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Protein

Beta-galactoside alpha-2,6-sialyltransferase 2

Gene

ST6GAL2

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids (By similarity).By similarity

Catalytic activityi

CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.99.1. 4497.

Protein family/group databases

CAZyiGT29. Glycosyltransferase Family 29.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactoside alpha-2,6-sialyltransferase 2 (EC:2.4.99.1)
Short name:
Alpha 2,6-ST 2
Alternative name(s):
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2
ST6Gal II
Short name:
ST6GalII
Sialyltransferase 2
Gene namesi
Name:ST6GAL2
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1111CytoplasmicSequence analysisAdd
BLAST
Transmembranei12 – 3221Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini33 – 529497LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 529529Beta-galactoside alpha-2,6-sialyltransferase 2PRO_0000314787Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi211 – 2111N-linked (GlcNAc...)Sequence analysis
Disulfide bondi253 ↔ 519By similarity
Disulfide bondi296 ↔ 448By similarity
Disulfide bondi466 ↔ 477By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ701R4.

Interactioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000040768.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 29 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2692. Eukaryota.
ENOG410XT8P. LUCA.
HOGENOMiHOG000013206.
HOVERGENiHBG052853.
InParanoidiQ701R4.
KOiK00779.

Family and domain databases

InterProiIPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR001675. Glyco_trans_29.
[Graphical view]
PfamiPF00777. Glyco_transf_29. 1 hit.
[Graphical view]
SUPFAMiSSF88713. SSF88713. 1 hit.

Sequencei

Sequence statusi: Complete.

Q701R4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPHLKQWRQ RMLFGLFAGG LLFLLIFIYF TDSNPAEPVP SSLSFLETRR
60 70 80 90 100
LLPVQGKQRA IMGAAHEPSP PGGLDARQAL PRAHPAGSFH AGPGDLQKWA
110 120 130 140 150
QSQDGFEHKE FFSSQVGRKS QSAFYPEDDD YFFAAGQPGW HSHSQGTLGF
160 170 180 190 200
PSPGEPGPRE GAFPAAQVQR RRVKKRHRRQ RRSHVLEEGD DGDRLYSSMS
210 220 230 240 250
RAFLYRLWKG NVSSKMLNPR LQKAMKDYLT ANKHGVRFRG KREAGLSRAQ
260 270 280 290 300
LLCQLRSRAR VRTLDGTEAP FSALGWRRLV PAVPLSQLHP RGLRSCAVVM
310 320 330 340 350
SAGAILNSSL GEEIDSHDAV LRFNSAPTRG YEKDVGNKTT VRIINSQILT
360 370 380 390 400
NPSHHFVDSS LYKDVILVAW DPAPYSANLN LWYKKPDYNL FTPYIQHRQR
410 420 430 440 450
NPNQPFYILH PKFIWQLWDI IQENTKEKIQ PNPPSSGFIG ILIMMSMCRE
460 470 480 490 500
VHVYEYIPSV RQTELCHYHE LYYDAACTLG AYHPLLYEKL LVQRLNTGTQ
510 520
GDLHRKGKVV LPGFQAVHCP APSPVIPHS
Length:529
Mass (Da):59,957
Last modified:July 5, 2004 - v1
Checksum:iE580804485A5F39E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ627625 mRNA. Translation: CAF29493.1.
RefSeqiNP_001181861.1. NM_001194932.1.
UniGeneiPtr.6301.

Genome annotation databases

GeneIDi450198.
KEGGiptr:450198.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ627625 mRNA. Translation: CAF29493.1.
RefSeqiNP_001181861.1. NM_001194932.1.
UniGeneiPtr.6301.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000040768.

Protein family/group databases

CAZyiGT29. Glycosyltransferase Family 29.

Proteomic databases

PaxDbiQ701R4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi450198.
KEGGiptr:450198.

Organism-specific databases

CTDi84620.

Phylogenomic databases

eggNOGiKOG2692. Eukaryota.
ENOG410XT8P. LUCA.
HOGENOMiHOG000013206.
HOVERGENiHBG052853.
InParanoidiQ701R4.
KOiK00779.

Enzyme and pathway databases

BRENDAi2.4.99.1. 4497.

Family and domain databases

InterProiIPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR001675. Glyco_trans_29.
[Graphical view]
PfamiPF00777. Glyco_transf_29. 1 hit.
[Graphical view]
SUPFAMiSSF88713. SSF88713. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach."
    Harduin-Lepers A., Mollicone R., Delannoy P., Oriol R.
    Glycobiology 15:805-817(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiSIAT2_PANTR
AccessioniPrimary (citable) accession number: Q701R4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.