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Q700K0

- SSPO_RAT

UniProt

Q700K0 - SSPO_RAT

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Protein

SCO-spondin

Gene

Sspo

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in the modulation of neuronal aggregation. May be involved in developmental events during the formation of the central nervous system (By similarity).By similarity

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
SCO-spondin
Gene namesi
Name:Sspo
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 4

Organism-specific databases

RGDi1549716. Sspo.

Subcellular locationi

Secretedextracellular space By similarity

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 51415124SCO-spondinPRO_0000245044Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi? ↔ 5133By similarity
Glycosylationi88 – 881N-linked (GlcNAc...)Sequence Analysis
Glycosylationi130 – 1301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi150 – 1501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence Analysis
Glycosylationi657 – 6571N-linked (GlcNAc...)Sequence Analysis
Glycosylationi822 – 8221N-linked (GlcNAc...)Sequence Analysis
Glycosylationi895 – 8951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi949 – 9491N-linked (GlcNAc...)Sequence Analysis
Glycosylationi991 – 9911N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1357 – 13571N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1381 ↔ 1394By similarity
Disulfide bondi1388 ↔ 1407By similarity
Disulfide bondi1401 ↔ 1416By similarity
Disulfide bondi1421 ↔ 1433By similarity
Disulfide bondi1428 ↔ 1446By similarity
Disulfide bondi1440 ↔ 1455By similarity
Disulfide bondi1457 ↔ 1469By similarity
Disulfide bondi1464 ↔ 1482By similarity
Disulfide bondi1476 ↔ 1491By similarity
Disulfide bondi1497 ↔ 1509By similarity
Disulfide bondi1504 ↔ 1522By similarity
Disulfide bondi1516 ↔ 1533By similarity
Disulfide bondi1570 ↔ 1582By similarity
Disulfide bondi1577 ↔ 1595By similarity
Disulfide bondi1589 ↔ 1604By similarity
Disulfide bondi1608 ↔ 1621By similarity
Disulfide bondi1615 ↔ 1634By similarity
Disulfide bondi1628 ↔ 1645By similarity
Glycosylationi1655 – 16551N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1661 ↔ 1671By similarity
Disulfide bondi1666 ↔ 1684By similarity
Glycosylationi1668 – 16681N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1678 ↔ 1699By similarity
Disulfide bondi1711 ↔ 1747By similarity
Disulfide bondi1715 ↔ 1752By similarity
Glycosylationi1725 – 17251N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1726 ↔ 1737By similarity
Disulfide bondi1767 ↔ 1964By similarity
Disulfide bondi1771 ↔ 1969By similarity
Disulfide bondi1781 ↔ 1791By similarity
Glycosylationi1814 – 18141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2035 – 20351N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi2070 ↔ 2226By similarity
Glycosylationi2130 – 21301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2148 – 21481N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi2236 ↔ 2248By similarity
Disulfide bondi2243 ↔ 2261By similarity
Disulfide bondi2255 ↔ 2270By similarity
Disulfide bondi2392 ↔ 2404By similarity
Disulfide bondi2399 ↔ 2417By similarity
Disulfide bondi2411 ↔ 2426By similarity
Disulfide bondi2449 ↔ 2461By similarity
Disulfide bondi2456 ↔ 2474By similarity
Disulfide bondi2468 ↔ 2483By similarity
Disulfide bondi2486 ↔ 2522By similarity
Disulfide bondi2497 ↔ 2501By similarity
Disulfide bondi2532 ↔ 2537By similarity
Disulfide bondi2552 ↔ 2589By similarity
Disulfide bondi2556 ↔ 2594By similarity
Disulfide bondi2567 ↔ 2579By similarity
Glycosylationi2630 – 26301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2679 – 26791N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi2701 ↔ 2739By similarity
Disulfide bondi2712 ↔ 2716By similarity
Disulfide bondi2749 ↔ 2753By similarity
Disulfide bondi2769 ↔ 2807By similarity
Disulfide bondi2773 ↔ 2812By similarity
Disulfide bondi2789 ↔ 2797By similarity
Disulfide bondi2827 ↔ 2862By similarity
Disulfide bondi2831 ↔ 2867By similarity
Disulfide bondi2842 ↔ 2852By similarity
Glycosylationi2921 – 29211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2951 – 29511N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi2970 ↔ 3008By similarity
Disulfide bondi2981 ↔ 2985By similarity
Disulfide bondi3018 ↔ 3023By similarity
Glycosylationi3046 – 30461N-linked (GlcNAc...)Sequence Analysis
Glycosylationi3101 – 31011N-linked (GlcNAc...)Sequence Analysis
Glycosylationi3148 – 31481N-linked (GlcNAc...)Sequence Analysis
Glycosylationi3158 – 31581N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi3180 ↔ 3229By similarity
Disulfide bondi3184 ↔ 3234By similarity
Disulfide bondi3195 ↔ 3219By similarity
Disulfide bondi3249 ↔ 3286By similarity
Disulfide bondi3253 ↔ 3291By similarity
Disulfide bondi3264 ↔ 3276By similarity
Glycosylationi3295 – 32951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi3384 – 33841N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi3405 ↔ 3448By similarity
Disulfide bondi3409 ↔ 3454By similarity
Disulfide bondi3420 ↔ 3432By similarity
Disulfide bondi3469 ↔ 3504By similarity
Disulfide bondi3472 ↔ 3511By similarity
Disulfide bondi3482 ↔ 3494By similarity
Glycosylationi3506 – 35061N-linked (GlcNAc...)Sequence Analysis
Glycosylationi3584 – 35841N-linked (GlcNAc...)Sequence Analysis
Glycosylationi3611 – 36111N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi3642 ↔ 3672By similarity
Disulfide bondi3646 ↔ 3677By similarity
Disulfide bondi3657 ↔ 3662By similarity
Glycosylationi3787 – 37871N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi3818 ↔ 3856By similarity
Disulfide bondi3822 ↔ 3861By similarity
Disulfide bondi3834 ↔ 3846By similarity
Glycosylationi3910 – 39101N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi3943 ↔ 3979By similarity
Disulfide bondi3954 ↔ 3958By similarity
Disulfide bondi3992 ↔ 3997By similarity
Disulfide bondi4012 ↔ 4049By similarity
Disulfide bondi4016 ↔ 4054By similarity
Disulfide bondi4027 ↔ 4039By similarity
Glycosylationi4135 – 41351N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi4156 ↔ 4192By similarity
Disulfide bondi4167 ↔ 4171By similarity
Disulfide bondi4202 ↔ 4207By similarity
Disulfide bondi4261 ↔ 4298By similarity
Disulfide bondi4265 ↔ 4303By similarity
Disulfide bondi4276 ↔ 4288By similarity
Glycosylationi4345 – 43451N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi4365 ↔ 4402By similarity
Disulfide bondi4376 ↔ 4378By similarity
Disulfide bondi4412 ↔ 4417By similarity
Glycosylationi4416 – 44161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi4557 – 45571N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi4609 ↔ 4643By similarity
Disulfide bondi4620 ↔ 4624By similarity
Disulfide bondi4653 ↔ 4658By similarity
Glycosylationi4727 – 47271N-linked (GlcNAc...)Sequence Analysis
Glycosylationi4744 – 47441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi4749 – 47491N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi4771 ↔ 4806By similarity
Disulfide bondi4775 ↔ 4811By similarity
Disulfide bondi4786 ↔ 4795By similarity
Glycosylationi4899 – 48991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi4942 – 49421N-linked (GlcNAc...)Sequence Analysis
Glycosylationi4949 – 49491N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi5047 ↔ 5095By similarity
Glycosylationi5055 – 50551N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi5061 ↔ 5112By similarity
Disulfide bondi5071 ↔ 5128By similarity
Disulfide bondi5075 ↔ 5130By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ700K0.
PRIDEiQ700K0.

Expressioni

Gene expression databases

GenevestigatoriQ700K0.

Interactioni

Protein-protein interaction databases

IntActiQ700K0. 1 interaction.
STRINGi10116.ENSRNOP00000037189.

Structurei

3D structure databases

ProteinModelPortaliQ700K0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 10285EMIAdd
BLAST
Domaini194 – 400207VWFD 1PROSITE-ProRule annotationAdd
BLAST
Domaini472 – 52756TIL 1Add
BLAST
Domaini566 – 776211VWFD 2PROSITE-ProRule annotationAdd
BLAST
Domaini830 – 88354TIL 2Add
BLAST
Domaini1018 – 1224207VWFD 3PROSITE-ProRule annotationAdd
BLAST
Domaini1280 – 133657TIL 3Add
BLAST
Domaini1380 – 141738LDL-receptor class A 1PROSITE-ProRule annotationAdd
BLAST
Domaini1420 – 145637LDL-receptor class A 2PROSITE-ProRule annotationAdd
BLAST
Domaini1456 – 149237LDL-receptor class A 3PROSITE-ProRule annotationAdd
BLAST
Domaini1496 – 153439LDL-receptor class A 4PROSITE-ProRule annotationAdd
BLAST
Domaini1569 – 160537LDL-receptor class A 5PROSITE-ProRule annotationAdd
BLAST
Domaini1607 – 164640LDL-receptor class A 6PROSITE-ProRule annotationAdd
BLAST
Domaini1660 – 170041LDL-receptor class A 7PROSITE-ProRule annotationAdd
BLAST
Domaini1699 – 175355TSP type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini1755 – 1970216TSP type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini1829 – 186840EGF-like 1Add
BLAST
Domaini1869 – 189527EGF-like 2Add
BLAST
Domaini1970 – 203061VWFC 1PROSITE-ProRule annotationAdd
BLAST
Domaini2070 – 2226157F5/8 type CPROSITE-ProRule annotationAdd
BLAST
Domaini2235 – 227137LDL-receptor class A 8PROSITE-ProRule annotationAdd
BLAST
Domaini2391 – 242737LDL-receptor class A 9PROSITE-ProRule annotationAdd
BLAST
Domaini2448 – 248437LDL-receptor class A 10PROSITE-ProRule annotationAdd
BLAST
Domaini2485 – 253854TSP type-1 3PROSITE-ProRule annotationAdd
BLAST
Domaini2540 – 259556TSP type-1 4PROSITE-ProRule annotationAdd
BLAST
Domaini2617 – 266044TIL 4Add
BLAST
Domaini2700 – 275455TSP type-1 5PROSITE-ProRule annotationAdd
BLAST
Domaini2758 – 281356TSP type-1 6PROSITE-ProRule annotationAdd
BLAST
Domaini2815 – 286854TSP type-1 7PROSITE-ProRule annotationAdd
BLAST
Domaini2969 – 302456TSP type-1 8PROSITE-ProRule annotationAdd
BLAST
Domaini3025 – 306844TSP type-1 9PROSITE-ProRule annotationAdd
BLAST
Domaini3075 – 312753TIL 5Add
BLAST
Domaini3168 – 323568TSP type-1 10PROSITE-ProRule annotationAdd
BLAST
Domaini3237 – 329256TSP type-1 11PROSITE-ProRule annotationAdd
BLAST
Domaini3303 – 335048TIL 6Add
BLAST
Domaini3393 – 345563TSP type-1 12PROSITE-ProRule annotationAdd
BLAST
Domaini3457 – 351256TSP type-1 13PROSITE-ProRule annotationAdd
BLAST
Domaini3630 – 367849TSP type-1 14PROSITE-ProRule annotationAdd
BLAST
Domaini3806 – 386257TSP type-1 15PROSITE-ProRule annotationAdd
BLAST
Domaini3876 – 392853TSP type-1 16PROSITE-ProRule annotationAdd
BLAST
Domaini3942 – 399857TSP type-1 17PROSITE-ProRule annotationAdd
BLAST
Domaini4000 – 405556TSP type-1 18PROSITE-ProRule annotationAdd
BLAST
Domaini4058 – 411356TIL 7Add
BLAST
Domaini4155 – 420854TSP type-1 19PROSITE-ProRule annotationAdd
BLAST
Domaini4249 – 430456TSP type-1 20PROSITE-ProRule annotationAdd
BLAST
Domaini4306 – 436257TSP type-1 21PROSITE-ProRule annotationAdd
BLAST
Domaini4364 – 441855TSP type-1 22PROSITE-ProRule annotationAdd
BLAST
Domaini4608 – 465952TSP type-1 23PROSITE-ProRule annotationAdd
BLAST
Domaini4759 – 481254TSP type-1 24PROSITE-ProRule annotationAdd
BLAST
Domaini4978 – 503659VWFC 2PROSITE-ProRule annotationAdd
BLAST
Domaini5047 – 513488CTCKPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi896 – 8994Poly-Thr

Sequence similaritiesi

Belongs to the thrombospondin family.Curated
Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
Contains 2 EGF-like domains.Curated
Contains 1 EMI domain.Curated
Contains 1 F5/8 type C domain.PROSITE-ProRule annotation
Contains 10 LDL-receptor class A domains.PROSITE-ProRule annotation
Contains 24 TSP type-1 domains.PROSITE-ProRule annotation
Contains 2 VWFC domains.PROSITE-ProRule annotation
Contains 3 VWFD domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00760000118896.
HOGENOMiHOG000154433.
HOVERGENiHBG080794.
InParanoidiQ700K0.
OMAiCLDPEAN.
OrthoDBiEOG73V6J9.
PhylomeDBiQ700K0.
TreeFamiTF344272.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
4.10.400.10. 10 hits.
InterProiIPR000421. Coagulation_fac_5/8-C_type_dom.
IPR006207. Cys_knot_C.
IPR008979. Galactose-bd-like.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR000884. Thrombospondin_1_rpt.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR006552. VWC_out.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF08742. C8. 3 hits.
PF00754. F5_F8_type_C. 1 hit.
PF00057. Ldl_recept_a. 8 hits.
PF01826. TIL. 14 hits.
PF00090. TSP_1. 22 hits.
PF00093. VWC. 1 hit.
PF00094. VWD. 3 hits.
[Graphical view]
PRINTSiPR00261. LDLRECEPTOR.
SMARTiSM00832. C8. 3 hits.
SM00192. LDLa. 10 hits.
SM00209. TSP1. 25 hits.
SM00214. VWC. 4 hits.
SM00215. VWC_out. 1 hit.
SM00216. VWD. 3 hits.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF57424. SSF57424. 10 hits.
SSF57567. SSF57567. 15 hits.
SSF82895. SSF82895. 25 hits.
PROSITEiPS01225. CTCK_2. 1 hit.
PS01186. EGF_2. 2 hits.
PS50022. FA58C_3. 1 hit.
PS01209. LDLRA_1. 8 hits.
PS50068. LDLRA_2. 10 hits.
PS50092. TSP1. 24 hits.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 2 hits.
PS51233. VWFD. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q700K0-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MLLPALLFGM LWAPANGHWC EQIETVHVEE EVTPRREDLV PCTSLYHYSR
60 70 80 90 100
LGWKLDLSWG GHVGLTRPPA LGLCAIYKPP ETRPATWNRT VRACCPGWGG
110 120 130 140 150
IHCTEALAEA SPKGHCFVTW HCQPLAGSAN SSAGSLEECC AQPWGHSWWN
160 170 180 190 200
SSSQMCLSCS GQHRPGNASS EGLLQPLAGA VGQLWSQRQR PSATCATWSG
210 220 230 240 250
FHYQTFDGQH YHFLGQCTYL LAGAMDSTWA VHLRPSVHCP QPRQCWLVQV
260 270 280 290 300
IMGPEEVLIQ DGEVSVKGQP VPVGESQLLH GMSLQWQGDW LVLSGGLGVV
310 320 330 340 350
VRLDRSSSII ISVDHEFWGR TQGLCGLYNG RPEDDFVEPG GGLAMLAATF
360 370 380 390 400
GNSWRLPGYE PGCLDTVEVA RGCEGLLEGT LTGLEAGKLQ AQAQDLCHQL
410 420 430 440 450
LEDPFSQCHG QVPPDEYHET CLFAYCVGAT AGSGPEEQVK AVCATFANYA
460 470 480 490 500
QACARQHIYV HWRKPGFCER LCPGGQLYSD CISSCPPSCS AVAQGEEGSC
510 520 530 540 550
GKECVSGCEC PTGLFWDGAL CVPAAHCPCY YRRQRYAPGD TVKQQCNPCV
560 570 580 590 600
CQDGRWHCAQ APCPAECAVG GDGHYCTFDG RSFSFRGNPG CQYSLVQDSV
610 620 630 640 650
KGQLLVVLEH GACETGSCLH ALSAFLGKTH IQLRYSGAVL VDGQDVDLPW
660 670 680 690 700
IGAEGFNVSH ASSTFLLLRW PGAWVLWGVA DPAVYITLDP RHAYQVQGLC
710 720 730 740 750
GTFTWKQQDD FLTPAGDIET SVTAFASKFQ VSGDGRCPLV DNTPLSSCST
760 770 780 790 800
YSQRLAFAEA ACAALHGHAF QECHGLVERE PFRLRCLESM CSCAPGRDCL
810 820 830 840 850
CSVLSAYAHH CAQEGVLLQW RNETLCSVPC PGGQVYQECA PACGHYCGEP
860 870 880 890 900
EDCKELGSCV AGCNCPPGLL WDLEGQCVPP SMCPCQLGGH RYAFNTTTTL
910 920 930 940 950
KDCSHCICQE RGLWNCIAHH CPRQWALCPQ ELIYAPGACL LTCDSLGANH
960 970 980 990 1000
SCLAGSTDGC VCPSGTVLLD KHCVSPDLCP CRHNGQWYPP NATIQEDCNI
1010 1020 1030 1040 1050
CVCQNQRWHC TGQRCSGWCQ ASGAPHYVTF DGLVFTFPGA CEYLLVREAG
1060 1070 1080 1090 1100
GRFSVSIQNL PCGASGLTCT KALAVRLDST VVHMLRGQAV TVNGVSIKLP
1110 1120 1130 1140 1150
KVYTGPGLSL HHAGLFLLLT TRLGLTLLWD GGTRVLVQLS PHFHGRVTGL
1160 1170 1180 1190 1200
CGNFDGDVSN DLRSRQGVLE PTAELTAHSW RLNPLCPEPG DLPHPCSVNA
1210 1220 1230 1240 1250
HRVNWARAHC EVILQPIFAP CHTEVPPQQY YEWCVYDACG CDTGGDCECL
1260 1270 1280 1290 1300
CSAIATYADE CARHRHHVRW RSQELCPLQC EGGQVYEPCG STCPPTCHDH
1310 1320 1330 1340 1350
HPELRWHCQA ITCVEGCFCP EGTLLHGGTC VELTDCPCEW QGSFFPPGAV
1360 1370 1380 1390 1400
LQKDCGNCTC QESQWHCNPS GAPCEEMEPG CAEGEALCRE SGHCVPLEWL
1410 1420 1430 1440 1450
CDNQDDCGDG SDEEGCDTSV CGEGQMSCQS GRCLPLSLIC DGQDDCGDGT
1460 1470 1480 1490 1500
DEQGCLCPQG FLACADGRCL PPALLCDGHP DCLDAADEES CLGWVSCTSG
1510 1520 1530 1540 1550
EVSCVDGPCI RTIQLCDGVW DCPDGADEGP VHCSSPSLPT PPAGIGQNPS
1560 1570 1580 1590 1600
TSSPDTSPSP VGSASPASPC SLSEFQCNSG ECTPRGWRCD REEDCTDGSD
1610 1620 1630 1640 1650
ELDCGGPCKL YQMPCAHGPH CLSPGQLCDG VAQCPDGSDE DPDVCEERSA
1660 1670 1680 1690 1700
SGGPNGTAVP CPEFSCPNGT CIDFLLVCDG SPDCELADET EPSLDEQGCG
1710 1720 1730 1740 1750
TWGSWGPWEP CSQTCGPGIQ SRNRNCSISS LHVLQNCPGL QHQSQSCFTE
1760 1770 1780 1790 1800
ACPVDGEWSS WSLWSPCSEP CGGTMTRHRQ CRPPQNGGQD CALLPGSTHS
1810 1820 1830 1840 1850
THQTSPCPQE GCLNVTCFGE LVFRPCAPCP LTCDDISGEA VCSPDRPCSS
1860 1870 1880 1890 1900
PGCWCPEGKV LGTEGRCVRP RQCPCLVDGI RYWPGQRIKM DCQLCFCQDG
1910 1920 1930 1940 1950
QPHRCRPNPE CAVDCGWSSW SPWAECLGPC SSQSLQWSFR SPNNPRLSGH
1960 1970 1980 1990 2000
GRQCRGIHRK ARRCQTEPCE GCEQWGLTYH VGERWRGGPC TVCECLHRSI
2010 2020 2030 2040 2050
TRCSPYCPIG SCPQSWVLVE GMGESCCHCA LPGKNQTMIP VTTPAPVPTP
2060 2070 2080 2090 2100
SPQIGASLVT YVLPPMSDAC YSPLGLAGLP TWAPSQPLEH STRAAPVEAP
2110 2120 2130 2140 2150
TAGPGPREDA YAEWHTQPLY LQLDLLWPRN LTGIMVQRAG SSAAYISNLS
2160 2170 2180 2190 2200
LQFSSDGLQW HSVLNSLSST LPPPKPSPES SNHMVPEVWT FDQMVQARYI
2210 2220 2230 2240 2250
RVWPHGSHLR DNNQQDIFLW VELLGCKPVP PLAPLCPGTR HRCANGDCAL
2260 2270 2280 2290 2300
KGGPCDGAVD CEDGSDEEGC GPLRASTASR VHSTARTPAL SPTQPGKFPF
2310 2320 2330 2340 2350
HPREGLADME HQQPKQESPM PSAGVSPSAS EGLLPVSGQS MQTLTTTSTF
2360 2370 2380 2390 2400
PPGLKSLHPG MAAVTVHSPH SVMPGTPVGQ SVSPRPFPLM RCGPGQVPCD
2410 2420 2430 2440 2450
VLGCVEQEQL CDGREDCLDG SDEQHCASPE PFTVPTTALP GLPASRALCS
2460 2470 2480 2490 2500
PSQLSCGSGE CLPLEHRCDL QVNCQDGSDE DDCVDCVLAP WSGWSDCSRS
2510 2520 2530 2540 2550
CGLGLIFQHR ELLRPPLPGG SCLLDQLRSQ PCFVQACPVA GAWAKWGPWE
2560 2570 2580 2590 2600
PCSVSCGGGH QSRQRSCVDP PPKNGGAPCP GPSHEKVLCN LQLCPGDTDC
2610 2620 2630 2640 2650
EPGRVHVNAE LCQKGLLPPC PPSCLDPEAN RSCSGHCVEG CRCPPGLFLQ
2660 2670 2680 2690 2700
DSHCLPLSEC PCLVGQKLMQ PGLAFLLDNC SQCICESGIL LCKPAACSQS
2710 2720 2730 2740 2750
CGWSAWSPWT ACDHSCGSGV RARFRSPTNP PAAFGGSPCE GDRQELQACY
2760 2770 2780 2790 2800
TDCGTDIPGW TPWTSWSSCS QSCLVPGGDP GRRQRSRLCP SSRDTFCPGE
2810 2820 2830 2840 2850
ATQEEPCSPS LCPVPSAWGL WASWSACSAS CNGGIQTRGR SCSGSAPGNP
2860 2870 2880 2890 2900
VCLGPHTQTR DCNVHPCTAQ CPGNMVFRSA EKCLEEGGPC PQLCLAQDPG
2910 2920 2930 2940 2950
VECTGSCAPG CSCPPGLFLH NASCLPRSQC PCQLHGQLYA PGAVARLDCN
2960 2970 2980 2990 3000
NCTCSSGEMV CTSERCPVAC GWSPWTPWSP CSQSCNVGIR RRFRAGTAPP
3010 3020 3030 3040 3050
AAFGGAECRG PNLDAEFCTL RPCQGPGAAW SSWTPCSVPC GGGYRNRTQG
3060 3070 3080 3090 3100
SGRHSPVEFS TCSLQPCAGP VPGVCPKDQQ WLDCAQGPAS CAHLSTPREA
3110 3120 3130 3140 3150
NQTCHPGCYC LSGMLLLNNV CVPAQDCPCA HRGRLHSPGS AVILPCENCS
3160 3170 3180 3190 3200
CVSGLITNCS SWPCEEGQPA WSSWTPWSVC SASCSPARRH RRRFCVRPST
3210 3220 3230 3240 3250
TAPFSLDLPT TVAAPTMLCP GPEAEEEPCL LPGCNQAGVW GPWSPWSGCS
3260 3270 3280 3290 3300
RSCGGGLRSR TRACDKPPPQ GLGDFCEGPQ AQGEACQAQP CPVANCSTIE
3310 3320 3330 3340 3350
GAEYSPCGPP CPRSCDDLVH CMWHCQPGCY CPPGKVLSAD GAICVQPHHC
3360 3370 3380 3390 3400
SCLDLLTGKR HHPGSQLMRP DGCNHCTCME GRLNCTDLPC QVSGDWCPWS
3410 3420 3430 3440 3450
EWTACSQPCR GQTRTRSRAC VCPAPQHGGA PCPEEAGETG VQHQMEACPN
3460 3470 3480 3490 3500
PTACPVDGAW SPWGSWSPCD ACLGQSYRSR MCSHPPPSDG GTPCLGGHQQ
3510 3520 3530 3540 3550
SRPCRNSSTP CTDCGGGQDL LPCGQPCPHS CQDLSLGSTC QPGSSGCQSG
3560 3570 3580 3590 3600
CGCPPGQLSQ DGLCVFPADC HCHFQPKAMG IPENQSRSVG SALSSWESLE
3610 3620 3630 3640 3650
PGEVVTGPCD NCTCVAGVLQ CHEVPSCPGP GIWSSWGPWE KCSVPCGGGE
3660 3670 3680 3690 3700
QLRSRQCARP PCPGLAQQSR TCHIHVCRET GCPAGRLYRE CQPSEGCPFS
3710 3720 3730 3740 3750
CAHVTGQVAC FSESCEEGCH CPEGTFQHHS ACVQECPCVL TVSLLQELGV
3760 3770 3780 3790 3800
ASTALRSYPV LLGDEGQPLG PGDELDPGQM LQTVCGNCSC VHGKLSCSME
3810 3820 3830 3840 3850
ECSRVRGYFG PWGMWSLCSH SCGGLGTRTR TRQCVLPTLA PAGLSCRGPL
3860 3870 3880 3890 3900
QDLEYCFSPE CPGTAGSTVE PVTGLAGGWG PWSPWSPCSH SCTDLTHPAW
3910 3920 3930 3940 3950
RSRTRLCLAN CTVGDSSQER PCNLPSCTTL PLCPGPGCGS ENCFWTSWAP
3960 3970 3980 3990 4000
WEPCSRSCGV GQQRRLRAYH PPGPGGHWCP DILTAYQERR FCNLRACPVP
4010 4020 4030 4040 4050
GGWSHWSPWS WCDRSCGGGR SLRSRSCSSP PPKNGGASCV GERHHVRSCN
4060 4070 4080 4090 4100
PMPCEKDCPA GMEMVSCANR CPYSCSDLQE AVMCQEDQAC QLGCRCSEGF
4110 4120 4130 4140 4150
LEQDGGCVPV GHCECTDAQG RSWAPGSQHQ DACNNCSCQA GQLSCTAQPC
4160 4170 4180 4190 4200
PPPAHCAWSH WSAWSACSHS CGPHGQQSRF RSSTSGSWAL ECQKEQSQSQ
4210 4220 4230 4240 4250
PCPEDPCPPL CLHEAHLHVL GDNWLHGECQ QCSCTPEGVI CKDTDCAVPG
4260 4270 4280 4290 4300
GWTLWSSWSY CSVSCGGGSQ VRTRSCMVSA PQHGSPSCQG PDTQTQHCGQ
4310 4320 4330 4340 4350
QLCLQLLEIC SWGPWGPCSR SCGTGLASRS GSCPCLLTKE DSECNDTFSG
4360 4370 4380 4390 4400
LDTQACYPGP CQEDCMWSDW SSWTRCSCKI LVQQRYRHQV PAPGQAGEGT
4410 4420 4430 4440 4450
LCTGLDGHFR PCAIGNCSED SCLPPFEFQS CGSPCAGLCA THLSHQLCQD
4460 4470 4480 4490 4500
LPPCQPGCYC PMGLLEQDGG CILPEQCNCW HTSGEGARVT LAPGHRLQLG
4510 4520 4530 4540 4550
CKECVCQSGE LQCSSQGCEG LLPLTGWSEW SPCGPCLPQS ALAPDSRTAL
4560 4570 4580 4590 4600
EVHWPLNTSV TLLASEQYRH RLCLDPETGR PWAGDPALCT VPLSQQRLCS
4610 4620 4630 4640 4650
DPGACHDTCQ WGPWGPWSPC QVPCSGGFKL RWREASDNSV GECRGPWAQT
4660 4670 4680 4690 4700
ESCNMGSCPG ESCETRDTVF TLDCANQCPR SCADLWEGVQ CLQGPCSPGC
4710 4720 4730 4740 4750
RCPPGQLVQD GHCVPISSCR CGLPSANASW ELAPTQVVQL DCHNCTCING
4760 4770 4780 4790 4800
TLMCPYPECP VLGPWSPWSE CSAVCGGGTM VRYRSCEEHP DSAPCQALDM
4810 4820 4830 4840 4850
EQRVECNLQT CPECPPGQVL STCATLCPSF CSHLWPGTIC VREPCQLGCG
4860 4870 4880 4890 4900
CPGGQLLHSG TCIPPEACPC TRLSLPWGLT LPLEEQAQEL PSGTVLTWNC
4910 4920 4930 4940 4950
THCTCQGGVF TCSHTDCQEC PPGEILQLGE LRPCEKTCLE MNKTQAWSNC
4960 4970 4980 4990 5000
TEAQVPGCVC QLGHFRSHTG LCVPEDHCEC WHHGSPHLPG SEWQEACESC
5010 5020 5030 5040 5050
RCLHGKSVCT QHCPELSCAQ GEVVVQEPGS CCPICQQDTL EEEPVSCRHL
5060 5070 5080 5090 5100
TELRNLTKGP CHLDQVEVSY CSGHCRSSTN VMTEEPYLQS QCDCCSYRLD
5110 5120 5130 5140
PDSPVRILNL LCPDGRTEPV LLPVIHNCHC SACQGGEFSK H
Length:5,141
Mass (Da):550,649
Last modified:July 5, 2004 - v1
Checksum:i1772AE67F02CA5E3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ629845 mRNA. Translation: CAF33425.1.
RefSeqiNP_001007017.1. NM_001007016.1.
UniGeneiRn.124116.

Genome annotation databases

EnsembliENSRNOT00000035906; ENSRNOP00000037189; ENSRNOG00000025848.
GeneIDi474348.
KEGGirno:474348.
UCSCiRGD:1549716. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ629845 mRNA. Translation: CAF33425.1 .
RefSeqi NP_001007017.1. NM_001007016.1.
UniGenei Rn.124116.

3D structure databases

ProteinModelPortali Q700K0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q700K0. 1 interaction.
STRINGi 10116.ENSRNOP00000037189.

Proteomic databases

PaxDbi Q700K0.
PRIDEi Q700K0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000035906 ; ENSRNOP00000037189 ; ENSRNOG00000025848 .
GeneIDi 474348.
KEGGi rno:474348.
UCSCi RGD:1549716. rat.

Organism-specific databases

CTDi 23145.
RGDi 1549716. Sspo.

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00760000118896.
HOGENOMi HOG000154433.
HOVERGENi HBG080794.
InParanoidi Q700K0.
OMAi CLDPEAN.
OrthoDBi EOG73V6J9.
PhylomeDBi Q700K0.
TreeFami TF344272.

Miscellaneous databases

NextBioi 697202.
PROi Q700K0.

Gene expression databases

Genevestigatori Q700K0.

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
4.10.400.10. 10 hits.
InterProi IPR000421. Coagulation_fac_5/8-C_type_dom.
IPR006207. Cys_knot_C.
IPR008979. Galactose-bd-like.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR000884. Thrombospondin_1_rpt.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR006552. VWC_out.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view ]
Pfami PF08742. C8. 3 hits.
PF00754. F5_F8_type_C. 1 hit.
PF00057. Ldl_recept_a. 8 hits.
PF01826. TIL. 14 hits.
PF00090. TSP_1. 22 hits.
PF00093. VWC. 1 hit.
PF00094. VWD. 3 hits.
[Graphical view ]
PRINTSi PR00261. LDLRECEPTOR.
SMARTi SM00832. C8. 3 hits.
SM00192. LDLa. 10 hits.
SM00209. TSP1. 25 hits.
SM00214. VWC. 4 hits.
SM00215. VWC_out. 1 hit.
SM00216. VWD. 3 hits.
[Graphical view ]
SUPFAMi SSF49785. SSF49785. 1 hit.
SSF57424. SSF57424. 10 hits.
SSF57567. SSF57567. 15 hits.
SSF82895. SSF82895. 25 hits.
PROSITEi PS01225. CTCK_2. 1 hit.
PS01186. EGF_2. 2 hits.
PS50022. FA58C_3. 1 hit.
PS01209. LDLRA_1. 8 hits.
PS50068. LDLRA_2. 10 hits.
PS50092. TSP1. 24 hits.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 2 hits.
PS51233. VWFD. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Conservation of mammalian SCO-spondin."
    Meiniel O.
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiSSPO_RAT
AccessioniPrimary (citable) accession number: Q700K0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3