ID SSPO_RAT Reviewed; 5141 AA. AC Q700K0; DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot. DT 05-JUL-2004, sequence version 1. DT 27-MAR-2024, entry version 119. DE RecName: Full=SCO-spondin; DE Flags: Precursor; GN Name=Sspo {ECO:0000312|RGD:1549716}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Meiniel O.; RT "Conservation of mammalian SCO-spondin."; RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Involved in the modulation of neuronal aggregation (By CC similarity). May be involved in developmental events during the CC formation of the central nervous system (By similarity). CC {ECO:0000250|UniProtKB:P98167}. CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space CC {ECO:0000250|UniProtKB:P98167}. CC -!- SIMILARITY: Belongs to the thrombospondin family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ629845; CAF33425.1; -; mRNA. DR RefSeq; NP_001007017.1; NM_001007016.1. DR SMR; Q700K0; -. DR IntAct; Q700K0; 1. DR STRING; 10116.ENSRNOP00000037189; -. DR GlyCosmos; Q700K0; 43 sites, No reported glycans. DR GlyGen; Q700K0; 43 sites. DR PhosphoSitePlus; Q700K0; -. DR PaxDb; 10116-ENSRNOP00000037189; -. DR Ensembl; ENSRNOT00000035906.4; ENSRNOP00000037189.2; ENSRNOG00000025848.5. DR GeneID; 474348; -. DR KEGG; rno:474348; -. DR UCSC; RGD:1549716; rat. DR AGR; RGD:1549716; -. DR CTD; 243369; -. DR RGD; 1549716; Sspo. DR eggNOG; KOG1215; Eukaryota. DR eggNOG; KOG1216; Eukaryota. DR eggNOG; KOG3509; Eukaryota. DR eggNOG; KOG3538; Eukaryota. DR eggNOG; KOG4475; Eukaryota. DR GeneTree; ENSGT00940000155829; -. DR HOGENOM; CLU_223278_0_0_1; -. DR InParanoid; Q700K0; -. DR OMA; QTKNELC; -. DR OrthoDB; 2872912at2759; -. DR PhylomeDB; Q700K0; -. DR TreeFam; TF344272; -. DR Reactome; R-RNO-5173214; O-glycosylation of TSR domain-containing proteins. DR PRO; PR:Q700K0; -. DR Proteomes; UP000002494; Chromosome 4. DR Bgee; ENSRNOG00000025848; Expressed in adult mammalian kidney and 4 other cell types or tissues. DR GO; GO:0005737; C:cytoplasm; ISO:RGD. DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW. DR CDD; cd00112; LDLa; 9. DR CDD; cd19941; TIL; 14. DR Gene3D; 2.40.128.620; -; 1. DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1. DR Gene3D; 2.10.25.10; Laminin; 15. DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 9. DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 24. DR InterPro; IPR006207; Cys_knot_C. DR InterPro; IPR000421; FA58C. DR InterPro; IPR008979; Galactose-bd-like_sf. DR InterPro; IPR036055; LDL_receptor-like_sf. DR InterPro; IPR023415; LDLR_class-A_CS. DR InterPro; IPR002172; LDrepeatLR_classA_rpt. DR InterPro; IPR036084; Ser_inhib-like_sf. DR InterPro; IPR002919; TIL_dom. DR InterPro; IPR000884; TSP1_rpt. DR InterPro; IPR036383; TSP1_rpt_sf. DR InterPro; IPR014853; VWF/SSPO/ZAN-like_Cys-rich_dom. DR InterPro; IPR001007; VWF_dom. DR InterPro; IPR001846; VWF_type-D. DR PANTHER; PTHR11339; EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED; 1. DR PANTHER; PTHR11339:SF373; HEMOLECTIN, ISOFORM A; 1. DR Pfam; PF08742; C8; 3. DR Pfam; PF00754; F5_F8_type_C; 1. DR Pfam; PF00057; Ldl_recept_a; 8. DR Pfam; PF01826; TIL; 12. DR Pfam; PF00090; TSP_1; 22. DR Pfam; PF00093; VWC; 1. DR Pfam; PF00094; VWD; 3. DR PRINTS; PR00261; LDLRECEPTOR. DR SMART; SM00832; C8; 3. DR SMART; SM00192; LDLa; 10. DR SMART; SM00209; TSP1; 25. DR SMART; SM00214; VWC; 5. DR SMART; SM00215; VWC_out; 9. DR SMART; SM00216; VWD; 3. DR SUPFAM; SSF57603; FnI-like domain; 4. DR SUPFAM; SSF49785; Galactose-binding domain-like; 1. DR SUPFAM; SSF57424; LDL receptor-like module; 10. DR SUPFAM; SSF57567; Serine protease inhibitors; 15. DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 25. DR PROSITE; PS01225; CTCK_2; 1. DR PROSITE; PS01186; EGF_2; 2. DR PROSITE; PS50022; FA58C_3; 1. DR PROSITE; PS01209; LDLRA_1; 8. DR PROSITE; PS50068; LDLRA_2; 10. DR PROSITE; PS50092; TSP1; 24. DR PROSITE; PS01208; VWFC_1; 1. DR PROSITE; PS50184; VWFC_2; 2. DR PROSITE; PS51233; VWFD; 3. PE 2: Evidence at transcript level; KW Calcium; Cell adhesion; Disulfide bond; EGF-like domain; Glycoprotein; KW Reference proteome; Repeat; Secreted; Signal. FT SIGNAL 1..17 FT /evidence="ECO:0000255" FT CHAIN 18..5141 FT /note="SCO-spondin" FT /id="PRO_0000245044" FT DOMAIN 18..102 FT /note="EMI" FT DOMAIN 193..364 FT /note="VWFD 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580" FT DOMAIN 472..527 FT /note="TIL 1" FT /evidence="ECO:0000255" FT DOMAIN 565..738 FT /note="VWFD 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580" FT DOMAIN 830..883 FT /note="TIL 2" FT /evidence="ECO:0000255" FT DOMAIN 1017..1187 FT /note="VWFD 3" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580" FT DOMAIN 1280..1336 FT /note="TIL 3" FT /evidence="ECO:0000255" FT DOMAIN 1380..1417 FT /note="LDL-receptor class A 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124" FT DOMAIN 1420..1456 FT /note="LDL-receptor class A 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124" FT DOMAIN 1456..1492 FT /note="LDL-receptor class A 3" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124" FT DOMAIN 1496..1534 FT /note="LDL-receptor class A 4" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124" FT DOMAIN 1569..1605 FT /note="LDL-receptor class A 5" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124" FT DOMAIN 1607..1646 FT /note="LDL-receptor class A 6" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124" FT DOMAIN 1660..1700 FT /note="LDL-receptor class A 7" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124" FT DOMAIN 1699..1753 FT /note="TSP type-1 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DOMAIN 1755..1970 FT /note="TSP type-1 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DOMAIN 1829..1868 FT /note="EGF-like 1" FT DOMAIN 1869..1895 FT /note="EGF-like 2" FT DOMAIN 1970..2030 FT /note="VWFC 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00220" FT DOMAIN 2070..2226 FT /note="F5/8 type C" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00081" FT DOMAIN 2235..2271 FT /note="LDL-receptor class A 8" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124" FT DOMAIN 2391..2427 FT /note="LDL-receptor class A 9" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124" FT DOMAIN 2448..2484 FT /note="LDL-receptor class A 10" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124" FT DOMAIN 2485..2538 FT /note="TSP type-1 3" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DOMAIN 2540..2595 FT /note="TSP type-1 4" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DOMAIN 2618..2660 FT /note="TIL 4" FT /evidence="ECO:0000255" FT DOMAIN 2700..2754 FT /note="TSP type-1 5" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DOMAIN 2758..2813 FT /note="TSP type-1 6" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DOMAIN 2815..2868 FT /note="TSP type-1 7" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DOMAIN 2969..3024 FT /note="TSP type-1 8" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DOMAIN 3025..3068 FT /note="TSP type-1 9" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DOMAIN 3075..3127 FT /note="TIL 5" FT /evidence="ECO:0000255" FT DOMAIN 3168..3235 FT /note="TSP type-1 10" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DOMAIN 3237..3292 FT /note="TSP type-1 11" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DOMAIN 3300..3350 FT /note="TIL 6" FT /evidence="ECO:0000255" FT DOMAIN 3393..3455 FT /note="TSP type-1 12" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DOMAIN 3457..3512 FT /note="TSP type-1 13" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DOMAIN 3514..3570 FT /note="TIL 7" FT /evidence="ECO:0000255" FT DOMAIN 3630..3678 FT /note="TSP type-1 14" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DOMAIN 3806..3862 FT /note="TSP type-1 15" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DOMAIN 3876..3928 FT /note="TSP type-1 16" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DOMAIN 3942..3998 FT /note="TSP type-1 17" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DOMAIN 4000..4055 FT /note="TSP type-1 18" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DOMAIN 4058..4113 FT /note="TIL 8" FT /evidence="ECO:0000255" FT DOMAIN 4155..4208 FT /note="TSP type-1 19" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DOMAIN 4249..4304 FT /note="TSP type-1 20" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DOMAIN 4306..4362 FT /note="TSP type-1 21" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DOMAIN 4364..4418 FT /note="TSP type-1 22" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DOMAIN 4422..4477 FT /note="TIL 9" FT /evidence="ECO:0000255" FT DOMAIN 4608..4659 FT /note="TSP type-1 23" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DOMAIN 4673..4719 FT /note="TIL 10" FT /evidence="ECO:0000255" FT DOMAIN 4759..4812 FT /note="TSP type-1 24" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DOMAIN 4814..4868 FT /note="TIL 11" FT /evidence="ECO:0000255" FT DOMAIN 4920..4978 FT /note="TIL 12" FT /evidence="ECO:0000255" FT DOMAIN 4978..5036 FT /note="VWFC 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00220" FT DOMAIN 5047..5134 FT /note="CTCK" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039" FT REGION 1533..1567 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2087..2109 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2262..2335 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1540..1567 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2277..2291 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT CARBOHYD 88 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 130 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 150 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 167 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 657 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 822 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 895 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 949 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 991 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 1357 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 1655 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 1668 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 1725 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 1814 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 2035 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 2130 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 2148 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 2630 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 2679 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 2921 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 2951 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 3046 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 3101 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 3148 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 3158 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 3295 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 3384 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 3506 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 3584 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 3611 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 3787 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 3910 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 4135 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 4345 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 4416 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 4557 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 4727 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 4744 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 4749 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 4899 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 4942 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 4949 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 5055 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 195..325 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580" FT DISULFID 217..363 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580" FT DISULFID 239..245 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580" FT DISULFID 567..700 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580" FT DISULFID 591..737 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580" FT DISULFID 1019..1151 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580" FT DISULFID 1041..1186 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580" FT DISULFID 1062..1069 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580" FT DISULFID 1381..1394 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124" FT DISULFID 1388..1407 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124" FT DISULFID 1401..1416 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124" FT DISULFID 1421..1433 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124" FT DISULFID 1428..1446 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124" FT DISULFID 1440..1455 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124" FT DISULFID 1457..1469 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124" FT DISULFID 1464..1482 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124" FT DISULFID 1476..1491 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124" FT DISULFID 1497..1509 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124" FT DISULFID 1504..1522 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124" FT DISULFID 1516..1533 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124" FT DISULFID 1570..1582 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124" FT DISULFID 1577..1595 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124" FT DISULFID 1589..1604 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124" FT DISULFID 1608..1621 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124" FT DISULFID 1615..1634 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124" FT DISULFID 1628..1645 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124" FT DISULFID 1661..1671 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124" FT DISULFID 1666..1684 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124" FT DISULFID 1678..1699 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124" FT DISULFID 1711..1747 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 1715..1752 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 1726..1737 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 1767..1964 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 1771..1969 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 1781..1791 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 2070..2226 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00081" FT DISULFID 2236..2248 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124" FT DISULFID 2243..2261 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124" FT DISULFID 2255..2270 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124" FT DISULFID 2392..2404 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124" FT DISULFID 2399..2417 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124" FT DISULFID 2411..2426 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124" FT DISULFID 2449..2461 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124" FT DISULFID 2456..2474 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124" FT DISULFID 2468..2483 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124" FT DISULFID 2486..2522 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 2497..2501 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 2532..2537 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 2552..2589 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 2556..2594 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 2567..2579 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 2701..2739 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 2712..2716 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 2749..2753 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 2769..2807 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 2773..2812 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 2789..2797 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 2827..2862 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 2831..2867 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 2842..2852 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 2970..3008 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 2981..2985 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 3018..3023 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 3180..3229 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 3184..3234 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 3195..3219 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 3249..3286 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 3253..3291 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 3264..3276 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 3405..3448 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 3409..3454 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 3420..3432 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 3469..3504 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 3472..3511 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 3482..3494 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 3642..3672 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 3646..3677 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 3657..3662 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 3818..3856 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 3822..3861 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 3834..3846 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 3943..3979 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 3954..3958 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 3992..3997 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 4012..4049 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 4016..4054 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 4027..4039 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 4156..4192 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 4167..4171 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 4202..4207 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 4261..4298 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 4265..4303 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 4276..4288 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 4365..4402 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 4376..4378 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 4412..4417 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 4609..4643 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 4620..4624 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 4653..4658 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 4771..4806 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 4775..4811 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 4786..4795 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00210" FT DISULFID 5047..5095 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039" FT DISULFID 5061..5112 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039" FT DISULFID 5071..5128 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039" FT DISULFID 5075..5130 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039" SQ SEQUENCE 5141 AA; 550649 MW; 1772AE67F02CA5E3 CRC64; MLLPALLFGM LWAPANGHWC EQIETVHVEE EVTPRREDLV PCTSLYHYSR LGWKLDLSWG GHVGLTRPPA LGLCAIYKPP ETRPATWNRT VRACCPGWGG IHCTEALAEA SPKGHCFVTW HCQPLAGSAN SSAGSLEECC AQPWGHSWWN SSSQMCLSCS GQHRPGNASS EGLLQPLAGA VGQLWSQRQR PSATCATWSG FHYQTFDGQH YHFLGQCTYL LAGAMDSTWA VHLRPSVHCP QPRQCWLVQV IMGPEEVLIQ DGEVSVKGQP VPVGESQLLH GMSLQWQGDW LVLSGGLGVV VRLDRSSSII ISVDHEFWGR TQGLCGLYNG RPEDDFVEPG GGLAMLAATF GNSWRLPGYE PGCLDTVEVA RGCEGLLEGT LTGLEAGKLQ AQAQDLCHQL LEDPFSQCHG QVPPDEYHET CLFAYCVGAT AGSGPEEQVK AVCATFANYA QACARQHIYV HWRKPGFCER LCPGGQLYSD CISSCPPSCS AVAQGEEGSC GKECVSGCEC PTGLFWDGAL CVPAAHCPCY YRRQRYAPGD TVKQQCNPCV CQDGRWHCAQ APCPAECAVG GDGHYCTFDG RSFSFRGNPG CQYSLVQDSV KGQLLVVLEH GACETGSCLH ALSAFLGKTH IQLRYSGAVL VDGQDVDLPW IGAEGFNVSH ASSTFLLLRW PGAWVLWGVA DPAVYITLDP RHAYQVQGLC GTFTWKQQDD FLTPAGDIET SVTAFASKFQ VSGDGRCPLV DNTPLSSCST YSQRLAFAEA ACAALHGHAF QECHGLVERE PFRLRCLESM CSCAPGRDCL CSVLSAYAHH CAQEGVLLQW RNETLCSVPC PGGQVYQECA PACGHYCGEP EDCKELGSCV AGCNCPPGLL WDLEGQCVPP SMCPCQLGGH RYAFNTTTTL KDCSHCICQE RGLWNCIAHH CPRQWALCPQ ELIYAPGACL LTCDSLGANH SCLAGSTDGC VCPSGTVLLD KHCVSPDLCP CRHNGQWYPP NATIQEDCNI CVCQNQRWHC TGQRCSGWCQ ASGAPHYVTF DGLVFTFPGA CEYLLVREAG GRFSVSIQNL PCGASGLTCT KALAVRLDST VVHMLRGQAV TVNGVSIKLP KVYTGPGLSL HHAGLFLLLT TRLGLTLLWD GGTRVLVQLS PHFHGRVTGL CGNFDGDVSN DLRSRQGVLE PTAELTAHSW RLNPLCPEPG DLPHPCSVNA HRVNWARAHC EVILQPIFAP CHTEVPPQQY YEWCVYDACG CDTGGDCECL CSAIATYADE CARHRHHVRW RSQELCPLQC EGGQVYEPCG STCPPTCHDH HPELRWHCQA ITCVEGCFCP EGTLLHGGTC VELTDCPCEW QGSFFPPGAV LQKDCGNCTC QESQWHCNPS GAPCEEMEPG CAEGEALCRE SGHCVPLEWL CDNQDDCGDG SDEEGCDTSV CGEGQMSCQS GRCLPLSLIC DGQDDCGDGT DEQGCLCPQG FLACADGRCL PPALLCDGHP DCLDAADEES CLGWVSCTSG EVSCVDGPCI RTIQLCDGVW DCPDGADEGP VHCSSPSLPT PPAGIGQNPS TSSPDTSPSP VGSASPASPC SLSEFQCNSG ECTPRGWRCD REEDCTDGSD ELDCGGPCKL YQMPCAHGPH CLSPGQLCDG VAQCPDGSDE DPDVCEERSA SGGPNGTAVP CPEFSCPNGT CIDFLLVCDG SPDCELADET EPSLDEQGCG TWGSWGPWEP CSQTCGPGIQ SRNRNCSISS LHVLQNCPGL QHQSQSCFTE ACPVDGEWSS WSLWSPCSEP CGGTMTRHRQ CRPPQNGGQD CALLPGSTHS THQTSPCPQE GCLNVTCFGE LVFRPCAPCP LTCDDISGEA VCSPDRPCSS PGCWCPEGKV LGTEGRCVRP RQCPCLVDGI RYWPGQRIKM DCQLCFCQDG QPHRCRPNPE CAVDCGWSSW SPWAECLGPC SSQSLQWSFR SPNNPRLSGH GRQCRGIHRK ARRCQTEPCE GCEQWGLTYH VGERWRGGPC TVCECLHRSI TRCSPYCPIG SCPQSWVLVE GMGESCCHCA LPGKNQTMIP VTTPAPVPTP SPQIGASLVT YVLPPMSDAC YSPLGLAGLP TWAPSQPLEH STRAAPVEAP TAGPGPREDA YAEWHTQPLY LQLDLLWPRN LTGIMVQRAG SSAAYISNLS LQFSSDGLQW HSVLNSLSST LPPPKPSPES SNHMVPEVWT FDQMVQARYI RVWPHGSHLR DNNQQDIFLW VELLGCKPVP PLAPLCPGTR HRCANGDCAL KGGPCDGAVD CEDGSDEEGC GPLRASTASR VHSTARTPAL SPTQPGKFPF HPREGLADME HQQPKQESPM PSAGVSPSAS EGLLPVSGQS MQTLTTTSTF PPGLKSLHPG MAAVTVHSPH SVMPGTPVGQ SVSPRPFPLM RCGPGQVPCD VLGCVEQEQL CDGREDCLDG SDEQHCASPE PFTVPTTALP GLPASRALCS PSQLSCGSGE CLPLEHRCDL QVNCQDGSDE DDCVDCVLAP WSGWSDCSRS CGLGLIFQHR ELLRPPLPGG SCLLDQLRSQ PCFVQACPVA GAWAKWGPWE PCSVSCGGGH QSRQRSCVDP PPKNGGAPCP GPSHEKVLCN LQLCPGDTDC EPGRVHVNAE LCQKGLLPPC PPSCLDPEAN RSCSGHCVEG CRCPPGLFLQ DSHCLPLSEC PCLVGQKLMQ PGLAFLLDNC SQCICESGIL LCKPAACSQS CGWSAWSPWT ACDHSCGSGV RARFRSPTNP PAAFGGSPCE GDRQELQACY TDCGTDIPGW TPWTSWSSCS QSCLVPGGDP GRRQRSRLCP SSRDTFCPGE ATQEEPCSPS LCPVPSAWGL WASWSACSAS CNGGIQTRGR SCSGSAPGNP VCLGPHTQTR DCNVHPCTAQ CPGNMVFRSA EKCLEEGGPC PQLCLAQDPG VECTGSCAPG CSCPPGLFLH NASCLPRSQC PCQLHGQLYA PGAVARLDCN NCTCSSGEMV CTSERCPVAC GWSPWTPWSP CSQSCNVGIR RRFRAGTAPP AAFGGAECRG PNLDAEFCTL RPCQGPGAAW SSWTPCSVPC GGGYRNRTQG SGRHSPVEFS TCSLQPCAGP VPGVCPKDQQ WLDCAQGPAS CAHLSTPREA NQTCHPGCYC LSGMLLLNNV CVPAQDCPCA HRGRLHSPGS AVILPCENCS CVSGLITNCS SWPCEEGQPA WSSWTPWSVC SASCSPARRH RRRFCVRPST TAPFSLDLPT TVAAPTMLCP GPEAEEEPCL LPGCNQAGVW GPWSPWSGCS RSCGGGLRSR TRACDKPPPQ GLGDFCEGPQ AQGEACQAQP CPVANCSTIE GAEYSPCGPP CPRSCDDLVH CMWHCQPGCY CPPGKVLSAD GAICVQPHHC SCLDLLTGKR HHPGSQLMRP DGCNHCTCME GRLNCTDLPC QVSGDWCPWS EWTACSQPCR GQTRTRSRAC VCPAPQHGGA PCPEEAGETG VQHQMEACPN PTACPVDGAW SPWGSWSPCD ACLGQSYRSR MCSHPPPSDG GTPCLGGHQQ SRPCRNSSTP CTDCGGGQDL LPCGQPCPHS CQDLSLGSTC QPGSSGCQSG CGCPPGQLSQ DGLCVFPADC HCHFQPKAMG IPENQSRSVG SALSSWESLE PGEVVTGPCD NCTCVAGVLQ CHEVPSCPGP GIWSSWGPWE KCSVPCGGGE QLRSRQCARP PCPGLAQQSR TCHIHVCRET GCPAGRLYRE CQPSEGCPFS CAHVTGQVAC FSESCEEGCH CPEGTFQHHS ACVQECPCVL TVSLLQELGV ASTALRSYPV LLGDEGQPLG PGDELDPGQM LQTVCGNCSC VHGKLSCSME ECSRVRGYFG PWGMWSLCSH SCGGLGTRTR TRQCVLPTLA PAGLSCRGPL QDLEYCFSPE CPGTAGSTVE PVTGLAGGWG PWSPWSPCSH SCTDLTHPAW RSRTRLCLAN CTVGDSSQER PCNLPSCTTL PLCPGPGCGS ENCFWTSWAP WEPCSRSCGV GQQRRLRAYH PPGPGGHWCP DILTAYQERR FCNLRACPVP GGWSHWSPWS WCDRSCGGGR SLRSRSCSSP PPKNGGASCV GERHHVRSCN PMPCEKDCPA GMEMVSCANR CPYSCSDLQE AVMCQEDQAC QLGCRCSEGF LEQDGGCVPV GHCECTDAQG RSWAPGSQHQ DACNNCSCQA GQLSCTAQPC PPPAHCAWSH WSAWSACSHS CGPHGQQSRF RSSTSGSWAL ECQKEQSQSQ PCPEDPCPPL CLHEAHLHVL GDNWLHGECQ QCSCTPEGVI CKDTDCAVPG GWTLWSSWSY CSVSCGGGSQ VRTRSCMVSA PQHGSPSCQG PDTQTQHCGQ QLCLQLLEIC SWGPWGPCSR SCGTGLASRS GSCPCLLTKE DSECNDTFSG LDTQACYPGP CQEDCMWSDW SSWTRCSCKI LVQQRYRHQV PAPGQAGEGT LCTGLDGHFR PCAIGNCSED SCLPPFEFQS CGSPCAGLCA THLSHQLCQD LPPCQPGCYC PMGLLEQDGG CILPEQCNCW HTSGEGARVT LAPGHRLQLG CKECVCQSGE LQCSSQGCEG LLPLTGWSEW SPCGPCLPQS ALAPDSRTAL EVHWPLNTSV TLLASEQYRH RLCLDPETGR PWAGDPALCT VPLSQQRLCS DPGACHDTCQ WGPWGPWSPC QVPCSGGFKL RWREASDNSV GECRGPWAQT ESCNMGSCPG ESCETRDTVF TLDCANQCPR SCADLWEGVQ CLQGPCSPGC RCPPGQLVQD GHCVPISSCR CGLPSANASW ELAPTQVVQL DCHNCTCING TLMCPYPECP VLGPWSPWSE CSAVCGGGTM VRYRSCEEHP DSAPCQALDM EQRVECNLQT CPECPPGQVL STCATLCPSF CSHLWPGTIC VREPCQLGCG CPGGQLLHSG TCIPPEACPC TRLSLPWGLT LPLEEQAQEL PSGTVLTWNC THCTCQGGVF TCSHTDCQEC PPGEILQLGE LRPCEKTCLE MNKTQAWSNC TEAQVPGCVC QLGHFRSHTG LCVPEDHCEC WHHGSPHLPG SEWQEACESC RCLHGKSVCT QHCPELSCAQ GEVVVQEPGS CCPICQQDTL EEEPVSCRHL TELRNLTKGP CHLDQVEVSY CSGHCRSSTN VMTEEPYLQS QCDCCSYRLD PDSPVRILNL LCPDGRTEPV LLPVIHNCHC SACQGGEFSK H //