Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q703I1

- OSER1_RAT

UniProt

Q703I1 - OSER1_RAT

Protein

Oxidative stress-responsive serine-rich protein 1

Gene

Oser1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Biological processi

    1. cellular response to hydrogen peroxide Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oxidative stress-responsive serine-rich protein 1
    Alternative name(s):
    Oxidative stress-responsive protein 1
    Peroxide-inducible transcript 1 protein
    Gene namesi
    Name:Oser1
    Synonyms:Osr1, Perit1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 3

    Organism-specific databases

    RGDi1303142. Oser1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 291291Oxidative stress-responsive serine-rich protein 1PRO_0000422974Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei143 – 1431Phosphothreonine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Expressioni

    Tissue specificityi

    Isoform 1 is ubiquitous with high level in testis, placenta and cardiac myocytes. Isoform 2 is expressed in testis, unpreganant uterus and cardiac myocytes.1 Publication

    Inductioni

    Isoform 1 and isoform 2 are both up-regulated by DNA damaging agents like H2O2 in cardiac myocytes.1 Publication

    Gene expression databases

    GenevestigatoriQ703I1.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000011610.

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi78 – 814Poly-Arg

    Phylogenomic databases

    eggNOGiNOG80760.
    GeneTreeiENSGT00390000018547.
    HOGENOMiHOG000230950.
    HOVERGENiHBG051188.
    InParanoidiQ703I1.
    OMAiDYSQSLH.
    OrthoDBiEOG7327PJ.
    PhylomeDBiQ703I1.
    TreeFamiTF331727.

    Family and domain databases

    InterProiIPR008494. DUF776.
    [Graphical view]
    PfamiPF05604. DUF776. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q703I1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKSEAKDGEE ESLQTAFKKL RVDASGSIVS LSVGEGTSVR ASVRTTVDDT    50
    KPKTMCAPKD SWHGSTRKSS RGAVRIQRRR RSKSPVLHPP KFIHCSTTAS 100
    PSSSQLKQRS QTEPLDGSSG RGISTPKEFS TGENSTSLDI NHTGAAIEPL 150
    RSSVLRLPSE SKTEELSDAT QVSPESLTAN DLSDFQSVSK LSQGKPCVCV 200
    GKACQCKRWH DMEVYSFSGL QNVPPLAPER RSLEDYSQSL HTRTLSGSPR 250
    SCSEQARVYV DDVTIEDLAG YMEYYLYIPK KMSHMAEMMY T 291
    Length:291
    Mass (Da):32,008
    Last modified:July 5, 2004 - v1
    Checksum:i1FFA4CAD8FAF8A2E
    GO
    Isoform 2 (identifier: Q703I1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         60-280: Missing.

    Show »
    Length:70
    Mass (Da):7,601
    Checksum:i4304A57BD7502FFE
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei60 – 280221Missing in isoform 2. 1 PublicationVSP_047453Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ621831 mRNA. Translation: CAF21998.1.
    AABR06027504 Genomic DNA. No translation available.
    CH474005 Genomic DNA. Translation: EDL96584.1.
    CH474005 Genomic DNA. Translation: EDL96585.1.
    BC082096 mRNA. Translation: AAH82096.1.
    RefSeqiNP_963854.1. NM_201560.2. [Q703I1-1]
    XP_006235589.1. XM_006235527.1. [Q703I1-1]
    XP_006235590.1. XM_006235528.1. [Q703I1-1]
    UniGeneiRn.41273.

    Genome annotation databases

    EnsembliENSRNOT00000011610; ENSRNOP00000011610; ENSRNOG00000008297. [Q703I1-1]
    GeneIDi296346.
    KEGGirno:296346.
    UCSCiRGD:1303142. rat. [Q703I1-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ621831 mRNA. Translation: CAF21998.1 .
    AABR06027504 Genomic DNA. No translation available.
    CH474005 Genomic DNA. Translation: EDL96584.1 .
    CH474005 Genomic DNA. Translation: EDL96585.1 .
    BC082096 mRNA. Translation: AAH82096.1 .
    RefSeqi NP_963854.1. NM_201560.2. [Q703I1-1 ]
    XP_006235589.1. XM_006235527.1. [Q703I1-1 ]
    XP_006235590.1. XM_006235528.1. [Q703I1-1 ]
    UniGenei Rn.41273.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000011610.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000011610 ; ENSRNOP00000011610 ; ENSRNOG00000008297 . [Q703I1-1 ]
    GeneIDi 296346.
    KEGGi rno:296346.
    UCSCi RGD:1303142. rat. [Q703I1-1 ]

    Organism-specific databases

    CTDi 51526.
    RGDi 1303142. Oser1.

    Phylogenomic databases

    eggNOGi NOG80760.
    GeneTreei ENSGT00390000018547.
    HOGENOMi HOG000230950.
    HOVERGENi HBG051188.
    InParanoidi Q703I1.
    OMAi DYSQSLH.
    OrthoDBi EOG7327PJ.
    PhylomeDBi Q703I1.
    TreeFami TF331727.

    Miscellaneous databases

    NextBioi 641039.

    Gene expression databases

    Genevestigatori Q703I1.

    Family and domain databases

    InterProi IPR008494. DUF776.
    [Graphical view ]
    Pfami PF05604. DUF776. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cardiac myocyte gene expression profiling during H2O2-induced apoptosis."
      Clerk A., Kemp T.J., Zoumpoulidou G., Sugden P.H.
      Physiol. Genomics 29:118-127(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, INDUCTION.
    2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown Norway.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown Norway.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    5. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
      Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.
      Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-143, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiOSER1_RAT
    AccessioniPrimary (citable) accession number: Q703I1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2013
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    External Data

    Dasty 3