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Protein

Keratin-associated protein 5-2

Gene

KRTAP5-2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 5-2
Alternative name(s):
Keratin-associated protein 5-8
Keratin-associated protein 5.2
Keratin-associated protein 5.8
Ultrahigh sulfur keratin-associated protein 5.2
Gene namesi
Name:KRTAP5-2
Synonyms:KAP5-8, KAP5.2, KRTAP5-8, KRTAP5.2, KRTAP5.8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11, UP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:23597. KRTAP5-2.

Subcellular locationi

GO - Cellular componenti

  1. keratin filament Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134981423.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 177177Keratin-associated protein 5-2PRO_0000184100Add
BLAST

Proteomic databases

PaxDbiQ701N4.
PRIDEiQ701N4.

Expressioni

Tissue specificityi

Restricted to hair root, not detected in any other tissues.1 Publication

Gene expression databases

BgeeiQ701N4.
CleanExiHS_KRTAP5-2.
HS_KRTAP5-8.
GenevestigatoriQ701N4.

Interactioni

Subunit structurei

Interacts with hair keratins.

Structurei

3D structure databases

ProteinModelPortaliQ701N4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati62 – 6541
Repeati118 – 12142
Repeati137 – 14043
Repeati147 – 15044
Repeati157 – 16045
Repeati167 – 17046

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni62 – 1701096 X 4 AA repeats of C-C-X-PAdd
BLAST

Sequence similaritiesi

Belongs to the KRTAP type 5 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

OMAiWVPACSC.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 1 hit.

Sequencei

Sequence statusi: Complete.

Q701N4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCCGCSRGC GSGCGGCGSS CGGCGSGCGG CGSGRGGCGS GCGGCSSSCG
60 70 80 90 100
GCGSRCYVPV CCCKPVCSWV PACSCTSCGS CGGSKGGCGS CGGSKGGCGS
110 120 130 140 150
CGGSKGGCGS CGCSQSSCCK PCCCSSGCGS SCCQSSCCKP CCCQSSCCVP
160 170
VCCQSSCCKP CCCQSNCCVP VCCQCKI
Length:177
Mass (Da):16,271
Last modified:July 5, 2004 - v1
Checksum:iBFA74666188A185C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB126071 mRNA. Translation: BAD20198.1.
AJ628245 mRNA. Translation: CAF31637.1.
BC132882 mRNA. Translation: AAI32883.1.
BC132908 mRNA. Translation: AAI32909.1.
CCDSiCCDS31331.1.
RefSeqiNP_001004325.1. NM_001004325.1.
UniGeneiHs.633229.
Hs.673618.

Genome annotation databases

EnsembliENST00000412090; ENSP00000400041; ENSG00000205867.
ENST00000612541; ENSP00000484511; ENSG00000278489.
GeneIDi440021.
KEGGihsa:440021.
UCSCiuc001ltv.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB126071 mRNA. Translation: BAD20198.1.
AJ628245 mRNA. Translation: CAF31637.1.
BC132882 mRNA. Translation: AAI32883.1.
BC132908 mRNA. Translation: AAI32909.1.
CCDSiCCDS31331.1.
RefSeqiNP_001004325.1. NM_001004325.1.
UniGeneiHs.633229.
Hs.673618.

3D structure databases

ProteinModelPortaliQ701N4.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ701N4.
PRIDEiQ701N4.

Protocols and materials databases

DNASUi440021.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000412090; ENSP00000400041; ENSG00000205867.
ENST00000612541; ENSP00000484511; ENSG00000278489.
GeneIDi440021.
KEGGihsa:440021.
UCSCiuc001ltv.3. human.

Organism-specific databases

CTDi440021.
GeneCardsiGC11M001618.
H-InvDBHIX0035833.
HGNCiHGNC:23597. KRTAP5-2.
neXtProtiNX_Q701N4.
PharmGKBiPA134981423.
GenAtlasiSearch...

Phylogenomic databases

OMAiWVPACSC.

Miscellaneous databases

GenomeRNAii440021.
NextBioi108833.
PROiQ701N4.

Gene expression databases

BgeeiQ701N4.
CleanExiHS_KRTAP5-2.
HS_KRTAP5-8.
GenevestigatoriQ701N4.

Family and domain databases

InterProiIPR002494. KAP.
[Graphical view]
PANTHERiPTHR23262. PTHR23262. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of two novel clusters of ultrahigh-sulfur keratin-associated protein genes on human chromosome 11."
    Yahagi S., Shibuya K., Obayashi I., Masaki H., Kurata Y., Kudoh J., Shimizu N.
    Biochem. Biophys. Res. Commun. 318:655-664(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Hair root.
  2. "Characterization of two domains of keratin associated protein (KAP) family members on human chromosome 11."
    Rogers M.A., Langbein L., Winter H., Praetzel S., Schweizer J.
    Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Scalp.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum.

Entry informationi

Entry nameiKRA52_HUMAN
AccessioniPrimary (citable) accession number: Q701N4
Secondary accession number(s): A9JTZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: July 5, 2004
Last modified: February 4, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.