Q708T3 (MT_PODSI) Reviewed, UniProtKB/Swiss-Prot
Last modified
October 19, 2011.
Version 31.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Metallothionein Short name=MT |
| Organism | Podarcis sicula (Italian wall lizard) |
| Taxonomic identifier | 65484 [NCBI] |
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Scleroglossa › Scincomorpha › Lacertoidea › Lacertidae › Podarcis |
Protein attributes
| Sequence length | 63 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Metallothioneins have a high content of cysteine residues that bind various heavy metals By similarity. |
| Domain | Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines. |
| Sequence similarities | Belongs to the metallothionein superfamily. Type 1 family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | Metal-binding Metal-thiolate cluster |
| Gene Ontology (GO) | |
| Molecular function | metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 63 | 63 | Metallothionein | PRO_0000197267 | |||||
Regions | |||||||||
| Region | 1 – 30 | 30 | Beta | ||||||
| Region | 31 – 63 | 33 | Alpha | ||||||
Sites | |||||||||
| Metal binding | 6 | 1 | Divalent metal cation; cluster B By similarity | ||||||
| Metal binding | 8 | 1 | Divalent metal cation; cluster B By similarity | ||||||
| Metal binding | 14 | 1 | Divalent metal cation; cluster B By similarity | ||||||
| Metal binding | 16 | 1 | Divalent metal cation; cluster B By similarity | ||||||
| Metal binding | 20 | 1 | Divalent metal cation; cluster B By similarity | ||||||
| Metal binding | 22 | 1 | Divalent metal cation; cluster B By similarity | ||||||
| Metal binding | 25 | 1 | Divalent metal cation; cluster B By similarity | ||||||
| Metal binding | 27 | 1 | Divalent metal cation; cluster B By similarity | ||||||
| Metal binding | 30 | 1 | Divalent metal cation; cluster B By similarity | ||||||
| Metal binding | 34 | 1 | Divalent metal cation; cluster A By similarity | ||||||
| Metal binding | 35 | 1 | Divalent metal cation; cluster A By similarity | ||||||
| Metal binding | 37 | 1 | Divalent metal cation; cluster A By similarity | ||||||
| Metal binding | 38 | 1 | Divalent metal cation; cluster A By similarity | ||||||
| Metal binding | 42 | 1 | Divalent metal cation; cluster A By similarity | ||||||
| Metal binding | 45 | 1 | Divalent metal cation; cluster A By similarity | ||||||
| Metal binding | 49 | 1 | Divalent metal cation; cluster A By similarity | ||||||
| Metal binding | 51 | 1 | Divalent metal cation; cluster A By similarity | ||||||
| Metal binding | 59 | 1 | Divalent metal cation; cluster A By similarity | ||||||
| Metal binding | 61 | 1 | Divalent metal cation; cluster A By similarity | ||||||
| Metal binding | 62 | 1 | Divalent metal cation; cluster A By similarity | ||||||
Sequences
References
| [1] | "Accumulation of zinc, copper and metallothionein mRNA in lizard ovary proceeds without a concomitant increase in metallothionein content." Riggio M., Trinchella F., Filosa S., Parisi E., Scudiero R. Mol. Reprod. Dev. 66:374-382(2003) [PubMed: 14579413] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AJ609541 mRNA. Translation: CAE81349.1. |
3D structure databases | |
| ProteinModelPortal | Q708T3. |
| SMR | Q708T3. Positions 32-63. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Family and domain databases | |
| InterPro | IPR017854. Metalthion_dom. IPR023587. Metalthion_dom_vert. IPR003019. Metalthion_sfam_euk. IPR000006. Metalthion_vert. IPR018064. Metalthion_vert_metal_BS. [Graphical view] |
| Gene3D | G3DSA:4.10.10.10. Metallothionein_vert. 1 hit. |
| PANTHER | PTHR23299. Metallothionein_vert. 1 hit. |
| Pfam | PF00131. Metallothio. 1 hit. [Graphical view] |
| PRINTS | PR00860. MTVERTEBRATE. |
| SUPFAM | SSF57868. Metallothionein_sfam. 1 hit. |
| PROSITE | PS00203. METALLOTHIONEIN_VRT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MT_PODSI | ||||||||
| Accession | Primary (citable) accession number: Q708T3 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| Metallothioneins Classification of metallothioneins and list of entries |
| SIMILARITY comments Index of protein domains and families |