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Q701N4

- KRA52_HUMAN

UniProt

Q701N4 - KRA52_HUMAN

Protein

Keratin-associated protein 5-2

Gene

KRTAP5-2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Keratin-associated protein 5-2
    Alternative name(s):
    Keratin-associated protein 5-8
    Keratin-associated protein 5.2
    Keratin-associated protein 5.8
    Ultrahigh sulfur keratin-associated protein 5.2
    Gene namesi
    Name:KRTAP5-2
    Synonyms:KAP5-8, KAP5.2, KRTAP5-8, KRTAP5.2, KRTAP5.8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:23597. KRTAP5-2.

    Subcellular locationi

    GO - Cellular componenti

    1. keratin filament Source: InterPro

    Keywords - Cellular componenti

    Keratin

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134981423.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 177177Keratin-associated protein 5-2PRO_0000184100Add
    BLAST

    Proteomic databases

    PaxDbiQ701N4.
    PRIDEiQ701N4.

    Expressioni

    Tissue specificityi

    Restricted to hair root, not detected in any other tissues.1 Publication

    Gene expression databases

    BgeeiQ701N4.
    CleanExiHS_KRTAP5-2.
    HS_KRTAP5-8.
    GenevestigatoriQ701N4.

    Interactioni

    Subunit structurei

    Interacts with hair keratins.

    Structurei

    3D structure databases

    ProteinModelPortaliQ701N4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati62 – 6541
    Repeati118 – 12142
    Repeati137 – 14043
    Repeati147 – 15044
    Repeati157 – 16045
    Repeati167 – 17046

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni62 – 1701096 X 4 AA repeats of C-C-X-PAdd
    BLAST

    Sequence similaritiesi

    Belongs to the KRTAP type 5 family.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    OMAiCCYSSGC.

    Family and domain databases

    InterProiIPR002494. KAP.
    [Graphical view]
    PANTHERiPTHR23262. PTHR23262. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q701N4-1 [UniParc]FASTAAdd to Basket

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    MGCCGCSRGC GSGCGGCGSS CGGCGSGCGG CGSGRGGCGS GCGGCSSSCG    50
    GCGSRCYVPV CCCKPVCSWV PACSCTSCGS CGGSKGGCGS CGGSKGGCGS 100
    CGGSKGGCGS CGCSQSSCCK PCCCSSGCGS SCCQSSCCKP CCCQSSCCVP 150
    VCCQSSCCKP CCCQSNCCVP VCCQCKI 177
    Length:177
    Mass (Da):16,271
    Last modified:July 5, 2004 - v1
    Checksum:iBFA74666188A185C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB126071 mRNA. Translation: BAD20198.1.
    AJ628245 mRNA. Translation: CAF31637.1.
    BC132882 mRNA. Translation: AAI32883.1.
    BC132908 mRNA. Translation: AAI32909.1.
    CCDSiCCDS31331.1.
    RefSeqiNP_001004325.1. NM_001004325.1.
    UniGeneiHs.633229.
    Hs.673618.

    Genome annotation databases

    EnsembliENST00000412090; ENSP00000400041; ENSG00000205867.
    GeneIDi440021.
    KEGGihsa:440021.
    UCSCiuc001ltv.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB126071 mRNA. Translation: BAD20198.1 .
    AJ628245 mRNA. Translation: CAF31637.1 .
    BC132882 mRNA. Translation: AAI32883.1 .
    BC132908 mRNA. Translation: AAI32909.1 .
    CCDSi CCDS31331.1.
    RefSeqi NP_001004325.1. NM_001004325.1.
    UniGenei Hs.633229.
    Hs.673618.

    3D structure databases

    ProteinModelPortali Q701N4.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q701N4.
    PRIDEi Q701N4.

    Protocols and materials databases

    DNASUi 440021.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000412090 ; ENSP00000400041 ; ENSG00000205867 .
    GeneIDi 440021.
    KEGGi hsa:440021.
    UCSCi uc001ltv.3. human.

    Organism-specific databases

    CTDi 440021.
    GeneCardsi GC11M001618.
    H-InvDB HIX0035833.
    HGNCi HGNC:23597. KRTAP5-2.
    neXtProti NX_Q701N4.
    PharmGKBi PA134981423.
    GenAtlasi Search...

    Phylogenomic databases

    OMAi CCYSSGC.

    Miscellaneous databases

    GenomeRNAii 440021.
    NextBioi 108833.
    PROi Q701N4.

    Gene expression databases

    Bgeei Q701N4.
    CleanExi HS_KRTAP5-2.
    HS_KRTAP5-8.
    Genevestigatori Q701N4.

    Family and domain databases

    InterProi IPR002494. KAP.
    [Graphical view ]
    PANTHERi PTHR23262. PTHR23262. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of two novel clusters of ultrahigh-sulfur keratin-associated protein genes on human chromosome 11."
      Yahagi S., Shibuya K., Obayashi I., Masaki H., Kurata Y., Kudoh J., Shimizu N.
      Biochem. Biophys. Res. Commun. 318:655-664(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Hair root.
    2. "Characterization of two domains of keratin associated protein (KAP) family members on human chromosome 11."
      Rogers M.A., Langbein L., Winter H., Praetzel S., Schweizer J.
      Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Scalp.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Cerebellum.

    Entry informationi

    Entry nameiKRA52_HUMAN
    AccessioniPrimary (citable) accession number: Q701N4
    Secondary accession number(s): A9JTZ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 21, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3