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Protein

Xin actin-binding repeat-containing protein 1

Gene

XIRP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Protects actin filaments from depolymerization.1 Publication

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Xin actin-binding repeat-containing protein 1
Alternative name(s):
Cardiomyopathy-associated protein 1
Gene namesi
Name:XIRP1
Synonyms:CMYA1, XIN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:14301. XIRP1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000168334.
PharmGKBiPA162409336.

Polymorphism and mutation databases

BioMutaiXIRP1.
DMDMi74712579.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003169831 – 1843Xin actin-binding repeat-containing protein 1Add BLAST1843

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei205PhosphoserineBy similarity1
Modified residuei208PhosphoserineBy similarity1
Modified residuei213PhosphoserineBy similarity1
Modified residuei295PhosphoserineCombined sources1
Modified residuei332PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ702N8.
PaxDbiQ702N8.
PeptideAtlasiQ702N8.
PRIDEiQ702N8.

PTM databases

iPTMnetiQ702N8.
PhosphoSitePlusiQ702N8.

Expressioni

Tissue specificityi

Isoform A, isoform B and isoform C are expressed in heart.1 Publication

Gene expression databases

BgeeiENSG00000168334.
GenevisibleiQ702N8. HS.

Organism-specific databases

HPAiCAB026391.
HPA016750.
HPA018458.

Interactioni

Subunit structurei

Interacts with CTNNB1 (By similarity). Interacts with F-actin, FLNC and VASP.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
FLNCQ143154EBI-7851194,EBI-489954
VASPP505525EBI-7851194,EBI-748201

Protein-protein interaction databases

BioGridi127921. 7 interactors.
IntActiQ702N8. 5 interactors.
MINTiMINT-8330054.
STRINGi9606.ENSP00000343140.

Structurei

3D structure databases

ProteinModelPortaliQ702N8.
SMRiQ702N8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati89 – 104Xin 1Add BLAST16
Repeati121 – 136Xin 2Add BLAST16
Repeati151 – 166Xin 3Add BLAST16
Repeati186 – 201Xin 4Add BLAST16
Repeati226 – 241Xin 5Add BLAST16
Repeati264 – 279Xin 6Add BLAST16
Repeati302 – 317Xin 7Add BLAST16
Repeati340 – 355Xin 8Add BLAST16
Repeati376 – 391Xin 9Add BLAST16
Repeati436 – 451Xin 10Add BLAST16
Repeati507 – 522Xin 11Add BLAST16
Repeati545 – 560Xin 12Add BLAST16
Repeati589 – 604Xin 13Add BLAST16
Repeati621 – 636Xin 14Add BLAST16
Repeati654 – 669Xin 15Add BLAST16
Repeati691 – 706Xin 16Add BLAST16
Repeati723 – 738Xin 17Add BLAST16

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 54Interaction with VASP1 PublicationAdd BLAST54
Regioni531 – 632Interaction with CTNNB1By similarityAdd BLAST102
Regioni1685 – 1843Interaction with FLNC1 PublicationAdd BLAST159

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1462 – 1490Sequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi23 – 28Poly-Pro6
Compositional biasi343 – 346Poly-Gln4
Compositional biasi1247 – 1350Pro-richAdd BLAST104

Domaini

Xin repeats bind F-actin.

Sequence similaritiesi

Belongs to the Xin family.PROSITE-ProRule annotation
Contains 17 Xin repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IF8Z. Eukaryota.
ENOG410ZM11. LUCA.
GeneTreeiENSGT00530000063779.
HOVERGENiHBG106912.
InParanoidiQ702N8.
OMAiDGIYTAH.
OrthoDBiEOG091G02JL.
PhylomeDBiQ702N8.
TreeFamiTF330745.

Family and domain databases

InterProiIPR012510. Actin-binding_Xin_repeat.
IPR030072. XIRP1/XIRP2.
[Graphical view]
PANTHERiPTHR22591. PTHR22591. 1 hit.
PfamiPF08043. Xin. 9 hits.
[Graphical view]
PROSITEiPS51389. XIN. 17 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: Q702N8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADTQTQVAP TPTMRMATAE DLPLPPPPAL EDLPLPPPKE SFSKFHQQRQ
60 70 80 90 100
ASELRRLYRH IHPELRKNLA EAVAEDLAEV LGSEEPTEGD VQCMRWIFEN
110 120 130 140 150
WRLDAIGEHE RPAAKEPVLC GDVQATSRKF EEGSFANSTD QEPTRPQPGG
160 170 180 190 200
GDVRAARWLF ETKPLDELTG QAKELEATVR EPAASGDVQG TRMLFETRPL
210 220 230 240 250
DRLGSRPSLQ EQSPLELRSE IQELKGDVKK TVKLFQTEPL CAIQDAEGAI
260 270 280 290 300
HEVKAACREE IQSNAVRSAR WLFETRPLDA INQDPSQVRV IRGISLEEGA
310 320 330 340 350
RPDVSATRWI FETQPLDAIR EILVDEKDFQ PSPDLIPPGP DVQQQQHLFE
360 370 380 390 400
TRALDTLKGD EEAGAEAPPK EEVVPGDVRS TLWLFETKPL DAFRDKVQVG
410 420 430 440 450
HLQRVDPQDG EGHLSSDSSS ALPFSQSAPQ RDELKGDVKT FKNLFETLPL
460 470 480 490 500
DSIGQGEVLA HGSPSREEGT DSAGQAQGIG SPVYAMQDSK GRLHALTSVS
510 520 530 540 550
REQIVGGDVQ GYRWMFETQP LDQLGRSPST IDVVRGITRQ EVVAGDVGTA
560 570 580 590 600
RWLFETQPLE MIHQREQQER QKEEGKSQGD PQPEAPPKGD VQTIRWLFET
610 620 630 640 650
CPMSELAEKQ GSEVTDPTAK AEAQSCTWMF KPQPVDRPVG SREQHLQVSQ
660 670 680 690 700
VPAGERQTDR HVFETEPLQA SGRPCGRRPV RYCSRVEIPS GQVSRQKEVF
710 720 730 740 750
QALEAGKKEE QEPRVIAGSI PAGSVHKFTW LFENCPMGSL AAESIQGGNL
760 770 780 790 800
LEEQPMSPSG NRMQESQETA AEGTLRTLHA TPGILHHGGI LMEARGPGEL
810 820 830 840 850
CLAKYVLSGT GQGHPYIRKE ELVSGELPRI ICQVLRRPDV DQQGLLVQED
860 870 880 890 900
PTGQLQLKPL RLPTPGSSGN IEDMDPELQQ LLACGLGTSV ARTGLVMQET
910 920 930 940 950
EQGLVALTAY SLQPRLTSKA SERSSVQLLA SCIDKGDLSG LHSLRWEPPA
960 970 980 990 1000
DPSPVPASEG AQSLHPTESI IHVPPLDPSM GMGHLRASGA TPCPPQAIGK
1010 1020 1030 1040 1050
AVPLAGEAAA PAQLQNTEKQ EDSHSGQKGM AVLGKSEGAT TTPPGPGAPD
1060 1070 1080 1090 1100
LLAAMQSLRM ATAEAQSLHQ QVLNKHKQGP TPTATSNPIQ DGLRKAGATQ
1110 1120 1130 1140 1150
SNIRPGGGSD PRIPAAPRKV SREEQALPRG LPGGWVTIQD GIYTAHPVRT
1160 1170 1180 1190 1200
FDPPGGVQLS QREPQSRHRE TALSVQAPRP LQGGPGQSTG PGREEPGGCT
1210 1220 1230 1240 1250
QMAWGPPGKA MAEVCPGGLQ AAETTLKTAP LGRHILASGP QAAGASPHPH
1260 1270 1280 1290 1300
NAFVPPPPTL PAAVTGPDFP AGAHRAEDSI QQASEPLKDP LLHSHSSPAG
1310 1320 1330 1340 1350
QRTPGGSQTK TPKLDPTMPP KKKPQLPPKP AHLTQSHPPQ RLPKPLPLSP
1360 1370 1380 1390 1400
SFSSEVGQRE HQRGERDTAI PQPAKVPTTV DQGHIPLARC PSGHSQPSLQ
1410 1420 1430 1440 1450
HGLSTTAPRP TKNQATGSNA QSSEPPKLNA LNHDPTSPQW GPGPSGEQPM
1460 1470 1480 1490 1500
EGSHQGAPES PDSLQRNQKE LQGLLNQVQA LEKEAASSVD VQALRRLFEA
1510 1520 1530 1540 1550
VPQLGGAAPQ APAAHQKPEA SVEQAFGELT RVSTEVAQLK EQTLARLLDI
1560 1570 1580 1590 1600
EEAVHKALSS MSSLQPEASA RGHFQGPPKD HSAHKISVTV SSSARPSGSG
1610 1620 1630 1640 1650
QEVGGQTAVK NQAKVECHTE AQSQVKIRNH TEARGHTAST APSTRRQETS
1660 1670 1680 1690 1700
REYLCPPRVL PSSRDSPSSP TFISIQSATR KPLETPSFKG NPDVSVKSTQ
1710 1720 1730 1740 1750
LAQDIGQALL HQKGVQDKTG KKDITQCSVQ PEPAPPSASP LPRGWQKSVL
1760 1770 1780 1790 1800
ELQTGPGSSQ HYGAMRTVTE QYEEVDQFGN TVLMSSTTVT EQAEPPRNPG
1810 1820 1830 1840
SHLGLHASPL LRQFLHSPAG FSSDLTEAET VQVSCSYSQP AAQ
Length:1,843
Mass (Da):198,561
Last modified:July 5, 2004 - v1
Checksum:i41A5CC13FE1955CB
GO
Isoform B (identifier: Q702N8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1120-1121: VS → LL
     1122-1843: Missing.

Show »
Length:1,121
Mass (Da):122,134
Checksum:i6BC1414DF33DE804
GO
Isoform C (identifier: Q702N8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1317: Missing.

Show »
Length:526
Mass (Da):56,273
Checksum:i79911F6ED688EBE6
GO

Sequence cautioni

The sequence BAC86519 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAC81057 differs from that shown. Reason: Frameshift at position 1594.Curated
The sequence CAD28459 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21D → G in CAH18268 (PubMed:17974005).Curated1
Sequence conflicti106I → T in CAH18268 (PubMed:17974005).Curated1
Sequence conflicti274E → G in CAH18268 (PubMed:17974005).Curated1
Sequence conflicti754Q → P in CAH18268 (PubMed:17974005).Curated1
Sequence conflicti813G → R in CAH18268 (PubMed:17974005).Curated1
Sequence conflicti1556K → R in BAC04783 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0384393D → N.Corresponds to variant rs2271488dbSNPEnsembl.1
Natural variantiVAR_038440346Q → R.1 PublicationCorresponds to variant rs6805248dbSNPEnsembl.1
Natural variantiVAR_038441551R → Q.Corresponds to variant rs34121641dbSNPEnsembl.1
Natural variantiVAR_061722695R → C.Corresponds to variant rs60540208dbSNPEnsembl.1
Natural variantiVAR_061723776R → W.Corresponds to variant rs9823779dbSNPEnsembl.1
Natural variantiVAR_038442929L → H in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_038443965H → P.Corresponds to variant rs11711871dbSNPEnsembl.1
Natural variantiVAR_0384441046P → A.Corresponds to variant rs35649793dbSNPEnsembl.1
Natural variantiVAR_0617241061A → V.Corresponds to variant rs35795536dbSNPEnsembl.1
Natural variantiVAR_0384451604G → R.1 PublicationCorresponds to variant rs3732383dbSNPEnsembl.1
Natural variantiVAR_0384461608A → V.Corresponds to variant rs34810344dbSNPEnsembl.1
Natural variantiVAR_0384471634R → K in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs768911526dbSNPEnsembl.1
Natural variantiVAR_0617251707Q → H.Corresponds to variant rs34053674dbSNPEnsembl.1
Natural variantiVAR_0384481724I → V.Corresponds to variant rs9827576dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0308431 – 1317Missing in isoform C. 2 PublicationsAdd BLAST1317
Alternative sequenceiVSP_0308441120 – 1121VS → LL in isoform B. 2 Publications2
Alternative sequenceiVSP_0308451122 – 1843Missing in isoform B. 2 PublicationsAdd BLAST722

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ626899 mRNA. Translation: CAF25191.1.
AJ626900 mRNA. Translation: CAF25192.1.
AY375160 mRNA. Translation: AAQ64003.1.
AK095941 mRNA. Translation: BAC04655.1.
AK096421 mRNA. Translation: BAC04783.1.
AK126299 mRNA. Translation: BAC86519.1. Different initiation.
AL713648 mRNA. Translation: CAD28459.1. Different initiation.
CR749430 mRNA. Translation: CAH18268.1.
BC127119 mRNA. Translation: AAI27120.1.
BC139782 mRNA. Translation: AAI39783.1.
AJ271461 mRNA. Translation: CAC81057.1. Frameshift.
CCDSiCCDS2683.1. [Q702N8-1]
CCDS56245.1. [Q702N8-2]
RefSeqiNP_001185550.1. NM_001198621.2. [Q702N8-2]
NP_919269.2. NM_194293.2. [Q702N8-1]
XP_005264966.1. XM_005264909.3. [Q702N8-1]
UniGeneiHs.447868.
Hs.737550.

Genome annotation databases

EnsembliENST00000340369; ENSP00000343140; ENSG00000168334. [Q702N8-1]
ENST00000396251; ENSP00000379550; ENSG00000168334. [Q702N8-2]
ENST00000421646; ENSP00000391645; ENSG00000168334. [Q702N8-3]
GeneIDi165904.
KEGGihsa:165904.
UCSCiuc003cji.4. human. [Q702N8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ626899 mRNA. Translation: CAF25191.1.
AJ626900 mRNA. Translation: CAF25192.1.
AY375160 mRNA. Translation: AAQ64003.1.
AK095941 mRNA. Translation: BAC04655.1.
AK096421 mRNA. Translation: BAC04783.1.
AK126299 mRNA. Translation: BAC86519.1. Different initiation.
AL713648 mRNA. Translation: CAD28459.1. Different initiation.
CR749430 mRNA. Translation: CAH18268.1.
BC127119 mRNA. Translation: AAI27120.1.
BC139782 mRNA. Translation: AAI39783.1.
AJ271461 mRNA. Translation: CAC81057.1. Frameshift.
CCDSiCCDS2683.1. [Q702N8-1]
CCDS56245.1. [Q702N8-2]
RefSeqiNP_001185550.1. NM_001198621.2. [Q702N8-2]
NP_919269.2. NM_194293.2. [Q702N8-1]
XP_005264966.1. XM_005264909.3. [Q702N8-1]
UniGeneiHs.447868.
Hs.737550.

3D structure databases

ProteinModelPortaliQ702N8.
SMRiQ702N8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127921. 7 interactors.
IntActiQ702N8. 5 interactors.
MINTiMINT-8330054.
STRINGi9606.ENSP00000343140.

PTM databases

iPTMnetiQ702N8.
PhosphoSitePlusiQ702N8.

Polymorphism and mutation databases

BioMutaiXIRP1.
DMDMi74712579.

Proteomic databases

EPDiQ702N8.
PaxDbiQ702N8.
PeptideAtlasiQ702N8.
PRIDEiQ702N8.

Protocols and materials databases

DNASUi165904.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340369; ENSP00000343140; ENSG00000168334. [Q702N8-1]
ENST00000396251; ENSP00000379550; ENSG00000168334. [Q702N8-2]
ENST00000421646; ENSP00000391645; ENSG00000168334. [Q702N8-3]
GeneIDi165904.
KEGGihsa:165904.
UCSCiuc003cji.4. human. [Q702N8-1]

Organism-specific databases

CTDi165904.
GeneCardsiXIRP1.
H-InvDBHIX0003187.
HGNCiHGNC:14301. XIRP1.
HPAiCAB026391.
HPA016750.
HPA018458.
MIMi609777. gene.
neXtProtiNX_Q702N8.
OpenTargetsiENSG00000168334.
PharmGKBiPA162409336.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF8Z. Eukaryota.
ENOG410ZM11. LUCA.
GeneTreeiENSGT00530000063779.
HOVERGENiHBG106912.
InParanoidiQ702N8.
OMAiDGIYTAH.
OrthoDBiEOG091G02JL.
PhylomeDBiQ702N8.
TreeFamiTF330745.

Miscellaneous databases

ChiTaRSiXIRP1. human.
GenomeRNAii165904.
PROiQ702N8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168334.
GenevisibleiQ702N8. HS.

Family and domain databases

InterProiIPR012510. Actin-binding_Xin_repeat.
IPR030072. XIRP1/XIRP2.
[Graphical view]
PANTHERiPTHR22591. PTHR22591. 1 hit.
PfamiPF08043. Xin. 9 hits.
[Graphical view]
PROSITEiPS51389. XIN. 17 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiXIRP1_HUMAN
AccessioniPrimary (citable) accession number: Q702N8
Secondary accession number(s): A0JP25
, A4QPE2, Q68DF2, Q6ZTR3, Q702N9, Q8IVN7, Q8N1N3, Q8N904, Q8TCG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

'Xin' means 'heart' in Chinese.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.