Q6ZZC6 (MDH_MYXXA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Malate dehydrogenase
EC=1.1.1.37

Gene names

Name:

mdh

Organism

Myxococcus xanthus

Taxonomic identifier

34 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Myxococcus

Protein attributes

Sequence length	314 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the reversible oxidation of malate to oxaloacetate By similarity. HAMAP-Rule MF_00487
Catalytic activity	(S)-malate + NAD+ = oxaloacetate + NADH. HAMAP-Rule MF_00487
Sequence similarities	Belongs to the LDH/MDH superfamily. MDH type 3 family.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	cellular carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro malate metabolic process Inferred from electronic annotation. Source: InterPro tricarboxylic acid cycle Inferred from electronic annotation. Source: HAMAP
Molecular_function	L-malate dehydrogenase activity Inferred from electronic annotation. Source: HAMAP nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 314	314	Malate dehydrogenase HAMAP-Rule MF_00487		PRO_0000113458
Regions
	Nucleotide binding	13 – 18	6	NAD By similarity
	Nucleotide binding	124 – 126	3	NAD By similarity
Sites
	Active site	181	1	Proton acceptor By similarity
	Binding site	37	1	NAD By similarity
	Binding site	88	1	Substrate By similarity
	Binding site	94	1	Substrate By similarity
	Binding site	101	1	NAD By similarity
	Binding site	126	1	Substrate By similarity
	Binding site	157	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6ZZC6 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 3CBABF2D0D6D6CDD	FASTA	314	33,043
	10 20 30 40 50 60 MAQNGKKKIG LIGGGQIGGN LALLAVQKSL GDVVLYDIPA AEGLVKGKAL DINQLAAVDG 70 80 90 100 110 120 YDCRVKGTTD WKDVAGSDVI IITAGMPRKP GMSREDLLEI NLKIMTDVAG NIKQHAPNAF 130 140 150 160 170 180 VINVANPLDA MVFALHKIAG LPKHMVAGMA GVLDTSRFKC FVAEALGCSI RDVEALVLGG 190 200 210 220 230 240 HGDDMVPLVR HSTVGGVPLT ELIAKDKLDA IIKRTREGGA ELVGLYKTGS AYFGPAASAI 250 260 270 280 290 300 AMAESFLQDR KRVLPAAALL EGQYGINGYF FGVPVQIGAG GVEKIHTVEL NDGEKAELEK 310 SFQSVKKTVD SVKL

References

[1]

"Three two-component regulatory systems of the family PhoR/PhoP control the expression of phosphatases and genes involved in energy metabolism and protein synthesis during Myxococcus xanthus development." Munoz-Dorado J., Carrero-Lerida J., Moraleda-Munoz A., Perez J., Hofmann D. Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ633546 Genomic DNA. Translation: CAG17588.1.
3D structure databases
ProteinModelPortal	Q6ZZC6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.40.50.720. 1 hit. 3.90.110.10. 1 hit.
HAMAP	MF_00487. Malate_dehydrog_3.
InterPro	IPR001557. L-lactate/malate_DH. IPR022383. Lactate/malate_DH_C. IPR001236. Lactate/malate_DH_N. IPR015955. Lactate_DH/Glyco_Ohase_4_C. IPR011275. Malate_DH_type3. IPR016040. NAD(P)-bd_dom. [Graphical view]
PANTHER	PTHR11540. PTHR11540. 1 hit.
Pfam	PF02866. Ldh_1_C. 1 hit. PF00056. Ldh_1_N. 1 hit. [Graphical view]
PIRSF	PIRSF000102. Lac_mal_DH. 1 hit.
PRINTS	PR00086. LLDHDRGNASE.
SUPFAM	SSF56327. Lactate_DH/Glyco_hydro_4_C. 1 hit.
TIGRFAMs	TIGR01763. MalateDH_bact. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MDH_MYXXA

Accession

Primary (citable) accession number: Q6ZZC6

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	July 5, 2004
Last modified:	April 3, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program