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Q703I1

- OSER1_RAT

UniProt

Q703I1 - OSER1_RAT

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Protein

Oxidative stress-responsive serine-rich protein 1

Gene

Oser1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. cellular response to hydrogen peroxide Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Oxidative stress-responsive serine-rich protein 1
Alternative name(s):
Oxidative stress-responsive protein 1
Peroxide-inducible transcript 1 protein
Gene namesi
Name:Oser1
Synonyms:Osr1, Perit1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 3

Organism-specific databases

RGDi1303142. Oser1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 291291Oxidative stress-responsive serine-rich protein 1PRO_0000422974Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei143 – 1431Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Expressioni

Tissue specificityi

Isoform 1 is ubiquitous with high level in testis, placenta and cardiac myocytes. Isoform 2 is expressed in testis, unpreganant uterus and cardiac myocytes.1 Publication

Inductioni

Isoform 1 and isoform 2 are both up-regulated by DNA damaging agents like H2O2 in cardiac myocytes.1 Publication

Gene expression databases

GenevestigatoriQ703I1.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011610.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi78 – 814Poly-Arg

Phylogenomic databases

eggNOGiNOG80760.
GeneTreeiENSGT00390000018547.
HOGENOMiHOG000230950.
HOVERGENiHBG051188.
InParanoidiQ703I1.
OMAiDYSQSLH.
OrthoDBiEOG7327PJ.
PhylomeDBiQ703I1.
TreeFamiTF331727.

Family and domain databases

InterProiIPR008494. DUF776.
[Graphical view]
PfamiPF05604. DUF776. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q703I1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKSEAKDGEE ESLQTAFKKL RVDASGSIVS LSVGEGTSVR ASVRTTVDDT
60 70 80 90 100
KPKTMCAPKD SWHGSTRKSS RGAVRIQRRR RSKSPVLHPP KFIHCSTTAS
110 120 130 140 150
PSSSQLKQRS QTEPLDGSSG RGISTPKEFS TGENSTSLDI NHTGAAIEPL
160 170 180 190 200
RSSVLRLPSE SKTEELSDAT QVSPESLTAN DLSDFQSVSK LSQGKPCVCV
210 220 230 240 250
GKACQCKRWH DMEVYSFSGL QNVPPLAPER RSLEDYSQSL HTRTLSGSPR
260 270 280 290
SCSEQARVYV DDVTIEDLAG YMEYYLYIPK KMSHMAEMMY T
Length:291
Mass (Da):32,008
Last modified:July 5, 2004 - v1
Checksum:i1FFA4CAD8FAF8A2E
GO
Isoform 2 (identifier: Q703I1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-280: Missing.

Show »
Length:70
Mass (Da):7,601
Checksum:i4304A57BD7502FFE
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei60 – 280221Missing in isoform 2. 1 PublicationVSP_047453Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ621831 mRNA. Translation: CAF21998.1.
AABR06027504 Genomic DNA. No translation available.
CH474005 Genomic DNA. Translation: EDL96584.1.
CH474005 Genomic DNA. Translation: EDL96585.1.
BC082096 mRNA. Translation: AAH82096.1.
RefSeqiNP_963854.1. NM_201560.2. [Q703I1-1]
XP_006235590.1. XM_006235528.2. [Q703I1-1]
UniGeneiRn.41273.

Genome annotation databases

EnsembliENSRNOT00000011610; ENSRNOP00000011610; ENSRNOG00000008297. [Q703I1-1]
GeneIDi296346.
KEGGirno:296346.
UCSCiRGD:1303142. rat. [Q703I1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ621831 mRNA. Translation: CAF21998.1 .
AABR06027504 Genomic DNA. No translation available.
CH474005 Genomic DNA. Translation: EDL96584.1 .
CH474005 Genomic DNA. Translation: EDL96585.1 .
BC082096 mRNA. Translation: AAH82096.1 .
RefSeqi NP_963854.1. NM_201560.2. [Q703I1-1 ]
XP_006235590.1. XM_006235528.2. [Q703I1-1 ]
UniGenei Rn.41273.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000011610.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000011610 ; ENSRNOP00000011610 ; ENSRNOG00000008297 . [Q703I1-1 ]
GeneIDi 296346.
KEGGi rno:296346.
UCSCi RGD:1303142. rat. [Q703I1-1 ]

Organism-specific databases

CTDi 51526.
RGDi 1303142. Oser1.

Phylogenomic databases

eggNOGi NOG80760.
GeneTreei ENSGT00390000018547.
HOGENOMi HOG000230950.
HOVERGENi HBG051188.
InParanoidi Q703I1.
OMAi DYSQSLH.
OrthoDBi EOG7327PJ.
PhylomeDBi Q703I1.
TreeFami TF331727.

Miscellaneous databases

NextBioi 641039.

Gene expression databases

Genevestigatori Q703I1.

Family and domain databases

InterProi IPR008494. DUF776.
[Graphical view ]
Pfami PF05604. DUF776. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cardiac myocyte gene expression profiling during H2O2-induced apoptosis."
    Clerk A., Kemp T.J., Zoumpoulidou G., Sugden P.H.
    Physiol. Genomics 29:118-127(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, INDUCTION.
  2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  5. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
    Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.
    Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-143, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiOSER1_RAT
AccessioniPrimary (citable) accession number: Q703I1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2013
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3