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Q709C8

- VP13C_HUMAN

UniProt

Q709C8 - VP13C_HUMAN

Protein

Vacuolar protein sorting-associated protein 13C

Gene

VPS13C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vacuolar protein sorting-associated protein 13C
    Gene namesi
    Name:VPS13CImported
    Synonyms:KIAA1421Imported
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:23594. VPS13C.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134990089.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 37533753Vacuolar protein sorting-associated protein 13CPRO_0000262949Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei614 – 6141Phosphothreonine1 Publication
    Modified residuei619 – 6191Phosphoserine1 Publication
    Modified residuei624 – 6241Phosphothreonine1 Publication
    Modified residuei737 – 7371Phosphoserine1 Publication
    Modified residuei1979 – 19791PhosphoserineBy similarity
    Cross-linki2357 – 2357Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
    Modified residuei3538 – 35381N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiQ709C8.
    PaxDbiQ709C8.
    PRIDEiQ709C8.

    PTM databases

    PhosphoSiteiQ709C8.

    Expressioni

    Tissue specificityi

    Widely expressed.1 Publication

    Gene expression databases

    ArrayExpressiQ709C8.
    BgeeiQ709C8.
    CleanExiHS_VPS13C.
    GenevestigatoriQ709C8.

    Organism-specific databases

    HPAiHPA043356.
    HPA043507.

    Interactioni

    Protein-protein interaction databases

    BioGridi120186. 2 interactions.
    IntActiQ709C8. 2 interactions.
    STRINGi9606.ENSP00000261517.

    Structurei

    3D structure databases

    ProteinModelPortaliQ709C8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi145 – 17935Lys-richSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the VPS13 family.Sequence Analysis

    Phylogenomic databases

    eggNOGiCOG5043.
    HOVERGENiHBG079736.
    InParanoidiQ709C8.
    OMAiTHIIETR.
    OrthoDBiEOG7S4X52.
    PhylomeDBiQ709C8.
    TreeFamiTF300316.

    Family and domain databases

    InterProiIPR015412. Autophagy-rel_C.
    IPR026847. VPS13.
    IPR026854. VPS13A_N.
    IPR009543. VPSAP_dom.
    [Graphical view]
    PANTHERiPTHR16166. PTHR16166. 1 hit.
    PfamiPF09333. ATG_C. 1 hit.
    PF12624. Chorein_N. 1 hit.
    PF06650. DUF1162. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 11 Publication (identifier: Q709C8-1) [UniParc]FASTAAdd to Basket

    Also known as: 2A1 Publication

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVLESVVADL LNRFLGDYVE NLNKSQLKLG IWGGNVALDN LQIKENALSE     50
    LDVPFKVKAG QIDKLTLKIP WKNLYGEAVV ATLEGLYLLV VPGASIKYDA 100
    VKEEKSLQDV KQKELSRIEE ALQKAAEKGT HSGEFIYGLE NFVYKDIKPG 150
    RKRKKHKKHF KKPFKGLDRS KDKPKEAKKD TFVEKLATQV IKNVQVKITD 200
    IHIKYEDDVT DPKRPLSFGV TLGELSLLTA NEHWTPCILN EADKIIYKLI 250
    RLDSLSAYWN VNCSMSYQRS REQILDQLKN EILTSGNIPP NYQYIFQPIS 300
    ASAKLYMNPY AESELKTPKL DCNIEIQNIA IELTKPQYLS MIDLLESVDY 350
    MVRNAPYRKY KPYLPLHTNG RRWWKYAIDS VLEVHIRRYT QMWSWSNIKK 400
    HRQLLKSYKI AYKNKLTQSK VSEEIQKEIQ DLEKTLDVFN IILARQQAQV 450
    EVIRSGQKLR KKSADTGEKR GGWFSGLWGK KESKKKDEES LIPETIDDLM 500
    TPEEKDKLFT AIGYSESTHN LTLPKQYVAH IMTLKLVSTS VTIRENKNIP 550
    EILKIQIIGL GTQVSQRPGA QALKVEAKLE HWYITGLRQQ DIVPSLVASI 600
    GDTTSSLLKI KFETNPEDSP ADQTLIVQSQ PVEVIYDAKT VNAVVEFFQS 650
    NKGLDLEQIT SATLMKLEEI KERTATGLTH IIETRKVLDL RINLKPSYLV 700
    VPQTGFHHEK SDLLILDFGT FQLNSKDQGL QKTTNSSLEE IMDKAYDKFD 750
    VEIKNVQLLF ARAEETWKKC RFQHPSTMHI LQPMDIHVEL AKAMVEKDIR 800
    MARFKVSGGL PLMHVRISDQ KMKDVLYLMN SIPLPQKSSA QSPERQVSSI 850
    PIISGGTKGL LGTSLLLDTV ESESDDEYFD AEDGEPQTCK SMKGSELKKA 900
    AEVPNEELIN LLLKFEIKEV ILEFTKQQKE EDTILVFNVT QLGTEATMRT 950
    FDLTVVSYLK KISLDYHEIE GSKRKPLHLI SSSDKPGLDL LKVEYIKADK 1000
    NGPSFQTAFG KTEQTVKVAF SSLNLLLQTQ ALVASINYLT TIIPSDDQSI 1050
    SVAKEVQIST EKQQKNSTLP KAIVSSRDSD IIDFRLFAKL NAFCVIVCNE 1100
    KNNIAEIKIQ GLDSSLSLQS RKQSLFARLE NIIVTDVDPK TVHKKAVSIM 1150
    GNEVFRFNLD LYPDATEGDL YTDMSKVDGV LSLNVGCIQI VYLHKFLMSL 1200
    LNFLNNFQTA KESLSAATAQ AAERAATSVK DLAQRSFRVS INIDLKAPVI 1250
    VIPQSSISTN AVVVDLGLIR VHNQFSLVSD EDYLNPPVID RMDVQLTKLT 1300
    LYRTVIQPGI YHPDIQLLHP INLEFLVNRN LAASWYHKVP VVEIKGHLDS 1350
    MNVSLNQEDL NLLFRILTEN LCEGTEDLDK VKPRVQETGE IKEPLEISIS 1400
    QDVHDSKNTL TTGVEEIRSV DIINMLLNFE IKEVVVTLMK KSEKKGRPLH 1450
    ELNVLQLGME AKVKTYDMTA KAYLKKISMQ CFDFTDSKGE PLHIINSSNV 1500
    TDEPLLKMLL TKADSDGPEF KTIHDSTKQR LKVSFASLDL VLHLEALLSF 1550
    MDFLSSAAPF SEPSSSEKES ELKPLVGESR SIAVKAVSSN ISQKDVFDLK 1600
    ITAELNAFNV FVCDQKCNIA DIKIHGMDAS ISVKPKQTDV FARLKDIIVM 1650
    NVDLQSIHKK AVSILGDEVF RFQLTLYPDA TEGEAYADMS KVDGKLSFKV 1700
    GCIQIVYVHK FFMSLLNFLN NFQTAKEALS TATVQAAERA ASSMKDLAQK 1750
    SFRLLMDINL KAPVIIIPQS SVSPNAVIAD LGLIRVENKF SLVPMEHYSL 1800
    PPVIDKMNIE LTQLKLSRTI LQASLPQNDI EILKPVNMLL SIQRNLAAAW 1850
    YVQIPGMEIK GKLKPMQVAL SEDDLTVLMK ILLENLGEAS SQPSPTQSVQ 1900
    ETVRVRKVDV SSVPDHLKEQ EDWTDSKLSM NQIVSLQFDF HFESLSIILY 1950
    NNDINQESGV AFHNDSFQLG ELRLHLMASS GKMFKDGSMN VSVKLKTCTL 2000
    DDLREGIERA TSRMIDRKND QDNNSSMIDI SYKQDKNGSQ IDAVLDKLYV 2050
    CASVEFLMTV ADFFIKAVPQ SPENVAKETQ ILPRQTATGK VKIEKDDSVR 2100
    PNMTLKAMIT DPEVVFVASL TKADAPALTA SFQCNLSLST SKLEQMMEAS 2150
    VRDLKVLACP FLREKRGKNI TTVLQPCSLF MEKCTWASGK QNINIMVKEF 2200
    IIKISPIILN TVLTIMAALS PKTKEDGSKD TSKEMENLWG IKSINDYNTW 2250
    FLGVDTATEI TESFKGIEHS LIEENCGVVV ESIQVTLECG LGHRTVPLLL 2300
    AESKFSGNIK NWTSLMAAVA DVTLQVHYYN EIHAVWEPLI ERVEGKRQWN 2350
    LRLDVKKNPV QDKSLLPGDD FIPEPQMAIH ISSGNTMNIT ISKSCLNVFN 2400
    NLAKGFSEGT ASTFDYSLKD RAPFTVKNAV GVPIKVKPNC NLRVMGFPEK 2450
    SDIFDVDAGQ NLELEYASMV PSSQGNLSIL SRQESSFFTL TIVPHGYTEV 2500
    ANIPVARPGR RLYNVRNPNA SHSDSVLVQI DATEGNKVIT LRSPLQIKNH 2550
    FSIAFIIYKF VKNVKLLERI GIARPEEEFH VPLDSYRCQL FIQPAGILEH 2600
    QYKESTTYIS WKEELHRSRE VRCMLQCPSV EVSFLPLIVN TVALPDELSY 2650
    ICTHGEDWDV AYIIHLYPSL TLRNLLPYSL RYLLEGTAET HELAEGSTAD 2700
    VLHSRISGEI MELVLVKYQG KNWNGHFRIR DTLPEFFPVC FSSDSTEVTT 2750
    VDLSVHVRRI GSRMVLSVFS PYWLINKTTR VLQYRSEDIH VKHPADFRDI 2800
    ILFSFKKKNI FTKNKVQLKI STSAWSSSFS LDTVGSYGCV KCPANNMEYL 2850
    VGVSIKMSSF NLSRIVTLTP FCTIANKSSL ELEVGEIASD GSMPTNKWNY 2900
    IASSECLPFW PESLSGKLCV RVVGCEGSSK PFFYNRQDNG TLLSLEDLNG 2950
    GILVDVNTAE HSTVITFSDY HEGSAPALIM NHTPWDILTY KQSGSPEEMV 3000
    LLPRQARLFA WADPTGTRKL TWTYAANVGE HDLLKDGCGQ FPYDANIQIH 3050
    WVSFLDGRQR VLLFTDDVAL VSKALQAEEM EQADYEITLS LHSLGLSLVN 3100
    NESKQEVSYI GITSSGVVWE VKPKQKWKPF SQKQIILLEQ SYQKHQISRD 3150
    HGWIKLDNNF EVNFDKDPME MRLPIRSPIK RDFLSGIQIE FKQSSHQRSL 3200
    RARLYWLQVD NQLPGAMFPV VFHPVAPPKS IALDSEPKPF IDVSVITRFN 3250
    EYSKVLQFKY FMVLIQEMAL KIDQGFLGAI IALFTPTTDP EAERRRTKLI 3300
    QQDIDALNAE LMETSMTDMS ILSFFEHFHI SPVKLHLSLS LGSGGEESDK 3350
    EKQEMFAVHS VNLLLKSIGA TLTDVDDLIF KLAYYEIRYQ FYKRDQLIWS 3400
    VVRHYSEQFL KQMYVLVLGL DVLGNPFGLI RGLSEGVEAL FYEPFQGAVQ 3450
    GPEEFAEGLV IGVRSLFGHT VGGAAGVVSR ITGSVGKGLA AITMDKEYQQ 3500
    KRREELSRQP RDFGDSLARG GKGFLRGVVG GVTGIITKPV EGAKKEGAAG 3550
    FFKGIGKGLV GAVARPTGGI VDMASSTFQG IQRAAESTEE VSSLRPPRLI 3600
    HEDGIIRPYD RQESEGSDLL ENHIKKLEGE TYRYHCAIPG SKKTILMVTN 3650
    RRVLCIKEVE ILGLMCVDWQ CPFEDFVFPP SVSENVLKIS VKEQGLFHKK 3700
    DSANQGCVRK VYLKDTATAE RACNAIEDAQ STRQQQKLMK QSSVRLLRPQ 3750
    LPS 3753
    Length:3,753
    Mass (Da):422,390
    Last modified:July 5, 2004 - v1
    Checksum:i8B51A6778A89F639
    GO
    Isoform 21 Publication (identifier: Q709C8-2) [UniParc]FASTAAdd to Basket

    Also known as: 2B1 Publication

    The sequence of this isoform differs from the canonical sequence as follows:
         3622-3627: NHIKKL → QELEIQE
         3628-3753: Missing.

    Show »
    Length:3,628
    Mass (Da):408,198
    Checksum:i23C6AE1C69EEB060
    GO
    Isoform 31 Publication (identifier: Q709C8-3) [UniParc]FASTAAdd to Basket

    Also known as: 1A1 Publication

    The sequence of this isoform differs from the canonical sequence as follows:
         129-171: Missing.

    Show »
    Length:3,710
    Mass (Da):417,276
    Checksum:i80E0633970F14F4B
    GO
    Isoform 41 Publication (identifier: Q709C8-4) [UniParc]FASTAAdd to Basket

    Also known as: 1B1 Publication

    The sequence of this isoform differs from the canonical sequence as follows:
         129-171: Missing.
         3622-3627: NHIKKL → QELEIQE
         3628-3753: Missing.

    Show »
    Length:3,585
    Mass (Da):403,084
    Checksum:i433756079CA119A0
    GO

    Sequence cautioni

    The sequence BAA90972.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAA92659.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti153 – 1531R → H.
    Corresponds to variant rs12595158 [ dbSNP | Ensembl ].
    VAR_029548
    Natural varianti974 – 9741R → K.1 Publication
    Corresponds to variant rs3784634 [ dbSNP | Ensembl ].
    VAR_029549
    Natural varianti1132 – 11321I → V.
    Corresponds to variant rs3784635 [ dbSNP | Ensembl ].
    VAR_029550
    Natural varianti1302 – 13021Y → C.
    Corresponds to variant rs2303405 [ dbSNP | Ensembl ].
    VAR_029551
    Natural varianti1485 – 14851T → A.
    Corresponds to variant rs8026956 [ dbSNP | Ensembl ].
    VAR_029552
    Natural varianti1495 – 14951I → V.
    Corresponds to variant rs11629598 [ dbSNP | Ensembl ].
    VAR_029553
    Natural varianti1592 – 15921S → Y.
    Corresponds to variant rs11629838 [ dbSNP | Ensembl ].
    VAR_029554
    Natural varianti2322 – 23221V → M.
    Corresponds to variant rs12907567 [ dbSNP | Ensembl ].
    VAR_029555
    Natural varianti2808 – 28081K → R.
    Corresponds to variant rs34060567 [ dbSNP | Ensembl ].
    VAR_053808
    Natural varianti2913 – 29131S → N.
    Corresponds to variant rs10851704 [ dbSNP | Ensembl ].
    VAR_029556

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei129 – 17143Missing in isoform 3 and isoform 4. 1 PublicationVSP_052243Add
    BLAST
    Alternative sequencei3622 – 36276NHIKKL → QELEIQE in isoform 2 and isoform 4. 1 PublicationVSP_052244
    Alternative sequencei3628 – 3753126Missing in isoform 2 and isoform 4. 1 PublicationVSP_052245Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ608770 mRNA. Translation: CAE75582.1.
    AJ608771 mRNA. Translation: CAE75583.1.
    AJ626860 mRNA. Translation: CAF25187.1.
    AJ626861 mRNA. Translation: CAF25188.1.
    AB037842 mRNA. Translation: BAA92659.1. Different initiation.
    AK000143 mRNA. Translation: BAA90972.1. Different initiation.
    BC069387 mRNA. Translation: AAH69387.1.
    CCDSiCCDS10180.1. [Q709C8-3]
    CCDS32257.1. [Q709C8-1]
    CCDS45272.1. [Q709C8-2]
    CCDS58367.1. [Q709C8-4]
    RefSeqiNP_001018098.1. NM_001018088.2. [Q709C8-2]
    NP_060154.3. NM_017684.4. [Q709C8-3]
    NP_060550.2. NM_018080.3. [Q709C8-4]
    NP_065872.1. NM_020821.2. [Q709C8-1]
    UniGeneiHs.511668.

    Genome annotation databases

    EnsembliENST00000249837; ENSP00000249837; ENSG00000129003. [Q709C8-3]
    ENST00000261517; ENSP00000261517; ENSG00000129003. [Q709C8-1]
    ENST00000395896; ENSP00000379233; ENSG00000129003. [Q709C8-2]
    ENST00000395898; ENSP00000379235; ENSG00000129003. [Q709C8-4]
    GeneIDi54832.
    KEGGihsa:54832.
    UCSCiuc002agz.3. human. [Q709C8-1]
    uc002aha.3. human. [Q709C8-3]
    uc002ahb.2. human. [Q709C8-2]
    uc002ahc.2. human. [Q709C8-4]

    Polymorphism databases

    DMDMi74712594.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ608770 mRNA. Translation: CAE75582.1 .
    AJ608771 mRNA. Translation: CAE75583.1 .
    AJ626860 mRNA. Translation: CAF25187.1 .
    AJ626861 mRNA. Translation: CAF25188.1 .
    AB037842 mRNA. Translation: BAA92659.1 . Different initiation.
    AK000143 mRNA. Translation: BAA90972.1 . Different initiation.
    BC069387 mRNA. Translation: AAH69387.1 .
    CCDSi CCDS10180.1. [Q709C8-3 ]
    CCDS32257.1. [Q709C8-1 ]
    CCDS45272.1. [Q709C8-2 ]
    CCDS58367.1. [Q709C8-4 ]
    RefSeqi NP_001018098.1. NM_001018088.2. [Q709C8-2 ]
    NP_060154.3. NM_017684.4. [Q709C8-3 ]
    NP_060550.2. NM_018080.3. [Q709C8-4 ]
    NP_065872.1. NM_020821.2. [Q709C8-1 ]
    UniGenei Hs.511668.

    3D structure databases

    ProteinModelPortali Q709C8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120186. 2 interactions.
    IntActi Q709C8. 2 interactions.
    STRINGi 9606.ENSP00000261517.

    PTM databases

    PhosphoSitei Q709C8.

    Polymorphism databases

    DMDMi 74712594.

    Proteomic databases

    MaxQBi Q709C8.
    PaxDbi Q709C8.
    PRIDEi Q709C8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000249837 ; ENSP00000249837 ; ENSG00000129003 . [Q709C8-3 ]
    ENST00000261517 ; ENSP00000261517 ; ENSG00000129003 . [Q709C8-1 ]
    ENST00000395896 ; ENSP00000379233 ; ENSG00000129003 . [Q709C8-2 ]
    ENST00000395898 ; ENSP00000379235 ; ENSG00000129003 . [Q709C8-4 ]
    GeneIDi 54832.
    KEGGi hsa:54832.
    UCSCi uc002agz.3. human. [Q709C8-1 ]
    uc002aha.3. human. [Q709C8-3 ]
    uc002ahb.2. human. [Q709C8-2 ]
    uc002ahc.2. human. [Q709C8-4 ]

    Organism-specific databases

    CTDi 54832.
    GeneCardsi GC15M062144.
    HGNCi HGNC:23594. VPS13C.
    HPAi HPA043356.
    HPA043507.
    MIMi 608879. gene.
    neXtProti NX_Q709C8.
    PharmGKBi PA134990089.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5043.
    HOVERGENi HBG079736.
    InParanoidi Q709C8.
    OMAi THIIETR.
    OrthoDBi EOG7S4X52.
    PhylomeDBi Q709C8.
    TreeFami TF300316.

    Miscellaneous databases

    ChiTaRSi VPS13C. human.
    GenomeRNAii 54832.
    NextBioi 57616.
    PROi Q709C8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q709C8.
    Bgeei Q709C8.
    CleanExi HS_VPS13C.
    Genevestigatori Q709C8.

    Family and domain databases

    InterProi IPR015412. Autophagy-rel_C.
    IPR026847. VPS13.
    IPR026854. VPS13A_N.
    IPR009543. VPSAP_dom.
    [Graphical view ]
    PANTHERi PTHR16166. PTHR16166. 1 hit.
    Pfami PF09333. ATG_C. 1 hit.
    PF12624. Chorein_N. 1 hit.
    PF06650. DUF1162. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), TISSUE SPECIFICITY.
      Tissue: Lymphoblast1 Publication.
    2. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
      DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1439 (ISOFORMS 1/2), VARIANT LYS-974.
      Tissue: BrainImported.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3305-3753 (ISOFORMS 1/3).
      Tissue: ColonImported.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3305-3753 (ISOFORMS 1/3).
    5. "Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry."
      Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.
      Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-2357.
      Tissue: Mammary cancer.
    6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-614; SER-619; THR-624 AND SER-737, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-3538, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiVP13C_HUMAN
    AccessioniPrimary (citable) accession number: Q709C8
    Secondary accession number(s): Q6ISR4
    , Q702P2, Q702P3, Q709C9, Q9NXN8, Q9P2C6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3