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Q6ZXC9 (SIA8D_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase

EC=2.4.99.-
Alternative name(s):
Alpha-2,8-sialyltransferase 8D
Polysialyltransferase-1
Sialyltransferase 8D
Short name=SIAT8-D
Sialytransferase St8Sia IV
Short name=ST8SiaIV
Gene names
Name:ST8SIA4
Synonyms:SIAT8D
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid (PSA), which is present on the embryonic neural cell adhesion molecule (N-CAM), necessary for plasticity of neural cells By similarity.

Pathway

Protein modification; protein glycosylation.

Subcellular location

Golgi apparatus membrane; Single-pass type II membrane protein Potential.

Sequence similarities

Belongs to the glycosyltransferase 29 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 359359CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase
PRO_0000247931

Regions

Topological domain1 – 77Cytoplasmic Potential
Transmembrane8 – 2013Helical; Signal-anchor for type II membrane protein; Potential
Topological domain21 – 359339Lumenal Potential

Amino acid modifications

Glycosylation501N-linked (GlcNAc...) Potential
Glycosylation741N-linked (GlcNAc...) Potential
Glycosylation1191N-linked (GlcNAc...) Potential
Glycosylation2041N-linked (GlcNAc...) Potential
Glycosylation2191N-linked (GlcNAc...) Potential
Disulfide bond142 ↔ 292 By similarity
Disulfide bond156 ↔ 356 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6ZXC9 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: C7C0B4FFCDA967C4

FASTA35941,162
        10         20         30         40         50         60 
MRSIRKRWTI CTISLLLIFY KTKEMARTEE HQETQLIGDG ELSLSRSLVN SSDKIIRKAG 

        70         80         90        100        110        120 
SSIFQHSVEG GKINSSLVLE IRKNILRFLD AERDVSVVKS SFKPGDVIHY VLDRRRTLNI 

       130        140        150        160        170        180 
SQDLHSLLPE VSPMKNRRFK TCAVVGNSGI LLDSECGKEI DSHNFVIRCN LAPVVEFAAD 

       190        200        210        220        230        240 
VGTKSDFITM NPSVVQRAFG GFRNESDREK FVHRLSMLND SVLWIPAFMV KGGEKHVEWV 

       250        260        270        280        290        300 
NALILKNKLK VRTAYPSLRL IHAVRGYWLT NKVPIKRPST GLLMYTLATR FCDEIHLYGF 

       310        320        330        340        350 
WPFPKDLNGK AVKYHYYDDL KYRYFSNASP HRMPLEFKTL NVLHNRGALK LTTGKCIKQ 

« Hide

References

[1]"The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach."
Harduin-Lepers A., Mollicone R., Delannoy P., Oriol R.
Glycobiology 15:805-817(2005) [PubMed: 15843597] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ699421 mRNA. Translation: CAG27883.1.
IPIIPI00701492.
RefSeqNP_001001163.1. NM_001001163.1.
UniGeneBt.17789.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ6ZXC9.

Protein family/group databases

CAZyGT29. Glycosyltransferase Family 29.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID407768.
KEGGbta:407768.

Organism-specific databases

CTD7903.

Phylogenomic databases

eggNOGmaNOG14281.
GeneTreeENSGT00550000074407.
HOVERGENHBG056466.
InParanoidQ6ZXC9.
OrthoDBEOG4DFPNN.

Family and domain databases

InterProIPR001675. Glyco_trans_29.
IPR012163. Sialyl_trans.
[Graphical view]
KOK06614.
PfamPF00777. Glyco_transf_29. 1 hit.
[Graphical view]
PIRSFPIRSF005557. Sialyl_trans. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSIA8D_BOVIN
AccessionPrimary (citable) accession number: Q6ZXC9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 5, 2004
Last modified: November 16, 2011
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families