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Q700K0

- SSPO_RAT

UniProt

Q700K0 - SSPO_RAT

Protein

SCO-spondin

Gene

Sspo

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Involved in the modulation of neuronal aggregation. May be involved in developmental events during the formation of the central nervous system By similarity.By similarity

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SCO-spondin
    Gene namesi
    Name:Sspo
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 4

    Organism-specific databases

    RGDi1549716. Sspo.

    Subcellular locationi

    Secretedextracellular space By similarity

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. extracellular space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 51415124SCO-spondinPRO_0000245044Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi? ↔ 5133By similarity
    Glycosylationi88 – 881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi130 – 1301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi150 – 1501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi657 – 6571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi822 – 8221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi895 – 8951N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi949 – 9491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi991 – 9911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1357 – 13571N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1381 ↔ 1394By similarity
    Disulfide bondi1388 ↔ 1407By similarity
    Disulfide bondi1401 ↔ 1416By similarity
    Disulfide bondi1421 ↔ 1433By similarity
    Disulfide bondi1428 ↔ 1446By similarity
    Disulfide bondi1440 ↔ 1455By similarity
    Disulfide bondi1457 ↔ 1469By similarity
    Disulfide bondi1464 ↔ 1482By similarity
    Disulfide bondi1476 ↔ 1491By similarity
    Disulfide bondi1497 ↔ 1509By similarity
    Disulfide bondi1504 ↔ 1522By similarity
    Disulfide bondi1516 ↔ 1533By similarity
    Disulfide bondi1570 ↔ 1582By similarity
    Disulfide bondi1577 ↔ 1595By similarity
    Disulfide bondi1589 ↔ 1604By similarity
    Disulfide bondi1608 ↔ 1621By similarity
    Disulfide bondi1615 ↔ 1634By similarity
    Disulfide bondi1628 ↔ 1645By similarity
    Glycosylationi1655 – 16551N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1661 ↔ 1671By similarity
    Disulfide bondi1666 ↔ 1684By similarity
    Glycosylationi1668 – 16681N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1678 ↔ 1699By similarity
    Disulfide bondi1711 ↔ 1747By similarity
    Disulfide bondi1715 ↔ 1752By similarity
    Glycosylationi1725 – 17251N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1726 ↔ 1737By similarity
    Disulfide bondi1767 ↔ 1964By similarity
    Disulfide bondi1771 ↔ 1969By similarity
    Disulfide bondi1781 ↔ 1791By similarity
    Glycosylationi1814 – 18141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2035 – 20351N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi2070 ↔ 2226By similarity
    Glycosylationi2130 – 21301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2148 – 21481N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi2236 ↔ 2248By similarity
    Disulfide bondi2243 ↔ 2261By similarity
    Disulfide bondi2255 ↔ 2270By similarity
    Disulfide bondi2392 ↔ 2404By similarity
    Disulfide bondi2399 ↔ 2417By similarity
    Disulfide bondi2411 ↔ 2426By similarity
    Disulfide bondi2449 ↔ 2461By similarity
    Disulfide bondi2456 ↔ 2474By similarity
    Disulfide bondi2468 ↔ 2483By similarity
    Disulfide bondi2486 ↔ 2522By similarity
    Disulfide bondi2497 ↔ 2501By similarity
    Disulfide bondi2532 ↔ 2537By similarity
    Disulfide bondi2552 ↔ 2589By similarity
    Disulfide bondi2556 ↔ 2594By similarity
    Disulfide bondi2567 ↔ 2579By similarity
    Glycosylationi2630 – 26301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2679 – 26791N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi2701 ↔ 2739By similarity
    Disulfide bondi2712 ↔ 2716By similarity
    Disulfide bondi2749 ↔ 2753By similarity
    Disulfide bondi2769 ↔ 2807By similarity
    Disulfide bondi2773 ↔ 2812By similarity
    Disulfide bondi2789 ↔ 2797By similarity
    Disulfide bondi2827 ↔ 2862By similarity
    Disulfide bondi2831 ↔ 2867By similarity
    Disulfide bondi2842 ↔ 2852By similarity
    Glycosylationi2921 – 29211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2951 – 29511N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi2970 ↔ 3008By similarity
    Disulfide bondi2981 ↔ 2985By similarity
    Disulfide bondi3018 ↔ 3023By similarity
    Glycosylationi3046 – 30461N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3101 – 31011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3148 – 31481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3158 – 31581N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi3180 ↔ 3229By similarity
    Disulfide bondi3184 ↔ 3234By similarity
    Disulfide bondi3195 ↔ 3219By similarity
    Disulfide bondi3249 ↔ 3286By similarity
    Disulfide bondi3253 ↔ 3291By similarity
    Disulfide bondi3264 ↔ 3276By similarity
    Glycosylationi3295 – 32951N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3384 – 33841N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi3405 ↔ 3448By similarity
    Disulfide bondi3409 ↔ 3454By similarity
    Disulfide bondi3420 ↔ 3432By similarity
    Disulfide bondi3469 ↔ 3504By similarity
    Disulfide bondi3472 ↔ 3511By similarity
    Disulfide bondi3482 ↔ 3494By similarity
    Glycosylationi3506 – 35061N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3584 – 35841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3611 – 36111N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi3642 ↔ 3672By similarity
    Disulfide bondi3646 ↔ 3677By similarity
    Disulfide bondi3657 ↔ 3662By similarity
    Glycosylationi3787 – 37871N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi3818 ↔ 3856By similarity
    Disulfide bondi3822 ↔ 3861By similarity
    Disulfide bondi3834 ↔ 3846By similarity
    Glycosylationi3910 – 39101N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi3943 ↔ 3979By similarity
    Disulfide bondi3954 ↔ 3958By similarity
    Disulfide bondi3992 ↔ 3997By similarity
    Disulfide bondi4012 ↔ 4049By similarity
    Disulfide bondi4016 ↔ 4054By similarity
    Disulfide bondi4027 ↔ 4039By similarity
    Glycosylationi4135 – 41351N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi4156 ↔ 4192By similarity
    Disulfide bondi4167 ↔ 4171By similarity
    Disulfide bondi4202 ↔ 4207By similarity
    Disulfide bondi4261 ↔ 4298By similarity
    Disulfide bondi4265 ↔ 4303By similarity
    Disulfide bondi4276 ↔ 4288By similarity
    Glycosylationi4345 – 43451N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi4365 ↔ 4402By similarity
    Disulfide bondi4376 ↔ 4378By similarity
    Disulfide bondi4412 ↔ 4417By similarity
    Glycosylationi4416 – 44161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4557 – 45571N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi4609 ↔ 4643By similarity
    Disulfide bondi4620 ↔ 4624By similarity
    Disulfide bondi4653 ↔ 4658By similarity
    Glycosylationi4727 – 47271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4744 – 47441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4749 – 47491N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi4771 ↔ 4806By similarity
    Disulfide bondi4775 ↔ 4811By similarity
    Disulfide bondi4786 ↔ 4795By similarity
    Glycosylationi4899 – 48991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4942 – 49421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4949 – 49491N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi5047 ↔ 5095By similarity
    Glycosylationi5055 – 50551N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi5061 ↔ 5112By similarity
    Disulfide bondi5071 ↔ 5128By similarity
    Disulfide bondi5075 ↔ 5130By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ700K0.
    PRIDEiQ700K0.

    Expressioni

    Gene expression databases

    GenevestigatoriQ700K0.

    Interactioni

    Protein-protein interaction databases

    IntActiQ700K0. 1 interaction.
    STRINGi10116.ENSRNOP00000037189.

    Structurei

    3D structure databases

    ProteinModelPortaliQ700K0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini18 – 10285EMIAdd
    BLAST
    Domaini194 – 400207VWFD 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini472 – 52756TIL 1Add
    BLAST
    Domaini566 – 776211VWFD 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini830 – 88354TIL 2Add
    BLAST
    Domaini1018 – 1224207VWFD 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini1280 – 133657TIL 3Add
    BLAST
    Domaini1380 – 141738LDL-receptor class A 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1420 – 145637LDL-receptor class A 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1456 – 149237LDL-receptor class A 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini1496 – 153439LDL-receptor class A 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini1569 – 160537LDL-receptor class A 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini1607 – 164640LDL-receptor class A 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini1660 – 170041LDL-receptor class A 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini1699 – 175355TSP type-1 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1755 – 1970216TSP type-1 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1829 – 186840EGF-like 1Add
    BLAST
    Domaini1869 – 189527EGF-like 2Add
    BLAST
    Domaini1970 – 203061VWFC 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini2070 – 2226157F5/8 type CPROSITE-ProRule annotationAdd
    BLAST
    Domaini2235 – 227137LDL-receptor class A 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini2391 – 242737LDL-receptor class A 9PROSITE-ProRule annotationAdd
    BLAST
    Domaini2448 – 248437LDL-receptor class A 10PROSITE-ProRule annotationAdd
    BLAST
    Domaini2485 – 253854TSP type-1 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini2540 – 259556TSP type-1 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini2617 – 266044TIL 4Add
    BLAST
    Domaini2700 – 275455TSP type-1 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini2758 – 281356TSP type-1 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini2815 – 286854TSP type-1 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini2969 – 302456TSP type-1 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini3025 – 306844TSP type-1 9PROSITE-ProRule annotationAdd
    BLAST
    Domaini3075 – 312753TIL 5Add
    BLAST
    Domaini3168 – 323568TSP type-1 10PROSITE-ProRule annotationAdd
    BLAST
    Domaini3237 – 329256TSP type-1 11PROSITE-ProRule annotationAdd
    BLAST
    Domaini3303 – 335048TIL 6Add
    BLAST
    Domaini3393 – 345563TSP type-1 12PROSITE-ProRule annotationAdd
    BLAST
    Domaini3457 – 351256TSP type-1 13PROSITE-ProRule annotationAdd
    BLAST
    Domaini3630 – 367849TSP type-1 14PROSITE-ProRule annotationAdd
    BLAST
    Domaini3806 – 386257TSP type-1 15PROSITE-ProRule annotationAdd
    BLAST
    Domaini3876 – 392853TSP type-1 16PROSITE-ProRule annotationAdd
    BLAST
    Domaini3942 – 399857TSP type-1 17PROSITE-ProRule annotationAdd
    BLAST
    Domaini4000 – 405556TSP type-1 18PROSITE-ProRule annotationAdd
    BLAST
    Domaini4058 – 411356TIL 7Add
    BLAST
    Domaini4155 – 420854TSP type-1 19PROSITE-ProRule annotationAdd
    BLAST
    Domaini4249 – 430456TSP type-1 20PROSITE-ProRule annotationAdd
    BLAST
    Domaini4306 – 436257TSP type-1 21PROSITE-ProRule annotationAdd
    BLAST
    Domaini4364 – 441855TSP type-1 22PROSITE-ProRule annotationAdd
    BLAST
    Domaini4608 – 465952TSP type-1 23PROSITE-ProRule annotationAdd
    BLAST
    Domaini4759 – 481254TSP type-1 24PROSITE-ProRule annotationAdd
    BLAST
    Domaini4978 – 503659VWFC 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini5047 – 513488CTCKPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi896 – 8994Poly-Thr

    Sequence similaritiesi

    Belongs to the thrombospondin family.Curated
    Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
    Contains 2 EGF-like domains.Curated
    Contains 1 EMI domain.Curated
    Contains 1 F5/8 type C domain.PROSITE-ProRule annotation
    Contains 10 LDL-receptor class A domains.PROSITE-ProRule annotation
    Contains 24 TSP type-1 domains.PROSITE-ProRule annotation
    Contains 2 VWFC domains.PROSITE-ProRule annotation
    Contains 3 VWFD domains.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG12793.
    GeneTreeiENSGT00730000110607.
    HOGENOMiHOG000154433.
    HOVERGENiHBG080794.
    InParanoidiQ700K0.
    OMAiCLDPEAN.
    OrthoDBiEOG73V6J9.
    PhylomeDBiQ700K0.
    TreeFamiTF344272.

    Family and domain databases

    Gene3Di2.60.120.260. 1 hit.
    4.10.400.10. 10 hits.
    InterProiIPR000421. Coagulation_fac_5/8-C_type_dom.
    IPR006207. Cys_knot_C.
    IPR008979. Galactose-bd-like.
    IPR023415. LDLR_class-A_CS.
    IPR002172. LDrepeatLR_classA_rpt.
    IPR000884. Thrombospondin_1_rpt.
    IPR002919. TIL_dom.
    IPR014853. Unchr_dom_Cys-rich.
    IPR006552. VWC_out.
    IPR001007. VWF_C.
    IPR001846. VWF_type-D.
    [Graphical view]
    PfamiPF08742. C8. 3 hits.
    PF00754. F5_F8_type_C. 1 hit.
    PF00057. Ldl_recept_a. 8 hits.
    PF01826. TIL. 14 hits.
    PF00090. TSP_1. 22 hits.
    PF00093. VWC. 1 hit.
    PF00094. VWD. 3 hits.
    [Graphical view]
    PRINTSiPR00261. LDLRECEPTOR.
    SMARTiSM00832. C8. 3 hits.
    SM00192. LDLa. 10 hits.
    SM00209. TSP1. 25 hits.
    SM00214. VWC. 4 hits.
    SM00215. VWC_out. 1 hit.
    SM00216. VWD. 3 hits.
    [Graphical view]
    SUPFAMiSSF49785. SSF49785. 1 hit.
    SSF57424. SSF57424. 10 hits.
    SSF57567. SSF57567. 15 hits.
    SSF82895. SSF82895. 25 hits.
    PROSITEiPS01225. CTCK_2. 1 hit.
    PS01186. EGF_2. 2 hits.
    PS50022. FA58C_3. 1 hit.
    PS01209. LDLRA_1. 8 hits.
    PS50068. LDLRA_2. 10 hits.
    PS50092. TSP1. 24 hits.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 2 hits.
    PS51233. VWFD. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q700K0-1 [UniParc]FASTAAdd to Basket

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    MLLPALLFGM LWAPANGHWC EQIETVHVEE EVTPRREDLV PCTSLYHYSR     50
    LGWKLDLSWG GHVGLTRPPA LGLCAIYKPP ETRPATWNRT VRACCPGWGG 100
    IHCTEALAEA SPKGHCFVTW HCQPLAGSAN SSAGSLEECC AQPWGHSWWN 150
    SSSQMCLSCS GQHRPGNASS EGLLQPLAGA VGQLWSQRQR PSATCATWSG 200
    FHYQTFDGQH YHFLGQCTYL LAGAMDSTWA VHLRPSVHCP QPRQCWLVQV 250
    IMGPEEVLIQ DGEVSVKGQP VPVGESQLLH GMSLQWQGDW LVLSGGLGVV 300
    VRLDRSSSII ISVDHEFWGR TQGLCGLYNG RPEDDFVEPG GGLAMLAATF 350
    GNSWRLPGYE PGCLDTVEVA RGCEGLLEGT LTGLEAGKLQ AQAQDLCHQL 400
    LEDPFSQCHG QVPPDEYHET CLFAYCVGAT AGSGPEEQVK AVCATFANYA 450
    QACARQHIYV HWRKPGFCER LCPGGQLYSD CISSCPPSCS AVAQGEEGSC 500
    GKECVSGCEC PTGLFWDGAL CVPAAHCPCY YRRQRYAPGD TVKQQCNPCV 550
    CQDGRWHCAQ APCPAECAVG GDGHYCTFDG RSFSFRGNPG CQYSLVQDSV 600
    KGQLLVVLEH GACETGSCLH ALSAFLGKTH IQLRYSGAVL VDGQDVDLPW 650
    IGAEGFNVSH ASSTFLLLRW PGAWVLWGVA DPAVYITLDP RHAYQVQGLC 700
    GTFTWKQQDD FLTPAGDIET SVTAFASKFQ VSGDGRCPLV DNTPLSSCST 750
    YSQRLAFAEA ACAALHGHAF QECHGLVERE PFRLRCLESM CSCAPGRDCL 800
    CSVLSAYAHH CAQEGVLLQW RNETLCSVPC PGGQVYQECA PACGHYCGEP 850
    EDCKELGSCV AGCNCPPGLL WDLEGQCVPP SMCPCQLGGH RYAFNTTTTL 900
    KDCSHCICQE RGLWNCIAHH CPRQWALCPQ ELIYAPGACL LTCDSLGANH 950
    SCLAGSTDGC VCPSGTVLLD KHCVSPDLCP CRHNGQWYPP NATIQEDCNI 1000
    CVCQNQRWHC TGQRCSGWCQ ASGAPHYVTF DGLVFTFPGA CEYLLVREAG 1050
    GRFSVSIQNL PCGASGLTCT KALAVRLDST VVHMLRGQAV TVNGVSIKLP 1100
    KVYTGPGLSL HHAGLFLLLT TRLGLTLLWD GGTRVLVQLS PHFHGRVTGL 1150
    CGNFDGDVSN DLRSRQGVLE PTAELTAHSW RLNPLCPEPG DLPHPCSVNA 1200
    HRVNWARAHC EVILQPIFAP CHTEVPPQQY YEWCVYDACG CDTGGDCECL 1250
    CSAIATYADE CARHRHHVRW RSQELCPLQC EGGQVYEPCG STCPPTCHDH 1300
    HPELRWHCQA ITCVEGCFCP EGTLLHGGTC VELTDCPCEW QGSFFPPGAV 1350
    LQKDCGNCTC QESQWHCNPS GAPCEEMEPG CAEGEALCRE SGHCVPLEWL 1400
    CDNQDDCGDG SDEEGCDTSV CGEGQMSCQS GRCLPLSLIC DGQDDCGDGT 1450
    DEQGCLCPQG FLACADGRCL PPALLCDGHP DCLDAADEES CLGWVSCTSG 1500
    EVSCVDGPCI RTIQLCDGVW DCPDGADEGP VHCSSPSLPT PPAGIGQNPS 1550
    TSSPDTSPSP VGSASPASPC SLSEFQCNSG ECTPRGWRCD REEDCTDGSD 1600
    ELDCGGPCKL YQMPCAHGPH CLSPGQLCDG VAQCPDGSDE DPDVCEERSA 1650
    SGGPNGTAVP CPEFSCPNGT CIDFLLVCDG SPDCELADET EPSLDEQGCG 1700
    TWGSWGPWEP CSQTCGPGIQ SRNRNCSISS LHVLQNCPGL QHQSQSCFTE 1750
    ACPVDGEWSS WSLWSPCSEP CGGTMTRHRQ CRPPQNGGQD CALLPGSTHS 1800
    THQTSPCPQE GCLNVTCFGE LVFRPCAPCP LTCDDISGEA VCSPDRPCSS 1850
    PGCWCPEGKV LGTEGRCVRP RQCPCLVDGI RYWPGQRIKM DCQLCFCQDG 1900
    QPHRCRPNPE CAVDCGWSSW SPWAECLGPC SSQSLQWSFR SPNNPRLSGH 1950
    GRQCRGIHRK ARRCQTEPCE GCEQWGLTYH VGERWRGGPC TVCECLHRSI 2000
    TRCSPYCPIG SCPQSWVLVE GMGESCCHCA LPGKNQTMIP VTTPAPVPTP 2050
    SPQIGASLVT YVLPPMSDAC YSPLGLAGLP TWAPSQPLEH STRAAPVEAP 2100
    TAGPGPREDA YAEWHTQPLY LQLDLLWPRN LTGIMVQRAG SSAAYISNLS 2150
    LQFSSDGLQW HSVLNSLSST LPPPKPSPES SNHMVPEVWT FDQMVQARYI 2200
    RVWPHGSHLR DNNQQDIFLW VELLGCKPVP PLAPLCPGTR HRCANGDCAL 2250
    KGGPCDGAVD CEDGSDEEGC GPLRASTASR VHSTARTPAL SPTQPGKFPF 2300
    HPREGLADME HQQPKQESPM PSAGVSPSAS EGLLPVSGQS MQTLTTTSTF 2350
    PPGLKSLHPG MAAVTVHSPH SVMPGTPVGQ SVSPRPFPLM RCGPGQVPCD 2400
    VLGCVEQEQL CDGREDCLDG SDEQHCASPE PFTVPTTALP GLPASRALCS 2450
    PSQLSCGSGE CLPLEHRCDL QVNCQDGSDE DDCVDCVLAP WSGWSDCSRS 2500
    CGLGLIFQHR ELLRPPLPGG SCLLDQLRSQ PCFVQACPVA GAWAKWGPWE 2550
    PCSVSCGGGH QSRQRSCVDP PPKNGGAPCP GPSHEKVLCN LQLCPGDTDC 2600
    EPGRVHVNAE LCQKGLLPPC PPSCLDPEAN RSCSGHCVEG CRCPPGLFLQ 2650
    DSHCLPLSEC PCLVGQKLMQ PGLAFLLDNC SQCICESGIL LCKPAACSQS 2700
    CGWSAWSPWT ACDHSCGSGV RARFRSPTNP PAAFGGSPCE GDRQELQACY 2750
    TDCGTDIPGW TPWTSWSSCS QSCLVPGGDP GRRQRSRLCP SSRDTFCPGE 2800
    ATQEEPCSPS LCPVPSAWGL WASWSACSAS CNGGIQTRGR SCSGSAPGNP 2850
    VCLGPHTQTR DCNVHPCTAQ CPGNMVFRSA EKCLEEGGPC PQLCLAQDPG 2900
    VECTGSCAPG CSCPPGLFLH NASCLPRSQC PCQLHGQLYA PGAVARLDCN 2950
    NCTCSSGEMV CTSERCPVAC GWSPWTPWSP CSQSCNVGIR RRFRAGTAPP 3000
    AAFGGAECRG PNLDAEFCTL RPCQGPGAAW SSWTPCSVPC GGGYRNRTQG 3050
    SGRHSPVEFS TCSLQPCAGP VPGVCPKDQQ WLDCAQGPAS CAHLSTPREA 3100
    NQTCHPGCYC LSGMLLLNNV CVPAQDCPCA HRGRLHSPGS AVILPCENCS 3150
    CVSGLITNCS SWPCEEGQPA WSSWTPWSVC SASCSPARRH RRRFCVRPST 3200
    TAPFSLDLPT TVAAPTMLCP GPEAEEEPCL LPGCNQAGVW GPWSPWSGCS 3250
    RSCGGGLRSR TRACDKPPPQ GLGDFCEGPQ AQGEACQAQP CPVANCSTIE 3300
    GAEYSPCGPP CPRSCDDLVH CMWHCQPGCY CPPGKVLSAD GAICVQPHHC 3350
    SCLDLLTGKR HHPGSQLMRP DGCNHCTCME GRLNCTDLPC QVSGDWCPWS 3400
    EWTACSQPCR GQTRTRSRAC VCPAPQHGGA PCPEEAGETG VQHQMEACPN 3450
    PTACPVDGAW SPWGSWSPCD ACLGQSYRSR MCSHPPPSDG GTPCLGGHQQ 3500
    SRPCRNSSTP CTDCGGGQDL LPCGQPCPHS CQDLSLGSTC QPGSSGCQSG 3550
    CGCPPGQLSQ DGLCVFPADC HCHFQPKAMG IPENQSRSVG SALSSWESLE 3600
    PGEVVTGPCD NCTCVAGVLQ CHEVPSCPGP GIWSSWGPWE KCSVPCGGGE 3650
    QLRSRQCARP PCPGLAQQSR TCHIHVCRET GCPAGRLYRE CQPSEGCPFS 3700
    CAHVTGQVAC FSESCEEGCH CPEGTFQHHS ACVQECPCVL TVSLLQELGV 3750
    ASTALRSYPV LLGDEGQPLG PGDELDPGQM LQTVCGNCSC VHGKLSCSME 3800
    ECSRVRGYFG PWGMWSLCSH SCGGLGTRTR TRQCVLPTLA PAGLSCRGPL 3850
    QDLEYCFSPE CPGTAGSTVE PVTGLAGGWG PWSPWSPCSH SCTDLTHPAW 3900
    RSRTRLCLAN CTVGDSSQER PCNLPSCTTL PLCPGPGCGS ENCFWTSWAP 3950
    WEPCSRSCGV GQQRRLRAYH PPGPGGHWCP DILTAYQERR FCNLRACPVP 4000
    GGWSHWSPWS WCDRSCGGGR SLRSRSCSSP PPKNGGASCV GERHHVRSCN 4050
    PMPCEKDCPA GMEMVSCANR CPYSCSDLQE AVMCQEDQAC QLGCRCSEGF 4100
    LEQDGGCVPV GHCECTDAQG RSWAPGSQHQ DACNNCSCQA GQLSCTAQPC 4150
    PPPAHCAWSH WSAWSACSHS CGPHGQQSRF RSSTSGSWAL ECQKEQSQSQ 4200
    PCPEDPCPPL CLHEAHLHVL GDNWLHGECQ QCSCTPEGVI CKDTDCAVPG 4250
    GWTLWSSWSY CSVSCGGGSQ VRTRSCMVSA PQHGSPSCQG PDTQTQHCGQ 4300
    QLCLQLLEIC SWGPWGPCSR SCGTGLASRS GSCPCLLTKE DSECNDTFSG 4350
    LDTQACYPGP CQEDCMWSDW SSWTRCSCKI LVQQRYRHQV PAPGQAGEGT 4400
    LCTGLDGHFR PCAIGNCSED SCLPPFEFQS CGSPCAGLCA THLSHQLCQD 4450
    LPPCQPGCYC PMGLLEQDGG CILPEQCNCW HTSGEGARVT LAPGHRLQLG 4500
    CKECVCQSGE LQCSSQGCEG LLPLTGWSEW SPCGPCLPQS ALAPDSRTAL 4550
    EVHWPLNTSV TLLASEQYRH RLCLDPETGR PWAGDPALCT VPLSQQRLCS 4600
    DPGACHDTCQ WGPWGPWSPC QVPCSGGFKL RWREASDNSV GECRGPWAQT 4650
    ESCNMGSCPG ESCETRDTVF TLDCANQCPR SCADLWEGVQ CLQGPCSPGC 4700
    RCPPGQLVQD GHCVPISSCR CGLPSANASW ELAPTQVVQL DCHNCTCING 4750
    TLMCPYPECP VLGPWSPWSE CSAVCGGGTM VRYRSCEEHP DSAPCQALDM 4800
    EQRVECNLQT CPECPPGQVL STCATLCPSF CSHLWPGTIC VREPCQLGCG 4850
    CPGGQLLHSG TCIPPEACPC TRLSLPWGLT LPLEEQAQEL PSGTVLTWNC 4900
    THCTCQGGVF TCSHTDCQEC PPGEILQLGE LRPCEKTCLE MNKTQAWSNC 4950
    TEAQVPGCVC QLGHFRSHTG LCVPEDHCEC WHHGSPHLPG SEWQEACESC 5000
    RCLHGKSVCT QHCPELSCAQ GEVVVQEPGS CCPICQQDTL EEEPVSCRHL 5050
    TELRNLTKGP CHLDQVEVSY CSGHCRSSTN VMTEEPYLQS QCDCCSYRLD 5100
    PDSPVRILNL LCPDGRTEPV LLPVIHNCHC SACQGGEFSK H 5141
    Length:5,141
    Mass (Da):550,649
    Last modified:July 5, 2004 - v1
    Checksum:i1772AE67F02CA5E3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ629845 mRNA. Translation: CAF33425.1.
    RefSeqiNP_001007017.1. NM_001007016.1.
    UniGeneiRn.124116.

    Genome annotation databases

    EnsembliENSRNOT00000035906; ENSRNOP00000037189; ENSRNOG00000025848.
    GeneIDi474348.
    KEGGirno:474348.
    UCSCiRGD:1549716. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ629845 mRNA. Translation: CAF33425.1 .
    RefSeqi NP_001007017.1. NM_001007016.1.
    UniGenei Rn.124116.

    3D structure databases

    ProteinModelPortali Q700K0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q700K0. 1 interaction.
    STRINGi 10116.ENSRNOP00000037189.

    Proteomic databases

    PaxDbi Q700K0.
    PRIDEi Q700K0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000035906 ; ENSRNOP00000037189 ; ENSRNOG00000025848 .
    GeneIDi 474348.
    KEGGi rno:474348.
    UCSCi RGD:1549716. rat.

    Organism-specific databases

    CTDi 23145.
    RGDi 1549716. Sspo.

    Phylogenomic databases

    eggNOGi NOG12793.
    GeneTreei ENSGT00730000110607.
    HOGENOMi HOG000154433.
    HOVERGENi HBG080794.
    InParanoidi Q700K0.
    OMAi CLDPEAN.
    OrthoDBi EOG73V6J9.
    PhylomeDBi Q700K0.
    TreeFami TF344272.

    Miscellaneous databases

    NextBioi 697202.
    PROi Q700K0.

    Gene expression databases

    Genevestigatori Q700K0.

    Family and domain databases

    Gene3Di 2.60.120.260. 1 hit.
    4.10.400.10. 10 hits.
    InterProi IPR000421. Coagulation_fac_5/8-C_type_dom.
    IPR006207. Cys_knot_C.
    IPR008979. Galactose-bd-like.
    IPR023415. LDLR_class-A_CS.
    IPR002172. LDrepeatLR_classA_rpt.
    IPR000884. Thrombospondin_1_rpt.
    IPR002919. TIL_dom.
    IPR014853. Unchr_dom_Cys-rich.
    IPR006552. VWC_out.
    IPR001007. VWF_C.
    IPR001846. VWF_type-D.
    [Graphical view ]
    Pfami PF08742. C8. 3 hits.
    PF00754. F5_F8_type_C. 1 hit.
    PF00057. Ldl_recept_a. 8 hits.
    PF01826. TIL. 14 hits.
    PF00090. TSP_1. 22 hits.
    PF00093. VWC. 1 hit.
    PF00094. VWD. 3 hits.
    [Graphical view ]
    PRINTSi PR00261. LDLRECEPTOR.
    SMARTi SM00832. C8. 3 hits.
    SM00192. LDLa. 10 hits.
    SM00209. TSP1. 25 hits.
    SM00214. VWC. 4 hits.
    SM00215. VWC_out. 1 hit.
    SM00216. VWD. 3 hits.
    [Graphical view ]
    SUPFAMi SSF49785. SSF49785. 1 hit.
    SSF57424. SSF57424. 10 hits.
    SSF57567. SSF57567. 15 hits.
    SSF82895. SSF82895. 25 hits.
    PROSITEi PS01225. CTCK_2. 1 hit.
    PS01186. EGF_2. 2 hits.
    PS50022. FA58C_3. 1 hit.
    PS01209. LDLRA_1. 8 hits.
    PS50068. LDLRA_2. 10 hits.
    PS50092. TSP1. 24 hits.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 2 hits.
    PS51233. VWFD. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Conservation of mammalian SCO-spondin."
      Meiniel O.
      Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiSSPO_RAT
    AccessioniPrimary (citable) accession number: Q700K0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3