Reviewed, UniProtKB/Swiss-Prot Q701R4 (SIAT2_PANTR)

Names and origin

Protein names

Recommended name:
    Beta-galactoside alpha-2,6-sialyltransferase 2
    EC=2.4.99.1
Alternative name(s):
    CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2
      Short name=Alpha 2,6-ST 2
      Short name=Sialyltransferase 2
    ST6Gal-II
    ST6Gal II
      Short name=ST6GalII

Gene names

Name:

ST6GAL2

Organism

Pan troglodytes (Chimpanzee)

Taxonomic identifier

9598 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pan

Protein attributes

Sequence length	529 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids By similarity.
Catalytic activity	CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine.
Subcellular location	Golgi apparatus › Golgi stack membrane; Single-pass type II membrane protein By similarity.
Sequence similarities	Belongs to the glycosyltransferase 29 family.

Ontologies

Keywords
Cellular component	Golgi apparatus Membrane
Domain	Signal-anchor Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological process	oligosaccharide metabolic process Inferred from sequence or structural similarity. Source: UniProtKB protein amino acid glycosylation Inferred from electronic annotation. Source: InterPro
Cellular component	integral to Golgi membrane Inferred from electronic annotation. Source: InterPro
Molecular function	beta-galactoside alpha-2,6-sialyltransferase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 529	529	Beta-galactoside alpha-2,6-sialyltransferase 2		PRO_0000314787
Regions
	Topological domain	1 – 11	11	Cytoplasmic Potential
	Transmembrane	12 – 32	21	Signal-anchor for type II membrane protein Potential
	Topological domain	33 – 529	497	Lumenal Potential
Amino acid modifications
	Glycosylation	211	1	N-linked (GlcNAc...) Potential
	Disulfide bond	296 ↔ 448		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q701R4-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: E580804485A5F39E	FASTA	529	59,957
	10 20 30 40 50 60 MKPHLKQWRQ RMLFGLFAGG LLFLLIFIYF TDSNPAEPVP SSLSFLETRR LLPVQGKQRA 70 80 90 100 110 120 IMGAAHEPSP PGGLDARQAL PRAHPAGSFH AGPGDLQKWA QSQDGFEHKE FFSSQVGRKS 130 140 150 160 170 180 QSAFYPEDDD YFFAAGQPGW HSHSQGTLGF PSPGEPGPRE GAFPAAQVQR RRVKKRHRRQ 190 200 210 220 230 240 RRSHVLEEGD DGDRLYSSMS RAFLYRLWKG NVSSKMLNPR LQKAMKDYLT ANKHGVRFRG 250 260 270 280 290 300 KREAGLSRAQ LLCQLRSRAR VRTLDGTEAP FSALGWRRLV PAVPLSQLHP RGLRSCAVVM 310 320 330 340 350 360 SAGAILNSSL GEEIDSHDAV LRFNSAPTRG YEKDVGNKTT VRIINSQILT NPSHHFVDSS 370 380 390 400 410 420 LYKDVILVAW DPAPYSANLN LWYKKPDYNL FTPYIQHRQR NPNQPFYILH PKFIWQLWDI 430 440 450 460 470 480 IQENTKEKIQ PNPPSSGFIG ILIMMSMCRE VHVYEYIPSV RQTELCHYHE LYYDAACTLG 490 500 510 520 AYHPLLYEKL LVQRLNTGTQ GDLHRKGKVV LPGFQAVHCP APSPVIPHS

References

[1]	"The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach." Harduin-Lepers A., Mollicone R., Delannoy P., Oriol R. Glycobiology 15:805-817(2005) [PubMed: 15843597] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ627625 mRNA. Translation: CAF29493.1.
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GT29. Glycosyltransferase Family 29.
Genome annotation databases
Ensembl	ENSPTRT00000022867; ENSPTRP00000021103; ENSPTRG00000012323; Pan troglodytes. [Genome view] ENSPTRT00000044487; ENSPTRP00000040768; ENSPTRG00000012323; Pan troglodytes. [Genome view]
Phylogenomic databases
HOVERGEN	Q701R4.
Enzyme and pathway databases
BRENDA	2.4.99.1. 264977.
Family and domain databases
InterPro	IPR001675. Glyco_trans_29. [Graphical view]
Pfam	PF00777. Glyco_transf_29. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SIAT2_PANTR

Accession

Primary (citable) accession number: Q701R4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 5, 2004
Last modified:	September 22, 2009
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)