Q702N8 (XIRP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Xin actin-binding repeat-containing protein 1

Alternative name(s):
Cardiomyopathy-associated protein 1

Gene names

Name:	XIRP1
Synonyms:	CMYA1, XIN

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1843 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Protects actin filaments from depolymerization. Ref.1
Subunit structure	Interacts with CTNNB1 By similarity. Interacts with F-actin, FLNC and VASP. Ref.1 Ref.2
Subcellular location	Cell junction. Note: Colocalizes with actin stress fibers. Ref.1
Tissue specificity	Isoform A, isoform B and isoform C are expressed in heart. Ref.2
Domain	Xin repeats bind F-actin.
Miscellaneous	'Xin' means 'heart' in Chinese.
Sequence similarities	Belongs to the Xin family. Contains 17 Xin repeats.
Sequence caution	The sequence BAC86519.1 differs from that shown. Reason: Erroneous initiation. The sequence CAC81057.1 differs from that shown. Reason: Frameshift at position 1594. The sequence CAD28459.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cell junction
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Repeat
Ligand	Actin-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cardiac muscle cell development Inferred from electronic annotation. Source: Compara negative regulation of cell proliferation Inferred from electronic annotation. Source: Compara regulation of membrane potential Inferred from electronic annotation. Source: Compara sarcomere organization Inferred from electronic annotation. Source: Compara
Cellular_component	fascia adherens Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform A (identifier: Q702N8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform B (identifier: Q702N8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1120-1121: VS → LL
     1122-1843: Missing.

Isoform C (identifier: Q702N8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1317: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1843	1843	Xin actin-binding repeat-containing protein 1		PRO_0000316983
Regions
	Repeat	89 – 104	16	Xin 1
	Repeat	121 – 136	16	Xin 2
	Repeat	151 – 166	16	Xin 3
	Repeat	186 – 201	16	Xin 4
	Repeat	226 – 241	16	Xin 5
	Repeat	264 – 279	16	Xin 6
	Repeat	302 – 317	16	Xin 7
	Repeat	340 – 355	16	Xin 8
	Repeat	376 – 391	16	Xin 9
	Repeat	436 – 451	16	Xin 10
	Repeat	507 – 522	16	Xin 11
	Repeat	545 – 560	16	Xin 12
	Repeat	589 – 604	16	Xin 13
	Repeat	621 – 636	16	Xin 14
	Repeat	654 – 669	16	Xin 15
	Repeat	691 – 706	16	Xin 16
	Repeat	723 – 738	16	Xin 17
	Region	1 – 54	54	Interaction with VASP
	Region	531 – 632	102	Interaction with CTNNB1 By similarity
	Region	1685 – 1843	159	Interaction with FLNC
	Coiled coil	1462 – 1490	29	Potential
	Compositional bias	23 – 28	6	Poly-Pro
	Compositional bias	343 – 346	4	Poly-Gln
	Compositional bias	1247 – 1350	104	Pro-rich
Natural variations
	Alternative sequence	1 – 1317	1317	Missing in isoform C.		VSP_030843
	Alternative sequence	1120 – 1121	2	VS → LL in isoform B.		VSP_030844
	Alternative sequence	1122 – 1843	722	Missing in isoform B.		VSP_030845
	Natural variant	3	1	D → N. Corresponds to variant rs2271488 [ dbSNP | Ensembl ].		VAR_038439
	Natural variant	346	1	Q → R. Ref.5 Corresponds to variant rs6805248 [ dbSNP | Ensembl ].		VAR_038440
	Natural variant	551	1	R → Q. Corresponds to variant rs34121641 [ dbSNP | Ensembl ].		VAR_038441
	Natural variant	695	1	R → C. Corresponds to variant rs60540208 [ dbSNP | Ensembl ].		VAR_061722
	Natural variant	776	1	R → W. Corresponds to variant rs9823779 [ dbSNP | Ensembl ].		VAR_061723
	Natural variant	929	1	L → H in a breast cancer sample; somatic mutation. Ref.8		VAR_038442
	Natural variant	965	1	H → P. Corresponds to variant rs11711871 [ dbSNP | Ensembl ].		VAR_038443
	Natural variant	1046	1	P → A. Corresponds to variant rs35649793 [ dbSNP | Ensembl ].		VAR_038444
	Natural variant	1061	1	A → V. Corresponds to variant rs35795536 [ dbSNP | Ensembl ].		VAR_061724
	Natural variant	1604	1	G → R. Ref.6 Corresponds to variant rs3732383 [ dbSNP | Ensembl ].		VAR_038445
	Natural variant	1608	1	A → V. Corresponds to variant rs34810344 [ dbSNP | Ensembl ].		VAR_038446
	Natural variant	1634	1	R → K in a breast cancer sample; somatic mutation. Ref.8		VAR_038447
	Natural variant	1707	1	Q → H. Corresponds to variant rs34053674 [ dbSNP | Ensembl ].		VAR_061725
	Natural variant	1724	1	I → V. Corresponds to variant rs9827576 [ dbSNP | Ensembl ].		VAR_038448
Experimental info
	Sequence conflict	21	1	D → G in CAH18268. Ref.5
	Sequence conflict	106	1	I → T in CAH18268. Ref.5
	Sequence conflict	274	1	E → G in CAH18268. Ref.5
	Sequence conflict	754	1	Q → P in CAH18268. Ref.5
	Sequence conflict	813	1	G → R in CAH18268. Ref.5
	Sequence conflict	1556	1	K → R in BAC04783. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform A [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 41A5CC13FE1955CB	FASTA	1,843	198,561
	10 20 30 40 50 60 MADTQTQVAP TPTMRMATAE DLPLPPPPAL EDLPLPPPKE SFSKFHQQRQ ASELRRLYRH 70 80 90 100 110 120 IHPELRKNLA EAVAEDLAEV LGSEEPTEGD VQCMRWIFEN WRLDAIGEHE RPAAKEPVLC 130 140 150 160 170 180 GDVQATSRKF EEGSFANSTD QEPTRPQPGG GDVRAARWLF ETKPLDELTG QAKELEATVR 190 200 210 220 230 240 EPAASGDVQG TRMLFETRPL DRLGSRPSLQ EQSPLELRSE IQELKGDVKK TVKLFQTEPL 250 260 270 280 290 300 CAIQDAEGAI HEVKAACREE IQSNAVRSAR WLFETRPLDA INQDPSQVRV IRGISLEEGA 310 320 330 340 350 360 RPDVSATRWI FETQPLDAIR EILVDEKDFQ PSPDLIPPGP DVQQQQHLFE TRALDTLKGD 370 380 390 400 410 420 EEAGAEAPPK EEVVPGDVRS TLWLFETKPL DAFRDKVQVG HLQRVDPQDG EGHLSSDSSS 430 440 450 460 470 480 ALPFSQSAPQ RDELKGDVKT FKNLFETLPL DSIGQGEVLA HGSPSREEGT DSAGQAQGIG 490 500 510 520 530 540 SPVYAMQDSK GRLHALTSVS REQIVGGDVQ GYRWMFETQP LDQLGRSPST IDVVRGITRQ 550 560 570 580 590 600 EVVAGDVGTA RWLFETQPLE MIHQREQQER QKEEGKSQGD PQPEAPPKGD VQTIRWLFET 610 620 630 640 650 660 CPMSELAEKQ GSEVTDPTAK AEAQSCTWMF KPQPVDRPVG SREQHLQVSQ VPAGERQTDR 670 680 690 700 710 720 HVFETEPLQA SGRPCGRRPV RYCSRVEIPS GQVSRQKEVF QALEAGKKEE QEPRVIAGSI 730 740 750 760 770 780 PAGSVHKFTW LFENCPMGSL AAESIQGGNL LEEQPMSPSG NRMQESQETA AEGTLRTLHA 790 800 810 820 830 840 TPGILHHGGI LMEARGPGEL CLAKYVLSGT GQGHPYIRKE ELVSGELPRI ICQVLRRPDV 850 860 870 880 890 900 DQQGLLVQED PTGQLQLKPL RLPTPGSSGN IEDMDPELQQ LLACGLGTSV ARTGLVMQET 910 920 930 940 950 960 EQGLVALTAY SLQPRLTSKA SERSSVQLLA SCIDKGDLSG LHSLRWEPPA DPSPVPASEG 970 980 990 1000 1010 1020 AQSLHPTESI IHVPPLDPSM GMGHLRASGA TPCPPQAIGK AVPLAGEAAA PAQLQNTEKQ 1030 1040 1050 1060 1070 1080 EDSHSGQKGM AVLGKSEGAT TTPPGPGAPD LLAAMQSLRM ATAEAQSLHQ QVLNKHKQGP 1090 1100 1110 1120 1130 1140 TPTATSNPIQ DGLRKAGATQ SNIRPGGGSD PRIPAAPRKV SREEQALPRG LPGGWVTIQD 1150 1160 1170 1180 1190 1200 GIYTAHPVRT FDPPGGVQLS QREPQSRHRE TALSVQAPRP LQGGPGQSTG PGREEPGGCT 1210 1220 1230 1240 1250 1260 QMAWGPPGKA MAEVCPGGLQ AAETTLKTAP LGRHILASGP QAAGASPHPH NAFVPPPPTL 1270 1280 1290 1300 1310 1320 PAAVTGPDFP AGAHRAEDSI QQASEPLKDP LLHSHSSPAG QRTPGGSQTK TPKLDPTMPP 1330 1340 1350 1360 1370 1380 KKKPQLPPKP AHLTQSHPPQ RLPKPLPLSP SFSSEVGQRE HQRGERDTAI PQPAKVPTTV 1390 1400 1410 1420 1430 1440 DQGHIPLARC PSGHSQPSLQ HGLSTTAPRP TKNQATGSNA QSSEPPKLNA LNHDPTSPQW 1450 1460 1470 1480 1490 1500 GPGPSGEQPM EGSHQGAPES PDSLQRNQKE LQGLLNQVQA LEKEAASSVD VQALRRLFEA 1510 1520 1530 1540 1550 1560 VPQLGGAAPQ APAAHQKPEA SVEQAFGELT RVSTEVAQLK EQTLARLLDI EEAVHKALSS 1570 1580 1590 1600 1610 1620 MSSLQPEASA RGHFQGPPKD HSAHKISVTV SSSARPSGSG QEVGGQTAVK NQAKVECHTE 1630 1640 1650 1660 1670 1680 AQSQVKIRNH TEARGHTAST APSTRRQETS REYLCPPRVL PSSRDSPSSP TFISIQSATR 1690 1700 1710 1720 1730 1740 KPLETPSFKG NPDVSVKSTQ LAQDIGQALL HQKGVQDKTG KKDITQCSVQ PEPAPPSASP 1750 1760 1770 1780 1790 1800 LPRGWQKSVL ELQTGPGSSQ HYGAMRTVTE QYEEVDQFGN TVLMSSTTVT EQAEPPRNPG 1810 1820 1830 1840 SHLGLHASPL LRQFLHSPAG FSSDLTEAET VQVSCSYSQP AAQ
	Isoform B [UniParc]. Checksum: 6BC1414DF33DE804	FASTA	1,121	122,134
	10 20 30 40 50 60 MADTQTQVAP TPTMRMATAE DLPLPPPPAL EDLPLPPPKE SFSKFHQQRQ ASELRRLYRH 70 80 90 100 110 120 IHPELRKNLA EAVAEDLAEV LGSEEPTEGD VQCMRWIFEN WRLDAIGEHE RPAAKEPVLC 130 140 150 160 170 180 GDVQATSRKF EEGSFANSTD QEPTRPQPGG GDVRAARWLF ETKPLDELTG QAKELEATVR 190 200 210 220 230 240 EPAASGDVQG TRMLFETRPL DRLGSRPSLQ EQSPLELRSE IQELKGDVKK TVKLFQTEPL 250 260 270 280 290 300 CAIQDAEGAI HEVKAACREE IQSNAVRSAR WLFETRPLDA INQDPSQVRV IRGISLEEGA 310 320 330 340 350 360 RPDVSATRWI FETQPLDAIR EILVDEKDFQ PSPDLIPPGP DVQQQQHLFE TRALDTLKGD 370 380 390 400 410 420 EEAGAEAPPK EEVVPGDVRS TLWLFETKPL DAFRDKVQVG HLQRVDPQDG EGHLSSDSSS 430 440 450 460 470 480 ALPFSQSAPQ RDELKGDVKT FKNLFETLPL DSIGQGEVLA HGSPSREEGT DSAGQAQGIG 490 500 510 520 530 540 SPVYAMQDSK GRLHALTSVS REQIVGGDVQ GYRWMFETQP LDQLGRSPST IDVVRGITRQ 550 560 570 580 590 600 EVVAGDVGTA RWLFETQPLE MIHQREQQER QKEEGKSQGD PQPEAPPKGD VQTIRWLFET 610 620 630 640 650 660 CPMSELAEKQ GSEVTDPTAK AEAQSCTWMF KPQPVDRPVG SREQHLQVSQ VPAGERQTDR 670 680 690 700 710 720 HVFETEPLQA SGRPCGRRPV RYCSRVEIPS GQVSRQKEVF QALEAGKKEE QEPRVIAGSI 730 740 750 760 770 780 PAGSVHKFTW LFENCPMGSL AAESIQGGNL LEEQPMSPSG NRMQESQETA AEGTLRTLHA 790 800 810 820 830 840 TPGILHHGGI LMEARGPGEL CLAKYVLSGT GQGHPYIRKE ELVSGELPRI ICQVLRRPDV 850 860 870 880 890 900 DQQGLLVQED PTGQLQLKPL RLPTPGSSGN IEDMDPELQQ LLACGLGTSV ARTGLVMQET 910 920 930 940 950 960 EQGLVALTAY SLQPRLTSKA SERSSVQLLA SCIDKGDLSG LHSLRWEPPA DPSPVPASEG 970 980 990 1000 1010 1020 AQSLHPTESI IHVPPLDPSM GMGHLRASGA TPCPPQAIGK AVPLAGEAAA PAQLQNTEKQ 1030 1040 1050 1060 1070 1080 EDSHSGQKGM AVLGKSEGAT TTPPGPGAPD LLAAMQSLRM ATAEAQSLHQ QVLNKHKQGP 1090 1100 1110 1120 TPTATSNPIQ DGLRKAGATQ SNIRPGGGSD PRIPAAPRKL L
	Isoform C [UniParc]. Checksum: 79911F6ED688EBE6	FASTA	526	56,273
	10 20 30 40 50 60 MPPKKKPQLP PKPAHLTQSH PPQRLPKPLP LSPSFSSEVG QREHQRGERD TAIPQPAKVP 70 80 90 100 110 120 TTVDQGHIPL ARCPSGHSQP SLQHGLSTTA PRPTKNQATG SNAQSSEPPK LNALNHDPTS 130 140 150 160 170 180 PQWGPGPSGE QPMEGSHQGA PESPDSLQRN QKELQGLLNQ VQALEKEAAS SVDVQALRRL 190 200 210 220 230 240 FEAVPQLGGA APQAPAAHQK PEASVEQAFG ELTRVSTEVA QLKEQTLARL LDIEEAVHKA 250 260 270 280 290 300 LSSMSSLQPE ASARGHFQGP PKDHSAHKIS VTVSSSARPS GSGQEVGGQT AVKNQAKVEC 310 320 330 340 350 360 HTEAQSQVKI RNHTEARGHT ASTAPSTRRQ ETSREYLCPP RVLPSSRDSP SSPTFISIQS 370 380 390 400 410 420 ATRKPLETPS FKGNPDVSVK STQLAQDIGQ ALLHQKGVQD KTGKKDITQC SVQPEPAPPS 430 440 450 460 470 480 ASPLPRGWQK SVLELQTGPG SSQHYGAMRT VTEQYEEVDQ FGNTVLMSST TVTEQAEPPR 490 500 510 520 NPGSHLGLHA SPLLRQFLHS PAGFSSDLTE AETVQVSCSY SQPAAQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Xin repeats define a novel actin-binding motif." Pacholsky D., Vakeel P., Himmel M., Loewe T., Stradal T., Rottner K., Fuerst D.O., van der Ven P.F.M. J. Cell Sci. 117:5257-5268(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B), FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH F-ACTIN. Tissue: Skeletal muscle.
[2]	"Unusual splicing events result in distinct Xin isoforms that associate differentially with filamin c and Mena/VASP." van der Ven P.F.M., Ehler E., Vakeel P., Eulitz S., Schenk J.A., Milting H., Micheel B., Fuerst D.O. Exp. Cell Res. 312:2154-2167(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), ALTERNATIVE SPLICING (ISOFORMS B AND C), TISSUE SPECIFICITY, INTERACTION WITH FLNC AND VASP. Tissue: Skeletal muscle.
[3]	"A novel human gene, hXin, specifically expressed in human heart and skeletal muscle." Luo J., Liu M., Wu X. Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM C), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 444-1843 (ISOFORM A). Tissue: Heart, Tongue and Trachea.
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 570-1623 (ISOFORM A), VARIANT ARG-346. Tissue: Liver and Skeletal muscle.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM C), VARIANT ARG-1604.
[7]	"Study of a muscle specific transcript." Trevisan S., Lanfranchi G. Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1554-1843.
[8]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-929 AND LYS-1634.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ626899 mRNA. Translation: CAF25191.1. AJ626900 mRNA. Translation: CAF25192.1. AY375160 mRNA. Translation: AAQ64003.1. AK095941 mRNA. Translation: BAC04655.1. AK096421 mRNA. Translation: BAC04783.1. AK126299 mRNA. Translation: BAC86519.1. Different initiation. AL713648 mRNA. Translation: CAD28459.1. Different initiation. CR749430 mRNA. Translation: CAH18268.1. BC127119 mRNA. Translation: AAI27120.1. BC139782 mRNA. Translation: AAI39783.1. AJ271461 mRNA. Translation: CAC81057.1. Frameshift.
IPI	IPI00793675. IPI00794464. IPI00794625.
RefSeq	NP_001185550.1. NM_001198621.1. NP_919269.2. NM_194293.2.
UniGene	Hs.447868. Hs.737550.
3D structure databases
ProteinModelPortal	Q702N8.
ModBase	Search...
PTM databases
PhosphoSite	Q702N8.
Polymorphism databases
DMDM	74712579.
Proteomic databases
PaxDb	Q702N8.
PRIDE	Q702N8.
Protocols and materials databases
DNASU	165904.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000340369; ENSP00000343140; ENSG00000168334. ENST00000396251; ENSP00000379550; ENSG00000168334. ENST00000421646; ENSP00000391645; ENSG00000168334.
GeneID	165904.
KEGG	hsa:165904.
UCSC	uc003cji.3. human. uc003cjj.3. human. uc003cjk.2. human.
Organism-specific databases
CTD	165904.
GeneCards	GC03M039200.
H-InvDB	HIX0003187.
HGNC	HGNC:14301. XIRP1.
HPA	CAB026391. HPA016750. HPA018458.
MIM	609777. gene.
neXtProt	NX_Q702N8.
PharmGKB	PA162409336.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG85108.
HOVERGEN	HBG106912.
InParanoid	Q702N8.
OMA	YTAHPVR.
PhylomeDB	Q702N8.
Gene expression databases
Bgee	Q702N8.
Genevestigator	Q702N8.
Family and domain databases
InterPro	IPR012510. Actin-binding_Xin_repeat. [Graphical view]
Pfam	PF08043. Xin. 8 hits. [Graphical view]
PROSITE	PS51389. XIN. 17 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	165904.
NextBio	88568.
SOURCE	Search...

Entry information

Entry name

XIRP1_HUMAN

Accession

Primary (citable) accession number: Q702N8
Secondary accession number(s): A0JP25 , A4QPE2, Q68DF2, Q6ZTR3, Q702N9, Q8IVN7, Q8N1N3, Q8N904, Q8TCG7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	July 5, 2004
Last modified:	April 3, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.