Q701R0 (SIAT2_CHICK) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 50.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Beta-galactoside alpha-2,6-sialyltransferase 2 Short name=Alpha 2,6-ST 2 EC=2.4.99.1 Alternative name(s): CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2 ST6Gal II Short name=ST6GalII Sialyltransferase 2 | ||
| Gene names |
| ||
| Organism | Gallus gallus (Chicken) | ||
| Taxonomic identifier | 9031 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus |
Protein attributes
| Sequence length | 528 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates By similarity. |
| Catalytic activity | CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine. |
| Subcellular location | Golgi apparatus › Golgi stack membrane; Single-pass type II membrane protein By similarity. |
| Sequence similarities | Belongs to the glycosyltransferase 29 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Golgi apparatus Membrane |
| Domain | Signal-anchor Transmembrane Transmembrane helix |
| Molecular function | Glycosyltransferase Transferase |
| PTM | Disulfide bond Glycoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | protein glycosylation Inferred from electronic annotation. Source: InterPro |
| Cellular component | Golgi cisterna membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to Golgi membraneInferred from electronic annotation. Source: InterPro |
| Molecular function | beta-galactoside alpha-2,6-sialyltransferase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 528 | 528 | Beta-galactoside alpha-2,6-sialyltransferase 2 | PRO_0000314789 | |||||||
Regions | |||||||||||
| Topological domain | 1 – 10 | 10 | Cytoplasmic Potential | ||||||||
| Transmembrane | 11 – 31 | 21 | Helical; Signal-anchor for type II membrane protein; Potential | ||||||||
| Topological domain | 32 – 528 | 497 | Lumenal Potential | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 167 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 308 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 338 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 254 ↔ 519 | By similarity | |||||||||
| Disulfide bond | 297 ↔ 448 | By similarity | |||||||||
| Disulfide bond | 466 ↔ 477 | By similarity | |||||||||
Sequences
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References
| [1] | "The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach." Harduin-Lepers A., Mollicone R., Delannoy P., Oriol R. Glycobiology 15:805-817(2005) [PubMed: 15843597] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AJ627629 mRNA. Translation: CAF29497.1. |
| IPI | IPI00584412. |
| RefSeq | NP_001161219.1. NM_001167747.1. |
| UniGene | Gga.12886. |
3D structure databases | |
| ModBase | Search... |
Protein family/group databases | |
| CAZy | GT29. Glycosyltransferase Family 29. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 403122. |
| KEGG | gga:403122. |
Organism-specific databases | |
| CTD | 84620. |
Phylogenomic databases | |
| eggNOG | veNOG07811. |
| GeneTree | ENSGT00550000074444. |
| HOGENOM | HBG283896. |
| HOVERGEN | HBG052853. |
| InParanoid | Q701R0. |
| OrthoDB | EOG4V9TQT. |
Enzyme and pathway databases | |
| BRENDA | 2.4.99.1. 1306. |
Family and domain databases | |
| InterPro | IPR001675. Glyco_trans_29. [Graphical view] |
| KO | K00779. |
| Pfam | PF00777. Glyco_transf_29. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | SIAT2_CHICK | ||||||||
| Accession | Primary (citable) accession number: Q701R0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

Clusters with