Q700K0 (SSPO_RAT) Reviewed, UniProtKB/Swiss-Prot
Last modified
April 3, 2013.
Version 64.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: SCO-spondin | ||
| Gene names |
| ||
| Organism | Rattus norvegicus (Rat) [Reference proteome] | ||
| Taxonomic identifier | 10116 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 5141 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Involved in the modulation of neuronal aggregation. May be involved in developmental events during the formation of the central nervous system By similarity. |
| Subcellular location | Secreted › extracellular space By similarity. |
| Sequence similarities | Belongs to the thrombospondin family. Contains 1 CTCK (C-terminal cystine knot-like) domain. Contains 2 EGF-like domains. Contains 1 EMI domain. Contains 1 F5/8 type C domain. Contains 10 LDL-receptor class A domains. Contains 7 TIL (trypsin inhibitory-like) domains. Contains 24 TSP type-1 domains. Contains 2 VWFC domains. Contains 3 VWFD domains. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Cell adhesion |
| Cellular component | Secreted |
| Domain | EGF-like domain Repeat Signal |
| Ligand | Calcium |
| PTM | Disulfide bond Glycoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular_component | cytoplasm Inferred from electronic annotation. Source: Compara extracellular spaceInferred from electronic annotation. Source: UniProtKB-SubCell |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 17 | 17 | Potential | ||||||||
| Chain | 18 – 5141 | 5124 | SCO-spondin | PRO_0000245044 | |||||||
Regions | |||||||||||
| Domain | 18 – 102 | 85 | EMI | ||||||||
| Domain | 194 – 400 | 207 | VWFD 1 | ||||||||
| Domain | 472 – 527 | 56 | TIL 1 | ||||||||
| Domain | 566 – 776 | 211 | VWFD 2 | ||||||||
| Domain | 830 – 883 | 54 | TIL 2 | ||||||||
| Domain | 1018 – 1224 | 207 | VWFD 3 | ||||||||
| Domain | 1280 – 1336 | 57 | TIL 3 | ||||||||
| Domain | 1380 – 1417 | 38 | LDL-receptor class A 1 | ||||||||
| Domain | 1420 – 1456 | 37 | LDL-receptor class A 2 | ||||||||
| Domain | 1456 – 1492 | 37 | LDL-receptor class A 3 | ||||||||
| Domain | 1496 – 1534 | 39 | LDL-receptor class A 4 | ||||||||
| Domain | 1569 – 1605 | 37 | LDL-receptor class A 5 | ||||||||
| Domain | 1607 – 1646 | 40 | LDL-receptor class A 6 | ||||||||
| Domain | 1660 – 1700 | 41 | LDL-receptor class A 7 | ||||||||
| Domain | 1699 – 1753 | 55 | TSP type-1 1 | ||||||||
| Domain | 1755 – 1970 | 216 | TSP type-1 2 | ||||||||
| Domain | 1829 – 1868 | 40 | EGF-like 1 | ||||||||
| Domain | 1869 – 1895 | 27 | EGF-like 2 | ||||||||
| Domain | 1970 – 2030 | 61 | VWFC 1 | ||||||||
| Domain | 2070 – 2226 | 157 | F5/8 type C | ||||||||
| Domain | 2235 – 2271 | 37 | LDL-receptor class A 8 | ||||||||
| Domain | 2391 – 2427 | 37 | LDL-receptor class A 9 | ||||||||
| Domain | 2448 – 2484 | 37 | LDL-receptor class A 10 | ||||||||
| Domain | 2485 – 2538 | 54 | TSP type-1 3 | ||||||||
| Domain | 2540 – 2595 | 56 | TSP type-1 4 | ||||||||
| Domain | 2617 – 2660 | 44 | TIL 4 | ||||||||
| Domain | 2700 – 2754 | 55 | TSP type-1 5 | ||||||||
| Domain | 2758 – 2813 | 56 | TSP type-1 6 | ||||||||
| Domain | 2815 – 2868 | 54 | TSP type-1 7 | ||||||||
| Domain | 2969 – 3024 | 56 | TSP type-1 8 | ||||||||
| Domain | 3025 – 3068 | 44 | TSP type-1 9 | ||||||||
| Domain | 3075 – 3127 | 53 | TIL 5 | ||||||||
| Domain | 3168 – 3235 | 68 | TSP type-1 10 | ||||||||
| Domain | 3237 – 3292 | 56 | TSP type-1 11 | ||||||||
| Domain | 3303 – 3350 | 48 | TIL 6 | ||||||||
| Domain | 3393 – 3455 | 63 | TSP type-1 12 | ||||||||
| Domain | 3457 – 3512 | 56 | TSP type-1 13 | ||||||||
| Domain | 3630 – 3678 | 49 | TSP type-1 14 | ||||||||
| Domain | 3806 – 3862 | 57 | TSP type-1 15 | ||||||||
| Domain | 3876 – 3928 | 53 | TSP type-1 16 | ||||||||
| Domain | 3942 – 3998 | 57 | TSP type-1 17 | ||||||||
| Domain | 4000 – 4055 | 56 | TSP type-1 18 | ||||||||
| Domain | 4058 – 4113 | 56 | TIL 7 | ||||||||
| Domain | 4155 – 4208 | 54 | TSP type-1 19 | ||||||||
| Domain | 4249 – 4304 | 56 | TSP type-1 20 | ||||||||
| Domain | 4306 – 4362 | 57 | TSP type-1 21 | ||||||||
| Domain | 4364 – 4418 | 55 | TSP type-1 22 | ||||||||
| Domain | 4608 – 4659 | 52 | TSP type-1 23 | ||||||||
| Domain | 4759 – 4812 | 54 | TSP type-1 24 | ||||||||
| Domain | 4978 – 5036 | 59 | VWFC 2 | ||||||||
| Domain | 5047 – 5134 | 88 | CTCK | ||||||||
| Compositional bias | 896 – 899 | 4 | Poly-Thr | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 88 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 130 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 150 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 167 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 657 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 822 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 895 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 949 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 991 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 1357 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 1655 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 1668 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 1725 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 1814 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 2035 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 2130 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 2148 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 2630 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 2679 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 2921 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 2951 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 3046 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 3101 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 3148 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 3158 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 3295 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 3384 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 3506 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 3584 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 3611 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 3787 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 3910 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 4135 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 4345 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 4416 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 4557 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 4727 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 4744 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 4749 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 4899 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 4942 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 4949 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 5055 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 1381 ↔ 1394 | By similarity | |||||||||
| Disulfide bond | 1388 ↔ 1407 | By similarity | |||||||||
| Disulfide bond | 1401 ↔ 1416 | By similarity | |||||||||
| Disulfide bond | 1421 ↔ 1433 | By similarity | |||||||||
| Disulfide bond | 1428 ↔ 1446 | By similarity | |||||||||
| Disulfide bond | 1440 ↔ 1455 | By similarity | |||||||||
| Disulfide bond | 1457 ↔ 1469 | By similarity | |||||||||
| Disulfide bond | 1464 ↔ 1482 | By similarity | |||||||||
| Disulfide bond | 1476 ↔ 1491 | By similarity | |||||||||
| Disulfide bond | 1497 ↔ 1509 | By similarity | |||||||||
| Disulfide bond | 1504 ↔ 1522 | By similarity | |||||||||
| Disulfide bond | 1516 ↔ 1533 | By similarity | |||||||||
| Disulfide bond | 1570 ↔ 1582 | By similarity | |||||||||
| Disulfide bond | 1577 ↔ 1595 | By similarity | |||||||||
| Disulfide bond | 1589 ↔ 1604 | By similarity | |||||||||
| Disulfide bond | 1608 ↔ 1621 | By similarity | |||||||||
| Disulfide bond | 1615 ↔ 1634 | By similarity | |||||||||
| Disulfide bond | 1628 ↔ 1645 | By similarity | |||||||||
| Disulfide bond | 1661 ↔ 1671 | By similarity | |||||||||
| Disulfide bond | 1666 ↔ 1684 | By similarity | |||||||||
| Disulfide bond | 1678 ↔ 1699 | By similarity | |||||||||
| Disulfide bond | 1711 ↔ 1747 | By similarity | |||||||||
| Disulfide bond | 1715 ↔ 1752 | By similarity | |||||||||
| Disulfide bond | 1726 ↔ 1737 | By similarity | |||||||||
| Disulfide bond | 1767 ↔ 1964 | By similarity | |||||||||
| Disulfide bond | 1771 ↔ 1969 | By similarity | |||||||||
| Disulfide bond | 1781 ↔ 1791 | By similarity | |||||||||
| Disulfide bond | 2070 ↔ 2226 | By similarity | |||||||||
| Disulfide bond | 2236 ↔ 2248 | By similarity | |||||||||
| Disulfide bond | 2243 ↔ 2261 | By similarity | |||||||||
| Disulfide bond | 2255 ↔ 2270 | By similarity | |||||||||
| Disulfide bond | 2392 ↔ 2404 | By similarity | |||||||||
| Disulfide bond | 2399 ↔ 2417 | By similarity | |||||||||
| Disulfide bond | 2411 ↔ 2426 | By similarity | |||||||||
| Disulfide bond | 2449 ↔ 2461 | By similarity | |||||||||
| Disulfide bond | 2456 ↔ 2474 | By similarity | |||||||||
| Disulfide bond | 2468 ↔ 2483 | By similarity | |||||||||
| Disulfide bond | 2486 ↔ 2522 | By similarity | |||||||||
| Disulfide bond | 2497 ↔ 2501 | By similarity | |||||||||
| Disulfide bond | 2532 ↔ 2537 | By similarity | |||||||||
| Disulfide bond | 2552 ↔ 2589 | By similarity | |||||||||
| Disulfide bond | 2556 ↔ 2594 | By similarity | |||||||||
| Disulfide bond | 2567 ↔ 2579 | By similarity | |||||||||
| Disulfide bond | 2701 ↔ 2739 | By similarity | |||||||||
| Disulfide bond | 2712 ↔ 2716 | By similarity | |||||||||
| Disulfide bond | 2749 ↔ 2753 | By similarity | |||||||||
| Disulfide bond | 2769 ↔ 2807 | By similarity | |||||||||
| Disulfide bond | 2773 ↔ 2812 | By similarity | |||||||||
| Disulfide bond | 2789 ↔ 2797 | By similarity | |||||||||
| Disulfide bond | 2827 ↔ 2862 | By similarity | |||||||||
| Disulfide bond | 2831 ↔ 2867 | By similarity | |||||||||
| Disulfide bond | 2842 ↔ 2852 | By similarity | |||||||||
| Disulfide bond | 2970 ↔ 3008 | By similarity | |||||||||
| Disulfide bond | 2981 ↔ 2985 | By similarity | |||||||||
| Disulfide bond | 3018 ↔ 3023 | By similarity | |||||||||
| Disulfide bond | 3180 ↔ 3229 | By similarity | |||||||||
| Disulfide bond | 3184 ↔ 3234 | By similarity | |||||||||
| Disulfide bond | 3195 ↔ 3219 | By similarity | |||||||||
| Disulfide bond | 3249 ↔ 3286 | By similarity | |||||||||
| Disulfide bond | 3253 ↔ 3291 | By similarity | |||||||||
| Disulfide bond | 3264 ↔ 3276 | By similarity | |||||||||
| Disulfide bond | 3405 ↔ 3448 | By similarity | |||||||||
| Disulfide bond | 3409 ↔ 3454 | By similarity | |||||||||
| Disulfide bond | 3420 ↔ 3432 | By similarity | |||||||||
| Disulfide bond | 3469 ↔ 3504 | By similarity | |||||||||
| Disulfide bond | 3472 ↔ 3511 | By similarity | |||||||||
| Disulfide bond | 3482 ↔ 3494 | By similarity | |||||||||
| Disulfide bond | 3642 ↔ 3672 | By similarity | |||||||||
| Disulfide bond | 3646 ↔ 3677 | By similarity | |||||||||
| Disulfide bond | 3657 ↔ 3662 | By similarity | |||||||||
| Disulfide bond | 3818 ↔ 3856 | By similarity | |||||||||
| Disulfide bond | 3822 ↔ 3861 | By similarity | |||||||||
| Disulfide bond | 3834 ↔ 3846 | By similarity | |||||||||
| Disulfide bond | 3943 ↔ 3979 | By similarity | |||||||||
| Disulfide bond | 3954 ↔ 3958 | By similarity | |||||||||
| Disulfide bond | 3992 ↔ 3997 | By similarity | |||||||||
| Disulfide bond | 4012 ↔ 4049 | By similarity | |||||||||
| Disulfide bond | 4016 ↔ 4054 | By similarity | |||||||||
| Disulfide bond | 4027 ↔ 4039 | By similarity | |||||||||
| Disulfide bond | 4156 ↔ 4192 | By similarity | |||||||||
| Disulfide bond | 4167 ↔ 4171 | By similarity | |||||||||
| Disulfide bond | 4202 ↔ 4207 | By similarity | |||||||||
| Disulfide bond | 4261 ↔ 4298 | By similarity | |||||||||
| Disulfide bond | 4265 ↔ 4303 | By similarity | |||||||||
| Disulfide bond | 4276 ↔ 4288 | By similarity | |||||||||
| Disulfide bond | 4365 ↔ 4402 | By similarity | |||||||||
| Disulfide bond | 4376 ↔ 4378 | By similarity | |||||||||
| Disulfide bond | 4412 ↔ 4417 | By similarity | |||||||||
| Disulfide bond | 4609 ↔ 4643 | By similarity | |||||||||
| Disulfide bond | 4620 ↔ 4624 | By similarity | |||||||||
| Disulfide bond | 4653 ↔ 4658 | By similarity | |||||||||
| Disulfide bond | 4771 ↔ 4806 | By similarity | |||||||||
| Disulfide bond | 4775 ↔ 4811 | By similarity | |||||||||
| Disulfide bond | 4786 ↔ 4795 | By similarity | |||||||||
| Disulfide bond | 5047 ↔ 5095 | By similarity | |||||||||
| Disulfide bond | 5061 ↔ 5112 | By similarity | |||||||||
| Disulfide bond | 5071 ↔ 5128 | By similarity | |||||||||
| Disulfide bond | 5075 ↔ 5130 | By similarity | |||||||||
| Disulfide bond | ? ↔ 5133 | By similarity | |||||||||
Sequences
| ||||||||||||||||||
References
| [1] | "Conservation of mammalian SCO-spondin." Meiniel O. Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AJ629845 mRNA. Translation: CAF33425.1. |
| IPI | IPI00421896. |
| RefSeq | NP_001007017.1. NM_001007016.1. |
| UniGene | Rn.124116. |
3D structure databases | |
| ProteinModelPortal | Q700K0. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q700K0. 1 interaction. |
| STRING | 10116.ENSRNOP00000037189. |
Proteomic databases | |
| PaxDb | Q700K0. |
| PRIDE | Q700K0. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENSRNOT00000035906; ENSRNOP00000037189; ENSRNOG00000025848. |
| GeneID | 474348. |
| KEGG | rno:474348. |
| UCSC | RGD:1549716. rat. |
Organism-specific databases | |
| CTD | 23145. |
| RGD | 1549716. Sspo. |
Phylogenomic databases | |
| eggNOG | NOG12793. |
| GeneTree | ENSGT00700000104340. |
| HOGENOM | HOG000154433. |
| HOVERGEN | HBG080794. |
| InParanoid | Q700K0. |
| OMA | CLDPEAN. |
| OrthoDB | EOG4BP1BV. |
Gene expression databases | |
| Genevestigator | Q700K0. |
Family and domain databases | |
| Gene3D | 4.10.400.10. 10 hits. |
| InterPro | IPR000421. Coagulation_fac_5/8-C_type_dom. IPR006207. Cys_knot_C. IPR008979. Galactose-bd-like. IPR023415. LDLR_class-A_CS. IPR002172. LDrepeatLR_classA_rpt. IPR000884. Thrombospondin_1_rpt. IPR002919. TIL_dom. IPR014853. Unchr_dom_Cys-rich. IPR006552. VWC_out. IPR001007. VWF_C. IPR001846. VWF_type-D. [Graphical view] |
| Pfam | PF08742. C8. 3 hits. PF00754. F5_F8_type_C. 1 hit. PF00057. Ldl_recept_a. 8 hits. PF01826. TIL. 14 hits. PF00090. TSP_1. 22 hits. PF00093. VWC. 1 hit. PF00094. VWD. 3 hits. [Graphical view] |
| SMART | SM00832. C8. 3 hits. SM00192. LDLa. 10 hits. SM00209. TSP1. 25 hits. SM00214. VWC. 4 hits. SM00215. VWC_out. 1 hit. SM00216. VWD. 3 hits. [Graphical view] |
| SUPFAM | SSF57567. Cysrich_TIL. 16 hits. SSF49785. Gal_bind_like. 1 hit. SSF57424. LDL_rcpt_classA_cys-rich. 9 hits. SSF82895. TSP1. 25 hits. |
| PROSITE | PS01185. CTCK_1. False negative. PS01225. CTCK_2. 1 hit. PS00022. EGF_1. False negative. PS01186. EGF_2. 2 hits. PS50026. EGF_3. False negative. PS51041. EMI. False negative. PS01285. FA58C_1. False negative. PS01286. FA58C_2. False negative. PS50022. FA58C_3. 1 hit. PS01209. LDLRA_1. 8 hits. PS50068. LDLRA_2. 10 hits. PS50092. TSP1. 24 hits. PS01208. VWFC_1. 1 hit. PS50184. VWFC_2. 2 hits. PS51233. VWFD. 3 hits. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 697202. |
Entry information
| Entry name | SSPO_RAT | ||||||||
| Accession | Primary (citable) accession number: Q700K0 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |