Q709C8 (VP13C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Vacuolar protein sorting-associated protein 13C

Gene names

Name:	VPS13C
Synonyms:	KIAA1421

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	3753 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Tissue specificity	Widely expressed. Ref.1
Sequence similarities	Belongs to the VPS13 family.
Sequence caution	The sequence BAA90972.1 differs from that shown. Reason: Erroneous initiation. The sequence BAA92659.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
PTM	Acetylation Isopeptide bond Phosphoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 Ref.1 (identifier: Q709C8-1)

Also known as: 2A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 Ref.1 (identifier: Q709C8-2)

Also known as: 2B;

The sequence of this isoform differs from the canonical sequence as follows:
     3622-3627: NHIKKL → QELEIQE
     3628-3753: Missing.

Isoform 3 Ref.1 (identifier: Q709C8-3)

Also known as: 1A;

The sequence of this isoform differs from the canonical sequence as follows:
     129-171: Missing.

Isoform 4 Ref.1 (identifier: Q709C8-4)

Also known as: 1B;

The sequence of this isoform differs from the canonical sequence as follows:
     129-171: Missing.
     3622-3627: NHIKKL → QELEIQE
     3628-3753: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 3753	3753	Vacuolar protein sorting-associated protein 13C		PRO_0000262949
Regions
	Compositional bias	145 – 179	35	Lys-rich
Amino acid modifications
	Modified residue	614	1	Phosphothreonine Ref.6
	Modified residue	619	1	Phosphoserine Ref.6
	Modified residue	624	1	Phosphothreonine Ref.6
	Modified residue	737	1	Phosphoserine Ref.6
	Modified residue	1437	1	Phosphothreonine By similarity
	Modified residue	1979	1	Phosphoserine By similarity
	Modified residue	3538	1	N6-acetyllysine Ref.7
	Cross-link	2357		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.5
Natural variations
	Alternative sequence	129 – 171	43	Missing in isoform 3 and isoform 4. Ref.1		VSP_052243
	Alternative sequence	3622 – 3627	6	NHIKKL → QELEIQE in isoform 2 and isoform 4. Ref.1		VSP_052244
	Alternative sequence	3628 – 3753	126	Missing in isoform 2 and isoform 4. Ref.1		VSP_052245
	Natural variant	153	1	R → H. Corresponds to variant rs12595158 [ dbSNP | Ensembl ].		VAR_029548
	Natural variant	974	1	R → K. Ref.2 Corresponds to variant rs3784634 [ dbSNP | Ensembl ].		VAR_029549
	Natural variant	1132	1	I → V. Corresponds to variant rs3784635 [ dbSNP | Ensembl ].		VAR_029550
	Natural variant	1302	1	Y → C. Corresponds to variant rs2303405 [ dbSNP | Ensembl ].		VAR_029551
	Natural variant	1485	1	T → A. Corresponds to variant rs8026956 [ dbSNP | Ensembl ].		VAR_029552
	Natural variant	1495	1	I → V. Corresponds to variant rs11629598 [ dbSNP | Ensembl ].		VAR_029553
	Natural variant	1592	1	S → Y. Corresponds to variant rs11629838 [ dbSNP | Ensembl ].		VAR_029554
	Natural variant	2322	1	V → M. Corresponds to variant rs12907567 [ dbSNP | Ensembl ].		VAR_029555
	Natural variant	2808	1	K → R. Corresponds to variant rs34060567 [ dbSNP | Ensembl ].		VAR_053808
	Natural variant	2913	1	S → N. Corresponds to variant rs10851704 [ dbSNP | Ensembl ].		VAR_029556

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (2A) [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 8B51A6778A89F639	FASTA	3,753	422,390
	10 20 30 40 50 60 MVLESVVADL LNRFLGDYVE NLNKSQLKLG IWGGNVALDN LQIKENALSE LDVPFKVKAG 70 80 90 100 110 120 QIDKLTLKIP WKNLYGEAVV ATLEGLYLLV VPGASIKYDA VKEEKSLQDV KQKELSRIEE 130 140 150 160 170 180 ALQKAAEKGT HSGEFIYGLE NFVYKDIKPG RKRKKHKKHF KKPFKGLDRS KDKPKEAKKD 190 200 210 220 230 240 TFVEKLATQV IKNVQVKITD IHIKYEDDVT DPKRPLSFGV TLGELSLLTA NEHWTPCILN 250 260 270 280 290 300 EADKIIYKLI RLDSLSAYWN VNCSMSYQRS REQILDQLKN EILTSGNIPP NYQYIFQPIS 310 320 330 340 350 360 ASAKLYMNPY AESELKTPKL DCNIEIQNIA IELTKPQYLS MIDLLESVDY MVRNAPYRKY 370 380 390 400 410 420 KPYLPLHTNG RRWWKYAIDS VLEVHIRRYT QMWSWSNIKK HRQLLKSYKI AYKNKLTQSK 430 440 450 460 470 480 VSEEIQKEIQ DLEKTLDVFN IILARQQAQV EVIRSGQKLR KKSADTGEKR GGWFSGLWGK 490 500 510 520 530 540 KESKKKDEES LIPETIDDLM TPEEKDKLFT AIGYSESTHN LTLPKQYVAH IMTLKLVSTS 550 560 570 580 590 600 VTIRENKNIP EILKIQIIGL GTQVSQRPGA QALKVEAKLE HWYITGLRQQ DIVPSLVASI 610 620 630 640 650 660 GDTTSSLLKI KFETNPEDSP ADQTLIVQSQ PVEVIYDAKT VNAVVEFFQS NKGLDLEQIT 670 680 690 700 710 720 SATLMKLEEI KERTATGLTH IIETRKVLDL RINLKPSYLV VPQTGFHHEK SDLLILDFGT 730 740 750 760 770 780 FQLNSKDQGL QKTTNSSLEE IMDKAYDKFD VEIKNVQLLF ARAEETWKKC RFQHPSTMHI 790 800 810 820 830 840 LQPMDIHVEL AKAMVEKDIR MARFKVSGGL PLMHVRISDQ KMKDVLYLMN SIPLPQKSSA 850 860 870 880 890 900 QSPERQVSSI PIISGGTKGL LGTSLLLDTV ESESDDEYFD AEDGEPQTCK SMKGSELKKA 910 920 930 940 950 960 AEVPNEELIN LLLKFEIKEV ILEFTKQQKE EDTILVFNVT QLGTEATMRT FDLTVVSYLK 970 980 990 1000 1010 1020 KISLDYHEIE GSKRKPLHLI SSSDKPGLDL LKVEYIKADK NGPSFQTAFG KTEQTVKVAF 1030 1040 1050 1060 1070 1080 SSLNLLLQTQ ALVASINYLT TIIPSDDQSI SVAKEVQIST EKQQKNSTLP KAIVSSRDSD 1090 1100 1110 1120 1130 1140 IIDFRLFAKL NAFCVIVCNE KNNIAEIKIQ GLDSSLSLQS RKQSLFARLE NIIVTDVDPK 1150 1160 1170 1180 1190 1200 TVHKKAVSIM GNEVFRFNLD LYPDATEGDL YTDMSKVDGV LSLNVGCIQI VYLHKFLMSL 1210 1220 1230 1240 1250 1260 LNFLNNFQTA KESLSAATAQ AAERAATSVK DLAQRSFRVS INIDLKAPVI VIPQSSISTN 1270 1280 1290 1300 1310 1320 AVVVDLGLIR VHNQFSLVSD EDYLNPPVID RMDVQLTKLT LYRTVIQPGI YHPDIQLLHP 1330 1340 1350 1360 1370 1380 INLEFLVNRN LAASWYHKVP VVEIKGHLDS MNVSLNQEDL NLLFRILTEN LCEGTEDLDK 1390 1400 1410 1420 1430 1440 VKPRVQETGE IKEPLEISIS QDVHDSKNTL TTGVEEIRSV DIINMLLNFE IKEVVVTLMK 1450 1460 1470 1480 1490 1500 KSEKKGRPLH ELNVLQLGME AKVKTYDMTA KAYLKKISMQ CFDFTDSKGE PLHIINSSNV 1510 1520 1530 1540 1550 1560 TDEPLLKMLL TKADSDGPEF KTIHDSTKQR LKVSFASLDL VLHLEALLSF MDFLSSAAPF 1570 1580 1590 1600 1610 1620 SEPSSSEKES ELKPLVGESR SIAVKAVSSN ISQKDVFDLK ITAELNAFNV FVCDQKCNIA 1630 1640 1650 1660 1670 1680 DIKIHGMDAS ISVKPKQTDV FARLKDIIVM NVDLQSIHKK AVSILGDEVF RFQLTLYPDA 1690 1700 1710 1720 1730 1740 TEGEAYADMS KVDGKLSFKV GCIQIVYVHK FFMSLLNFLN NFQTAKEALS TATVQAAERA 1750 1760 1770 1780 1790 1800 ASSMKDLAQK SFRLLMDINL KAPVIIIPQS SVSPNAVIAD LGLIRVENKF SLVPMEHYSL 1810 1820 1830 1840 1850 1860 PPVIDKMNIE LTQLKLSRTI LQASLPQNDI EILKPVNMLL SIQRNLAAAW YVQIPGMEIK 1870 1880 1890 1900 1910 1920 GKLKPMQVAL SEDDLTVLMK ILLENLGEAS SQPSPTQSVQ ETVRVRKVDV SSVPDHLKEQ 1930 1940 1950 1960 1970 1980 EDWTDSKLSM NQIVSLQFDF HFESLSIILY NNDINQESGV AFHNDSFQLG ELRLHLMASS 1990 2000 2010 2020 2030 2040 GKMFKDGSMN VSVKLKTCTL DDLREGIERA TSRMIDRKND QDNNSSMIDI SYKQDKNGSQ 2050 2060 2070 2080 2090 2100 IDAVLDKLYV CASVEFLMTV ADFFIKAVPQ SPENVAKETQ ILPRQTATGK VKIEKDDSVR 2110 2120 2130 2140 2150 2160 PNMTLKAMIT DPEVVFVASL TKADAPALTA SFQCNLSLST SKLEQMMEAS VRDLKVLACP 2170 2180 2190 2200 2210 2220 FLREKRGKNI TTVLQPCSLF MEKCTWASGK QNINIMVKEF IIKISPIILN TVLTIMAALS 2230 2240 2250 2260 2270 2280 PKTKEDGSKD TSKEMENLWG IKSINDYNTW FLGVDTATEI TESFKGIEHS LIEENCGVVV 2290 2300 2310 2320 2330 2340 ESIQVTLECG LGHRTVPLLL AESKFSGNIK NWTSLMAAVA DVTLQVHYYN EIHAVWEPLI 2350 2360 2370 2380 2390 2400 ERVEGKRQWN LRLDVKKNPV QDKSLLPGDD FIPEPQMAIH ISSGNTMNIT ISKSCLNVFN 2410 2420 2430 2440 2450 2460 NLAKGFSEGT ASTFDYSLKD RAPFTVKNAV GVPIKVKPNC NLRVMGFPEK SDIFDVDAGQ 2470 2480 2490 2500 2510 2520 NLELEYASMV PSSQGNLSIL SRQESSFFTL TIVPHGYTEV ANIPVARPGR RLYNVRNPNA 2530 2540 2550 2560 2570 2580 SHSDSVLVQI DATEGNKVIT LRSPLQIKNH FSIAFIIYKF VKNVKLLERI GIARPEEEFH 2590 2600 2610 2620 2630 2640 VPLDSYRCQL FIQPAGILEH QYKESTTYIS WKEELHRSRE VRCMLQCPSV EVSFLPLIVN 2650 2660 2670 2680 2690 2700 TVALPDELSY ICTHGEDWDV AYIIHLYPSL TLRNLLPYSL RYLLEGTAET HELAEGSTAD 2710 2720 2730 2740 2750 2760 VLHSRISGEI MELVLVKYQG KNWNGHFRIR DTLPEFFPVC FSSDSTEVTT VDLSVHVRRI 2770 2780 2790 2800 2810 2820 GSRMVLSVFS PYWLINKTTR VLQYRSEDIH VKHPADFRDI ILFSFKKKNI FTKNKVQLKI 2830 2840 2850 2860 2870 2880 STSAWSSSFS LDTVGSYGCV KCPANNMEYL VGVSIKMSSF NLSRIVTLTP FCTIANKSSL 2890 2900 2910 2920 2930 2940 ELEVGEIASD GSMPTNKWNY IASSECLPFW PESLSGKLCV RVVGCEGSSK PFFYNRQDNG 2950 2960 2970 2980 2990 3000 TLLSLEDLNG GILVDVNTAE HSTVITFSDY HEGSAPALIM NHTPWDILTY KQSGSPEEMV 3010 3020 3030 3040 3050 3060 LLPRQARLFA WADPTGTRKL TWTYAANVGE HDLLKDGCGQ FPYDANIQIH WVSFLDGRQR 3070 3080 3090 3100 3110 3120 VLLFTDDVAL VSKALQAEEM EQADYEITLS LHSLGLSLVN NESKQEVSYI GITSSGVVWE 3130 3140 3150 3160 3170 3180 VKPKQKWKPF SQKQIILLEQ SYQKHQISRD HGWIKLDNNF EVNFDKDPME MRLPIRSPIK 3190 3200 3210 3220 3230 3240 RDFLSGIQIE FKQSSHQRSL RARLYWLQVD NQLPGAMFPV VFHPVAPPKS IALDSEPKPF 3250 3260 3270 3280 3290 3300 IDVSVITRFN EYSKVLQFKY FMVLIQEMAL KIDQGFLGAI IALFTPTTDP EAERRRTKLI 3310 3320 3330 3340 3350 3360 QQDIDALNAE LMETSMTDMS ILSFFEHFHI SPVKLHLSLS LGSGGEESDK EKQEMFAVHS 3370 3380 3390 3400 3410 3420 VNLLLKSIGA TLTDVDDLIF KLAYYEIRYQ FYKRDQLIWS VVRHYSEQFL KQMYVLVLGL 3430 3440 3450 3460 3470 3480 DVLGNPFGLI RGLSEGVEAL FYEPFQGAVQ GPEEFAEGLV IGVRSLFGHT VGGAAGVVSR 3490 3500 3510 3520 3530 3540 ITGSVGKGLA AITMDKEYQQ KRREELSRQP RDFGDSLARG GKGFLRGVVG GVTGIITKPV 3550 3560 3570 3580 3590 3600 EGAKKEGAAG FFKGIGKGLV GAVARPTGGI VDMASSTFQG IQRAAESTEE VSSLRPPRLI 3610 3620 3630 3640 3650 3660 HEDGIIRPYD RQESEGSDLL ENHIKKLEGE TYRYHCAIPG SKKTILMVTN RRVLCIKEVE 3670 3680 3690 3700 3710 3720 ILGLMCVDWQ CPFEDFVFPP SVSENVLKIS VKEQGLFHKK DSANQGCVRK VYLKDTATAE 3730 3740 3750 RACNAIEDAQ STRQQQKLMK QSSVRLLRPQ LPS
	Isoform 2 (2B) [UniParc]. Checksum: 23C6AE1C69EEB060	FASTA	3,628	408,198
	10 20 30 40 50 60 MVLESVVADL LNRFLGDYVE NLNKSQLKLG IWGGNVALDN LQIKENALSE LDVPFKVKAG 70 80 90 100 110 120 QIDKLTLKIP WKNLYGEAVV ATLEGLYLLV VPGASIKYDA VKEEKSLQDV KQKELSRIEE 130 140 150 160 170 180 ALQKAAEKGT HSGEFIYGLE NFVYKDIKPG RKRKKHKKHF KKPFKGLDRS KDKPKEAKKD 190 200 210 220 230 240 TFVEKLATQV IKNVQVKITD IHIKYEDDVT DPKRPLSFGV TLGELSLLTA NEHWTPCILN 250 260 270 280 290 300 EADKIIYKLI RLDSLSAYWN VNCSMSYQRS REQILDQLKN EILTSGNIPP NYQYIFQPIS 310 320 330 340 350 360 ASAKLYMNPY AESELKTPKL DCNIEIQNIA IELTKPQYLS MIDLLESVDY MVRNAPYRKY 370 380 390 400 410 420 KPYLPLHTNG RRWWKYAIDS VLEVHIRRYT QMWSWSNIKK HRQLLKSYKI AYKNKLTQSK 430 440 450 460 470 480 VSEEIQKEIQ DLEKTLDVFN IILARQQAQV EVIRSGQKLR KKSADTGEKR GGWFSGLWGK 490 500 510 520 530 540 KESKKKDEES LIPETIDDLM TPEEKDKLFT AIGYSESTHN LTLPKQYVAH IMTLKLVSTS 550 560 570 580 590 600 VTIRENKNIP EILKIQIIGL GTQVSQRPGA QALKVEAKLE HWYITGLRQQ DIVPSLVASI 610 620 630 640 650 660 GDTTSSLLKI KFETNPEDSP ADQTLIVQSQ PVEVIYDAKT VNAVVEFFQS NKGLDLEQIT 670 680 690 700 710 720 SATLMKLEEI KERTATGLTH IIETRKVLDL RINLKPSYLV VPQTGFHHEK SDLLILDFGT 730 740 750 760 770 780 FQLNSKDQGL QKTTNSSLEE IMDKAYDKFD VEIKNVQLLF ARAEETWKKC RFQHPSTMHI 790 800 810 820 830 840 LQPMDIHVEL AKAMVEKDIR MARFKVSGGL PLMHVRISDQ KMKDVLYLMN SIPLPQKSSA 850 860 870 880 890 900 QSPERQVSSI PIISGGTKGL LGTSLLLDTV ESESDDEYFD AEDGEPQTCK SMKGSELKKA 910 920 930 940 950 960 AEVPNEELIN LLLKFEIKEV ILEFTKQQKE EDTILVFNVT QLGTEATMRT FDLTVVSYLK 970 980 990 1000 1010 1020 KISLDYHEIE GSKRKPLHLI SSSDKPGLDL LKVEYIKADK NGPSFQTAFG KTEQTVKVAF 1030 1040 1050 1060 1070 1080 SSLNLLLQTQ ALVASINYLT TIIPSDDQSI SVAKEVQIST EKQQKNSTLP KAIVSSRDSD 1090 1100 1110 1120 1130 1140 IIDFRLFAKL NAFCVIVCNE KNNIAEIKIQ GLDSSLSLQS RKQSLFARLE NIIVTDVDPK 1150 1160 1170 1180 1190 1200 TVHKKAVSIM GNEVFRFNLD LYPDATEGDL YTDMSKVDGV LSLNVGCIQI VYLHKFLMSL 1210 1220 1230 1240 1250 1260 LNFLNNFQTA KESLSAATAQ AAERAATSVK DLAQRSFRVS INIDLKAPVI VIPQSSISTN 1270 1280 1290 1300 1310 1320 AVVVDLGLIR VHNQFSLVSD EDYLNPPVID RMDVQLTKLT LYRTVIQPGI YHPDIQLLHP 1330 1340 1350 1360 1370 1380 INLEFLVNRN LAASWYHKVP VVEIKGHLDS MNVSLNQEDL NLLFRILTEN LCEGTEDLDK 1390 1400 1410 1420 1430 1440 VKPRVQETGE IKEPLEISIS QDVHDSKNTL TTGVEEIRSV DIINMLLNFE IKEVVVTLMK 1450 1460 1470 1480 1490 1500 KSEKKGRPLH ELNVLQLGME AKVKTYDMTA KAYLKKISMQ CFDFTDSKGE PLHIINSSNV 1510 1520 1530 1540 1550 1560 TDEPLLKMLL TKADSDGPEF KTIHDSTKQR LKVSFASLDL VLHLEALLSF MDFLSSAAPF 1570 1580 1590 1600 1610 1620 SEPSSSEKES ELKPLVGESR SIAVKAVSSN ISQKDVFDLK ITAELNAFNV FVCDQKCNIA 1630 1640 1650 1660 1670 1680 DIKIHGMDAS ISVKPKQTDV FARLKDIIVM NVDLQSIHKK AVSILGDEVF RFQLTLYPDA 1690 1700 1710 1720 1730 1740 TEGEAYADMS KVDGKLSFKV GCIQIVYVHK FFMSLLNFLN NFQTAKEALS TATVQAAERA 1750 1760 1770 1780 1790 1800 ASSMKDLAQK SFRLLMDINL KAPVIIIPQS SVSPNAVIAD LGLIRVENKF SLVPMEHYSL 1810 1820 1830 1840 1850 1860 PPVIDKMNIE LTQLKLSRTI LQASLPQNDI EILKPVNMLL SIQRNLAAAW YVQIPGMEIK 1870 1880 1890 1900 1910 1920 GKLKPMQVAL SEDDLTVLMK ILLENLGEAS SQPSPTQSVQ ETVRVRKVDV SSVPDHLKEQ 1930 1940 1950 1960 1970 1980 EDWTDSKLSM NQIVSLQFDF HFESLSIILY NNDINQESGV AFHNDSFQLG ELRLHLMASS 1990 2000 2010 2020 2030 2040 GKMFKDGSMN VSVKLKTCTL DDLREGIERA TSRMIDRKND QDNNSSMIDI SYKQDKNGSQ 2050 2060 2070 2080 2090 2100 IDAVLDKLYV CASVEFLMTV ADFFIKAVPQ SPENVAKETQ ILPRQTATGK VKIEKDDSVR 2110 2120 2130 2140 2150 2160 PNMTLKAMIT DPEVVFVASL TKADAPALTA SFQCNLSLST SKLEQMMEAS VRDLKVLACP 2170 2180 2190 2200 2210 2220 FLREKRGKNI TTVLQPCSLF MEKCTWASGK QNINIMVKEF IIKISPIILN TVLTIMAALS 2230 2240 2250 2260 2270 2280 PKTKEDGSKD TSKEMENLWG IKSINDYNTW FLGVDTATEI TESFKGIEHS LIEENCGVVV 2290 2300 2310 2320 2330 2340 ESIQVTLECG LGHRTVPLLL AESKFSGNIK NWTSLMAAVA DVTLQVHYYN EIHAVWEPLI 2350 2360 2370 2380 2390 2400 ERVEGKRQWN LRLDVKKNPV QDKSLLPGDD FIPEPQMAIH ISSGNTMNIT ISKSCLNVFN 2410 2420 2430 2440 2450 2460 NLAKGFSEGT ASTFDYSLKD RAPFTVKNAV GVPIKVKPNC NLRVMGFPEK SDIFDVDAGQ 2470 2480 2490 2500 2510 2520 NLELEYASMV PSSQGNLSIL SRQESSFFTL TIVPHGYTEV ANIPVARPGR RLYNVRNPNA 2530 2540 2550 2560 2570 2580 SHSDSVLVQI DATEGNKVIT LRSPLQIKNH FSIAFIIYKF VKNVKLLERI GIARPEEEFH 2590 2600 2610 2620 2630 2640 VPLDSYRCQL FIQPAGILEH QYKESTTYIS WKEELHRSRE VRCMLQCPSV EVSFLPLIVN 2650 2660 2670 2680 2690 2700 TVALPDELSY ICTHGEDWDV AYIIHLYPSL TLRNLLPYSL RYLLEGTAET HELAEGSTAD 2710 2720 2730 2740 2750 2760 VLHSRISGEI MELVLVKYQG KNWNGHFRIR DTLPEFFPVC FSSDSTEVTT VDLSVHVRRI 2770 2780 2790 2800 2810 2820 GSRMVLSVFS PYWLINKTTR VLQYRSEDIH VKHPADFRDI ILFSFKKKNI FTKNKVQLKI 2830 2840 2850 2860 2870 2880 STSAWSSSFS LDTVGSYGCV KCPANNMEYL VGVSIKMSSF NLSRIVTLTP FCTIANKSSL 2890 2900 2910 2920 2930 2940 ELEVGEIASD GSMPTNKWNY IASSECLPFW PESLSGKLCV RVVGCEGSSK PFFYNRQDNG 2950 2960 2970 2980 2990 3000 TLLSLEDLNG GILVDVNTAE HSTVITFSDY HEGSAPALIM NHTPWDILTY KQSGSPEEMV 3010 3020 3030 3040 3050 3060 LLPRQARLFA WADPTGTRKL TWTYAANVGE HDLLKDGCGQ FPYDANIQIH WVSFLDGRQR 3070 3080 3090 3100 3110 3120 VLLFTDDVAL VSKALQAEEM EQADYEITLS LHSLGLSLVN NESKQEVSYI GITSSGVVWE 3130 3140 3150 3160 3170 3180 VKPKQKWKPF SQKQIILLEQ SYQKHQISRD HGWIKLDNNF EVNFDKDPME MRLPIRSPIK 3190 3200 3210 3220 3230 3240 RDFLSGIQIE FKQSSHQRSL RARLYWLQVD NQLPGAMFPV VFHPVAPPKS IALDSEPKPF 3250 3260 3270 3280 3290 3300 IDVSVITRFN EYSKVLQFKY FMVLIQEMAL KIDQGFLGAI IALFTPTTDP EAERRRTKLI 3310 3320 3330 3340 3350 3360 QQDIDALNAE LMETSMTDMS ILSFFEHFHI SPVKLHLSLS LGSGGEESDK EKQEMFAVHS 3370 3380 3390 3400 3410 3420 VNLLLKSIGA TLTDVDDLIF KLAYYEIRYQ FYKRDQLIWS VVRHYSEQFL KQMYVLVLGL 3430 3440 3450 3460 3470 3480 DVLGNPFGLI RGLSEGVEAL FYEPFQGAVQ GPEEFAEGLV IGVRSLFGHT VGGAAGVVSR 3490 3500 3510 3520 3530 3540 ITGSVGKGLA AITMDKEYQQ KRREELSRQP RDFGDSLARG GKGFLRGVVG GVTGIITKPV 3550 3560 3570 3580 3590 3600 EGAKKEGAAG FFKGIGKGLV GAVARPTGGI VDMASSTFQG IQRAAESTEE VSSLRPPRLI 3610 3620 HEDGIIRPYD RQESEGSDLL EQELEIQE
	Isoform 3 (1A) [UniParc]. Checksum: 80E0633970F14F4B	FASTA	3,710	417,276
	10 20 30 40 50 60 MVLESVVADL LNRFLGDYVE NLNKSQLKLG IWGGNVALDN LQIKENALSE LDVPFKVKAG 70 80 90 100 110 120 QIDKLTLKIP WKNLYGEAVV ATLEGLYLLV VPGASIKYDA VKEEKSLQDV KQKELSRIEE 130 140 150 160 170 180 ALQKAAEKDK PKEAKKDTFV EKLATQVIKN VQVKITDIHI KYEDDVTDPK RPLSFGVTLG 190 200 210 220 230 240 ELSLLTANEH WTPCILNEAD KIIYKLIRLD SLSAYWNVNC SMSYQRSREQ ILDQLKNEIL 250 260 270 280 290 300 TSGNIPPNYQ YIFQPISASA KLYMNPYAES ELKTPKLDCN IEIQNIAIEL TKPQYLSMID 310 320 330 340 350 360 LLESVDYMVR NAPYRKYKPY LPLHTNGRRW WKYAIDSVLE VHIRRYTQMW SWSNIKKHRQ 370 380 390 400 410 420 LLKSYKIAYK NKLTQSKVSE EIQKEIQDLE KTLDVFNIIL ARQQAQVEVI RSGQKLRKKS 430 440 450 460 470 480 ADTGEKRGGW FSGLWGKKES KKKDEESLIP ETIDDLMTPE EKDKLFTAIG YSESTHNLTL 490 500 510 520 530 540 PKQYVAHIMT LKLVSTSVTI RENKNIPEIL KIQIIGLGTQ VSQRPGAQAL KVEAKLEHWY 550 560 570 580 590 600 ITGLRQQDIV PSLVASIGDT TSSLLKIKFE TNPEDSPADQ TLIVQSQPVE VIYDAKTVNA 610 620 630 640 650 660 VVEFFQSNKG LDLEQITSAT LMKLEEIKER TATGLTHIIE TRKVLDLRIN LKPSYLVVPQ 670 680 690 700 710 720 TGFHHEKSDL LILDFGTFQL NSKDQGLQKT TNSSLEEIMD KAYDKFDVEI KNVQLLFARA 730 740 750 760 770 780 EETWKKCRFQ HPSTMHILQP MDIHVELAKA MVEKDIRMAR FKVSGGLPLM HVRISDQKMK 790 800 810 820 830 840 DVLYLMNSIP LPQKSSAQSP ERQVSSIPII SGGTKGLLGT SLLLDTVESE SDDEYFDAED 850 860 870 880 890 900 GEPQTCKSMK GSELKKAAEV PNEELINLLL KFEIKEVILE FTKQQKEEDT ILVFNVTQLG 910 920 930 940 950 960 TEATMRTFDL TVVSYLKKIS LDYHEIEGSK RKPLHLISSS DKPGLDLLKV EYIKADKNGP 970 980 990 1000 1010 1020 SFQTAFGKTE QTVKVAFSSL NLLLQTQALV ASINYLTTII PSDDQSISVA KEVQISTEKQ 1030 1040 1050 1060 1070 1080 QKNSTLPKAI VSSRDSDIID FRLFAKLNAF CVIVCNEKNN IAEIKIQGLD SSLSLQSRKQ 1090 1100 1110 1120 1130 1140 SLFARLENII VTDVDPKTVH KKAVSIMGNE VFRFNLDLYP DATEGDLYTD MSKVDGVLSL 1150 1160 1170 1180 1190 1200 NVGCIQIVYL HKFLMSLLNF LNNFQTAKES LSAATAQAAE RAATSVKDLA QRSFRVSINI 1210 1220 1230 1240 1250 1260 DLKAPVIVIP QSSISTNAVV VDLGLIRVHN QFSLVSDEDY LNPPVIDRMD VQLTKLTLYR 1270 1280 1290 1300 1310 1320 TVIQPGIYHP DIQLLHPINL EFLVNRNLAA SWYHKVPVVE IKGHLDSMNV SLNQEDLNLL 1330 1340 1350 1360 1370 1380 FRILTENLCE GTEDLDKVKP RVQETGEIKE PLEISISQDV HDSKNTLTTG VEEIRSVDII 1390 1400 1410 1420 1430 1440 NMLLNFEIKE VVVTLMKKSE KKGRPLHELN VLQLGMEAKV KTYDMTAKAY LKKISMQCFD 1450 1460 1470 1480 1490 1500 FTDSKGEPLH IINSSNVTDE PLLKMLLTKA DSDGPEFKTI HDSTKQRLKV SFASLDLVLH 1510 1520 1530 1540 1550 1560 LEALLSFMDF LSSAAPFSEP SSSEKESELK PLVGESRSIA VKAVSSNISQ KDVFDLKITA 1570 1580 1590 1600 1610 1620 ELNAFNVFVC DQKCNIADIK IHGMDASISV KPKQTDVFAR LKDIIVMNVD LQSIHKKAVS 1630 1640 1650 1660 1670 1680 ILGDEVFRFQ LTLYPDATEG EAYADMSKVD GKLSFKVGCI QIVYVHKFFM SLLNFLNNFQ 1690 1700 1710 1720 1730 1740 TAKEALSTAT VQAAERAASS MKDLAQKSFR LLMDINLKAP VIIIPQSSVS PNAVIADLGL 1750 1760 1770 1780 1790 1800 IRVENKFSLV PMEHYSLPPV IDKMNIELTQ LKLSRTILQA SLPQNDIEIL KPVNMLLSIQ 1810 1820 1830 1840 1850 1860 RNLAAAWYVQ IPGMEIKGKL KPMQVALSED DLTVLMKILL ENLGEASSQP SPTQSVQETV 1870 1880 1890 1900 1910 1920 RVRKVDVSSV PDHLKEQEDW TDSKLSMNQI VSLQFDFHFE SLSIILYNND INQESGVAFH 1930 1940 1950 1960 1970 1980 NDSFQLGELR LHLMASSGKM FKDGSMNVSV KLKTCTLDDL REGIERATSR MIDRKNDQDN 1990 2000 2010 2020 2030 2040 NSSMIDISYK QDKNGSQIDA VLDKLYVCAS VEFLMTVADF FIKAVPQSPE NVAKETQILP 2050 2060 2070 2080 2090 2100 RQTATGKVKI EKDDSVRPNM TLKAMITDPE VVFVASLTKA DAPALTASFQ CNLSLSTSKL 2110 2120 2130 2140 2150 2160 EQMMEASVRD LKVLACPFLR EKRGKNITTV LQPCSLFMEK CTWASGKQNI NIMVKEFIIK 2170 2180 2190 2200 2210 2220 ISPIILNTVL TIMAALSPKT KEDGSKDTSK EMENLWGIKS INDYNTWFLG VDTATEITES 2230 2240 2250 2260 2270 2280 FKGIEHSLIE ENCGVVVESI QVTLECGLGH RTVPLLLAES KFSGNIKNWT SLMAAVADVT 2290 2300 2310 2320 2330 2340 LQVHYYNEIH AVWEPLIERV EGKRQWNLRL DVKKNPVQDK SLLPGDDFIP EPQMAIHISS 2350 2360 2370 2380 2390 2400 GNTMNITISK SCLNVFNNLA KGFSEGTAST FDYSLKDRAP FTVKNAVGVP IKVKPNCNLR 2410 2420 2430 2440 2450 2460 VMGFPEKSDI FDVDAGQNLE LEYASMVPSS QGNLSILSRQ ESSFFTLTIV PHGYTEVANI 2470 2480 2490 2500 2510 2520 PVARPGRRLY NVRNPNASHS DSVLVQIDAT EGNKVITLRS PLQIKNHFSI AFIIYKFVKN 2530 2540 2550 2560 2570 2580 VKLLERIGIA RPEEEFHVPL DSYRCQLFIQ PAGILEHQYK ESTTYISWKE ELHRSREVRC 2590 2600 2610 2620 2630 2640 MLQCPSVEVS FLPLIVNTVA LPDELSYICT HGEDWDVAYI IHLYPSLTLR NLLPYSLRYL 2650 2660 2670 2680 2690 2700 LEGTAETHEL AEGSTADVLH SRISGEIMEL VLVKYQGKNW NGHFRIRDTL PEFFPVCFSS 2710 2720 2730 2740 2750 2760 DSTEVTTVDL SVHVRRIGSR MVLSVFSPYW LINKTTRVLQ YRSEDIHVKH PADFRDIILF 2770 2780 2790 2800 2810 2820 SFKKKNIFTK NKVQLKISTS AWSSSFSLDT VGSYGCVKCP ANNMEYLVGV SIKMSSFNLS 2830 2840 2850 2860 2870 2880 RIVTLTPFCT IANKSSLELE VGEIASDGSM PTNKWNYIAS SECLPFWPES LSGKLCVRVV 2890 2900 2910 2920 2930 2940 GCEGSSKPFF YNRQDNGTLL SLEDLNGGIL VDVNTAEHST VITFSDYHEG SAPALIMNHT 2950 2960 2970 2980 2990 3000 PWDILTYKQS GSPEEMVLLP RQARLFAWAD PTGTRKLTWT YAANVGEHDL LKDGCGQFPY 3010 3020 3030 3040 3050 3060 DANIQIHWVS FLDGRQRVLL FTDDVALVSK ALQAEEMEQA DYEITLSLHS LGLSLVNNES 3070 3080 3090 3100 3110 3120 KQEVSYIGIT SSGVVWEVKP KQKWKPFSQK QIILLEQSYQ KHQISRDHGW IKLDNNFEVN 3130 3140 3150 3160 3170 3180 FDKDPMEMRL PIRSPIKRDF LSGIQIEFKQ SSHQRSLRAR LYWLQVDNQL PGAMFPVVFH 3190 3200 3210 3220 3230 3240 PVAPPKSIAL DSEPKPFIDV SVITRFNEYS KVLQFKYFMV LIQEMALKID QGFLGAIIAL 3250 3260 3270 3280 3290 3300 FTPTTDPEAE RRRTKLIQQD IDALNAELME TSMTDMSILS FFEHFHISPV KLHLSLSLGS 3310 3320 3330 3340 3350 3360 GGEESDKEKQ EMFAVHSVNL LLKSIGATLT DVDDLIFKLA YYEIRYQFYK RDQLIWSVVR 3370 3380 3390 3400 3410 3420 HYSEQFLKQM YVLVLGLDVL GNPFGLIRGL SEGVEALFYE PFQGAVQGPE EFAEGLVIGV 3430 3440 3450 3460 3470 3480 RSLFGHTVGG AAGVVSRITG SVGKGLAAIT MDKEYQQKRR EELSRQPRDF GDSLARGGKG 3490 3500 3510 3520 3530 3540 FLRGVVGGVT GIITKPVEGA KKEGAAGFFK GIGKGLVGAV ARPTGGIVDM ASSTFQGIQR 3550 3560 3570 3580 3590 3600 AAESTEEVSS LRPPRLIHED GIIRPYDRQE SEGSDLLENH IKKLEGETYR YHCAIPGSKK 3610 3620 3630 3640 3650 3660 TILMVTNRRV LCIKEVEILG LMCVDWQCPF EDFVFPPSVS ENVLKISVKE QGLFHKKDSA 3670 3680 3690 3700 3710 NQGCVRKVYL KDTATAERAC NAIEDAQSTR QQQKLMKQSS VRLLRPQLPS
	Isoform 4 (1B) [UniParc]. Checksum: 433756079CA119A0	FASTA	3,585	403,084
	10 20 30 40 50 60 MVLESVVADL LNRFLGDYVE NLNKSQLKLG IWGGNVALDN LQIKENALSE LDVPFKVKAG 70 80 90 100 110 120 QIDKLTLKIP WKNLYGEAVV ATLEGLYLLV VPGASIKYDA VKEEKSLQDV KQKELSRIEE 130 140 150 160 170 180 ALQKAAEKDK PKEAKKDTFV EKLATQVIKN VQVKITDIHI KYEDDVTDPK RPLSFGVTLG 190 200 210 220 230 240 ELSLLTANEH WTPCILNEAD KIIYKLIRLD SLSAYWNVNC SMSYQRSREQ ILDQLKNEIL 250 260 270 280 290 300 TSGNIPPNYQ YIFQPISASA KLYMNPYAES ELKTPKLDCN IEIQNIAIEL TKPQYLSMID 310 320 330 340 350 360 LLESVDYMVR NAPYRKYKPY LPLHTNGRRW WKYAIDSVLE VHIRRYTQMW SWSNIKKHRQ 370 380 390 400 410 420 LLKSYKIAYK NKLTQSKVSE EIQKEIQDLE KTLDVFNIIL ARQQAQVEVI RSGQKLRKKS 430 440 450 460 470 480 ADTGEKRGGW FSGLWGKKES KKKDEESLIP ETIDDLMTPE EKDKLFTAIG YSESTHNLTL 490 500 510 520 530 540 PKQYVAHIMT LKLVSTSVTI RENKNIPEIL KIQIIGLGTQ VSQRPGAQAL KVEAKLEHWY 550 560 570 580 590 600 ITGLRQQDIV PSLVASIGDT TSSLLKIKFE TNPEDSPADQ TLIVQSQPVE VIYDAKTVNA 610 620 630 640 650 660 VVEFFQSNKG LDLEQITSAT LMKLEEIKER TATGLTHIIE TRKVLDLRIN LKPSYLVVPQ 670 680 690 700 710 720 TGFHHEKSDL LILDFGTFQL NSKDQGLQKT TNSSLEEIMD KAYDKFDVEI KNVQLLFARA 730 740 750 760 770 780 EETWKKCRFQ HPSTMHILQP MDIHVELAKA MVEKDIRMAR FKVSGGLPLM HVRISDQKMK 790 800 810 820 830 840 DVLYLMNSIP LPQKSSAQSP ERQVSSIPII SGGTKGLLGT SLLLDTVESE SDDEYFDAED 850 860 870 880 890 900 GEPQTCKSMK GSELKKAAEV PNEELINLLL KFEIKEVILE FTKQQKEEDT ILVFNVTQLG 910 920 930 940 950 960 TEATMRTFDL TVVSYLKKIS LDYHEIEGSK RKPLHLISSS DKPGLDLLKV EYIKADKNGP 970 980 990 1000 1010 1020 SFQTAFGKTE QTVKVAFSSL NLLLQTQALV ASINYLTTII PSDDQSISVA KEVQISTEKQ 1030 1040 1050 1060 1070 1080 QKNSTLPKAI VSSRDSDIID FRLFAKLNAF CVIVCNEKNN IAEIKIQGLD SSLSLQSRKQ 1090 1100 1110 1120 1130 1140 SLFARLENII VTDVDPKTVH KKAVSIMGNE VFRFNLDLYP DATEGDLYTD MSKVDGVLSL 1150 1160 1170 1180 1190 1200 NVGCIQIVYL HKFLMSLLNF LNNFQTAKES LSAATAQAAE RAATSVKDLA QRSFRVSINI 1210 1220 1230 1240 1250 1260 DLKAPVIVIP QSSISTNAVV VDLGLIRVHN QFSLVSDEDY LNPPVIDRMD VQLTKLTLYR 1270 1280 1290 1300 1310 1320 TVIQPGIYHP DIQLLHPINL EFLVNRNLAA SWYHKVPVVE IKGHLDSMNV SLNQEDLNLL 1330 1340 1350 1360 1370 1380 FRILTENLCE GTEDLDKVKP RVQETGEIKE PLEISISQDV HDSKNTLTTG VEEIRSVDII 1390 1400 1410 1420 1430 1440 NMLLNFEIKE VVVTLMKKSE KKGRPLHELN VLQLGMEAKV KTYDMTAKAY LKKISMQCFD 1450 1460 1470 1480 1490 1500 FTDSKGEPLH IINSSNVTDE PLLKMLLTKA DSDGPEFKTI HDSTKQRLKV SFASLDLVLH 1510 1520 1530 1540 1550 1560 LEALLSFMDF LSSAAPFSEP SSSEKESELK PLVGESRSIA VKAVSSNISQ KDVFDLKITA 1570 1580 1590 1600 1610 1620 ELNAFNVFVC DQKCNIADIK IHGMDASISV KPKQTDVFAR LKDIIVMNVD LQSIHKKAVS 1630 1640 1650 1660 1670 1680 ILGDEVFRFQ LTLYPDATEG EAYADMSKVD GKLSFKVGCI QIVYVHKFFM SLLNFLNNFQ 1690 1700 1710 1720 1730 1740 TAKEALSTAT VQAAERAASS MKDLAQKSFR LLMDINLKAP VIIIPQSSVS PNAVIADLGL 1750 1760 1770 1780 1790 1800 IRVENKFSLV PMEHYSLPPV IDKMNIELTQ LKLSRTILQA SLPQNDIEIL KPVNMLLSIQ 1810 1820 1830 1840 1850 1860 RNLAAAWYVQ IPGMEIKGKL KPMQVALSED DLTVLMKILL ENLGEASSQP SPTQSVQETV 1870 1880 1890 1900 1910 1920 RVRKVDVSSV PDHLKEQEDW TDSKLSMNQI VSLQFDFHFE SLSIILYNND INQESGVAFH 1930 1940 1950 1960 1970 1980 NDSFQLGELR LHLMASSGKM FKDGSMNVSV KLKTCTLDDL REGIERATSR MIDRKNDQDN 1990 2000 2010 2020 2030 2040 NSSMIDISYK QDKNGSQIDA VLDKLYVCAS VEFLMTVADF FIKAVPQSPE NVAKETQILP 2050 2060 2070 2080 2090 2100 RQTATGKVKI EKDDSVRPNM TLKAMITDPE VVFVASLTKA DAPALTASFQ CNLSLSTSKL 2110 2120 2130 2140 2150 2160 EQMMEASVRD LKVLACPFLR EKRGKNITTV LQPCSLFMEK CTWASGKQNI NIMVKEFIIK 2170 2180 2190 2200 2210 2220 ISPIILNTVL TIMAALSPKT KEDGSKDTSK EMENLWGIKS INDYNTWFLG VDTATEITES 2230 2240 2250 2260 2270 2280 FKGIEHSLIE ENCGVVVESI QVTLECGLGH RTVPLLLAES KFSGNIKNWT SLMAAVADVT 2290 2300 2310 2320 2330 2340 LQVHYYNEIH AVWEPLIERV EGKRQWNLRL DVKKNPVQDK SLLPGDDFIP EPQMAIHISS 2350 2360 2370 2380 2390 2400 GNTMNITISK SCLNVFNNLA KGFSEGTAST FDYSLKDRAP FTVKNAVGVP IKVKPNCNLR 2410 2420 2430 2440 2450 2460 VMGFPEKSDI FDVDAGQNLE LEYASMVPSS QGNLSILSRQ ESSFFTLTIV PHGYTEVANI 2470 2480 2490 2500 2510 2520 PVARPGRRLY NVRNPNASHS DSVLVQIDAT EGNKVITLRS PLQIKNHFSI AFIIYKFVKN 2530 2540 2550 2560 2570 2580 VKLLERIGIA RPEEEFHVPL DSYRCQLFIQ PAGILEHQYK ESTTYISWKE ELHRSREVRC 2590 2600 2610 2620 2630 2640 MLQCPSVEVS FLPLIVNTVA LPDELSYICT HGEDWDVAYI IHLYPSLTLR NLLPYSLRYL 2650 2660 2670 2680 2690 2700 LEGTAETHEL AEGSTADVLH SRISGEIMEL VLVKYQGKNW NGHFRIRDTL PEFFPVCFSS 2710 2720 2730 2740 2750 2760 DSTEVTTVDL SVHVRRIGSR MVLSVFSPYW LINKTTRVLQ YRSEDIHVKH PADFRDIILF 2770 2780 2790 2800 2810 2820 SFKKKNIFTK NKVQLKISTS AWSSSFSLDT VGSYGCVKCP ANNMEYLVGV SIKMSSFNLS 2830 2840 2850 2860 2870 2880 RIVTLTPFCT IANKSSLELE VGEIASDGSM PTNKWNYIAS SECLPFWPES LSGKLCVRVV 2890 2900 2910 2920 2930 2940 GCEGSSKPFF YNRQDNGTLL SLEDLNGGIL VDVNTAEHST VITFSDYHEG SAPALIMNHT 2950 2960 2970 2980 2990 3000 PWDILTYKQS GSPEEMVLLP RQARLFAWAD PTGTRKLTWT YAANVGEHDL LKDGCGQFPY 3010 3020 3030 3040 3050 3060 DANIQIHWVS FLDGRQRVLL FTDDVALVSK ALQAEEMEQA DYEITLSLHS LGLSLVNNES 3070 3080 3090 3100 3110 3120 KQEVSYIGIT SSGVVWEVKP KQKWKPFSQK QIILLEQSYQ KHQISRDHGW IKLDNNFEVN 3130 3140 3150 3160 3170 3180 FDKDPMEMRL PIRSPIKRDF LSGIQIEFKQ SSHQRSLRAR LYWLQVDNQL PGAMFPVVFH 3190 3200 3210 3220 3230 3240 PVAPPKSIAL DSEPKPFIDV SVITRFNEYS KVLQFKYFMV LIQEMALKID QGFLGAIIAL 3250 3260 3270 3280 3290 3300 FTPTTDPEAE RRRTKLIQQD IDALNAELME TSMTDMSILS FFEHFHISPV KLHLSLSLGS 3310 3320 3330 3340 3350 3360 GGEESDKEKQ EMFAVHSVNL LLKSIGATLT DVDDLIFKLA YYEIRYQFYK RDQLIWSVVR 3370 3380 3390 3400 3410 3420 HYSEQFLKQM YVLVLGLDVL GNPFGLIRGL SEGVEALFYE PFQGAVQGPE EFAEGLVIGV 3430 3440 3450 3460 3470 3480 RSLFGHTVGG AAGVVSRITG SVGKGLAAIT MDKEYQQKRR EELSRQPRDF GDSLARGGKG 3490 3500 3510 3520 3530 3540 FLRGVVGGVT GIITKPVEGA KKEGAAGFFK GIGKGLVGAV ARPTGGIVDM ASSTFQGIQR 3550 3560 3570 3580 AAESTEEVSS LRPPRLIHED GIIRPYDRQE SEGSDLLEQE LEIQE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of the human VPS13 gene family." Velayos-Baeza A., Vettori A., Copley R.R., Dobson-Stone C., Monaco A.P. Genomics 84:536-549(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), TISSUE SPECIFICITY. Tissue: Lymphoblast.
[2]	"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1439 (ISOFORMS 1/2), VARIANT LYS-974. Tissue: Brain.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3305-3753 (ISOFORMS 1/3). Tissue: Colon.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3305-3753 (ISOFORMS 1/3).
[5]	"Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry." Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D. Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract] Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-2357, MASS SPECTROMETRY. Tissue: Mammary cancer.
[6]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-614; SER-619; THR-624 AND SER-737, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[7]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-3538, MASS SPECTROMETRY.
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ608770 mRNA. Translation: CAE75582.1. AJ608771 mRNA. Translation: CAE75583.1. AJ626860 mRNA. Translation: CAF25187.1. AJ626861 mRNA. Translation: CAF25188.1. AB037842 mRNA. Translation: BAA92659.1. Different initiation. AK000143 mRNA. Translation: BAA90972.1. Different initiation. BC069387 mRNA. Translation: AAH69387.1.
IPI	IPI00412216. IPI00465428. IPI00604778. IPI00797358.
RefSeq	NP_001018098.1. NM_001018088.2. NP_060154.3. NM_017684.4. NP_060550.2. NM_018080.3. NP_065872.1. NM_020821.2.
UniGene	Hs.511668.
3D structure databases
ProteinModelPortal	Q709C8.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q709C8. 2 interactions.
STRING	9606.ENSP00000261517.
PTM databases
PhosphoSite	Q709C8.
Polymorphism databases
DMDM	74712594.
Proteomic databases
PaxDb	Q709C8.
PRIDE	Q709C8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000249837; ENSP00000249837; ENSG00000129003. ENST00000261517; ENSP00000261517; ENSG00000129003. ENST00000395896; ENSP00000379233; ENSG00000129003. ENST00000395898; ENSP00000379235; ENSG00000129003.
GeneID	54832.
KEGG	hsa:54832.
UCSC	uc002agz.3. human. uc002aha.3. human. uc002ahb.2. human. uc002ahc.2. human.
Organism-specific databases
CTD	54832.
GeneCards	GC15M062144.
HGNC	HGNC:23594. VPS13C.
HPA	HPA043356. HPA043507.
MIM	608879. gene.
neXtProt	NX_Q709C8.
PharmGKB	PA134990089.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5043.
HOVERGEN	HBG079736.
InParanoid	Q709C8.
OMA	KAYDKFD.
Gene expression databases
ArrayExpress	Q709C8.
Bgee	Q709C8.
CleanEx	HS_VPS13C.
Genevestigator	Q709C8.
GermOnline	ENSG00000129003. Homo sapiens.
Family and domain databases
InterPro	IPR015412. Autophagy-rel_C. IPR026847. VPS13. IPR026854. VPS13A_N. IPR009543. VPSAP_dom. [Graphical view]
PANTHER	PTHR16166. PTHR16166. 1 hit.
Pfam	PF09333. ATG_C. 1 hit. PF12624. Chorein_N. 1 hit. PF06650. DUF1162. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	VPS13C. human.
GenomeRNAi	54832.
NextBio	57616.
SOURCE	Search...

Entry information

Entry name

VP13C_HUMAN

Accession

Primary (citable) accession number: Q709C8
Secondary accession number(s): Q6ISR4 , Q702P2, Q702P3, Q709C9, Q9NXN8, Q9P2C6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.