##gff-version 3 Q703G9 UniProtKB Chain 1 508 . . . ID=PRO_0000392599;Note=Precursor of VP2 Q703G9 UniProtKB Chain 1 442 . . . ID=PRO_0000227873;Note=Capsid protein VP2 Q703G9 UniProtKB Peptide 443 486 . . . ID=PRO_0000227874;Note=Structural peptide 1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15269363;Dbxref=PMID:15269363 Q703G9 UniProtKB Peptide 487 495 . . . ID=PRO_0000227875;Note=Structural peptide 2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15269363;Dbxref=PMID:15269363 Q703G9 UniProtKB Peptide 496 508 . . . ID=PRO_0000227876;Note=Structural peptide 3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10666235;Dbxref=PMID:10666235 Q703G9 UniProtKB Chain 509 734 . . . ID=PRO_0000227877;Note=Protease VP4 Q703G9 UniProtKB Chain 735 972 . . . ID=PRO_0000227878;Note=Capsid protein VP3 Q703G9 UniProtKB Domain 509 734 . . . Note=Peptidase S50;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00881 Q703G9 UniProtKB Region 794 817 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q703G9 UniProtKB Region 916 972 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q703G9 UniProtKB Compositional bias 798 817 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q703G9 UniProtKB Compositional bias 924 948 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q703G9 UniProtKB Active site 633 633 . . . Note=Nucleophile;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00881,ECO:0000269|PubMed:10666235;Dbxref=PMID:10666235 Q703G9 UniProtKB Active site 674 674 . . . Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00881,ECO:0000269|PubMed:10666235;Dbxref=PMID:10666235 Q703G9 UniProtKB Binding site 26 26 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q703G9 UniProtKB Site 442 443 . . . Note=Cleavage%3B by protease VP4 Q703G9 UniProtKB Site 486 487 . . . Note=Cleavage%3B by protease VP4 Q703G9 UniProtKB Site 495 496 . . . Note=Cleavage%3B by protease VP4 Q703G9 UniProtKB Site 508 509 . . . Note=Cleavage%3B by protease VP4 Q703G9 UniProtKB Site 715 716 . . . Note=Cleavage%3B by protease VP4%3B subsidiary Q703G9 UniProtKB Site 734 735 . . . Note=Cleavage%3B by protease VP4 Q703G9 UniProtKB Natural variant 36 36 . . . Note=In strain: Isolate Mason. Q->P Q703G9 UniProtKB Natural variant 46 46 . . . Note=In strain: Isolate Mason. S->P Q703G9 UniProtKB Natural variant 52 52 . . . Note=In strain: Isolate Mason%2C Isolate Tseng%2C Isolate Blake%2C Isolate Sp103%2C Isolate Sp116%2C Isolate Sp122%2C Isolate NVI-001%2C Isolate NVI-011%2C Isolate NVI-013%2C Isolate NVI-015%2C Isolate NVI-016%2C Isolate NVI-020 and NVI-023. V->I Q703G9 UniProtKB Natural variant 54 54 . . . Note=In strain: Isolate NVI-010. V->I Q703G9 UniProtKB Natural variant 82 85 . . . Note=In strain: Isolate Mason. WLET->CWRA Q703G9 UniProtKB Natural variant 152 152 . . . Note=In strain: Isolate Mason%2C Isolate Blake and Isolate Tseng. V->A Q703G9 UniProtKB Natural variant 192 192 . . . Note=In strain: Isolate Mason%2C Isolate Blake and Isolate Tseng. K->R Q703G9 UniProtKB Natural variant 199 199 . . . Note=In strain: Isolate Sp103 and Isolate Sp122. I->T Q703G9 UniProtKB Natural variant 212 212 . . . Note=In strain: Isolate Mason%2C Isolate Blake and Isolate Tseng. R->S Q703G9 UniProtKB Natural variant 217 217 . . . Note=In strain: Isolate Sp122%2C Isolate NVI-001%2C Isolate NVI-011%2C Isolate NVI-013%2C Isolate NVI-015%2C Isolate NVI-020 and Isolate NVI-023. P->T Q703G9 UniProtKB Natural variant 219 219 . . . Note=In strain: Isolate NVI-010. T->I Q703G9 UniProtKB Natural variant 221 221 . . . Note=In strain: Isolate NVI-001%2C Isolate NVI-013%2C Isolate NVI-015%2C Isolate Sp116 and Isolate NVI-023. T->A Q703G9 UniProtKB Natural variant 222 222 . . . Note=In strain: Isolate NVI-011. L->P Q703G9 UniProtKB Natural variant 234 234 . . . Note=In strain: Isolate Tseng. N->S Q703G9 UniProtKB Natural variant 247 247 . . . Note=In strain: Isolate Sp122%2C Isolate NVI-001%2C Isolate NVI-013%2C Isolate NVI-015 and Isolate NVI-023. A->T Q703G9 UniProtKB Natural variant 249 249 . . . Note=In strain: Isolate Tseng. Q->R Q703G9 UniProtKB Natural variant 252 252 . . . Note=In strain: Isolate Mason%2C Isolate Tseng%2C Isolate Blake%2C Isolate Sp103%2C Isolate NVI-010 and Isolate NVI-016. D->N Q703G9 UniProtKB Natural variant 252 252 . . . Note=In strain: Isolate NVI-001%2C Isolate NVI-011%2C Isolate NVI-013%2C Isolate NVI-015%2C Isolate NVI-020%2C Isolate NVI-023%2C Isolate Sp116 and Isolate Sp122. D->V Q703G9 UniProtKB Natural variant 255 255 . . . Note=In strain: Isolate Mason%2C Isolate Blake and Isolate Tseng. K->R Q703G9 UniProtKB Natural variant 262 262 . . . Note=In strain: Isolate Mason. F->L Q703G9 UniProtKB Natural variant 288 288 . . . Note=In strain: Isolate Sp116. V->A Q703G9 UniProtKB Natural variant 319 319 . . . Note=In strain: Isolate NVI-016. A->E Q703G9 UniProtKB Natural variant 323 323 . . . Note=In strain: Isolate NVI-020. V->A Q703G9 UniProtKB Natural variant 323 323 . . . Note=In strain: Isolate NVI-016. V->F Q703G9 UniProtKB Natural variant 432 434 . . . Note=In strain: Isolate Mason. DFS->EKT Q703G9 UniProtKB Natural variant 455 455 . . . Note=In strain: Isolate Mason. V->I Q703G9 UniProtKB Natural variant 473 473 . . . Note=In strain: Isolate Mason%2C Isolate Heppel and Isolate Blake. M->T Q703G9 UniProtKB Natural variant 500 500 . . . Note=In strain: Isolate Heppel%2C Isolate NVI-010%2C Isolate NVI-011%2C Isolate NVI-020%2C Isolate Sp103 and Isolate Sp116. Y->H Q703G9 UniProtKB Natural variant 565 565 . . . Note=In strain: Isolate Mason. P->R Q703G9 UniProtKB Natural variant 570 571 . . . Note=In strain: Isolate Mason. EL->SF Q703G9 UniProtKB Natural variant 672 672 . . . Note=In strain: Isolate NVI-016. D->A Q703G9 UniProtKB Natural variant 717 717 . . . Note=In strain: Isolate NVI-016. K->Q Q703G9 UniProtKB Natural variant 788 788 . . . Note=In strain: Isolate NVI-011. D->G Q703G9 UniProtKB Natural variant 788 788 . . . Note=In strain: Isolate NVI-001. D->Y Q703G9 UniProtKB Natural variant 802 802 . . . Note=In strain: Isolate NVI-015 and Isolate NVI-016. H->R Q703G9 UniProtKB Natural variant 841 841 . . . Note=In strain: Isolate NVI-016. L->M Q703G9 UniProtKB Natural variant 867 867 . . . Note=In strain: Isolate Mason and Isolate Blake. E->Q Q703G9 UniProtKB Natural variant 875 875 . . . Note=In strain: Isolate NVI-016. P->S Q703G9 UniProtKB Natural variant 882 882 . . . Note=In strain: Isolate Tseng. M->T Q703G9 UniProtKB Natural variant 953 954 . . . Note=In strain: Isolate Mason. AE->GK Q703G9 UniProtKB Natural variant 959 960 . . . Note=In strain: Isolate Mason. GR->DV Q703G9 UniProtKB Natural variant 968 968 . . . Note=In strain: Isolate Sp116. D->N Q703G9 UniProtKB Mutagenesis 508 509 . . . Note=Complete loss of pVP2-VP4 cleavage. AS->QL;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10666235;Dbxref=PMID:10666235 Q703G9 UniProtKB Mutagenesis 547 547 . . . Note=Strongly reduced VP4-VP3 cleavage. No effect on pVP2-VP4 cleavage. H->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10666235;Dbxref=PMID:10666235 Q703G9 UniProtKB Mutagenesis 573 573 . . . Note=No effect on polyprotein processing. D->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10666235;Dbxref=PMID:10666235 Q703G9 UniProtKB Mutagenesis 585 585 . . . Note=No effect on polyprotein processing. D->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10666235;Dbxref=PMID:10666235 Q703G9 UniProtKB Mutagenesis 595 595 . . . Note=No effect on polyprotein processing. D->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10666235;Dbxref=PMID:10666235 Q703G9 UniProtKB Mutagenesis 601 601 . . . Note=No effect on polyprotein processing. D->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10666235;Dbxref=PMID:10666235 Q703G9 UniProtKB Mutagenesis 633 633 . . . Note=Complete loss of protease activity. S->A%2CQ%2CT;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10666235;Dbxref=PMID:10666235 Q703G9 UniProtKB Mutagenesis 633 633 . . . Note=Partial loss of protease activity. S->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10666235;Dbxref=PMID:10666235 Q703G9 UniProtKB Mutagenesis 644 644 . . . Note=No effect on polyprotein processing. D->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10666235;Dbxref=PMID:10666235 Q703G9 UniProtKB Mutagenesis 660 661 . . . Note=No effect on polyprotein processing. DD->GS;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10666235;Dbxref=PMID:10666235 Q703G9 UniProtKB Mutagenesis 672 672 . . . Note=No effect on polyprotein processing. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10666235;Dbxref=PMID:10666235 Q703G9 UniProtKB Mutagenesis 674 674 . . . Note=Complete loss of protease activity. K->A%2CD%2CH%2CQ%2CR;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10666235;Dbxref=PMID:10666235 Q703G9 UniProtKB Mutagenesis 675 675 . . . Note=60%25 loss of pVP2-VP4 and VP4-VP3 cleavages. A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10666235;Dbxref=PMID:10666235 Q703G9 UniProtKB Mutagenesis 676 676 . . . Note=No effect on polyprotein processing. I->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10666235;Dbxref=PMID:10666235 Q703G9 UniProtKB Mutagenesis 677 677 . . . Note=60%25 loss of pVP2-VP4. Complete loss of VP4-VP3 cleavage. A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10666235;Dbxref=PMID:10666235 Q703G9 UniProtKB Mutagenesis 678 678 . . . Note=No effect on polyprotein processing. A->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10666235;Dbxref=PMID:10666235 Q703G9 UniProtKB Mutagenesis 679 679 . . . Note=Strongly reduced VP4-VP3 cleavage. No effect on pVP2-VP4 cleavage. H->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10666235;Dbxref=PMID:10666235 Q703G9 UniProtKB Mutagenesis 680 680 . . . Note=No effect on polyprotein processing. E->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10666235;Dbxref=PMID:10666235 Q703G9 UniProtKB Mutagenesis 682 682 . . . Note=No effect on polyprotein processing. G->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10666235;Dbxref=PMID:10666235 Q703G9 UniProtKB Mutagenesis 683 683 . . . Note=60%25 loss of pVP2-VP4 and VP4-VP3 cleavages. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10666235;Dbxref=PMID:10666235 Q703G9 UniProtKB Mutagenesis 684 684 . . . Note=No effect on polyprotein processing. P->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10666235;Dbxref=PMID:10666235 Q703G9 UniProtKB Mutagenesis 685 685 . . . Note=60%25 loss of pVP2-VP4 and VP4-VP3 cleavages. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10666235;Dbxref=PMID:10666235 Q703G9 UniProtKB Mutagenesis 686 686 . . . Note=20%25 loss of pVP2-VP4 and VP4-VP3 cleavages. I->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10666235;Dbxref=PMID:10666235 Q703G9 UniProtKB Mutagenesis 687 687 . . . Note=20%25 loss of pVP2-VP4 and VP4-VP3 cleavages. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10666235;Dbxref=PMID:10666235 Q703G9 UniProtKB Mutagenesis 689 689 . . . Note=No effect on polyprotein processing. Q->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10666235;Dbxref=PMID:10666235 Q703G9 UniProtKB Mutagenesis 693 693 . . . Note=Strongly reduced VP4-VP3 cleavage. No effect on pVP2-VP4 cleavage. D->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10666235;Dbxref=PMID:10666235 Q703G9 UniProtKB Mutagenesis 704 704 . . . Note=No effect on polyprotein processing. H->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10666235;Dbxref=PMID:10666235 Q703G9 UniProtKB Mutagenesis 734 735 . . . Note=Complete loss of VP4-VP3 cleavage. AS->LE;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10666235;Dbxref=PMID:10666235 Q703G9 UniProtKB Sequence conflict 883 883 . . . Note=N->Y;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q703G9 UniProtKB Helix 9 15 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IDE Q703G9 UniProtKB Helix 17 19 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IDE Q703G9 UniProtKB Beta strand 32 44 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IDE Q703G9 UniProtKB Beta strand 51 55 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IDE Q703G9 UniProtKB Beta strand 60 70 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IDE Q703G9 UniProtKB Beta strand 74 84 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IDE Q703G9 UniProtKB Helix 89 91 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IDE Q703G9 UniProtKB Beta strand 93 107 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IDE Q703G9 UniProtKB Beta strand 120 128 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IDE Q703G9 UniProtKB Helix 130 132 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IDE Q703G9 UniProtKB Helix 140 143 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IDE Q703G9 UniProtKB Helix 148 150 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IDE Q703G9 UniProtKB Beta strand 151 156 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IDE Q703G9 UniProtKB Turn 157 159 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IDE Q703G9 UniProtKB Beta strand 161 164 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IDE Q703G9 UniProtKB Beta strand 202 208 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IDE Q703G9 UniProtKB Beta strand 210 212 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IDE Q703G9 UniProtKB Beta strand 223 232 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IDE Q703G9 UniProtKB Beta strand 236 248 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IDE Q703G9 UniProtKB Beta strand 254 263 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IDE Q703G9 UniProtKB Beta strand 271 280 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IDE Q703G9 UniProtKB Turn 282 286 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IDE Q703G9 UniProtKB Beta strand 287 292 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IDE Q703G9 UniProtKB Helix 298 300 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IDE Q703G9 UniProtKB Beta strand 305 313 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IDE Q703G9 UniProtKB Helix 317 319 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IDE Q703G9 UniProtKB Beta strand 324 326 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IDE Q703G9 UniProtKB Helix 327 329 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IDE Q703G9 UniProtKB Beta strand 332 338 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IDE Q703G9 UniProtKB Turn 339 342 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IDE Q703G9 UniProtKB Turn 344 346 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IDE Q703G9 UniProtKB Beta strand 350 357 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IDE Q703G9 UniProtKB Beta strand 363 376 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IDE Q703G9 UniProtKB Helix 378 381 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IDE Q703G9 UniProtKB Helix 395 404 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IDE Q703G9 UniProtKB Turn 405 410 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IDE Q703G9 UniProtKB Beta strand 413 416 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IDE Q703G9 UniProtKB Helix 417 422 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IDE Q703G9 UniProtKB Helix 425 427 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3IDE