Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Beta-galactoside alpha-2,6-sialyltransferase 2

Gene

St6gal2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids (By similarity).By similarity

Catalytic activityi

CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.99.1. 5301.
ReactomeiR-RNO-4085001. Sialic acid metabolism.

Protein family/group databases

CAZyiGT29. Glycosyltransferase Family 29.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactoside alpha-2,6-sialyltransferase 2 (EC:2.4.99.1)
Short name:
Alpha 2,6-ST 2
Alternative name(s):
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2
ST6Gal II
Short name:
ST6GalII
Sialyltransferase 2
Gene namesi
Name:St6gal2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi1559663. St6gal2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1111CytoplasmicSequence analysisAdd
BLAST
Transmembranei12 – 3221Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini33 – 525493LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 525525Beta-galactoside alpha-2,6-sialyltransferase 2PRO_0000314788Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi249 ↔ 515By similarity
Disulfide bondi292 ↔ 444By similarity
Glycosylationi303 – 3031N-linked (GlcNAc...)Sequence analysis
Glycosylationi333 – 3331N-linked (GlcNAc...)Sequence analysis
Disulfide bondi462 ↔ 473By similarity
Glycosylationi521 – 5211N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ701R3.
PRIDEiQ701R3.

PTM databases

iPTMnetiQ701R3.
PhosphoSiteiQ701R3.

Expressioni

Gene expression databases

BgeeiENSRNOG00000046515.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067395.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 29 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2692. Eukaryota.
ENOG410XT8P. LUCA.
GeneTreeiENSGT00550000074444.
HOVERGENiHBG052853.
InParanoidiQ701R3.
KOiK00779.
OMAiYFTDSNP.
PhylomeDBiQ701R3.

Family and domain databases

InterProiIPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR001675. Glyco_trans_29.
[Graphical view]
PfamiPF00777. Glyco_transf_29. 1 hit.
[Graphical view]
SUPFAMiSSF88713. SSF88713. 1 hit.

Sequencei

Sequence statusi: Complete.

Q701R3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPHLKQWRQ RMLFAIFVWG LLFLAIFIYF TNSNPAAPMP SSFSFLESRG
60 70 80 90 100
LLPVQGKQRV IMGALQEPSL PRSLEPSKVL MDGHSASPFN SWPGDPQKGD
110 120 130 140 150
QAQDGFDNGD EFFTSQVGRK SQSAFYPEED NYFFVAGQPG LYHHRQGALG
160 170 180 190 200
LPSPGESSWQ SGPGQPKQEK LRHPRRGSLP EEAYDSDMLS TSMSRAFLYR
210 220 230 240 250
LWKGTVSSKM LNPRLQKAMR YYMSFNKHGV RFSRRGRREA RRTGPELLCE
260 270 280 290 300
MRKRVRVRTL DGKEAPFSGL GWRPLVPGVP LSQLHPRGLR SCAVVMSAGA
310 320 330 340 350
ILNSSLGEEI DSHDAVLRFN SAPTRGYEKD VGNKTTVRII NSQILANPSH
360 370 380 390 400
HFIDSSLYKD VILVAWDPAP YSANLNLWYK KPDYNLFTPY IQHRLKYPTQ
410 420 430 440 450
PFYILHPKFI WQLWDIIQEN TREKIQPNPP SSGFIGILVM MSMCQEVHVY
460 470 480 490 500
EYIPSVRQTE LCHYHELYYD AACTLGAYHP LLYEKLLVQR LNTGTQADLH
510 520
HKGKVVLPGF QTLRCPVTRP NNTNT
Length:525
Mass (Da):59,917
Last modified:July 5, 2004 - v1
Checksum:iE68DE58A6F73634F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ627626 mRNA. Translation: CAF29494.1.
RefSeqiNP_001094358.1. NM_001100888.1.
XP_006244322.1. XM_006244260.2.
XP_006244326.1. XM_006244264.2.
XP_006244327.1. XM_006244265.2.
XP_008764978.1. XM_008766756.1.
XP_008764979.1. XM_008766757.1.
UniGeneiRn.214119.

Genome annotation databases

EnsembliENSRNOT00000072796; ENSRNOP00000067395; ENSRNOG00000046515.
ENSRNOT00000079488; ENSRNOP00000071786; ENSRNOG00000046515.
GeneIDi301155.
KEGGirno:301155.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ627626 mRNA. Translation: CAF29494.1.
RefSeqiNP_001094358.1. NM_001100888.1.
XP_006244322.1. XM_006244260.2.
XP_006244326.1. XM_006244264.2.
XP_006244327.1. XM_006244265.2.
XP_008764978.1. XM_008766756.1.
XP_008764979.1. XM_008766757.1.
UniGeneiRn.214119.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067395.

Protein family/group databases

CAZyiGT29. Glycosyltransferase Family 29.

PTM databases

iPTMnetiQ701R3.
PhosphoSiteiQ701R3.

Proteomic databases

PaxDbiQ701R3.
PRIDEiQ701R3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000072796; ENSRNOP00000067395; ENSRNOG00000046515.
ENSRNOT00000079488; ENSRNOP00000071786; ENSRNOG00000046515.
GeneIDi301155.
KEGGirno:301155.

Organism-specific databases

CTDi84620.
RGDi1559663. St6gal2.

Phylogenomic databases

eggNOGiKOG2692. Eukaryota.
ENOG410XT8P. LUCA.
GeneTreeiENSGT00550000074444.
HOVERGENiHBG052853.
InParanoidiQ701R3.
KOiK00779.
OMAiYFTDSNP.
PhylomeDBiQ701R3.

Enzyme and pathway databases

BRENDAi2.4.99.1. 5301.
ReactomeiR-RNO-4085001. Sialic acid metabolism.

Miscellaneous databases

PROiQ701R3.

Gene expression databases

BgeeiENSRNOG00000046515.

Family and domain databases

InterProiIPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR001675. Glyco_trans_29.
[Graphical view]
PfamiPF00777. Glyco_transf_29. 1 hit.
[Graphical view]
SUPFAMiSSF88713. SSF88713. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSIAT2_RAT
AccessioniPrimary (citable) accession number: Q701R3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.