Q701N4 (KRA52_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Keratin-associated protein 5-2

Alternative name(s):
Keratin-associated protein 5-8
Keratin-associated protein 5.2
Keratin-associated protein 5.8
Ultrahigh sulfur keratin-associated protein 5.2

Gene names

Name:	KRTAP5-2
Synonyms:	KAP5-8, KAP5.2, KRTAP5-8, KRTAP5.2, KRTAP5.8

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	177 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Subunit structure	Interacts with hair keratins.
Tissue specificity	Restricted to hair root, not detected in any other tissues. Ref.1
Sequence similarities	Belongs to the KRTAP type 5 family.

Ontologies

Keywords
Cellular component	Keratin
Domain	Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	keratin filament Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 177	177	Keratin-associated protein 5-2		PRO_0000184100
Regions
	Repeat	62 – 65	4	1
	Repeat	118 – 121	4	2
	Repeat	137 – 140	4	3
	Repeat	147 – 150	4	4
	Repeat	157 – 160	4	5
	Repeat	167 – 170	4	6
	Region	62 – 170	109	6 X 4 AA repeats of C-C-X-P

Sequences

	Sequence		Length	Mass (Da)
	Q701N4 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: BFA74666188A185C	FASTA	177	16,271
	10 20 30 40 50 60 MGCCGCSRGC GSGCGGCGSS CGGCGSGCGG CGSGRGGCGS GCGGCSSSCG GCGSRCYVPV 70 80 90 100 110 120 CCCKPVCSWV PACSCTSCGS CGGSKGGCGS CGGSKGGCGS CGGSKGGCGS CGCSQSSCCK 130 140 150 160 170 PCCCSSGCGS SCCQSSCCKP CCCQSSCCVP VCCQSSCCKP CCCQSNCCVP VCCQCKI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of two novel clusters of ultrahigh-sulfur keratin-associated protein genes on human chromosome 11." Yahagi S., Shibuya K., Obayashi I., Masaki H., Kurata Y., Kudoh J., Shimizu N. Biochem. Biophys. Res. Commun. 318:655-664(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Hair root.
[2]	"Characterization of two domains of keratin associated protein (KAP) family members on human chromosome 11." Rogers M.A., Langbein L., Winter H., Praetzel S., Schweizer J. Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Scalp.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Cerebellum.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB126071 mRNA. Translation: BAD20198.1. AJ628245 mRNA. Translation: CAF31637.1. BC132882 mRNA. Translation: AAI32883.1. BC132908 mRNA. Translation: AAI32909.1.
IPI	IPI00555784.
RefSeq	NP_001004325.1. NM_001004325.1.
UniGene	Hs.633229. Hs.673618.
3D structure databases
ProteinModelPortal	Q701N4.
ModBase	Search...
Polymorphism databases
DMDM	56749065.
Proteomic databases
PaxDb	Q701N4.
PRIDE	Q701N4.
Protocols and materials databases
DNASU	440021.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000412090; ENSP00000400041; ENSG00000205867.
GeneID	440021.
KEGG	hsa:440021.
UCSC	uc001ltv.3. human.
Organism-specific databases
CTD	440021.
GeneCards	GC11M001618.
H-InvDB	HIX0035833.
HGNC	HGNC:23597. KRTAP5-2.
neXtProt	NX_Q701N4.
PharmGKB	PA134981423.
GenAtlas	Search...
Phylogenomic databases
OMA	WVPACSC.
Gene expression databases
Bgee	Q701N4.
CleanEx	HS_KRTAP5-2. HS_KRTAP5-8.
Genevestigator	Q701N4.
Family and domain databases
InterPro	IPR002494. Keratin-assoc. [Graphical view]
PANTHER	PTHR23262. PTHR23262. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	440021.
NextBio	108833.

Entry information

Entry name

KRA52_HUMAN

Accession

Primary (citable) accession number: Q701N4
Secondary accession number(s): A9JTZ1

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 21, 2004
Last sequence update:	July 5, 2004
Last modified:	April 3, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.