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Q702N8

- XIRP1_HUMAN

UniProt

Q702N8 - XIRP1_HUMAN

Protein

Xin actin-binding repeat-containing protein 1

Gene

XIRP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Protects actin filaments from depolymerization.1 Publication

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB

    GO - Biological processi

    1. cardiac muscle cell development Source: Ensembl
    2. negative regulation of cell proliferation Source: Ensembl
    3. regulation of membrane potential Source: Ensembl
    4. sarcomere organization Source: Ensembl

    Keywords - Ligandi

    Actin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Xin actin-binding repeat-containing protein 1
    Alternative name(s):
    Cardiomyopathy-associated protein 1
    Gene namesi
    Name:XIRP1
    Synonyms:CMYA1, XIN
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:14301. XIRP1.

    Subcellular locationi

    Cell junction 1 Publication
    Note: Colocalizes with actin stress fibers.

    GO - Cellular componenti

    1. fascia adherens Source: Ensembl

    Keywords - Cellular componenti

    Cell junction

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162409336.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 18431843Xin actin-binding repeat-containing protein 1PRO_0000316983Add
    BLAST

    Proteomic databases

    PaxDbiQ702N8.
    PRIDEiQ702N8.

    PTM databases

    PhosphoSiteiQ702N8.

    Expressioni

    Tissue specificityi

    Isoform A, isoform B and isoform C are expressed in heart.1 Publication

    Gene expression databases

    BgeeiQ702N8.
    GenevestigatoriQ702N8.

    Organism-specific databases

    HPAiCAB026391.
    HPA016750.
    HPA018458.

    Interactioni

    Subunit structurei

    Interacts with CTNNB1 By similarity. Interacts with F-actin, FLNC and VASP.By similarity2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    FLNCQ143154EBI-7851194,EBI-489954
    VASPP505525EBI-7851194,EBI-748201

    Protein-protein interaction databases

    IntActiQ702N8. 5 interactions.
    MINTiMINT-8330054.

    Structurei

    3D structure databases

    ProteinModelPortaliQ702N8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati89 – 10416Xin 1Add
    BLAST
    Repeati121 – 13616Xin 2Add
    BLAST
    Repeati151 – 16616Xin 3Add
    BLAST
    Repeati186 – 20116Xin 4Add
    BLAST
    Repeati226 – 24116Xin 5Add
    BLAST
    Repeati264 – 27916Xin 6Add
    BLAST
    Repeati302 – 31716Xin 7Add
    BLAST
    Repeati340 – 35516Xin 8Add
    BLAST
    Repeati376 – 39116Xin 9Add
    BLAST
    Repeati436 – 45116Xin 10Add
    BLAST
    Repeati507 – 52216Xin 11Add
    BLAST
    Repeati545 – 56016Xin 12Add
    BLAST
    Repeati589 – 60416Xin 13Add
    BLAST
    Repeati621 – 63616Xin 14Add
    BLAST
    Repeati654 – 66916Xin 15Add
    BLAST
    Repeati691 – 70616Xin 16Add
    BLAST
    Repeati723 – 73816Xin 17Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 5454Interaction with VASPAdd
    BLAST
    Regioni531 – 632102Interaction with CTNNB1By similarityAdd
    BLAST
    Regioni1685 – 1843159Interaction with FLNCAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1462 – 149029Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi23 – 286Poly-Pro
    Compositional biasi343 – 3464Poly-Gln
    Compositional biasi1247 – 1350104Pro-richAdd
    BLAST

    Domaini

    Xin repeats bind F-actin.

    Sequence similaritiesi

    Belongs to the Xin family.PROSITE-ProRule annotation
    Contains 17 Xin repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiNOG85108.
    HOVERGENiHBG106912.
    InParanoidiQ702N8.
    OMAiGWVTIQD.
    OrthoDBiEOG72C4ZN.
    PhylomeDBiQ702N8.
    TreeFamiTF330745.

    Family and domain databases

    InterProiIPR012510. Actin-binding_Xin_repeat.
    [Graphical view]
    PfamiPF08043. Xin. 8 hits.
    [Graphical view]
    PROSITEiPS51389. XIN. 17 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform A (identifier: Q702N8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MADTQTQVAP TPTMRMATAE DLPLPPPPAL EDLPLPPPKE SFSKFHQQRQ     50
    ASELRRLYRH IHPELRKNLA EAVAEDLAEV LGSEEPTEGD VQCMRWIFEN 100
    WRLDAIGEHE RPAAKEPVLC GDVQATSRKF EEGSFANSTD QEPTRPQPGG 150
    GDVRAARWLF ETKPLDELTG QAKELEATVR EPAASGDVQG TRMLFETRPL 200
    DRLGSRPSLQ EQSPLELRSE IQELKGDVKK TVKLFQTEPL CAIQDAEGAI 250
    HEVKAACREE IQSNAVRSAR WLFETRPLDA INQDPSQVRV IRGISLEEGA 300
    RPDVSATRWI FETQPLDAIR EILVDEKDFQ PSPDLIPPGP DVQQQQHLFE 350
    TRALDTLKGD EEAGAEAPPK EEVVPGDVRS TLWLFETKPL DAFRDKVQVG 400
    HLQRVDPQDG EGHLSSDSSS ALPFSQSAPQ RDELKGDVKT FKNLFETLPL 450
    DSIGQGEVLA HGSPSREEGT DSAGQAQGIG SPVYAMQDSK GRLHALTSVS 500
    REQIVGGDVQ GYRWMFETQP LDQLGRSPST IDVVRGITRQ EVVAGDVGTA 550
    RWLFETQPLE MIHQREQQER QKEEGKSQGD PQPEAPPKGD VQTIRWLFET 600
    CPMSELAEKQ GSEVTDPTAK AEAQSCTWMF KPQPVDRPVG SREQHLQVSQ 650
    VPAGERQTDR HVFETEPLQA SGRPCGRRPV RYCSRVEIPS GQVSRQKEVF 700
    QALEAGKKEE QEPRVIAGSI PAGSVHKFTW LFENCPMGSL AAESIQGGNL 750
    LEEQPMSPSG NRMQESQETA AEGTLRTLHA TPGILHHGGI LMEARGPGEL 800
    CLAKYVLSGT GQGHPYIRKE ELVSGELPRI ICQVLRRPDV DQQGLLVQED 850
    PTGQLQLKPL RLPTPGSSGN IEDMDPELQQ LLACGLGTSV ARTGLVMQET 900
    EQGLVALTAY SLQPRLTSKA SERSSVQLLA SCIDKGDLSG LHSLRWEPPA 950
    DPSPVPASEG AQSLHPTESI IHVPPLDPSM GMGHLRASGA TPCPPQAIGK 1000
    AVPLAGEAAA PAQLQNTEKQ EDSHSGQKGM AVLGKSEGAT TTPPGPGAPD 1050
    LLAAMQSLRM ATAEAQSLHQ QVLNKHKQGP TPTATSNPIQ DGLRKAGATQ 1100
    SNIRPGGGSD PRIPAAPRKV SREEQALPRG LPGGWVTIQD GIYTAHPVRT 1150
    FDPPGGVQLS QREPQSRHRE TALSVQAPRP LQGGPGQSTG PGREEPGGCT 1200
    QMAWGPPGKA MAEVCPGGLQ AAETTLKTAP LGRHILASGP QAAGASPHPH 1250
    NAFVPPPPTL PAAVTGPDFP AGAHRAEDSI QQASEPLKDP LLHSHSSPAG 1300
    QRTPGGSQTK TPKLDPTMPP KKKPQLPPKP AHLTQSHPPQ RLPKPLPLSP 1350
    SFSSEVGQRE HQRGERDTAI PQPAKVPTTV DQGHIPLARC PSGHSQPSLQ 1400
    HGLSTTAPRP TKNQATGSNA QSSEPPKLNA LNHDPTSPQW GPGPSGEQPM 1450
    EGSHQGAPES PDSLQRNQKE LQGLLNQVQA LEKEAASSVD VQALRRLFEA 1500
    VPQLGGAAPQ APAAHQKPEA SVEQAFGELT RVSTEVAQLK EQTLARLLDI 1550
    EEAVHKALSS MSSLQPEASA RGHFQGPPKD HSAHKISVTV SSSARPSGSG 1600
    QEVGGQTAVK NQAKVECHTE AQSQVKIRNH TEARGHTAST APSTRRQETS 1650
    REYLCPPRVL PSSRDSPSSP TFISIQSATR KPLETPSFKG NPDVSVKSTQ 1700
    LAQDIGQALL HQKGVQDKTG KKDITQCSVQ PEPAPPSASP LPRGWQKSVL 1750
    ELQTGPGSSQ HYGAMRTVTE QYEEVDQFGN TVLMSSTTVT EQAEPPRNPG 1800
    SHLGLHASPL LRQFLHSPAG FSSDLTEAET VQVSCSYSQP AAQ 1843
    Length:1,843
    Mass (Da):198,561
    Last modified:July 5, 2004 - v1
    Checksum:i41A5CC13FE1955CB
    GO
    Isoform B (identifier: Q702N8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1120-1121: VS → LL
         1122-1843: Missing.

    Show »
    Length:1,121
    Mass (Da):122,134
    Checksum:i6BC1414DF33DE804
    GO
    Isoform C (identifier: Q702N8-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1317: Missing.

    Show »
    Length:526
    Mass (Da):56,273
    Checksum:i79911F6ED688EBE6
    GO

    Sequence cautioni

    The sequence CAC81057.1 differs from that shown. Reason: Frameshift at position 1594.
    The sequence BAC86519.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAD28459.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti21 – 211D → G in CAH18268. (PubMed:17974005)Curated
    Sequence conflicti106 – 1061I → T in CAH18268. (PubMed:17974005)Curated
    Sequence conflicti274 – 2741E → G in CAH18268. (PubMed:17974005)Curated
    Sequence conflicti754 – 7541Q → P in CAH18268. (PubMed:17974005)Curated
    Sequence conflicti813 – 8131G → R in CAH18268. (PubMed:17974005)Curated
    Sequence conflicti1556 – 15561K → R in BAC04783. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti3 – 31D → N.
    Corresponds to variant rs2271488 [ dbSNP | Ensembl ].
    VAR_038439
    Natural varianti346 – 3461Q → R.1 Publication
    Corresponds to variant rs6805248 [ dbSNP | Ensembl ].
    VAR_038440
    Natural varianti551 – 5511R → Q.
    Corresponds to variant rs34121641 [ dbSNP | Ensembl ].
    VAR_038441
    Natural varianti695 – 6951R → C.
    Corresponds to variant rs60540208 [ dbSNP | Ensembl ].
    VAR_061722
    Natural varianti776 – 7761R → W.
    Corresponds to variant rs9823779 [ dbSNP | Ensembl ].
    VAR_061723
    Natural varianti929 – 9291L → H in a breast cancer sample; somatic mutation. 1 Publication
    VAR_038442
    Natural varianti965 – 9651H → P.
    Corresponds to variant rs11711871 [ dbSNP | Ensembl ].
    VAR_038443
    Natural varianti1046 – 10461P → A.
    Corresponds to variant rs35649793 [ dbSNP | Ensembl ].
    VAR_038444
    Natural varianti1061 – 10611A → V.
    Corresponds to variant rs35795536 [ dbSNP | Ensembl ].
    VAR_061724
    Natural varianti1604 – 16041G → R.1 Publication
    Corresponds to variant rs3732383 [ dbSNP | Ensembl ].
    VAR_038445
    Natural varianti1608 – 16081A → V.
    Corresponds to variant rs34810344 [ dbSNP | Ensembl ].
    VAR_038446
    Natural varianti1634 – 16341R → K in a breast cancer sample; somatic mutation. 1 Publication
    VAR_038447
    Natural varianti1707 – 17071Q → H.
    Corresponds to variant rs34053674 [ dbSNP | Ensembl ].
    VAR_061725
    Natural varianti1724 – 17241I → V.
    Corresponds to variant rs9827576 [ dbSNP | Ensembl ].
    VAR_038448

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 13171317Missing in isoform C. 2 PublicationsVSP_030843Add
    BLAST
    Alternative sequencei1120 – 11212VS → LL in isoform B. 2 PublicationsVSP_030844
    Alternative sequencei1122 – 1843722Missing in isoform B. 2 PublicationsVSP_030845Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ626899 mRNA. Translation: CAF25191.1.
    AJ626900 mRNA. Translation: CAF25192.1.
    AY375160 mRNA. Translation: AAQ64003.1.
    AK095941 mRNA. Translation: BAC04655.1.
    AK096421 mRNA. Translation: BAC04783.1.
    AK126299 mRNA. Translation: BAC86519.1. Different initiation.
    AL713648 mRNA. Translation: CAD28459.1. Different initiation.
    CR749430 mRNA. Translation: CAH18268.1.
    BC127119 mRNA. Translation: AAI27120.1.
    BC139782 mRNA. Translation: AAI39783.1.
    AJ271461 mRNA. Translation: CAC81057.1. Frameshift.
    CCDSiCCDS2683.1. [Q702N8-1]
    CCDS56245.1. [Q702N8-2]
    RefSeqiNP_001185550.1. NM_001198621.1. [Q702N8-2]
    NP_919269.2. NM_194293.2. [Q702N8-1]
    XP_005264966.1. XM_005264909.1. [Q702N8-1]
    UniGeneiHs.447868.
    Hs.737550.

    Genome annotation databases

    EnsembliENST00000340369; ENSP00000343140; ENSG00000168334. [Q702N8-1]
    ENST00000396251; ENSP00000379550; ENSG00000168334. [Q702N8-2]
    ENST00000421646; ENSP00000391645; ENSG00000168334. [Q702N8-3]
    GeneIDi165904.
    KEGGihsa:165904.
    UCSCiuc003cji.3. human. [Q702N8-2]
    uc003cjj.3. human. [Q702N8-3]
    uc003cjk.2. human. [Q702N8-1]

    Polymorphism databases

    DMDMi74712579.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ626899 mRNA. Translation: CAF25191.1 .
    AJ626900 mRNA. Translation: CAF25192.1 .
    AY375160 mRNA. Translation: AAQ64003.1 .
    AK095941 mRNA. Translation: BAC04655.1 .
    AK096421 mRNA. Translation: BAC04783.1 .
    AK126299 mRNA. Translation: BAC86519.1 . Different initiation.
    AL713648 mRNA. Translation: CAD28459.1 . Different initiation.
    CR749430 mRNA. Translation: CAH18268.1 .
    BC127119 mRNA. Translation: AAI27120.1 .
    BC139782 mRNA. Translation: AAI39783.1 .
    AJ271461 mRNA. Translation: CAC81057.1 . Frameshift.
    CCDSi CCDS2683.1. [Q702N8-1 ]
    CCDS56245.1. [Q702N8-2 ]
    RefSeqi NP_001185550.1. NM_001198621.1. [Q702N8-2 ]
    NP_919269.2. NM_194293.2. [Q702N8-1 ]
    XP_005264966.1. XM_005264909.1. [Q702N8-1 ]
    UniGenei Hs.447868.
    Hs.737550.

    3D structure databases

    ProteinModelPortali Q702N8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q702N8. 5 interactions.
    MINTi MINT-8330054.

    PTM databases

    PhosphoSitei Q702N8.

    Polymorphism databases

    DMDMi 74712579.

    Proteomic databases

    PaxDbi Q702N8.
    PRIDEi Q702N8.

    Protocols and materials databases

    DNASUi 165904.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000340369 ; ENSP00000343140 ; ENSG00000168334 . [Q702N8-1 ]
    ENST00000396251 ; ENSP00000379550 ; ENSG00000168334 . [Q702N8-2 ]
    ENST00000421646 ; ENSP00000391645 ; ENSG00000168334 . [Q702N8-3 ]
    GeneIDi 165904.
    KEGGi hsa:165904.
    UCSCi uc003cji.3. human. [Q702N8-2 ]
    uc003cjj.3. human. [Q702N8-3 ]
    uc003cjk.2. human. [Q702N8-1 ]

    Organism-specific databases

    CTDi 165904.
    GeneCardsi GC03M039200.
    H-InvDB HIX0003187.
    HGNCi HGNC:14301. XIRP1.
    HPAi CAB026391.
    HPA016750.
    HPA018458.
    MIMi 609777. gene.
    neXtProti NX_Q702N8.
    PharmGKBi PA162409336.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG85108.
    HOVERGENi HBG106912.
    InParanoidi Q702N8.
    OMAi GWVTIQD.
    OrthoDBi EOG72C4ZN.
    PhylomeDBi Q702N8.
    TreeFami TF330745.

    Miscellaneous databases

    GenomeRNAii 165904.
    NextBioi 88568.
    PROi Q702N8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q702N8.
    Genevestigatori Q702N8.

    Family and domain databases

    InterProi IPR012510. Actin-binding_Xin_repeat.
    [Graphical view ]
    Pfami PF08043. Xin. 8 hits.
    [Graphical view ]
    PROSITEi PS51389. XIN. 17 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B), FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH F-ACTIN.
      Tissue: Skeletal muscle.
    2. "Unusual splicing events result in distinct Xin isoforms that associate differentially with filamin c and Mena/VASP."
      van der Ven P.F.M., Ehler E., Vakeel P., Eulitz S., Schenk J.A., Milting H., Micheel B., Fuerst D.O.
      Exp. Cell Res. 312:2154-2167(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), ALTERNATIVE SPLICING (ISOFORMS B AND C), TISSUE SPECIFICITY, INTERACTION WITH FLNC AND VASP.
      Tissue: Skeletal muscle.
    3. "A novel human gene, hXin, specifically expressed in human heart and skeletal muscle."
      Luo J., Liu M., Wu X.
      Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM C), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 444-1843 (ISOFORM A).
      Tissue: Heart, Tongue and Trachea.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 570-1623 (ISOFORM A), VARIANT ARG-346.
      Tissue: Liver and Skeletal muscle.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM C), VARIANT ARG-1604.
    7. "Study of a muscle specific transcript."
      Trevisan S., Lanfranchi G.
      Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1554-1843.
    8. Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-929 AND LYS-1634.

    Entry informationi

    Entry nameiXIRP1_HUMAN
    AccessioniPrimary (citable) accession number: Q702N8
    Secondary accession number(s): A0JP25
    , A4QPE2, Q68DF2, Q6ZTR3, Q702N9, Q8IVN7, Q8N1N3, Q8N904, Q8TCG7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    'Xin' means 'heart' in Chinese.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

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