Q701R1 (SIAT2_XENTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Beta-galactoside alpha-2,6-sialyltransferase 2
Short name=Alpha 2,6-ST 2
EC=2.4.99.1

Alternative name(s):
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2
ST6Gal II
Short name=ST6GalII
Sialyltransferase 2

Gene names

Name:

st6gal2

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	517 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates By similarity.
Catalytic activity	CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine.
Subcellular location	Golgi apparatus › Golgi stack membrane; Single-pass type II membrane protein By similarity.
Sequence similarities	Belongs to the glycosyltransferase 29 family.

Ontologies

Keywords
Cellular component	Golgi apparatus Membrane
Domain	Signal-anchor Transmembrane Transmembrane helix
Molecular function	Glycosyltransferase Transferase
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein glycosylation Inferred from electronic annotation. Source: InterPro
Cellular component	Golgi cisterna membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to Golgi membrane Inferred from electronic annotation. Source: InterPro
Molecular function	beta-galactoside alpha-2,6-sialyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 517	517	Beta-galactoside alpha-2,6-sialyltransferase 2		PRO_0000314793
Regions
	Topological domain	1 – 10	10	Cytoplasmic Potential
	Transmembrane	11 – 31	21	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	32 – 517	486	Lumenal Potential
Amino acid modifications
	Glycosylation	201	1	N-linked (GlcNAc...) Potential
	Glycosylation	298	1	N-linked (GlcNAc...) Potential
	Glycosylation	328	1	N-linked (GlcNAc...) Potential
	Disulfide bond	244 ↔ 510		By similarity
	Disulfide bond	287 ↔ 439		By similarity
	Disulfide bond	457 ↔ 468		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q701R1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 1A8651A3BED6DE60	FASTA	517	59,959
	10 20 30 40 50 60 MKPNLKQWKQ FMLFGICAWG LLFLVIFVYF TDSNSVEPVP SAFSYVESKK HFPLQGKQRA 70 80 90 100 110 120 IMGAHQDQLF SYAIDDQDLL KEGILDSFIV GPGSMKKMAG ADNYFESEQE FIMSKKTQKS 130 140 150 160 170 180 TSNNHEDDDD EIYLHKNIDS VSGKKAPAYG KRYYHDTQRQ HKKIRRNMQR KKQHMIEDSY 190 200 210 220 230 240 DWNGFSSSMS KSFLQKLWKG NVSSKMLTPR LQKARREYLR ANKLGVNFNG KQNSRKLNPQ 250 260 270 280 290 300 ELLCVLKDRA QVKTLDGKDA PFSSLGWEKY FPKIALNKLY PHGFSTCAVV SSAGAILNSS 310 320 330 340 350 360 LGAEIDSHDA VLRFNSAPTR NYEKDVGNKT TLRIINSQIL TNPNHHFTDS SLYKDVTLIA 370 380 390 400 410 420 WDPSPYYADL HMWYHKPDYN LFPPYEKHRK RNPDQPFYIL HPKFTWELWK IIQENSNEKI 430 440 450 460 470 480 QPNPPSSGFI GILIMMSMCR TVHVYEYIPS YRQTDLCHYH EQYYDAACTL GAYHPLLYEK 490 500 510 MLIQRINQGT EDNLLRKGKV ILPGFSSIHC PIKDHIT

References

[1]	"The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach." Harduin-Lepers A., Mollicone R., Delannoy P., Oriol R. Glycobiology 15:805-817(2005) [PubMed: 15843597] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ627628 mRNA. Translation: CAF29496.1.
UniGene	Str.17205.
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GT29. Glycosyltransferase Family 29.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
Xenbase	XB-GENE-990439. st6gal2.
Phylogenomic databases
GeneTree	ENSGT00550000074444.
HOVERGEN	HBG052853.
Enzyme and pathway databases
BRENDA	2.4.99.1. 8483.
Gene expression databases
Bgee	Q701R1.
Family and domain databases
InterPro	IPR001675. Glyco_trans_29. [Graphical view]
Pfam	PF00777. Glyco_transf_29. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SIAT2_XENTR

Accession

Primary (citable) accession number: Q701R1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program