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Q701N4 (KRA52_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Keratin-associated protein 5-2
Alternative name(s):
Keratin-associated protein 5-8
Keratin-associated protein 5.2
Keratin-associated protein 5.8
Ultrahigh sulfur keratin-associated protein 5.2
Gene names
Name:KRTAP5-2
Synonyms:KAP5-8, KAP5.2, KRTAP5-8, KRTAP5.2, KRTAP5.8
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length177 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Subunit structure

Interacts with hair keratins.

Tissue specificity

Restricted to hair root, not detected in any other tissues. Ref.1

Sequence similarities

Belongs to the KRTAP type 5 family.

Ontologies

Keywords
   Cellular componentKeratin
   DomainRepeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentkeratin filament

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 177177Keratin-associated protein 5-2
PRO_0000184100

Regions

Repeat62 – 6541
Repeat118 – 12142
Repeat137 – 14043
Repeat147 – 15044
Repeat157 – 16045
Repeat167 – 17046
Region62 – 1701096 X 4 AA repeats of C-C-X-P

Sequences

Sequence LengthMass (Da)Tools
Q701N4 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: BFA74666188A185C

FASTA17716,271
        10         20         30         40         50         60 
MGCCGCSRGC GSGCGGCGSS CGGCGSGCGG CGSGRGGCGS GCGGCSSSCG GCGSRCYVPV 

        70         80         90        100        110        120 
CCCKPVCSWV PACSCTSCGS CGGSKGGCGS CGGSKGGCGS CGGSKGGCGS CGCSQSSCCK 

       130        140        150        160        170 
PCCCSSGCGS SCCQSSCCKP CCCQSSCCVP VCCQSSCCKP CCCQSNCCVP VCCQCKI 

« Hide

References

« Hide 'large scale' references
[1]"Identification of two novel clusters of ultrahigh-sulfur keratin-associated protein genes on human chromosome 11."
Yahagi S., Shibuya K., Obayashi I., Masaki H., Kurata Y., Kudoh J., Shimizu N.
Biochem. Biophys. Res. Commun. 318:655-664(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Hair root.
[2]"Characterization of two domains of keratin associated protein (KAP) family members on human chromosome 11."
Rogers M.A., Langbein L., Winter H., Praetzel S., Schweizer J.
Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Scalp.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Cerebellum.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB126071 mRNA. Translation: BAD20198.1.
AJ628245 mRNA. Translation: CAF31637.1.
BC132882 mRNA. Translation: AAI32883.1.
BC132908 mRNA. Translation: AAI32909.1.
CCDSCCDS31331.1.
RefSeqNP_001004325.1. NM_001004325.1.
UniGeneHs.633229.
Hs.673618.

3D structure databases

ProteinModelPortalQ701N4.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbQ701N4.
PRIDEQ701N4.

Protocols and materials databases

DNASU440021.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000412090; ENSP00000400041; ENSG00000205867.
GeneID440021.
KEGGhsa:440021.
UCSCuc001ltv.3. human.

Organism-specific databases

CTD440021.
GeneCardsGC11M001618.
H-InvDBHIX0035833.
HGNCHGNC:23597. KRTAP5-2.
neXtProtNX_Q701N4.
PharmGKBPA134981423.
GenAtlasSearch...

Phylogenomic databases

OMACCYSSGC.

Gene expression databases

BgeeQ701N4.
CleanExHS_KRTAP5-2.
HS_KRTAP5-8.
GenevestigatorQ701N4.

Family and domain databases

InterProIPR002494. KAP.
[Graphical view]
PANTHERPTHR23262. PTHR23262. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi440021.
NextBio108833.
PROQ701N4.

Entry information

Entry nameKRA52_HUMAN
AccessionPrimary (citable) accession number: Q701N4
Secondary accession number(s): A9JTZ1
Entry history
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM