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Protein

Keratin-associated protein 5-2

Gene

KRTAP5-2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6805567. Keratinization.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 5-2
Alternative name(s):
Keratin-associated protein 5-8
Keratin-associated protein 5.2
Keratin-associated protein 5.8
Ultrahigh sulfur keratin-associated protein 5.2
Gene namesi
Name:KRTAP5-2
Synonyms:KAP5-8, KAP5.2, KRTAP5-8, KRTAP5.2, KRTAP5.8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:23597. KRTAP5-2.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000205867.
PharmGKBiPA134981423.

Chemistry databases

DrugBankiDB02379. Beta-D-Glucose.
DB03088. Pyroglutamic Acid.

Polymorphism and mutation databases

BioMutaiKRTAP5-2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001841001 – 177Keratin-associated protein 5-2Add BLAST177

Proteomic databases

PaxDbiQ701N4.
PRIDEiQ701N4.

PTM databases

iPTMnetiQ701N4.
PhosphoSitePlusiQ701N4.

Expressioni

Tissue specificityi

Restricted to hair root, not detected in any other tissues.1 Publication

Gene expression databases

CleanExiHS_KRTAP5-2.
HS_KRTAP5-8.

Interactioni

Subunit structurei

Interacts with hair keratins.

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiQ701N4. 40 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ701N4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati62 – 6514
Repeati118 – 12124
Repeati137 – 14034
Repeati147 – 15044
Repeati157 – 16054
Repeati167 – 17064

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni62 – 1706 X 4 AA repeats of C-C-X-PAdd BLAST109

Sequence similaritiesi

Belongs to the KRTAP type 5 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

OMAiCCYSSGC.

Family and domain databases

InterProiView protein in InterPro
IPR002494. KAP.
PANTHERiPTHR23262. PTHR23262. 1 hit.
PfamiView protein in Pfam
PF13885. Keratin_B2_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q701N4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCCGCSRGC GSGCGGCGSS CGGCGSGCGG CGSGRGGCGS GCGGCSSSCG
60 70 80 90 100
GCGSRCYVPV CCCKPVCSWV PACSCTSCGS CGGSKGGCGS CGGSKGGCGS
110 120 130 140 150
CGGSKGGCGS CGCSQSSCCK PCCCSSGCGS SCCQSSCCKP CCCQSSCCVP
160 170
VCCQSSCCKP CCCQSNCCVP VCCQCKI
Length:177
Mass (Da):16,271
Last modified:July 5, 2004 - v1
Checksum:iBFA74666188A185C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB126071 mRNA. Translation: BAD20198.1.
AJ628245 mRNA. Translation: CAF31637.1.
BC132882 mRNA. Translation: AAI32883.1.
BC132908 mRNA. Translation: AAI32909.1.
CCDSiCCDS31331.1.
RefSeqiNP_001004325.1. NM_001004325.1.
UniGeneiHs.633229.
Hs.673618.

Genome annotation databases

EnsembliENST00000412090; ENSP00000400041; ENSG00000205867.
ENST00000612541; ENSP00000484511; ENSG00000278489.
ENST00000628787; ENSP00000487099; ENSG00000281533.
GeneIDi440021.
KEGGihsa:440021.
UCSCiuc001ltv.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB126071 mRNA. Translation: BAD20198.1.
AJ628245 mRNA. Translation: CAF31637.1.
BC132882 mRNA. Translation: AAI32883.1.
BC132908 mRNA. Translation: AAI32909.1.
CCDSiCCDS31331.1.
RefSeqiNP_001004325.1. NM_001004325.1.
UniGeneiHs.633229.
Hs.673618.

3D structure databases

ProteinModelPortaliQ701N4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ701N4. 40 interactors.

Chemistry databases

DrugBankiDB02379. Beta-D-Glucose.
DB03088. Pyroglutamic Acid.

PTM databases

iPTMnetiQ701N4.
PhosphoSitePlusiQ701N4.

Polymorphism and mutation databases

BioMutaiKRTAP5-2.

Proteomic databases

PaxDbiQ701N4.
PRIDEiQ701N4.

Protocols and materials databases

DNASUi440021.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000412090; ENSP00000400041; ENSG00000205867.
ENST00000612541; ENSP00000484511; ENSG00000278489.
ENST00000628787; ENSP00000487099; ENSG00000281533.
GeneIDi440021.
KEGGihsa:440021.
UCSCiuc001ltv.3. human.

Organism-specific databases

CTDi440021.
GeneCardsiKRTAP5-2.
H-InvDBHIX0035833.
HGNCiHGNC:23597. KRTAP5-2.
neXtProtiNX_Q701N4.
OpenTargetsiENSG00000205867.
PharmGKBiPA134981423.
GenAtlasiSearch...

Phylogenomic databases

OMAiCCYSSGC.

Enzyme and pathway databases

ReactomeiR-HSA-6805567. Keratinization.

Miscellaneous databases

GenomeRNAii440021.
PROiQ701N4.

Gene expression databases

CleanExiHS_KRTAP5-2.
HS_KRTAP5-8.

Family and domain databases

InterProiView protein in InterPro
IPR002494. KAP.
PANTHERiPTHR23262. PTHR23262. 1 hit.
PfamiView protein in Pfam
PF13885. Keratin_B2_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKRA52_HUMAN
AccessioniPrimary (citable) accession number: Q701N4
Secondary accession number(s): A9JTZ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: July 5, 2004
Last modified: March 15, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.