Reviewed, UniProtKB/Swiss-Prot Q6ZYA7 (GPD2_PICJA)

Names and origin

Protein names

Recommended name:
    Glycerol-3-phosphate dehydrogenase [NAD+] 2
    EC=1.1.1.8

Gene names

Name:

gpd2

Organism

Pichia jadinii (Yeast) (Candida utilis)

Taxonomic identifier

4903 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Pichia

Protein attributes

Sequence length	394 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH.
Sequence similarities	Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro glycerol-3-phosphate catabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	glycerol-3-phosphate dehydrogenase complex Inferred from electronic annotation. Source: InterPro
Molecular function	NAD binding Inferred from electronic annotation. Source: InterPro glycerol-3-phosphate dehydrogenase (NAD+) activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 394	394	Glycerol-3-phosphate dehydrogenase [NAD+] 2		PRO_0000138094
Regions
	Nucleotide binding	41 – 46	6	NAD By similarity
	Region	308 – 309	2	Substrate binding By similarity
Sites
	Active site	243	1	Proton acceptor By similarity
	Binding site	152	1	NAD; via amide nitrogen By similarity
	Binding site	152	1	Substrate By similarity
	Binding site	185	1	NAD; via amide nitrogen By similarity
	Binding site	308	1	NAD By similarity
	Binding site	337	1	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6ZYA7-1 [UniParc]. Last modified March 29, 2005. Version 2. Checksum: 5970F34B5D528C15	FASTA	394	43,530
	10 20 30 40 50 60 MTDIGESESD ISTDVSALPM LSHSVSYTSI QKPPFVVSVI GSGNWGTTVA KIIAENTREN 70 80 90 100 110 120 PLLFEQKVRM WVYEEEFEGS NLSDIINTEH VNKKYLPGIK LPDNLVAVPD LLEAVQYSNI 130 140 150 160 170 180 LIFNIPHQHL EKILSQLRGN IDPRARAISC LKGLRVNLDG VELLPDIIQD ALGIHCGVLA 190 200 210 220 230 240 GANLAQEVAE QRFSETTVGY PLPADYKPGD VDHTVLYTLF HRPYFHVHVI EDIAGISCAG 250 260 270 280 290 300 ALKNIIAISV GFVEGLEWGD NAKAAMLRRG LLEMIKFGRK FFPGCLVSSF TEESAGVADL 310 320 330 340 350 360 FTTCTGGRNF KLAKIMAQTG KSAHEVEKEI LNGQSAQGLI TAKEIHELIK NKGCEEEFPL 370 380 390 FETTYQILFH GVRIGILPYM LENKWSISKP NYSS

References

[1]

"Identification of the genes GPD1 and GPD2 of Pichia jadinii." Ostermann K., Richter M., Zscharnack M., Rothe R., Walther T., Roedel G. DNA Seq. 17:452-457(2006) [PubMed: 17381046] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 9950 / CBS 5609 / DSM 2361 / IFO 0998 / NRRL Y-900.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ635370 Genomic DNA. Translation: CAG25779.2. AJ632340 Genomic DNA. Translation: CAG15348.2.
3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR013328. DHase_multihelical. IPR016040. NAD(P)-bd. IPR017751. NAD-dep_Gly3P_DH_euk. IPR006168. NAD-dep_Gly3P_DHase. IPR011128. NAD-dep_Gly3P_DHase_N. IPR006109. NAD_Gly3P_DHase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
PANTHER	PTHR11728. NAD_Gly3P_DH. 1 hit.
Pfam	PF07479. NAD_Gly3P_dh_C. 1 hit. PF01210. NAD_Gly3P_dh_N. 1 hit. [Graphical view]
PIRSF	PIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTS	PR00077. GPDHDRGNASE.
ProDom	PD001278. NAD_Gly3P_C. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00957. NAD_G3PDH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPD2_PICJA

Accession

Primary (citable) accession number: Q6ZYA7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	March 29, 2005
Last modified:	November 25, 2008
This is version 25 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)