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Q6ZZC6

- MDH_MYXXA

UniProt

Q6ZZC6 - MDH_MYXXA

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Protein

Malate dehydrogenase

Gene
mdh
Organism
Myxococcus xanthus
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei37 – 371NAD By similarity
Binding sitei88 – 881Substrate By similarity
Binding sitei94 – 941Substrate By similarity
Binding sitei101 – 1011NAD By similarity
Binding sitei126 – 1261Substrate By similarity
Binding sitei157 – 1571Substrate By similarity
Active sitei181 – 1811Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 186NAD By similarity
Nucleotide bindingi124 – 1263NAD By similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
OrganismiMyxococcus xanthus
Taxonomic identifieri34 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeMyxococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Malate dehydrogenaseUniRule annotationPRO_0000113458Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6ZZC6.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6ZZC6-1 [UniParc]FASTAAdd to Basket

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MAQNGKKKIG LIGGGQIGGN LALLAVQKSL GDVVLYDIPA AEGLVKGKAL    50
DINQLAAVDG YDCRVKGTTD WKDVAGSDVI IITAGMPRKP GMSREDLLEI 100
NLKIMTDVAG NIKQHAPNAF VINVANPLDA MVFALHKIAG LPKHMVAGMA 150
GVLDTSRFKC FVAEALGCSI RDVEALVLGG HGDDMVPLVR HSTVGGVPLT 200
ELIAKDKLDA IIKRTREGGA ELVGLYKTGS AYFGPAASAI AMAESFLQDR 250
KRVLPAAALL EGQYGINGYF FGVPVQIGAG GVEKIHTVEL NDGEKAELEK 300
SFQSVKKTVD SVKL 314
Length:314
Mass (Da):33,043
Last modified:July 5, 2004 - v1
Checksum:i3CBABF2D0D6D6CDD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ633546 Genomic DNA. Translation: CAG17588.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ633546 Genomic DNA. Translation: CAG17588.1 .

3D structure databases

ProteinModelPortali Q6ZZC6.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00487. Malate_dehydrog_3.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Three two-component regulatory systems of the family PhoR/PhoP control the expression of phosphatases and genes involved in energy metabolism and protein synthesis during Myxococcus xanthus development."
    Munoz-Dorado J., Carrero-Lerida J., Moraleda-Munoz A., Perez J., Hofmann D.
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiMDH_MYXXA
AccessioniPrimary (citable) accession number: Q6ZZC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: July 5, 2004
Last modified: February 19, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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