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Q701T7 (Q701T7_9INFA) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesSubmitted name:
Hemagglutinin EMBL CAF33020.1
Gene names
Name:HA EMBL CAF33020.1
OrganismInfluenza A virus (A/turkey/Italy/220158/2002(H7N3)) EMBL CAF33020.1
Taxonomic identifier265121 [NCBI]
Taxonomic lineageViruses › ssRNA negative-strand viruses › Orthomyxoviridae › Influenzavirus A

Protein attributes

Sequence length560 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore By similarity. RuleBase RU003324 SAAS SAAS013828

Subunit structure

Homotrimer of disulfide-linked HA1-HA2 By similarity. RuleBase RU003324 SAAS SAAS013828

Sequence similarities

Belongs to the influenza viruses hemagglutinin family. RuleBase RU003324

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential EMBL CAF33020.1
Chain19 – 560542hemagglutinin EMBL CAF33020.1
PRO_5000072417

Sites

Binding site4211N-acetyl-D-glucosamine PDB 1TI8

Sequences

Sequence LengthMass (Da)Tools
Q701T7 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 847CA88C5DFA7FFE

FASTA56062,193
        10         20         30         40         50         60 
MNTQILVFAL VAIIPTNADK ICLGHHAVSN GTKVNTLTER GVEVVNATET VERTNVPRIC 

        70         80         90        100        110        120 
SKGKRTVDLG QCGLLGTITG PPQCDQFLEF SADLIIERRE GSDVCYPGKF VNEEALRQIL 

       130        140        150        160        170        180 
RESGGIDKET MGFTYSGIRT NGATSACRRS GSSFYAEMKW LLSNTDNAAF PQMTKSYKNT 

       190        200        210        220        230        240 
RKDPALIIWG IHHSGSTTEQ TKLYGSGNKL ITVGSSNYQQ SFVPSPGARP QVNGQSGRID 

       250        260        270        280        290        300 
FHWLMLNPND TVTFSFNGAF IAPDRASFLR GKSMGIQSSV QVDANCEGDC YHSGGTIISN 

       310        320        330        340        350        360 
LPFQNINSRA VGKCPRYVKQ ESLMLATGMK NVPEIPKGRG LFGAIAGFIE NGWEGLIDGW 

       370        380        390        400        410        420 
YGFRHQNAQG EGTAADYKST QSAIDQITGK LNRLIEKTNQ QFELIDNEFT EVEKQIGNVI 

       430        440        450        460        470        480 
NWTRDSMTEV WSYNAELLVA MENQHTIDLA DSEMNKLYER VKRQLRENAE EDGTGCFEIF 

       490        500        510        520        530        540 
HKCDDDCMAS IRNNTYDHSR YREEAMQNRI QIDPVKLSSG YKDVILWFSF GASCFILLAI 

       550        560 
AMGLVFICVK NGNMRCTICI

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References

[1]"Molecular characterization of low pathogenicity H7N3 Avian influenza viruses isolated in Italy."
Di Trani L., Bedini B., Cordioli P., Muscillo M., Vignolo E., Moreno A., Tollis M.
Avian Dis. 0:0-0(0)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: A/turkey/Italy/220158/2002 EMBL CAF33020.1.
[2]Muscillo M.
Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: A/turkey/Italy/220158/2002 EMBL CAF33020.1.
[3]"H1 and H7 influenza haemagglutinin structures extend a structural classification of haemagglutinin subtypes."
Russell R.J., Gamblin S.J., Haire L.F., Stevens D.J., Xiao B., Ha Y., Skehel J.J.
Virology 325:287-296(2004) [PubMed: 15246268] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 340-511 IN COMPLEX WITH N-ACETYL-D-GLUCOSAMINE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ627493 Genomic RNA. Translation: CAF33020.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1TI8X-ray3.00B340-511[»]
ProteinModelPortalQ701T7.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR008980. Capsid_hemagglutn.
IPR013828. Hemagglutn_HA1_a/b_dom.
IPR013827. Hemagglutn_HA1_b-rbn_dom.
IPR000149. Hemagglutn_influenz_A.
IPR001364. Hemagglutn_influenz_A/B.
IPR013829. Hemagglutn_stalk.
[Graphical view]
Gene3DG3DSA:3.90.209.20. Haemagglutn_HA1_a/b. 1 hit.
G3DSA:2.10.77.10. Haemagglutn_HA1_b-ribbon. 1 hit.
G3DSA:3.90.20.10. Haemagglutn_stalk. 1 hit.
PfamPF00509. Hemagglutinin. 1 hit.
[Graphical view]
PRINTSPR00330. HEMAGGLUTN1.
PR00329. HEMAGGLUTN12.
SUPFAMSSF49818. Capsid_hemag. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ701T7_9INFA
AccessionPrimary (citable) accession number: Q701T7
Entry history
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: January 25, 2012
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info