRNA. Translation: BAA25496.2 . Different initiation.
AC016747 Genomic DNA. No translation available.
AL050092 mRNA. Translation: CAB43264.1 .
AL831918 mRNA. Translation: CAD38579.1 .
AK125898 mRNA. Translation: BAG54261.1 . Different initiation.
AB018272 mRNA. Translation: BAA34449.1 .
BC022783 mRNA. Translation: AAH22783.1 .
BC062325 mRNA. Translation: AAH62325.1 .
BC107761 mRNA. Translation: AAI07762.1 . Frameshift.
CCDSi CCDS42686.1. [Q70CQ2-1 ]
PIRi T00338.
T13057.
RefSeqi NP_055524.3. NM_014709.3. [Q70CQ2-1 ]
UniGenei Hs.644708.

3D structure databases

ProteinModelPortali Q70CQ2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115085. 41 interactions.
IntActi Q70CQ2. 2 interactions.

Protein family/group databases

MEROPSi C19.067.

PTM databases

PhosphoSitei Q70CQ2.

Polymorphism databases

DMDMi 212276488.

Proteomic databases

MaxQBi Q70CQ2.
PaxDbi Q70CQ2.
PRIDEi Q70CQ2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000398571 ; ENSP00000381577 ; ENSG00000115464 . [Q70CQ2-1 ]
ENST00000453734 ; ENSP00000410559 ; ENSG00000115464 .
GeneIDi 9736.
KEGGi hsa:9736.
UCSCi uc002sbe.3. human. [Q70CQ2-1 ]

Organism-specific databases

CTDi 9736.
GeneCardsi GC02M061414.
H-InvDB HIX0002082.
HIX0161884.
HGNCi HGNC:20066. USP34.
HPAi HPA025815.
MIMi 615295. gene.
neXtProti NX_Q70CQ2.
PharmGKBi PA134897042.
HUGEi Search...
Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5077.
GeneTreei ENSGT00760000119158.
HOVERGENi HBG092616.
InParanoidi Q70CQ2.
KOi K11853.
OMAi CLISKTE.
PhylomeDBi Q70CQ2.
TreeFami TF323966.

Enzyme and pathway databases

Reactomei REACT_200777. TCF dependent signaling in response to WNT.

Miscellaneous databases

ChiTaRSi USP34. human.
GeneWikii USP34.
GenomeRNAii 9736.
NextBioi 36636.
PROi Q70CQ2.
SOURCEi Search...

Gene expression databases

Bgeei Q70CQ2.
CleanExi HS_USP34.
ExpressionAtlasi Q70CQ2. baseline and differential.
Genevestigatori Q70CQ2.

Family and domain databases

InterProi IPR016024. ARM-type_fold.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 4 hits.
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases."
    Quesada V., Diaz-Perales A., Gutierrez-Fernandez A., Garabaya C., Cal S., Lopez-Otin C.
    Biochem. Biophys. Res. Commun. 314:54-62(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, ENZYME ACTIVITY, VARIANT THR-661.
  2. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT THR-661.
    Tissue: Brain.
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1723-2532 AND 2629-3546 (ISOFORM 1).
    Tissue: Amygdala and Uterus.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1821-3338.
    Tissue: Testis.
  7. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2351-3546 (ISOFORM 2).
    Tissue: Brain.
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2561-3546 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3024-3546 (ISOFORM 3).
    Tissue: Brain, Colon and Kidney.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-649, VARIANT [LARGE SCALE ANALYSIS] THR-661, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-352; SER-3358; SER-3359 AND SER-3406, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2488, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "The Ubiquitin specific protease USP34 regulates Axin stability and Wnt/beta-catenin signaling."
    Lui T.T., Lacroix C., Ahmed S.M., Goldenberg S.J., Leach C.A., Daulat A.M., Angers S.
    Mol. Cell. Biol. 31:2053-2065(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY, INTERACTION WITH AXIN1 AND AXIN2, MUTAGENESIS OF CYS-1903.

Entry informationi

Entry nameiUBP34_HUMAN
AccessioniPrimary (citable) accession number: Q70CQ2
Secondary accession number(s): A8MWD0
, B3KWU9, O60316, O94834, Q3B777, Q6P6C9, Q7L8P6, Q8N3T9, Q8TBW2, Q9UGA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: November 4, 2008
Last modified: October 29, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3