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Q700K0

- SSPO_RAT

UniProt

Q700K0 - SSPO_RAT

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Protein

SCO-spondin

Gene
Sspo
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in the modulation of neuronal aggregation. May be involved in developmental events during the formation of the central nervous system By similarity.

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
SCO-spondin
Gene namesi
Name:Sspo
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 4

Organism-specific databases

RGDi1549716. Sspo.

Subcellular locationi

Secretedextracellular space By similarity

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. extracellular space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed predictionAdd
BLAST
Chaini18 – 51415124SCO-spondinPRO_0000245044Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi? ↔ 5133 By similarity
Glycosylationi88 – 881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi130 – 1301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi150 – 1501N-linked (GlcNAc...) Reviewed prediction
Glycosylationi167 – 1671N-linked (GlcNAc...) Reviewed prediction
Glycosylationi657 – 6571N-linked (GlcNAc...) Reviewed prediction
Glycosylationi822 – 8221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi895 – 8951N-linked (GlcNAc...) Reviewed prediction
Glycosylationi949 – 9491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi991 – 9911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1357 – 13571N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1381 ↔ 1394 By similarity
Disulfide bondi1388 ↔ 1407 By similarity
Disulfide bondi1401 ↔ 1416 By similarity
Disulfide bondi1421 ↔ 1433 By similarity
Disulfide bondi1428 ↔ 1446 By similarity
Disulfide bondi1440 ↔ 1455 By similarity
Disulfide bondi1457 ↔ 1469 By similarity
Disulfide bondi1464 ↔ 1482 By similarity
Disulfide bondi1476 ↔ 1491 By similarity
Disulfide bondi1497 ↔ 1509 By similarity
Disulfide bondi1504 ↔ 1522 By similarity
Disulfide bondi1516 ↔ 1533 By similarity
Disulfide bondi1570 ↔ 1582 By similarity
Disulfide bondi1577 ↔ 1595 By similarity
Disulfide bondi1589 ↔ 1604 By similarity
Disulfide bondi1608 ↔ 1621 By similarity
Disulfide bondi1615 ↔ 1634 By similarity
Disulfide bondi1628 ↔ 1645 By similarity
Glycosylationi1655 – 16551N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1661 ↔ 1671 By similarity
Disulfide bondi1666 ↔ 1684 By similarity
Glycosylationi1668 – 16681N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1678 ↔ 1699 By similarity
Disulfide bondi1711 ↔ 1747 By similarity
Disulfide bondi1715 ↔ 1752 By similarity
Glycosylationi1725 – 17251N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1726 ↔ 1737 By similarity
Disulfide bondi1767 ↔ 1964 By similarity
Disulfide bondi1771 ↔ 1969 By similarity
Disulfide bondi1781 ↔ 1791 By similarity
Glycosylationi1814 – 18141N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2035 – 20351N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2070 ↔ 2226 By similarity
Glycosylationi2130 – 21301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2148 – 21481N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2236 ↔ 2248 By similarity
Disulfide bondi2243 ↔ 2261 By similarity
Disulfide bondi2255 ↔ 2270 By similarity
Disulfide bondi2392 ↔ 2404 By similarity
Disulfide bondi2399 ↔ 2417 By similarity
Disulfide bondi2411 ↔ 2426 By similarity
Disulfide bondi2449 ↔ 2461 By similarity
Disulfide bondi2456 ↔ 2474 By similarity
Disulfide bondi2468 ↔ 2483 By similarity
Disulfide bondi2486 ↔ 2522 By similarity
Disulfide bondi2497 ↔ 2501 By similarity
Disulfide bondi2532 ↔ 2537 By similarity
Disulfide bondi2552 ↔ 2589 By similarity
Disulfide bondi2556 ↔ 2594 By similarity
Disulfide bondi2567 ↔ 2579 By similarity
Glycosylationi2630 – 26301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2679 – 26791N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2701 ↔ 2739 By similarity
Disulfide bondi2712 ↔ 2716 By similarity
Disulfide bondi2749 ↔ 2753 By similarity
Disulfide bondi2769 ↔ 2807 By similarity
Disulfide bondi2773 ↔ 2812 By similarity
Disulfide bondi2789 ↔ 2797 By similarity
Disulfide bondi2827 ↔ 2862 By similarity
Disulfide bondi2831 ↔ 2867 By similarity
Disulfide bondi2842 ↔ 2852 By similarity
Glycosylationi2921 – 29211N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2951 – 29511N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2970 ↔ 3008 By similarity
Disulfide bondi2981 ↔ 2985 By similarity
Disulfide bondi3018 ↔ 3023 By similarity
Glycosylationi3046 – 30461N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3101 – 31011N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3148 – 31481N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3158 – 31581N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi3180 ↔ 3229 By similarity
Disulfide bondi3184 ↔ 3234 By similarity
Disulfide bondi3195 ↔ 3219 By similarity
Disulfide bondi3249 ↔ 3286 By similarity
Disulfide bondi3253 ↔ 3291 By similarity
Disulfide bondi3264 ↔ 3276 By similarity
Glycosylationi3295 – 32951N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3384 – 33841N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi3405 ↔ 3448 By similarity
Disulfide bondi3409 ↔ 3454 By similarity
Disulfide bondi3420 ↔ 3432 By similarity
Disulfide bondi3469 ↔ 3504 By similarity
Disulfide bondi3472 ↔ 3511 By similarity
Disulfide bondi3482 ↔ 3494 By similarity
Glycosylationi3506 – 35061N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3584 – 35841N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3611 – 36111N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi3642 ↔ 3672 By similarity
Disulfide bondi3646 ↔ 3677 By similarity
Disulfide bondi3657 ↔ 3662 By similarity
Glycosylationi3787 – 37871N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi3818 ↔ 3856 By similarity
Disulfide bondi3822 ↔ 3861 By similarity
Disulfide bondi3834 ↔ 3846 By similarity
Glycosylationi3910 – 39101N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi3943 ↔ 3979 By similarity
Disulfide bondi3954 ↔ 3958 By similarity
Disulfide bondi3992 ↔ 3997 By similarity
Disulfide bondi4012 ↔ 4049 By similarity
Disulfide bondi4016 ↔ 4054 By similarity
Disulfide bondi4027 ↔ 4039 By similarity
Glycosylationi4135 – 41351N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi4156 ↔ 4192 By similarity
Disulfide bondi4167 ↔ 4171 By similarity
Disulfide bondi4202 ↔ 4207 By similarity
Disulfide bondi4261 ↔ 4298 By similarity
Disulfide bondi4265 ↔ 4303 By similarity
Disulfide bondi4276 ↔ 4288 By similarity
Glycosylationi4345 – 43451N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi4365 ↔ 4402 By similarity
Disulfide bondi4376 ↔ 4378 By similarity
Disulfide bondi4412 ↔ 4417 By similarity
Glycosylationi4416 – 44161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi4557 – 45571N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi4609 ↔ 4643 By similarity
Disulfide bondi4620 ↔ 4624 By similarity
Disulfide bondi4653 ↔ 4658 By similarity
Glycosylationi4727 – 47271N-linked (GlcNAc...) Reviewed prediction
Glycosylationi4744 – 47441N-linked (GlcNAc...) Reviewed prediction
Glycosylationi4749 – 47491N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi4771 ↔ 4806 By similarity
Disulfide bondi4775 ↔ 4811 By similarity
Disulfide bondi4786 ↔ 4795 By similarity
Glycosylationi4899 – 48991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi4942 – 49421N-linked (GlcNAc...) Reviewed prediction
Glycosylationi4949 – 49491N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi5047 ↔ 5095 By similarity
Glycosylationi5055 – 50551N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi5061 ↔ 5112 By similarity
Disulfide bondi5071 ↔ 5128 By similarity
Disulfide bondi5075 ↔ 5130 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ700K0.
PRIDEiQ700K0.

Expressioni

Gene expression databases

GenevestigatoriQ700K0.

Interactioni

Protein-protein interaction databases

IntActiQ700K0. 1 interaction.
STRINGi10116.ENSRNOP00000037189.

Structurei

3D structure databases

ProteinModelPortaliQ700K0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 10285EMIAdd
BLAST
Domaini194 – 400207VWFD 1Add
BLAST
Domaini472 – 52756TIL 1Add
BLAST
Domaini566 – 776211VWFD 2Add
BLAST
Domaini830 – 88354TIL 2Add
BLAST
Domaini1018 – 1224207VWFD 3Add
BLAST
Domaini1280 – 133657TIL 3Add
BLAST
Domaini1380 – 141738LDL-receptor class A 1Add
BLAST
Domaini1420 – 145637LDL-receptor class A 2Add
BLAST
Domaini1456 – 149237LDL-receptor class A 3Add
BLAST
Domaini1496 – 153439LDL-receptor class A 4Add
BLAST
Domaini1569 – 160537LDL-receptor class A 5Add
BLAST
Domaini1607 – 164640LDL-receptor class A 6Add
BLAST
Domaini1660 – 170041LDL-receptor class A 7Add
BLAST
Domaini1699 – 175355TSP type-1 1Add
BLAST
Domaini1755 – 1970216TSP type-1 2Add
BLAST
Domaini1829 – 186840EGF-like 1Add
BLAST
Domaini1869 – 189527EGF-like 2Add
BLAST
Domaini1970 – 203061VWFC 1Add
BLAST
Domaini2070 – 2226157F5/8 type CAdd
BLAST
Domaini2235 – 227137LDL-receptor class A 8Add
BLAST
Domaini2391 – 242737LDL-receptor class A 9Add
BLAST
Domaini2448 – 248437LDL-receptor class A 10Add
BLAST
Domaini2485 – 253854TSP type-1 3Add
BLAST
Domaini2540 – 259556TSP type-1 4Add
BLAST
Domaini2617 – 266044TIL 4Add
BLAST
Domaini2700 – 275455TSP type-1 5Add
BLAST
Domaini2758 – 281356TSP type-1 6Add
BLAST
Domaini2815 – 286854TSP type-1 7Add
BLAST
Domaini2969 – 302456TSP type-1 8Add
BLAST
Domaini3025 – 306844TSP type-1 9Add
BLAST
Domaini3075 – 312753TIL 5Add
BLAST
Domaini3168 – 323568TSP type-1 10Add
BLAST
Domaini3237 – 329256TSP type-1 11Add
BLAST
Domaini3303 – 335048TIL 6Add
BLAST
Domaini3393 – 345563TSP type-1 12Add
BLAST
Domaini3457 – 351256TSP type-1 13Add
BLAST
Domaini3630 – 367849TSP type-1 14Add
BLAST
Domaini3806 – 386257TSP type-1 15Add
BLAST
Domaini3876 – 392853TSP type-1 16Add
BLAST
Domaini3942 – 399857TSP type-1 17Add
BLAST
Domaini4000 – 405556TSP type-1 18Add
BLAST
Domaini4058 – 411356TIL 7Add
BLAST
Domaini4155 – 420854TSP type-1 19Add
BLAST
Domaini4249 – 430456TSP type-1 20Add
BLAST
Domaini4306 – 436257TSP type-1 21Add
BLAST
Domaini4364 – 441855TSP type-1 22Add
BLAST
Domaini4608 – 465952TSP type-1 23Add
BLAST
Domaini4759 – 481254TSP type-1 24Add
BLAST
Domaini4978 – 503659VWFC 2Add
BLAST
Domaini5047 – 513488CTCKAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi896 – 8994Poly-Thr

Sequence similaritiesi

Belongs to the thrombospondin family.
Contains 2 EGF-like domains.
Contains 1 EMI domain.
Contains 1 F5/8 type C domain.
Contains 24 TSP type-1 domains.
Contains 2 VWFC domains.
Contains 3 VWFD domains.

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00730000110607.
HOGENOMiHOG000154433.
HOVERGENiHBG080794.
InParanoidiQ700K0.
OMAiCLDPEAN.
OrthoDBiEOG73V6J9.
PhylomeDBiQ700K0.
TreeFamiTF344272.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
4.10.400.10. 10 hits.
InterProiIPR000421. Coagulation_fac_5/8-C_type_dom.
IPR006207. Cys_knot_C.
IPR008979. Galactose-bd-like.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR000884. Thrombospondin_1_rpt.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR006552. VWC_out.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF08742. C8. 3 hits.
PF00754. F5_F8_type_C. 1 hit.
PF00057. Ldl_recept_a. 8 hits.
PF01826. TIL. 14 hits.
PF00090. TSP_1. 22 hits.
PF00093. VWC. 1 hit.
PF00094. VWD. 3 hits.
[Graphical view]
PRINTSiPR00261. LDLRECEPTOR.
SMARTiSM00832. C8. 3 hits.
SM00192. LDLa. 10 hits.
SM00209. TSP1. 25 hits.
SM00214. VWC. 4 hits.
SM00215. VWC_out. 1 hit.
SM00216. VWD. 3 hits.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF57424. SSF57424. 10 hits.
SSF57567. SSF57567. 15 hits.
SSF82895. SSF82895. 25 hits.
PROSITEiPS01225. CTCK_2. 1 hit.
PS01186. EGF_2. 2 hits.
PS50022. FA58C_3. 1 hit.
PS01209. LDLRA_1. 8 hits.
PS50068. LDLRA_2. 10 hits.
PS50092. TSP1. 24 hits.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 2 hits.
PS51233. VWFD. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

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MLLPALLFGM LWAPANGHWC EQIETVHVEE EVTPRREDLV PCTSLYHYSR     50
LGWKLDLSWG GHVGLTRPPA LGLCAIYKPP ETRPATWNRT VRACCPGWGG 100
IHCTEALAEA SPKGHCFVTW HCQPLAGSAN SSAGSLEECC AQPWGHSWWN 150
SSSQMCLSCS GQHRPGNASS EGLLQPLAGA VGQLWSQRQR PSATCATWSG 200
FHYQTFDGQH YHFLGQCTYL LAGAMDSTWA VHLRPSVHCP QPRQCWLVQV 250
IMGPEEVLIQ DGEVSVKGQP VPVGESQLLH GMSLQWQGDW LVLSGGLGVV 300
VRLDRSSSII ISVDHEFWGR TQGLCGLYNG RPEDDFVEPG GGLAMLAATF 350
GNSWRLPGYE PGCLDTVEVA RGCEGLLEGT LTGLEAGKLQ AQAQDLCHQL 400
LEDPFSQCHG QVPPDEYHET CLFAYCVGAT AGSGPEEQVK AVCATFANYA 450
QACARQHIYV HWRKPGFCER LCPGGQLYSD CISSCPPSCS AVAQGEEGSC 500
GKECVSGCEC PTGLFWDGAL CVPAAHCPCY YRRQRYAPGD TVKQQCNPCV 550
CQDGRWHCAQ APCPAECAVG GDGHYCTFDG RSFSFRGNPG CQYSLVQDSV 600
KGQLLVVLEH GACETGSCLH ALSAFLGKTH IQLRYSGAVL VDGQDVDLPW 650
IGAEGFNVSH ASSTFLLLRW PGAWVLWGVA DPAVYITLDP RHAYQVQGLC 700
GTFTWKQQDD FLTPAGDIET SVTAFASKFQ VSGDGRCPLV DNTPLSSCST 750
YSQRLAFAEA ACAALHGHAF QECHGLVERE PFRLRCLESM CSCAPGRDCL 800
CSVLSAYAHH CAQEGVLLQW RNETLCSVPC PGGQVYQECA PACGHYCGEP 850
EDCKELGSCV AGCNCPPGLL WDLEGQCVPP SMCPCQLGGH RYAFNTTTTL 900
KDCSHCICQE RGLWNCIAHH CPRQWALCPQ ELIYAPGACL LTCDSLGANH 950
SCLAGSTDGC VCPSGTVLLD KHCVSPDLCP CRHNGQWYPP NATIQEDCNI 1000
CVCQNQRWHC TGQRCSGWCQ ASGAPHYVTF DGLVFTFPGA CEYLLVREAG 1050
GRFSVSIQNL PCGASGLTCT KALAVRLDST VVHMLRGQAV TVNGVSIKLP 1100
KVYTGPGLSL HHAGLFLLLT TRLGLTLLWD GGTRVLVQLS PHFHGRVTGL 1150
CGNFDGDVSN DLRSRQGVLE PTAELTAHSW RLNPLCPEPG DLPHPCSVNA 1200
HRVNWARAHC EVILQPIFAP CHTEVPPQQY YEWCVYDACG CDTGGDCECL 1250
CSAIATYADE CARHRHHVRW RSQELCPLQC EGGQVYEPCG STCPPTCHDH 1300
HPELRWHCQA ITCVEGCFCP EGTLLHGGTC VELTDCPCEW QGSFFPPGAV 1350
LQKDCGNCTC QESQWHCNPS GAPCEEMEPG CAEGEALCRE SGHCVPLEWL 1400
CDNQDDCGDG SDEEGCDTSV CGEGQMSCQS GRCLPLSLIC DGQDDCGDGT 1450
DEQGCLCPQG FLACADGRCL PPALLCDGHP DCLDAADEES CLGWVSCTSG 1500
EVSCVDGPCI RTIQLCDGVW DCPDGADEGP VHCSSPSLPT PPAGIGQNPS 1550
TSSPDTSPSP VGSASPASPC SLSEFQCNSG ECTPRGWRCD REEDCTDGSD 1600
ELDCGGPCKL YQMPCAHGPH CLSPGQLCDG VAQCPDGSDE DPDVCEERSA 1650
SGGPNGTAVP CPEFSCPNGT CIDFLLVCDG SPDCELADET EPSLDEQGCG 1700
TWGSWGPWEP CSQTCGPGIQ SRNRNCSISS LHVLQNCPGL QHQSQSCFTE 1750
ACPVDGEWSS WSLWSPCSEP CGGTMTRHRQ CRPPQNGGQD CALLPGSTHS 1800
THQTSPCPQE GCLNVTCFGE LVFRPCAPCP LTCDDISGEA VCSPDRPCSS 1850
PGCWCPEGKV LGTEGRCVRP RQCPCLVDGI RYWPGQRIKM DCQLCFCQDG 1900
QPHRCRPNPE CAVDCGWSSW SPWAECLGPC SSQSLQWSFR SPNNPRLSGH 1950
GRQCRGIHRK ARRCQTEPCE GCEQWGLTYH VGERWRGGPC TVCECLHRSI 2000
TRCSPYCPIG SCPQSWVLVE GMGESCCHCA LPGKNQTMIP VTTPAPVPTP 2050
SPQIGASLVT YVLPPMSDAC YSPLGLAGLP TWAPSQPLEH STRAAPVEAP 2100
TAGPGPREDA YAEWHTQPLY LQLDLLWPRN LTGIMVQRAG SSAAYISNLS 2150
LQFSSDGLQW HSVLNSLSST LPPPKPSPES SNHMVPEVWT FDQMVQARYI 2200
RVWPHGSHLR DNNQQDIFLW VELLGCKPVP PLAPLCPGTR HRCANGDCAL 2250
KGGPCDGAVD CEDGSDEEGC GPLRASTASR VHSTARTPAL SPTQPGKFPF 2300
HPREGLADME HQQPKQESPM PSAGVSPSAS EGLLPVSGQS MQTLTTTSTF 2350
PPGLKSLHPG MAAVTVHSPH SVMPGTPVGQ SVSPRPFPLM RCGPGQVPCD 2400
VLGCVEQEQL CDGREDCLDG SDEQHCASPE PFTVPTTALP GLPASRALCS 2450
PSQLSCGSGE CLPLEHRCDL QVNCQDGSDE DDCVDCVLAP WSGWSDCSRS 2500
CGLGLIFQHR ELLRPPLPGG SCLLDQLRSQ PCFVQACPVA GAWAKWGPWE 2550
PCSVSCGGGH QSRQRSCVDP PPKNGGAPCP GPSHEKVLCN LQLCPGDTDC 2600
EPGRVHVNAE LCQKGLLPPC PPSCLDPEAN RSCSGHCVEG CRCPPGLFLQ 2650
DSHCLPLSEC PCLVGQKLMQ PGLAFLLDNC SQCICESGIL LCKPAACSQS 2700
CGWSAWSPWT ACDHSCGSGV RARFRSPTNP PAAFGGSPCE GDRQELQACY 2750
TDCGTDIPGW TPWTSWSSCS QSCLVPGGDP GRRQRSRLCP SSRDTFCPGE 2800
ATQEEPCSPS LCPVPSAWGL WASWSACSAS CNGGIQTRGR SCSGSAPGNP 2850
VCLGPHTQTR DCNVHPCTAQ CPGNMVFRSA EKCLEEGGPC PQLCLAQDPG 2900
VECTGSCAPG CSCPPGLFLH NASCLPRSQC PCQLHGQLYA PGAVARLDCN 2950
NCTCSSGEMV CTSERCPVAC GWSPWTPWSP CSQSCNVGIR RRFRAGTAPP 3000
AAFGGAECRG PNLDAEFCTL RPCQGPGAAW SSWTPCSVPC GGGYRNRTQG 3050
SGRHSPVEFS TCSLQPCAGP VPGVCPKDQQ WLDCAQGPAS CAHLSTPREA 3100
NQTCHPGCYC LSGMLLLNNV CVPAQDCPCA HRGRLHSPGS AVILPCENCS 3150
CVSGLITNCS SWPCEEGQPA WSSWTPWSVC SASCSPARRH RRRFCVRPST 3200
TAPFSLDLPT TVAAPTMLCP GPEAEEEPCL LPGCNQAGVW GPWSPWSGCS 3250
RSCGGGLRSR TRACDKPPPQ GLGDFCEGPQ AQGEACQAQP CPVANCSTIE 3300
GAEYSPCGPP CPRSCDDLVH CMWHCQPGCY CPPGKVLSAD GAICVQPHHC 3350
SCLDLLTGKR HHPGSQLMRP DGCNHCTCME GRLNCTDLPC QVSGDWCPWS 3400
EWTACSQPCR GQTRTRSRAC VCPAPQHGGA PCPEEAGETG VQHQMEACPN 3450
PTACPVDGAW SPWGSWSPCD ACLGQSYRSR MCSHPPPSDG GTPCLGGHQQ 3500
SRPCRNSSTP CTDCGGGQDL LPCGQPCPHS CQDLSLGSTC QPGSSGCQSG 3550
CGCPPGQLSQ DGLCVFPADC HCHFQPKAMG IPENQSRSVG SALSSWESLE 3600
PGEVVTGPCD NCTCVAGVLQ CHEVPSCPGP GIWSSWGPWE KCSVPCGGGE 3650
QLRSRQCARP PCPGLAQQSR TCHIHVCRET GCPAGRLYRE CQPSEGCPFS 3700
CAHVTGQVAC FSESCEEGCH CPEGTFQHHS ACVQECPCVL TVSLLQELGV 3750
ASTALRSYPV LLGDEGQPLG PGDELDPGQM LQTVCGNCSC VHGKLSCSME 3800
ECSRVRGYFG PWGMWSLCSH SCGGLGTRTR TRQCVLPTLA PAGLSCRGPL 3850
QDLEYCFSPE CPGTAGSTVE PVTGLAGGWG PWSPWSPCSH SCTDLTHPAW 3900
RSRTRLCLAN CTVGDSSQER PCNLPSCTTL PLCPGPGCGS ENCFWTSWAP 3950
WEPCSRSCGV GQQRRLRAYH PPGPGGHWCP DILTAYQERR FCNLRACPVP 4000
GGWSHWSPWS WCDRSCGGGR SLRSRSCSSP PPKNGGASCV GERHHVRSCN 4050
PMPCEKDCPA GMEMVSCANR CPYSCSDLQE AVMCQEDQAC QLGCRCSEGF 4100
LEQDGGCVPV GHCECTDAQG RSWAPGSQHQ DACNNCSCQA GQLSCTAQPC 4150
PPPAHCAWSH WSAWSACSHS CGPHGQQSRF RSSTSGSWAL ECQKEQSQSQ 4200
PCPEDPCPPL CLHEAHLHVL GDNWLHGECQ QCSCTPEGVI CKDTDCAVPG 4250
GWTLWSSWSY CSVSCGGGSQ VRTRSCMVSA PQHGSPSCQG PDTQTQHCGQ 4300
QLCLQLLEIC SWGPWGPCSR SCGTGLASRS GSCPCLLTKE DSECNDTFSG 4350
LDTQACYPGP CQEDCMWSDW SSWTRCSCKI LVQQRYRHQV PAPGQAGEGT 4400
LCTGLDGHFR PCAIGNCSED SCLPPFEFQS CGSPCAGLCA THLSHQLCQD 4450
LPPCQPGCYC PMGLLEQDGG CILPEQCNCW HTSGEGARVT LAPGHRLQLG 4500
CKECVCQSGE LQCSSQGCEG LLPLTGWSEW SPCGPCLPQS ALAPDSRTAL 4550
EVHWPLNTSV TLLASEQYRH RLCLDPETGR PWAGDPALCT VPLSQQRLCS 4600
DPGACHDTCQ WGPWGPWSPC QVPCSGGFKL RWREASDNSV GECRGPWAQT 4650
ESCNMGSCPG ESCETRDTVF TLDCANQCPR SCADLWEGVQ CLQGPCSPGC 4700
RCPPGQLVQD GHCVPISSCR CGLPSANASW ELAPTQVVQL DCHNCTCING 4750
TLMCPYPECP VLGPWSPWSE CSAVCGGGTM VRYRSCEEHP DSAPCQALDM 4800
EQRVECNLQT CPECPPGQVL STCATLCPSF CSHLWPGTIC VREPCQLGCG 4850
CPGGQLLHSG TCIPPEACPC TRLSLPWGLT LPLEEQAQEL PSGTVLTWNC 4900
THCTCQGGVF TCSHTDCQEC PPGEILQLGE LRPCEKTCLE MNKTQAWSNC 4950
TEAQVPGCVC QLGHFRSHTG LCVPEDHCEC WHHGSPHLPG SEWQEACESC 5000
RCLHGKSVCT QHCPELSCAQ GEVVVQEPGS CCPICQQDTL EEEPVSCRHL 5050
TELRNLTKGP CHLDQVEVSY CSGHCRSSTN VMTEEPYLQS QCDCCSYRLD 5100
PDSPVRILNL LCPDGRTEPV LLPVIHNCHC SACQGGEFSK H 5141
Length:5,141
Mass (Da):550,649
Last modified:July 5, 2004 - v1
Checksum:i1772AE67F02CA5E3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ629845 mRNA. Translation: CAF33425.1.
RefSeqiNP_001007017.1. NM_001007016.1.
UniGeneiRn.124116.

Genome annotation databases

EnsembliENSRNOT00000035906; ENSRNOP00000037189; ENSRNOG00000025848.
GeneIDi474348.
KEGGirno:474348.
UCSCiRGD:1549716. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ629845 mRNA. Translation: CAF33425.1 .
RefSeqi NP_001007017.1. NM_001007016.1.
UniGenei Rn.124116.

3D structure databases

ProteinModelPortali Q700K0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q700K0. 1 interaction.
STRINGi 10116.ENSRNOP00000037189.

Proteomic databases

PaxDbi Q700K0.
PRIDEi Q700K0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000035906 ; ENSRNOP00000037189 ; ENSRNOG00000025848 .
GeneIDi 474348.
KEGGi rno:474348.
UCSCi RGD:1549716. rat.

Organism-specific databases

CTDi 23145.
RGDi 1549716. Sspo.

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00730000110607.
HOGENOMi HOG000154433.
HOVERGENi HBG080794.
InParanoidi Q700K0.
OMAi CLDPEAN.
OrthoDBi EOG73V6J9.
PhylomeDBi Q700K0.
TreeFami TF344272.

Miscellaneous databases

NextBioi 697202.
PROi Q700K0.

Gene expression databases

Genevestigatori Q700K0.

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
4.10.400.10. 10 hits.
InterProi IPR000421. Coagulation_fac_5/8-C_type_dom.
IPR006207. Cys_knot_C.
IPR008979. Galactose-bd-like.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR000884. Thrombospondin_1_rpt.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR006552. VWC_out.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view ]
Pfami PF08742. C8. 3 hits.
PF00754. F5_F8_type_C. 1 hit.
PF00057. Ldl_recept_a. 8 hits.
PF01826. TIL. 14 hits.
PF00090. TSP_1. 22 hits.
PF00093. VWC. 1 hit.
PF00094. VWD. 3 hits.
[Graphical view ]
PRINTSi PR00261. LDLRECEPTOR.
SMARTi SM00832. C8. 3 hits.
SM00192. LDLa. 10 hits.
SM00209. TSP1. 25 hits.
SM00214. VWC. 4 hits.
SM00215. VWC_out. 1 hit.
SM00216. VWD. 3 hits.
[Graphical view ]
SUPFAMi SSF49785. SSF49785. 1 hit.
SSF57424. SSF57424. 10 hits.
SSF57567. SSF57567. 15 hits.
SSF82895. SSF82895. 25 hits.
PROSITEi PS01225. CTCK_2. 1 hit.
PS01186. EGF_2. 2 hits.
PS50022. FA58C_3. 1 hit.
PS01209. LDLRA_1. 8 hits.
PS50068. LDLRA_2. 10 hits.
PS50092. TSP1. 24 hits.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 2 hits.
PS51233. VWFD. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Conservation of mammalian SCO-spondin."
    Meiniel O.
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiSSPO_RAT
AccessioniPrimary (citable) accession number: Q700K0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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