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Q704B2

- MDH_THETK

UniProt

Q704B2 - MDH_THETK

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Protein

Malate dehydrogenase

Gene

mdh

Organism
Thermoproteus tenax (strain ATCC 35583 / NBRC 100435 / JCM 9277 / Kra 1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei31 – 311NADUniRule annotation
Binding sitei80 – 801SubstrateUniRule annotation
Binding sitei86 – 861SubstrateUniRule annotation
Binding sitei93 – 931NADUniRule annotation
Binding sitei118 – 1181SubstrateUniRule annotation
Binding sitei149 – 1491SubstrateUniRule annotation
Active sitei173 – 1731Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi6 – 116NADUniRule annotation
Nucleotide bindingi116 – 1183NADUniRule annotation

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciTTEN768679:GJSY-1402-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:TTX_1427
OrganismiThermoproteus tenax (strain ATCC 35583 / NBRC 100435 / JCM 9277 / Kra 1)
Taxonomic identifieri768679 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaeThermoproteus
ProteomesiUP000002654: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308Malate dehydrogenasePRO_0000113496Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ704B2.
SMRiQ704B2. Positions 1-308.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

KOiK00024.
OMAiYGQNDIC.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.

Sequencei

Sequence statusi: Complete.

Q704B2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MITVVGSGRV GATTAAMLGV LGVDNKIVLI DIIKGLPQGE ALDLNHMSSI
60 70 80 90 100
LGLDVYYTGS NDYADMKGSD LVIVTAGLAR KPGMTREQLL EQNAQIVANI
110 120 130 140 150
GKEIAKYAPD SVVILTTNPL DAMTYVMWRA TGFSRERVVG FSGVLDGGRL
160 170 180 190 200
AFYAGQKLGI SPASIIPIVL GQHGESMFPV PSKSFVFGVP LDKLLKPEEI
210 220 230 240 250
KEAVEETVKA GARITELRGF SSNWAPGAGV AIMAKAVKRD ERRALIASVV
260 270 280 290 300
LDGEYGVRGI PVEVPVVLGR GGAIKVLEVE LSPEEKQRFQ QSVEAISKLL

NSLPAQYK
Length:308
Mass (Da):32,861
Last modified:July 5, 2004 - v1
Checksum:i6DB990BB5CFF19F2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ621301 Genomic DNA. Translation: CAF18482.1.
FN869859 Genomic DNA. Translation: CCC82058.1.
RefSeqiWP_014127312.1. NC_016070.1.
YP_004893136.1. NC_016070.1.

Genome annotation databases

EnsemblBacteriaiCCC82058; CCC82058; TTX_1427.
GeneIDi11262306.
KEGGittn:TTX_1427.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ621301 Genomic DNA. Translation: CAF18482.1 .
FN869859 Genomic DNA. Translation: CCC82058.1 .
RefSeqi WP_014127312.1. NC_016070.1.
YP_004893136.1. NC_016070.1.

3D structure databases

ProteinModelPortali Q704B2.
SMRi Q704B2. Positions 1-308.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CCC82058 ; CCC82058 ; TTX_1427 .
GeneIDi 11262306.
KEGGi ttn:TTX_1427.

Phylogenomic databases

KOi K00024.
OMAi YGQNDIC.

Enzyme and pathway databases

BioCyci TTEN768679:GJSY-1402-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00487. Malate_dehydrog_3.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Reconstruction of the central carbohydrate metabolism of Thermoproteus tenax using genomic and biochemical data."
    Siebers B., Tjaden B., Michalke K., Doerr C., Ahmed H., Zaparty M., Gordon P., Sensen C.W., Zibat A., Klenk H.-P., Schuster S.C., Hensel R.
    J. Bacteriol. 186:2179-2194(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 35583 / NBRC 100435 / JCM 9277 / Kra 1.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35583 / NBRC 100435 / JCM 9277 / Kra 1.

Entry informationi

Entry nameiMDH_THETK
AccessioniPrimary (citable) accession number: Q704B2
Secondary accession number(s): G4RKG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: July 5, 2004
Last modified: October 1, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3