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Protein

ATP-binding cassette sub-family B member 7, mitochondrial

Gene

Abcb7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei481 – 4811ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi505 – 51612ATPPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family B member 7, mitochondrial
Alternative name(s):
ATP-binding cassette transporter 7
Short name:
ABC transporter 7 protein
Gene namesi
Name:Abcb7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1303086. Abcb7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei141 – 16121HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei186 – 20621HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei260 – 28021HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei291 – 31121HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei383 – 40321HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei410 – 43021HelicalPROSITE-ProRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 752ATP-binding cassette sub-family B member 7, mitochondrialPRO_0000000250
Transit peptidei1 – ?MitochondrionSequence analysis

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei216 – 2161N6-acetyllysineBy similarity
Modified residuei251 – 2511N6-acetyllysineBy similarity
Modified residuei336 – 3361PhosphoserineCombined sources
Modified residuei340 – 3401PhosphotyrosineCombined sources
Modified residuei342 – 3421PhosphothreonineCombined sources
Modified residuei350 – 3501N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ704E8.
PRIDEiQ704E8.

PTM databases

iPTMnetiQ704E8.
PhosphoSiteiQ704E8.

Interactioni

Subunit structurei

Homodimer or heterodimer.Curated

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003739.

Structurei

3D structure databases

ProteinModelPortaliQ704E8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini140 – 436297ABC transmembrane type-1PROSITE-ProRule annotationAdd
BLAST
Domaini472 – 706235ABC transporterPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation
Contains 1 ABC transporter domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0057. Eukaryota.
COG5265. LUCA.
HOVERGENiHBG080194.
InParanoidiQ704E8.
KOiK05662.
PhylomeDBiQ704E8.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q704E8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLAIHSWR WAAAAVAFEK HKHSAVLTRS LVSICGSGLR WSSYQSGASG
60 70 80 90 100
SARLSQTTES LRNSTQQRWE KNNSRQLLDA SKVLQAWPLI EKRTCWHGHA
110 120 130 140 150
GGGLHTDPKE GLKDVDTRKI IKAMLSYVWP KDRPDLRARV AISLGFLGGA
160 170 180 190 200
KAMNIVVPFM FKYAVDSLNQ MSGNMLNLSD APNTVATMAT AVLIGYGVSR
210 220 230 240 250
AGAAFFNEVR NAVFGKVAQN SIRRIAKNVF LHLHNLDLGF HLSRQTGALS
260 270 280 290 300
KAIDRGTRGI SFVLSALVFN LLPIVFEMTL VSSVLYYKCG AQFALVTLGT
310 320 330 340 350
LGAYTAFTVA VTRWRTRFRI EMNKADNDAG NAAIDSLLNY ETVKYFNNEK
360 370 380 390 400
YEAQRYDGFL KTYETASLKS TSTLAMLNFG QSAIFSVGLT AIMVLASQGI
410 420 430 440 450
VAGALTVGDL VMVNGLLFQL SLPLNFLGTV YRETRQALID MNTLFTLLKV
460 470 480 490 500
DTRIKDKAMA SPLQITPQTA TVAFDNVHFE YIEGQKVLSG VSFEVPAGKK
510 520 530 540 550
VAIVGGSGSG KSTIVRLLFR FYEPQKGSIY LAGQNIQDVS LESLRRAVGV
560 570 580 590 600
VPQDAVLFHN TIYYNLLYGN INASPEEVYA VAKLAGLHDA ILRMPHGYDT
610 620 630 640 650
QVGERGLKLS GGEKQRVAIA RAILKDPPVI LYDEATSSLD SITEETILGA
660 670 680 690 700
MRDVVKHRTS IFIAHRLSTV VDADEIIVLS QGKVAERGTH YGLLANSSSI
710 720 730 740 750
YSEMWHTQST RIQNHDNLGW DAKKESLSKE EERKKLQEEI VNSVKGCGNC

SC
Length:752
Mass (Da):82,558
Last modified:July 5, 2004 - v1
Checksum:i83AB45A9ACA4F8AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ621255 mRNA. Translation: CAF18435.1.
RefSeqiNP_997683.1. NM_212518.1.
UniGeneiRn.20068.

Genome annotation databases

GeneIDi302395.
KEGGirno:302395.
UCSCiRGD:1303086. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ621255 mRNA. Translation: CAF18435.1.
RefSeqiNP_997683.1. NM_212518.1.
UniGeneiRn.20068.

3D structure databases

ProteinModelPortaliQ704E8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003739.

PTM databases

iPTMnetiQ704E8.
PhosphoSiteiQ704E8.

Proteomic databases

PaxDbiQ704E8.
PRIDEiQ704E8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi302395.
KEGGirno:302395.
UCSCiRGD:1303086. rat.

Organism-specific databases

CTDi22.
RGDi1303086. Abcb7.

Phylogenomic databases

eggNOGiKOG0057. Eukaryota.
COG5265. LUCA.
HOVERGENiHBG080194.
InParanoidiQ704E8.
KOiK05662.
PhylomeDBiQ704E8.

Miscellaneous databases

NextBioi649550.
PROiQ704E8.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of Abcb7 in rat hepatocytes."
    Jakimenko A., Petry F., Hirsch-Ernst K.I.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
  2. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
    Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.
    Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-336; TYR-340 AND THR-342, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiABCB7_RAT
AccessioniPrimary (citable) accession number: Q704E8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.