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Q704B2

- MDH_THETK

UniProt

Q704B2 - MDH_THETK

Protein

Malate dehydrogenase

Gene

mdh

Organism
Thermoproteus tenax (strain ATCC 35583 / NBRC 100435 / JCM 9277 / Kra 1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei31 – 311NADUniRule annotation
    Binding sitei80 – 801SubstrateUniRule annotation
    Binding sitei86 – 861SubstrateUniRule annotation
    Binding sitei93 – 931NADUniRule annotation
    Binding sitei118 – 1181SubstrateUniRule annotation
    Binding sitei149 – 1491SubstrateUniRule annotation
    Active sitei173 – 1731Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi6 – 116NADUniRule annotation
    Nucleotide bindingi116 – 1183NADUniRule annotation

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciTTEN768679:GJSY-1402-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
    Gene namesi
    Name:mdhUniRule annotation
    Ordered Locus Names:TTX_1427
    OrganismiThermoproteus tenax (strain ATCC 35583 / NBRC 100435 / JCM 9277 / Kra 1)
    Taxonomic identifieri768679 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaeThermoproteus
    ProteomesiUP000002654: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 308308Malate dehydrogenasePRO_0000113496Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ704B2.
    SMRiQ704B2. Positions 1-308.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

    Phylogenomic databases

    KOiK00024.
    OMAiYGQNDIC.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_00487. Malate_dehydrog_3.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSiPR00086. LLDHDRGNASE.
    SUPFAMiSSF56327. SSF56327. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q704B2-1 [UniParc]FASTAAdd to Basket

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    MITVVGSGRV GATTAAMLGV LGVDNKIVLI DIIKGLPQGE ALDLNHMSSI    50
    LGLDVYYTGS NDYADMKGSD LVIVTAGLAR KPGMTREQLL EQNAQIVANI 100
    GKEIAKYAPD SVVILTTNPL DAMTYVMWRA TGFSRERVVG FSGVLDGGRL 150
    AFYAGQKLGI SPASIIPIVL GQHGESMFPV PSKSFVFGVP LDKLLKPEEI 200
    KEAVEETVKA GARITELRGF SSNWAPGAGV AIMAKAVKRD ERRALIASVV 250
    LDGEYGVRGI PVEVPVVLGR GGAIKVLEVE LSPEEKQRFQ QSVEAISKLL 300
    NSLPAQYK 308
    Length:308
    Mass (Da):32,861
    Last modified:July 5, 2004 - v1
    Checksum:i6DB990BB5CFF19F2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ621301 Genomic DNA. Translation: CAF18482.1.
    FN869859 Genomic DNA. Translation: CCC82058.1.
    RefSeqiWP_014127312.1. NC_016070.1.
    YP_004893136.1. NC_016070.1.

    Genome annotation databases

    EnsemblBacteriaiCCC82058; CCC82058; TTX_1427.
    GeneIDi11262306.
    KEGGittn:TTX_1427.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ621301 Genomic DNA. Translation: CAF18482.1 .
    FN869859 Genomic DNA. Translation: CCC82058.1 .
    RefSeqi WP_014127312.1. NC_016070.1.
    YP_004893136.1. NC_016070.1.

    3D structure databases

    ProteinModelPortali Q704B2.
    SMRi Q704B2. Positions 1-308.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CCC82058 ; CCC82058 ; TTX_1427 .
    GeneIDi 11262306.
    KEGGi ttn:TTX_1427.

    Phylogenomic databases

    KOi K00024.
    OMAi YGQNDIC.

    Enzyme and pathway databases

    BioCyci TTEN768679:GJSY-1402-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_00487. Malate_dehydrog_3.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSi PR00086. LLDHDRGNASE.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Reconstruction of the central carbohydrate metabolism of Thermoproteus tenax using genomic and biochemical data."
      Siebers B., Tjaden B., Michalke K., Doerr C., Ahmed H., Zaparty M., Gordon P., Sensen C.W., Zibat A., Klenk H.-P., Schuster S.C., Hensel R.
      J. Bacteriol. 186:2179-2194(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 35583 / NBRC 100435 / JCM 9277 / Kra 1.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35583 / NBRC 100435 / JCM 9277 / Kra 1.

    Entry informationi

    Entry nameiMDH_THETK
    AccessioniPrimary (citable) accession number: Q704B2
    Secondary accession number(s): G4RKG3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3