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Q709C8 (VP13C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Vacuolar protein sorting-associated protein 13C
Gene names
Name:VPS13C
Synonyms:KIAA1421
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length3753 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Tissue specificity

Widely expressed. Ref.1

Sequence similarities

Belongs to the VPS13 family.

Sequence caution

The sequence BAA90972.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAA92659.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 Ref.1 (identifier: Q709C8-1)

Also known as: 2A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 Ref.1 (identifier: Q709C8-2)

Also known as: 2B;

The sequence of this isoform differs from the canonical sequence as follows:
     3622-3627: NHIKKL → QELEIQE
     3628-3753: Missing.
Isoform 3 Ref.1 (identifier: Q709C8-3)

Also known as: 1A;

The sequence of this isoform differs from the canonical sequence as follows:
     129-171: Missing.
Isoform 4 Ref.1 (identifier: Q709C8-4)

Also known as: 1B;

The sequence of this isoform differs from the canonical sequence as follows:
     129-171: Missing.
     3622-3627: NHIKKL → QELEIQE
     3628-3753: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 37533753Vacuolar protein sorting-associated protein 13C
PRO_0000262949

Regions

Compositional bias145 – 17935Lys-rich

Amino acid modifications

Modified residue6141Phosphothreonine Ref.7
Modified residue6191Phosphoserine Ref.7
Modified residue6241Phosphothreonine Ref.7
Modified residue7371Phosphoserine Ref.7
Modified residue19791Phosphoserine By similarity
Modified residue35381N6-acetyllysine Ref.8
Cross-link2357Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.5

Natural variations

Alternative sequence129 – 17143Missing in isoform 3 and isoform 4. Ref.1
VSP_052243
Alternative sequence3622 – 36276NHIKKL → QELEIQE in isoform 2 and isoform 4. Ref.1
VSP_052244
Alternative sequence3628 – 3753126Missing in isoform 2 and isoform 4. Ref.1
VSP_052245
Natural variant1531R → H.
Corresponds to variant rs12595158 [ dbSNP | Ensembl ].
VAR_029548
Natural variant9741R → K. Ref.2
Corresponds to variant rs3784634 [ dbSNP | Ensembl ].
VAR_029549
Natural variant11321I → V.
Corresponds to variant rs3784635 [ dbSNP | Ensembl ].
VAR_029550
Natural variant13021Y → C.
Corresponds to variant rs2303405 [ dbSNP | Ensembl ].
VAR_029551
Natural variant14851T → A.
Corresponds to variant rs8026956 [ dbSNP | Ensembl ].
VAR_029552
Natural variant14951I → V.
Corresponds to variant rs11629598 [ dbSNP | Ensembl ].
VAR_029553
Natural variant15921S → Y.
Corresponds to variant rs11629838 [ dbSNP | Ensembl ].
VAR_029554
Natural variant23221V → M.
Corresponds to variant rs12907567 [ dbSNP | Ensembl ].
VAR_029555
Natural variant28081K → R.
Corresponds to variant rs34060567 [ dbSNP | Ensembl ].
VAR_053808
Natural variant29131S → N.
Corresponds to variant rs10851704 [ dbSNP | Ensembl ].
VAR_029556

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (2A) [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 8B51A6778A89F639

FASTA3,753422,390
        10         20         30         40         50         60 
MVLESVVADL LNRFLGDYVE NLNKSQLKLG IWGGNVALDN LQIKENALSE LDVPFKVKAG 

        70         80         90        100        110        120 
QIDKLTLKIP WKNLYGEAVV ATLEGLYLLV VPGASIKYDA VKEEKSLQDV KQKELSRIEE 

       130        140        150        160        170        180 
ALQKAAEKGT HSGEFIYGLE NFVYKDIKPG RKRKKHKKHF KKPFKGLDRS KDKPKEAKKD 

       190        200        210        220        230        240 
TFVEKLATQV IKNVQVKITD IHIKYEDDVT DPKRPLSFGV TLGELSLLTA NEHWTPCILN 

       250        260        270        280        290        300 
EADKIIYKLI RLDSLSAYWN VNCSMSYQRS REQILDQLKN EILTSGNIPP NYQYIFQPIS 

       310        320        330        340        350        360 
ASAKLYMNPY AESELKTPKL DCNIEIQNIA IELTKPQYLS MIDLLESVDY MVRNAPYRKY 

       370        380        390        400        410        420 
KPYLPLHTNG RRWWKYAIDS VLEVHIRRYT QMWSWSNIKK HRQLLKSYKI AYKNKLTQSK 

       430        440        450        460        470        480 
VSEEIQKEIQ DLEKTLDVFN IILARQQAQV EVIRSGQKLR KKSADTGEKR GGWFSGLWGK 

       490        500        510        520        530        540 
KESKKKDEES LIPETIDDLM TPEEKDKLFT AIGYSESTHN LTLPKQYVAH IMTLKLVSTS 

       550        560        570        580        590        600 
VTIRENKNIP EILKIQIIGL GTQVSQRPGA QALKVEAKLE HWYITGLRQQ DIVPSLVASI 

       610        620        630        640        650        660 
GDTTSSLLKI KFETNPEDSP ADQTLIVQSQ PVEVIYDAKT VNAVVEFFQS NKGLDLEQIT 

       670        680        690        700        710        720 
SATLMKLEEI KERTATGLTH IIETRKVLDL RINLKPSYLV VPQTGFHHEK SDLLILDFGT 

       730        740        750        760        770        780 
FQLNSKDQGL QKTTNSSLEE IMDKAYDKFD VEIKNVQLLF ARAEETWKKC RFQHPSTMHI 

       790        800        810        820        830        840 
LQPMDIHVEL AKAMVEKDIR MARFKVSGGL PLMHVRISDQ KMKDVLYLMN SIPLPQKSSA 

       850        860        870        880        890        900 
QSPERQVSSI PIISGGTKGL LGTSLLLDTV ESESDDEYFD AEDGEPQTCK SMKGSELKKA 

       910        920        930        940        950        960 
AEVPNEELIN LLLKFEIKEV ILEFTKQQKE EDTILVFNVT QLGTEATMRT FDLTVVSYLK 

       970        980        990       1000       1010       1020 
KISLDYHEIE GSKRKPLHLI SSSDKPGLDL LKVEYIKADK NGPSFQTAFG KTEQTVKVAF 

      1030       1040       1050       1060       1070       1080 
SSLNLLLQTQ ALVASINYLT TIIPSDDQSI SVAKEVQIST EKQQKNSTLP KAIVSSRDSD 

      1090       1100       1110       1120       1130       1140 
IIDFRLFAKL NAFCVIVCNE KNNIAEIKIQ GLDSSLSLQS RKQSLFARLE NIIVTDVDPK 

      1150       1160       1170       1180       1190       1200 
TVHKKAVSIM GNEVFRFNLD LYPDATEGDL YTDMSKVDGV LSLNVGCIQI VYLHKFLMSL 

      1210       1220       1230       1240       1250       1260 
LNFLNNFQTA KESLSAATAQ AAERAATSVK DLAQRSFRVS INIDLKAPVI VIPQSSISTN 

      1270       1280       1290       1300       1310       1320 
AVVVDLGLIR VHNQFSLVSD EDYLNPPVID RMDVQLTKLT LYRTVIQPGI YHPDIQLLHP 

      1330       1340       1350       1360       1370       1380 
INLEFLVNRN LAASWYHKVP VVEIKGHLDS MNVSLNQEDL NLLFRILTEN LCEGTEDLDK 

      1390       1400       1410       1420       1430       1440 
VKPRVQETGE IKEPLEISIS QDVHDSKNTL TTGVEEIRSV DIINMLLNFE IKEVVVTLMK 

      1450       1460       1470       1480       1490       1500 
KSEKKGRPLH ELNVLQLGME AKVKTYDMTA KAYLKKISMQ CFDFTDSKGE PLHIINSSNV 

      1510       1520       1530       1540       1550       1560 
TDEPLLKMLL TKADSDGPEF KTIHDSTKQR LKVSFASLDL VLHLEALLSF MDFLSSAAPF 

      1570       1580       1590       1600       1610       1620 
SEPSSSEKES ELKPLVGESR SIAVKAVSSN ISQKDVFDLK ITAELNAFNV FVCDQKCNIA 

      1630       1640       1650       1660       1670       1680 
DIKIHGMDAS ISVKPKQTDV FARLKDIIVM NVDLQSIHKK AVSILGDEVF RFQLTLYPDA 

      1690       1700       1710       1720       1730       1740 
TEGEAYADMS KVDGKLSFKV GCIQIVYVHK FFMSLLNFLN NFQTAKEALS TATVQAAERA 

      1750       1760       1770       1780       1790       1800 
ASSMKDLAQK SFRLLMDINL KAPVIIIPQS SVSPNAVIAD LGLIRVENKF SLVPMEHYSL 

      1810       1820       1830       1840       1850       1860 
PPVIDKMNIE LTQLKLSRTI LQASLPQNDI EILKPVNMLL SIQRNLAAAW YVQIPGMEIK 

      1870       1880       1890       1900       1910       1920 
GKLKPMQVAL SEDDLTVLMK ILLENLGEAS SQPSPTQSVQ ETVRVRKVDV SSVPDHLKEQ 

      1930       1940       1950       1960       1970       1980 
EDWTDSKLSM NQIVSLQFDF HFESLSIILY NNDINQESGV AFHNDSFQLG ELRLHLMASS 

      1990       2000       2010       2020       2030       2040 
GKMFKDGSMN VSVKLKTCTL DDLREGIERA TSRMIDRKND QDNNSSMIDI SYKQDKNGSQ 

      2050       2060       2070       2080       2090       2100 
IDAVLDKLYV CASVEFLMTV ADFFIKAVPQ SPENVAKETQ ILPRQTATGK VKIEKDDSVR 

      2110       2120       2130       2140       2150       2160 
PNMTLKAMIT DPEVVFVASL TKADAPALTA SFQCNLSLST SKLEQMMEAS VRDLKVLACP 

      2170       2180       2190       2200       2210       2220 
FLREKRGKNI TTVLQPCSLF MEKCTWASGK QNINIMVKEF IIKISPIILN TVLTIMAALS 

      2230       2240       2250       2260       2270       2280 
PKTKEDGSKD TSKEMENLWG IKSINDYNTW FLGVDTATEI TESFKGIEHS LIEENCGVVV 

      2290       2300       2310       2320       2330       2340 
ESIQVTLECG LGHRTVPLLL AESKFSGNIK NWTSLMAAVA DVTLQVHYYN EIHAVWEPLI 

      2350       2360       2370       2380       2390       2400 
ERVEGKRQWN LRLDVKKNPV QDKSLLPGDD FIPEPQMAIH ISSGNTMNIT ISKSCLNVFN 

      2410       2420       2430       2440       2450       2460 
NLAKGFSEGT ASTFDYSLKD RAPFTVKNAV GVPIKVKPNC NLRVMGFPEK SDIFDVDAGQ 

      2470       2480       2490       2500       2510       2520 
NLELEYASMV PSSQGNLSIL SRQESSFFTL TIVPHGYTEV ANIPVARPGR RLYNVRNPNA 

      2530       2540       2550       2560       2570       2580 
SHSDSVLVQI DATEGNKVIT LRSPLQIKNH FSIAFIIYKF VKNVKLLERI GIARPEEEFH 

      2590       2600       2610       2620       2630       2640 
VPLDSYRCQL FIQPAGILEH QYKESTTYIS WKEELHRSRE VRCMLQCPSV EVSFLPLIVN 

      2650       2660       2670       2680       2690       2700 
TVALPDELSY ICTHGEDWDV AYIIHLYPSL TLRNLLPYSL RYLLEGTAET HELAEGSTAD 

      2710       2720       2730       2740       2750       2760 
VLHSRISGEI MELVLVKYQG KNWNGHFRIR DTLPEFFPVC FSSDSTEVTT VDLSVHVRRI 

      2770       2780       2790       2800       2810       2820 
GSRMVLSVFS PYWLINKTTR VLQYRSEDIH VKHPADFRDI ILFSFKKKNI FTKNKVQLKI 

      2830       2840       2850       2860       2870       2880 
STSAWSSSFS LDTVGSYGCV KCPANNMEYL VGVSIKMSSF NLSRIVTLTP FCTIANKSSL 

      2890       2900       2910       2920       2930       2940 
ELEVGEIASD GSMPTNKWNY IASSECLPFW PESLSGKLCV RVVGCEGSSK PFFYNRQDNG 

      2950       2960       2970       2980       2990       3000 
TLLSLEDLNG GILVDVNTAE HSTVITFSDY HEGSAPALIM NHTPWDILTY KQSGSPEEMV 

      3010       3020       3030       3040       3050       3060 
LLPRQARLFA WADPTGTRKL TWTYAANVGE HDLLKDGCGQ FPYDANIQIH WVSFLDGRQR 

      3070       3080       3090       3100       3110       3120 
VLLFTDDVAL VSKALQAEEM EQADYEITLS LHSLGLSLVN NESKQEVSYI GITSSGVVWE 

      3130       3140       3150       3160       3170       3180 
VKPKQKWKPF SQKQIILLEQ SYQKHQISRD HGWIKLDNNF EVNFDKDPME MRLPIRSPIK 

      3190       3200       3210       3220       3230       3240 
RDFLSGIQIE FKQSSHQRSL RARLYWLQVD NQLPGAMFPV VFHPVAPPKS IALDSEPKPF 

      3250       3260       3270       3280       3290       3300 
IDVSVITRFN EYSKVLQFKY FMVLIQEMAL KIDQGFLGAI IALFTPTTDP EAERRRTKLI 

      3310       3320       3330       3340       3350       3360 
QQDIDALNAE LMETSMTDMS ILSFFEHFHI SPVKLHLSLS LGSGGEESDK EKQEMFAVHS 

      3370       3380       3390       3400       3410       3420 
VNLLLKSIGA TLTDVDDLIF KLAYYEIRYQ FYKRDQLIWS VVRHYSEQFL KQMYVLVLGL 

      3430       3440       3450       3460       3470       3480 
DVLGNPFGLI RGLSEGVEAL FYEPFQGAVQ GPEEFAEGLV IGVRSLFGHT VGGAAGVVSR 

      3490       3500       3510       3520       3530       3540 
ITGSVGKGLA AITMDKEYQQ KRREELSRQP RDFGDSLARG GKGFLRGVVG GVTGIITKPV 

      3550       3560       3570       3580       3590       3600 
EGAKKEGAAG FFKGIGKGLV GAVARPTGGI VDMASSTFQG IQRAAESTEE VSSLRPPRLI 

      3610       3620       3630       3640       3650       3660 
HEDGIIRPYD RQESEGSDLL ENHIKKLEGE TYRYHCAIPG SKKTILMVTN RRVLCIKEVE 

      3670       3680       3690       3700       3710       3720 
ILGLMCVDWQ CPFEDFVFPP SVSENVLKIS VKEQGLFHKK DSANQGCVRK VYLKDTATAE 

      3730       3740       3750 
RACNAIEDAQ STRQQQKLMK QSSVRLLRPQ LPS 

« Hide

Isoform 2 (2B) [UniParc].

Checksum: 23C6AE1C69EEB060
Show »

FASTA3,628408,198
Isoform 3 (1A) [UniParc].

Checksum: 80E0633970F14F4B
Show »

FASTA3,710417,276
Isoform 4 (1B) [UniParc].

Checksum: 433756079CA119A0
Show »

FASTA3,585403,084

References

« Hide 'large scale' references
[1]"Analysis of the human VPS13 gene family."
Velayos-Baeza A., Vettori A., Copley R.R., Dobson-Stone C., Monaco A.P.
Genomics 84:536-549(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), TISSUE SPECIFICITY.
Tissue: Lymphoblast.
[2]"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1439 (ISOFORMS 1/2), VARIANT LYS-974.
Tissue: Brain.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3305-3753 (ISOFORMS 1/3).
Tissue: Colon.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3305-3753 (ISOFORMS 1/3).
[5]"Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry."
Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.
Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-2357.
Tissue: Mammary cancer.
[6]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-614; SER-619; THR-624 AND SER-737, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[8]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-3538, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ608770 mRNA. Translation: CAE75582.1.
AJ608771 mRNA. Translation: CAE75583.1.
AJ626860 mRNA. Translation: CAF25187.1.
AJ626861 mRNA. Translation: CAF25188.1.
AB037842 mRNA. Translation: BAA92659.1. Different initiation.
AK000143 mRNA. Translation: BAA90972.1. Different initiation.
BC069387 mRNA. Translation: AAH69387.1.
CCDSCCDS10180.1. [Q709C8-3]
CCDS32257.1. [Q709C8-1]
CCDS45272.1. [Q709C8-2]
CCDS58367.1. [Q709C8-4]
RefSeqNP_001018098.1. NM_001018088.2. [Q709C8-2]
NP_060154.3. NM_017684.4. [Q709C8-3]
NP_060550.2. NM_018080.3. [Q709C8-4]
NP_065872.1. NM_020821.2. [Q709C8-1]
UniGeneHs.511668.

3D structure databases

ProteinModelPortalQ709C8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120186. 2 interactions.
IntActQ709C8. 2 interactions.
STRING9606.ENSP00000261517.

PTM databases

PhosphoSiteQ709C8.

Polymorphism databases

DMDM74712594.

Proteomic databases

MaxQBQ709C8.
PaxDbQ709C8.
PRIDEQ709C8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000249837; ENSP00000249837; ENSG00000129003. [Q709C8-3]
ENST00000261517; ENSP00000261517; ENSG00000129003. [Q709C8-1]
ENST00000395896; ENSP00000379233; ENSG00000129003. [Q709C8-2]
ENST00000395898; ENSP00000379235; ENSG00000129003. [Q709C8-4]
GeneID54832.
KEGGhsa:54832.
UCSCuc002agz.3. human. [Q709C8-1]
uc002aha.3. human. [Q709C8-3]
uc002ahb.2. human. [Q709C8-2]
uc002ahc.2. human. [Q709C8-4]

Organism-specific databases

CTD54832.
GeneCardsGC15M062144.
HGNCHGNC:23594. VPS13C.
HPAHPA043356.
HPA043507.
MIM608879. gene.
neXtProtNX_Q709C8.
PharmGKBPA134990089.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5043.
HOVERGENHBG079736.
InParanoidQ709C8.
OMATHIIETR.
OrthoDBEOG7S4X52.
PhylomeDBQ709C8.
TreeFamTF300316.

Gene expression databases

ArrayExpressQ709C8.
BgeeQ709C8.
CleanExHS_VPS13C.
GenevestigatorQ709C8.

Family and domain databases

InterProIPR015412. Autophagy-rel_C.
IPR026847. VPS13.
IPR026854. VPS13A_N.
IPR009543. VPSAP_dom.
[Graphical view]
PANTHERPTHR16166. PTHR16166. 1 hit.
PfamPF09333. ATG_C. 1 hit.
PF12624. Chorein_N. 1 hit.
PF06650. DUF1162. 1 hit.
[Graphical view]
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Other

ChiTaRSVPS13C. human.
GenomeRNAi54832.
NextBio57616.
PROQ709C8.
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Entry information

Entry nameVP13C_HUMAN
AccessionPrimary (citable) accession number: Q709C8
Secondary accession number(s): Q6ISR4 expand/collapse secondary AC list , Q702P2, Q702P3, Q709C9, Q9NXN8, Q9P2C6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM