Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q702W0 (HOG1_BLAAD) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitogen-activated protein kinase hog1

Short name=AHOG1
Short name=MAP kinase hog1
EC=2.7.11.24
Gene names
Name:hog1
OrganismBlastobotrys adeninivorans (Yeast) (Arxula adeninivorans)
Taxonomic identifier409370 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesBlastobotrys

Protein attributes

Sequence length400 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes By similarity. Ref.1

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Cofactor

Magnesium By similarity.

Enzyme regulation

Activated by tyrosine and threonine phosphorylation By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Induction

By salt stress. Ref.1

Domain

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Post-translational modification

Dually phosphorylated on Thr-171 and Tyr-173, which activates the enzyme By similarity. Phosphorylation is induced by osmotic stress. Ref.1

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.

Contains 1 protein kinase domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 400400Mitogen-activated protein kinase hog1
PRO_0000289672

Regions

Domain20 – 299280Protein kinase
Nucleotide binding26 – 349ATP By similarity
Motif171 – 1733TXY
Compositional bias350 – 39546Gln-rich

Sites

Active site1411Proton acceptor By similarity
Binding site491ATP By similarity

Amino acid modifications

Modified residue1711Phosphothreonine By similarity
Modified residue1731Phosphotyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q702W0 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 3AD93B7F8F952518

FASTA40045,877
        10         20         30         40         50         60 
MADFIRTQIF GTCFEITSRY VDLNPVGMGA FGLVCSARDQ LTNQNVAIKK IMKPFSTPVL 

        70         80         90        100        110        120 
AKRTYRELKL LKHLRHENLI TLSDIFISPL EDIYFVTELL GTDLHRLLTS RPLEHQFIQY 

       130        140        150        160        170        180 
FLYQILRGLK YVHSAGVVHR DLKPSNILIN ENCDLKICDF GLARIQDPQM TGYVSTRYYR 

       190        200        210        220        230        240 
APEIMLTWQK YDVEVDIWSA GCIFAEMLRG KPLFPGKDHV HQFSIITELL GNPPDDVIET 

       250        260        270        280        290        300 
IGSENTLNFV KSLPKRERIP LSQKFPNADP DAVDLLEKML VFDPRKRINA ADALAHPYLA 

       310        320        330        340        350        360 
PYHEPSDEPV ASEKFDWSFN DADLPVDTWK VMMYSEILDF HNVDSSAVEQ QQQQPQPPQP 

       370        380        390        400 
QLQQQQQPPQ QPQQPQQPQX AQQPVQPVQG DYVPQVAPRS 

« Hide

References

[1]"Characterization of the Arxula adeninivorans AHOG1 gene and the encoded mitogen-activated protein kinase."
Boeer E., Wartmann T., Dlubatz K., Gellissen G., Kunze G.
Curr. Genet. 46:269-276(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION, PHOSPHORYLATION.
Strain: LS3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ626723 Genomic DNA. Translation: CAF25030.1.

3D structure databases

ProteinModelPortalQ702W0.
SMRQ702W0. Positions 3-342.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008352. MAPK_p38.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSPR01773. P38MAPKINASE.
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHOG1_BLAAD
AccessionPrimary (citable) accession number: Q702W0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families