Q701R0 (SIAT2_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Beta-galactoside alpha-2,6-sialyltransferase 2
Short name=Alpha 2,6-ST 2
EC=2.4.99.1

Alternative name(s):
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2
ST6Gal II
Short name=ST6GalII
Sialyltransferase 2

Gene names

Name:

ST6GAL2

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	528 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates By similarity.
Catalytic activity	CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine.
Subcellular location	Golgi apparatus › Golgi stack membrane; Single-pass type II membrane protein By similarity.
Sequence similarities	Belongs to the glycosyltransferase 29 family.

Ontologies

Keywords
Cellular component	Golgi apparatus Membrane
Domain	Signal-anchor Transmembrane Transmembrane helix
Molecular function	Glycosyltransferase Transferase
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein glycosylation Inferred from electronic annotation. Source: InterPro
Cellular component	Golgi cisterna membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to Golgi membrane Inferred from electronic annotation. Source: InterPro
Molecular function	beta-galactoside alpha-2,6-sialyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 528	528	Beta-galactoside alpha-2,6-sialyltransferase 2		PRO_0000314789
Regions
	Topological domain	1 – 10	10	Cytoplasmic Potential
	Transmembrane	11 – 31	21	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	32 – 528	497	Lumenal Potential
Amino acid modifications
	Glycosylation	167	1	N-linked (GlcNAc...) Potential
	Glycosylation	308	1	N-linked (GlcNAc...) Potential
	Glycosylation	338	1	N-linked (GlcNAc...) Potential
	Disulfide bond	254 ↔ 519		By similarity
	Disulfide bond	297 ↔ 448		By similarity
	Disulfide bond	466 ↔ 477		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q701R0 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: E890384CA0E4AC40	FASTA	528	61,043
	10 20 30 40 50 60 MKPNLKQWKQ LMLFGIFAWG LLFLVIFIYF TDSNSAEPVP SSFSYIETKR LLPLQGKQRV 70 80 90 100 110 120 IMGAIHDPSF SEAIDGNEVL LNEDLLDTFK SETGSIKKWT DLEDAFRSED EFFPSQIGRK 130 140 150 160 170 180 SKSAFYQVND DYLFAAGQPM SHNSFQEIAK FISADEDNPK ESILQNNWSR QRRMRRRSTK 190 200 210 220 230 240 HRRSQMLDES DDWDGLYSTM SKSFLYKLWK GDVSSKMLNP RLQKAMKDYL STNKHGVRFK 250 260 270 280 290 300 GKRNSKLTGD QLFCELKERV DVKTIDGKEA PFSTLGWEKH VPQIPLGKLY THGFGSCAVV 310 320 330 340 350 360 MSAGAILNSS LGDEIDSHDA VLRFNSAPTR GYEKDVGNKT TMRIINSQIL TNPNHHFVDS 370 380 390 400 410 420 SLYKDVILVA WDPAPYSANL NWYKKPDYNL FTPYVQHRKK NPNQPFYILH PKFIWQLWDI 430 440 450 460 470 480 IQENTKEKIQ PNPPSSGFIG ILIMMSMCNE VHVYEYIPSV RQTDLCHYHE LYYDAACTLG 490 500 510 520 AYHPLLYEKL LVQRMNKGLQ DDLYRKGKVI LPGFKSVKCP ERNNFPPL

References

[1]	"The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach." Harduin-Lepers A., Mollicone R., Delannoy P., Oriol R. Glycobiology 15:805-817(2005) [PubMed: 15843597] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ627629 mRNA. Translation: CAF29497.1.
IPI	IPI00584412.
RefSeq	NP_001161219.1. NM_001167747.1.
UniGene	Gga.12886.
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GT29. Glycosyltransferase Family 29.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	403122.
KEGG	gga:403122.
Organism-specific databases
CTD	84620.
Phylogenomic databases
eggNOG	veNOG07811.
GeneTree	ENSGT00550000074444.
HOGENOM	HBG283896.
HOVERGEN	HBG052853.
InParanoid	Q701R0.
OrthoDB	EOG4V9TQT.
Enzyme and pathway databases
BRENDA	2.4.99.1. 1306.
Family and domain databases
InterPro	IPR001675. Glyco_trans_29. [Graphical view]
KO	K00779.
Pfam	PF00777. Glyco_transf_29. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SIAT2_CHICK

Accession

Primary (citable) accession number: Q701R0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program