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Reviewed, UniProtKB/Swiss-Prot Q701R3 (SIAT2_RAT)

Last modified February 9, 2010. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Beta-galactoside alpha-2,6-sialyltransferase 2
      Short name=Alpha 2,6-ST 2
    EC=2.4.99.1
Alternative name(s):
    CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2
    Sialyltransferase 2
    ST6Gal II
      Short name=ST6GalII
Gene names
Name: St6gal2
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length525 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids By similarity.

Catalytic activity

CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine.

Subcellular location

Golgi apparatusGolgi stack membrane; Single-pass type II membrane protein By similarity.

Sequence similarities

Belongs to the glycosyltransferase 29 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 525525Beta-galactoside alpha-2,6-sialyltransferase 2
PRO_0000314788

Regions

Topological domain1 – 1111Cytoplasmic Potential
Transmembrane12 – 3221Signal-anchor for type II membrane protein Potential
Topological domain33 – 525493Lumenal Potential

Amino acid modifications

Glycosylation3031N-linked (GlcNAc...) Potential
Glycosylation3331N-linked (GlcNAc...) Potential
Glycosylation5211N-linked (GlcNAc...) Potential
Disulfide bond292 ↔ 444 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q701R3-1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: E68DE58A6F73634F

FASTA52559,917
        10         20         30         40         50         60 
MKPHLKQWRQ RMLFAIFVWG LLFLAIFIYF TNSNPAAPMP SSFSFLESRG LLPVQGKQRV 

        70         80         90        100        110        120 
IMGALQEPSL PRSLEPSKVL MDGHSASPFN SWPGDPQKGD QAQDGFDNGD EFFTSQVGRK 

       130        140        150        160        170        180 
SQSAFYPEED NYFFVAGQPG LYHHRQGALG LPSPGESSWQ SGPGQPKQEK LRHPRRGSLP 

       190        200        210        220        230        240 
EEAYDSDMLS TSMSRAFLYR LWKGTVSSKM LNPRLQKAMR YYMSFNKHGV RFSRRGRREA 

       250        260        270        280        290        300 
RRTGPELLCE MRKRVRVRTL DGKEAPFSGL GWRPLVPGVP LSQLHPRGLR SCAVVMSAGA 

       310        320        330        340        350        360 
ILNSSLGEEI DSHDAVLRFN SAPTRGYEKD VGNKTTVRII NSQILANPSH HFIDSSLYKD 

       370        380        390        400        410        420 
VILVAWDPAP YSANLNLWYK KPDYNLFTPY IQHRLKYPTQ PFYILHPKFI WQLWDIIQEN 

       430        440        450        460        470        480 
TREKIQPNPP SSGFIGILVM MSMCQEVHVY EYIPSVRQTE LCHYHELYYD AACTLGAYHP 

       490        500        510        520 
LLYEKLLVQR LNTGTQADLH HKGKVVLPGF QTLRCPVTRP NNTNT 

« Hide

References

[1]"The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach."
Harduin-Lepers A., Mollicone R., Delannoy P., Oriol R.
Glycobiology 15:805-817(2005) [PubMed: 15843597] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Wistar.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ627626 mRNA. Translation: CAF29494.1.
IPIIPI00371538.
RefSeqXP_001058146.1.
XP_236826.2.
UniGeneRn.214119

3D structure databases

ModBaseSearch...

Protein family/group databases

CAZyGT29. Glycosyltransferase Family 29.

Genome annotation databases

GeneID301155.
KEGGrno:301155.

Organism-specific databases

CTD301155.
RGD1559663. St6gal2.

Phylogenomic databases

HOVERGENQ701R3.

Enzyme and pathway databases

BRENDA2.4.99.1. 248.

Gene expression databases

GenevestigatorQ701R3.

Family and domain databases

InterProIPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR001675. Glyco_trans_29.
[Graphical view]
PfamPF00777. Glyco_transf_29. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio648263.

Entry information

Entry nameSIAT2_RAT
AccessionPrimary (citable) accession number: Q701R3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: February 9, 2010
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents