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Q701N4

- KRA52_HUMAN

UniProt

Q701N4 - KRA52_HUMAN

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Protein
Keratin-associated protein 5-2
Gene
KRTAP5-2, KAP5-8, KAP5.2, KRTAP5-8, KRTAP5.2, KRTAP5.8
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 5-2
Alternative name(s):
Keratin-associated protein 5-8
Keratin-associated protein 5.2
Keratin-associated protein 5.8
Ultrahigh sulfur keratin-associated protein 5.2
Gene namesi
Synonyms:KAP5-8, KAP5.2, KRTAP5-8, KRTAP5.2, KRTAP5.8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:23597. KRTAP5-2.

Subcellular locationi

GO - Cellular componenti

  1. keratin filament Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134981423.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 177177Keratin-associated protein 5-2
PRO_0000184100Add
BLAST

Proteomic databases

PaxDbiQ701N4.
PRIDEiQ701N4.

Expressioni

Tissue specificityi

Restricted to hair root, not detected in any other tissues.1 Publication

Gene expression databases

BgeeiQ701N4.
CleanExiHS_KRTAP5-2.
HS_KRTAP5-8.
GenevestigatoriQ701N4.

Interactioni

Subunit structurei

Interacts with hair keratins.

Structurei

3D structure databases

ProteinModelPortaliQ701N4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati62 – 6541
Repeati118 – 12142
Repeati137 – 14043
Repeati147 – 15044
Repeati157 – 16045
Repeati167 – 17046

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni62 – 1701096 X 4 AA repeats of C-C-X-P
Add
BLAST

Sequence similaritiesi

Belongs to the KRTAP type 5 family.

Keywords - Domaini

Repeat

Phylogenomic databases

OMAiCCYSSGC.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 1 hit.

Sequencei

Sequence statusi: Complete.

Q701N4-1 [UniParc]FASTAAdd to Basket

« Hide

MGCCGCSRGC GSGCGGCGSS CGGCGSGCGG CGSGRGGCGS GCGGCSSSCG    50
GCGSRCYVPV CCCKPVCSWV PACSCTSCGS CGGSKGGCGS CGGSKGGCGS 100
CGGSKGGCGS CGCSQSSCCK PCCCSSGCGS SCCQSSCCKP CCCQSSCCVP 150
VCCQSSCCKP CCCQSNCCVP VCCQCKI 177
Length:177
Mass (Da):16,271
Last modified:July 5, 2004 - v1
Checksum:iBFA74666188A185C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB126071 mRNA. Translation: BAD20198.1.
AJ628245 mRNA. Translation: CAF31637.1.
BC132882 mRNA. Translation: AAI32883.1.
BC132908 mRNA. Translation: AAI32909.1.
CCDSiCCDS31331.1.
RefSeqiNP_001004325.1. NM_001004325.1.
UniGeneiHs.633229.
Hs.673618.

Genome annotation databases

EnsembliENST00000412090; ENSP00000400041; ENSG00000205867.
GeneIDi440021.
KEGGihsa:440021.
UCSCiuc001ltv.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB126071 mRNA. Translation: BAD20198.1 .
AJ628245 mRNA. Translation: CAF31637.1 .
BC132882 mRNA. Translation: AAI32883.1 .
BC132908 mRNA. Translation: AAI32909.1 .
CCDSi CCDS31331.1.
RefSeqi NP_001004325.1. NM_001004325.1.
UniGenei Hs.633229.
Hs.673618.

3D structure databases

ProteinModelPortali Q701N4.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q701N4.
PRIDEi Q701N4.

Protocols and materials databases

DNASUi 440021.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000412090 ; ENSP00000400041 ; ENSG00000205867 .
GeneIDi 440021.
KEGGi hsa:440021.
UCSCi uc001ltv.3. human.

Organism-specific databases

CTDi 440021.
GeneCardsi GC11M001618.
H-InvDB HIX0035833.
HGNCi HGNC:23597. KRTAP5-2.
neXtProti NX_Q701N4.
PharmGKBi PA134981423.
GenAtlasi Search...

Phylogenomic databases

OMAi CCYSSGC.

Miscellaneous databases

GenomeRNAii 440021.
NextBioi 108833.
PROi Q701N4.

Gene expression databases

Bgeei Q701N4.
CleanExi HS_KRTAP5-2.
HS_KRTAP5-8.
Genevestigatori Q701N4.

Family and domain databases

InterProi IPR002494. KAP.
[Graphical view ]
PANTHERi PTHR23262. PTHR23262. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of two novel clusters of ultrahigh-sulfur keratin-associated protein genes on human chromosome 11."
    Yahagi S., Shibuya K., Obayashi I., Masaki H., Kurata Y., Kudoh J., Shimizu N.
    Biochem. Biophys. Res. Commun. 318:655-664(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Hair root.
  2. "Characterization of two domains of keratin associated protein (KAP) family members on human chromosome 11."
    Rogers M.A., Langbein L., Winter H., Praetzel S., Schweizer J.
    Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Scalp.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum.

Entry informationi

Entry nameiKRA52_HUMAN
AccessioniPrimary (citable) accession number: Q701N4
Secondary accession number(s): A9JTZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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