Reviewed,
UniProtKB/Swiss-Prot Q6ZXC9 (SIA8D_BOVIN)
Last modified
December 15, 2009.
Version 30.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase EC=2.4.99.- Alternative name(s): Alpha-2,8-sialyltransferase 8D ST8Sia IV Polysialyltransferase-1 | ||||
| Gene names |
| ||||
| Organism | Bos taurus (Bovine) | ||||
| Taxonomic identifier | 9913 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Protein attributes
| Sequence length | 359 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid (PSA), which is present on the embryonic neural cell adhesion molecule (N-CAM), necessary for plasticity of neural cells By similarity. |
| Pathway | |
| Subcellular location | Golgi apparatus membrane; Single-pass type II membrane protein Potential. |
| Sequence similarities | Belongs to the glycosyltransferase 29 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Golgi apparatus Membrane |
| Domain | Signal-anchor Transmembrane |
| Molecular function | Glycosyltransferase Transferase |
| PTM | Disulfide bond Glycoprotein |
| Gene Ontology (GO) | |
| Biological process | protein amino acid glycosylation Inferred from electronic annotation. Source: InterPro |
| Cellular component | integral to Golgi membrane Inferred from electronic annotation. Source: InterPro |
| Molecular function | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity Inferred from sequence or structural similarity. Source: AgBase |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 359 | 359 | CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase | PRO_0000247931 | |||||||
Regions | |||||||||||
| Topological domain | 1 – 7 | 7 | Cytoplasmic Potential | ||||||||
| Transmembrane | 8 – 20 | 13 | Signal-anchor for type II membrane protein Potential | ||||||||
| Topological domain | 21 – 359 | 339 | Lumenal Potential | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 50 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 74 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 119 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 204 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 219 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 142 ↔ 292 | By similarity | |||||||||
| Disulfide bond | 156 ↔ 356 | By similarity | |||||||||
Sequences
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References
| [1] | "The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach." Harduin-Lepers A., Mollicone R., Delannoy P., Oriol R. Glycobiology 15:805-817(2005) [PubMed: 15843597] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
Cross-references
Sequence databases | |
|---|---|
| AJ699421 mRNA. Translation: CAG27883.1. | |
| IPI | IPI00701492. |
| RefSeq | NP_001001163.1. |
| UniGene | Bt.17789 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q6ZXC9. |
Protein family/group databases | |
| CAZy | GT29. Glycosyltransferase Family 29. |
Genome annotation databases | |
| Ensembl | ENSBTAT00000028590; ENSBTAP00000028590; ENSBTAG00000021445; Bos taurus. [Genome view] |
| GeneID | 407768. |
| KEGG | bta:407768. |
Organism-specific databases | |
| CTD | 407768. |
Phylogenomic databases | |
| HOVERGEN | Q6ZXC9. |
| InParanoid | Q6ZXC9. |
Family and domain databases | |
| InterPro | IPR001675. Glyco_trans_29. IPR012163. Sialyl_trans. [Graphical view] |
| Pfam | PF00777. Glyco_transf_29. 1 hit. [Graphical view] |
| PIRSF | PIRSF005557. Sialyl_trans. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | SIA8D_BOVIN | ||||||||
| Accession | Primary (citable) accession number: Q6ZXC9 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


