Q701R3 (SIAT2_RAT) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 46.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Beta-galactoside alpha-2,6-sialyltransferase 2 Short name=Alpha 2,6-ST 2 EC=2.4.99.1 Alternative name(s): CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2 ST6Gal II Short name=ST6GalII Sialyltransferase 2 | ||
| Gene names |
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| Organism | Rattus norvegicus (Rat) | ||
| Taxonomic identifier | 10116 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 525 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids By similarity. |
| Catalytic activity | CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine. |
| Subcellular location | Golgi apparatus › Golgi stack membrane; Single-pass type II membrane protein By similarity. |
| Sequence similarities | Belongs to the glycosyltransferase 29 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Golgi apparatus Membrane |
| Domain | Signal-anchor Transmembrane Transmembrane helix |
| Molecular function | Glycosyltransferase Transferase |
| PTM | Disulfide bond Glycoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | oligosaccharide metabolic process Inferred from sequence or structural similarity. Source: UniProtKB protein glycosylationInferred from electronic annotation. Source: InterPro |
| Cellular component | Golgi cisterna membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to Golgi membraneInferred from electronic annotation. Source: InterPro |
| Molecular function | beta-galactoside alpha-2,6-sialyltransferase activity Inferred from sequence or structural similarity. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 525 | 525 | Beta-galactoside alpha-2,6-sialyltransferase 2 | PRO_0000314788 | |||||||
Regions | |||||||||||
| Topological domain | 1 – 11 | 11 | Cytoplasmic Potential | ||||||||
| Transmembrane | 12 – 32 | 21 | Helical; Signal-anchor for type II membrane protein; Potential | ||||||||
| Topological domain | 33 – 525 | 493 | Lumenal Potential | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 303 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 333 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 521 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 249 ↔ 515 | By similarity | |||||||||
| Disulfide bond | 292 ↔ 444 | By similarity | |||||||||
| Disulfide bond | 462 ↔ 473 | By similarity | |||||||||
Sequences
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References
| [1] | "The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach." Harduin-Lepers A., Mollicone R., Delannoy P., Oriol R. Glycobiology 15:805-817(2005) [PubMed: 15843597] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Wistar. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AJ627626 mRNA. Translation: CAF29494.1. |
| IPI | IPI00371538. |
| RefSeq | XP_001058146.1. XM_001058146.2. XP_236826.2. XM_236826.3. |
| UniGene | Rn.214119. |
3D structure databases | |
| ModBase | Search... |
Protein family/group databases | |
| CAZy | GT29. Glycosyltransferase Family 29. |
Proteomic databases | |
| PRIDE | Q701R3. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 301155. |
| KEGG | rno:301155. |
Organism-specific databases | |
| CTD | 84620. |
| RGD | 1559663. St6gal2. |
Phylogenomic databases | |
| HOVERGEN | HBG052853. |
Enzyme and pathway databases | |
| BRENDA | 2.4.99.1. 5301. |
Gene expression databases | |
| Genevestigator | Q701R3. |
Family and domain databases | |
| InterPro | IPR011330. Glyco_hydro/deAcase_b/a-brl. IPR001675. Glyco_trans_29. [Graphical view] |
| KO | K00779. |
| Pfam | PF00777. Glyco_transf_29. 1 hit. [Graphical view] |
| SUPFAM | SSF88713. Glyco_hydro/deAcase_b/a-brl. 1 hit. |
| ProtoNet | Search... |
Other | |
| NextBio | 648263. |
Entry information
| Entry name | SIAT2_RAT | ||||||||
| Accession | Primary (citable) accession number: Q701R3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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