Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Beta-galactoside alpha-2,6-sialyltransferase 2

Gene

St6gal2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids.By similarity

Catalytic activityi

CMP-N-acetyl-beta-neuraminate + beta-D-galactosyl-R = CMP + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-R.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.99.1 5301
ReactomeiR-RNO-4085001 Sialic acid metabolism

Protein family/group databases

CAZyiGT29 Glycosyltransferase Family 29

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactoside alpha-2,6-sialyltransferase 2 (EC:2.4.99.1By similarity)
Short name:
Alpha 2,6-ST 2
Alternative name(s):
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2
ST6Gal II
Short name:
ST6GalII
Sialyltransferase 2
Gene namesi
Name:St6gal2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi1559663 St6gal2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
Transmembranei12 – 32Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini33 – 525LumenalSequence analysisAdd BLAST493

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003147881 – 525Beta-galactoside alpha-2,6-sialyltransferase 2Add BLAST525

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi249 ↔ 515By similarity
Disulfide bondi292 ↔ 444By similarity
Glycosylationi303N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi333N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi462 ↔ 473By similarity
Glycosylationi521N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ701R3
PRIDEiQ701R3

PTM databases

iPTMnetiQ701R3
PhosphoSitePlusiQ701R3

Expressioni

Gene expression databases

BgeeiENSRNOG00000046515

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067395

Structurei

3D structure databases

SMRiQ701R3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 29 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2692 Eukaryota
ENOG410XT8P LUCA
GeneTreeiENSGT00550000074444
HOVERGENiHBG052853
InParanoidiQ701R3
KOiK00779
OMAiRLWKGNV
PhylomeDBiQ701R3

Family and domain databases

Gene3Di3.90.1480.20, 1 hit
InterProiView protein in InterPro
IPR011330 Glyco_hydro/deAcase_b/a-brl
IPR001675 Glyco_trans_29
IPR038578 GT29-like_sf
PfamiView protein in Pfam
PF00777 Glyco_transf_29, 1 hit
SUPFAMiSSF88713 SSF88713, 1 hit

Sequencei

Sequence statusi: Complete.

Q701R3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPHLKQWRQ RMLFAIFVWG LLFLAIFIYF TNSNPAAPMP SSFSFLESRG
60 70 80 90 100
LLPVQGKQRV IMGALQEPSL PRSLEPSKVL MDGHSASPFN SWPGDPQKGD
110 120 130 140 150
QAQDGFDNGD EFFTSQVGRK SQSAFYPEED NYFFVAGQPG LYHHRQGALG
160 170 180 190 200
LPSPGESSWQ SGPGQPKQEK LRHPRRGSLP EEAYDSDMLS TSMSRAFLYR
210 220 230 240 250
LWKGTVSSKM LNPRLQKAMR YYMSFNKHGV RFSRRGRREA RRTGPELLCE
260 270 280 290 300
MRKRVRVRTL DGKEAPFSGL GWRPLVPGVP LSQLHPRGLR SCAVVMSAGA
310 320 330 340 350
ILNSSLGEEI DSHDAVLRFN SAPTRGYEKD VGNKTTVRII NSQILANPSH
360 370 380 390 400
HFIDSSLYKD VILVAWDPAP YSANLNLWYK KPDYNLFTPY IQHRLKYPTQ
410 420 430 440 450
PFYILHPKFI WQLWDIIQEN TREKIQPNPP SSGFIGILVM MSMCQEVHVY
460 470 480 490 500
EYIPSVRQTE LCHYHELYYD AACTLGAYHP LLYEKLLVQR LNTGTQADLH
510 520
HKGKVVLPGF QTLRCPVTRP NNTNT
Length:525
Mass (Da):59,917
Last modified:July 5, 2004 - v1
Checksum:iE68DE58A6F73634F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ627626 mRNA Translation: CAF29494.1
RefSeqiNP_001094358.1, NM_001100888.1
XP_006244322.1, XM_006244260.3
XP_006244326.1, XM_006244264.3
XP_006244327.1, XM_006244265.3
XP_008764978.1, XM_008766756.2
XP_008764979.1, XM_008766757.2
XP_017451813.1, XM_017596324.1
UniGeneiRn.214119

Genome annotation databases

EnsembliENSRNOT00000072796; ENSRNOP00000067395; ENSRNOG00000046515
ENSRNOT00000079488; ENSRNOP00000071786; ENSRNOG00000046515
GeneIDi301155
KEGGirno:301155

Similar proteinsi

Entry informationi

Entry nameiSIAT2_RAT
AccessioniPrimary (citable) accession number: Q701R3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health