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Protein

40S ribosomal protein S12

Gene

Rps12-ps3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal proteinUniRule annotationImported

Enzyme and pathway databases

ReactomeiR-MMU-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-MMU-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-MMU-72649. Translation initiation complex formation.
R-MMU-72689. Formation of a pool of free 40S subunits.
R-MMU-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-MMU-72702. Ribosomal scanning and start codon recognition.
R-MMU-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-MMU-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-MMU-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S12UniRule annotation
Gene namesi
Name:Rps12-ps3Imported
Synonyms:Rps12Imported
ORF Names:mCG_132913Imported, mCG_6749Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componentsi: Chromosome 10, Chromosome 19

Organism-specific databases

MGIiMGI:98105. Rps12.
MGI:3704503. Rps12-ps3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

TopDownProteomicsiQ6ZWZ6.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000100481.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 11094Ribosomal_L7AeInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ribosomal protein S12e family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3406. Eukaryota.
COG1358. LUCA.
GeneTreeiENSGT00390000018318.
HOVERGENiHBG001720.
KOiK02951.
OMAiNCDEPTY.
OrthoDBiEOG7H1JP3.
TreeFamiTF300196.

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
InterProiIPR029064. L30e-like.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
IPR000530. Ribosomal_S12e.
[Graphical view]
PANTHERiPTHR11843. PTHR11843. 1 hit.
PfamiPF01248. Ribosomal_L7Ae. 1 hit.
[Graphical view]
PRINTSiPR00972. RIBSOMALS12E.
SUPFAMiSSF55315. SSF55315. 1 hit.
PROSITEiPS01189. RIBOSOMAL_S12E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZWZ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEEGIAAGG VMDVNTALQE VLKTALIHDG LARGIREAAK ALDKRQAHLC
60 70 80 90 100
VLASNCDEPM YVKLVEALCA EHQINLIKVD DNKKLGEWVG LCKIDREGKP
110 120 130
RKVVGCSCVV VKDYGKESQA KDVIEEYFKC KK
Length:132
Mass (Da):14,515
Last modified:July 5, 2004 - v1
Checksum:i45AD1274D55FFA25
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC139040 Genomic DNA. No translation available.
AC160147 Genomic DNA. No translation available.
BC002079 mRNA. Translation: AAH02079.1.
BC089338 mRNA. Translation: AAH89338.1.
BC089339 mRNA. Translation: AAH89339.1.
BC090257 mRNA. Translation: AAH90257.1.
BC092044 mRNA. Translation: AAH92044.1.
BC096653 mRNA. Translation: AAH96653.1.
BC099377 mRNA. Translation: AAH99377.1.
AK002848 mRNA. Translation: BAB22404.1.
AK008057 mRNA. Translation: BAB25433.1.
AK032757 mRNA. Translation: BAC28009.1.
AK166923 mRNA. Translation: BAE39118.1.
AK166992 mRNA. Translation: BAE39171.1.
AK168324 mRNA. Translation: BAE40263.1.
AK169215 mRNA. Translation: BAE40986.1.
CH466540 Genomic DNA. Translation: EDL04768.1.
CH466525 Genomic DNA. Translation: EDL11714.1.
RefSeqiNP_035425.2. NM_011295.6.
UniGeneiMm.371846.
Mm.386780.
Mm.440324.
Mm.442130.
Mm.490389.

Genome annotation databases

EnsembliENSMUST00000073926; ENSMUSP00000073581; ENSMUSG00000061983.
ENSMUST00000086764; ENSMUSP00000083973; ENSMUSG00000067038.
GeneIDi20042.
KEGGimmu:20042.
UCSCiuc007epx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC139040 Genomic DNA. No translation available.
AC160147 Genomic DNA. No translation available.
BC002079 mRNA. Translation: AAH02079.1.
BC089338 mRNA. Translation: AAH89338.1.
BC089339 mRNA. Translation: AAH89339.1.
BC090257 mRNA. Translation: AAH90257.1.
BC092044 mRNA. Translation: AAH92044.1.
BC096653 mRNA. Translation: AAH96653.1.
BC099377 mRNA. Translation: AAH99377.1.
AK002848 mRNA. Translation: BAB22404.1.
AK008057 mRNA. Translation: BAB25433.1.
AK032757 mRNA. Translation: BAC28009.1.
AK166923 mRNA. Translation: BAE39118.1.
AK166992 mRNA. Translation: BAE39171.1.
AK168324 mRNA. Translation: BAE40263.1.
AK169215 mRNA. Translation: BAE40986.1.
CH466540 Genomic DNA. Translation: EDL04768.1.
CH466525 Genomic DNA. Translation: EDL11714.1.
RefSeqiNP_035425.2. NM_011295.6.
UniGeneiMm.371846.
Mm.386780.
Mm.440324.
Mm.442130.
Mm.490389.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000100481.

Proteomic databases

TopDownProteomicsiQ6ZWZ6.

Protocols and materials databases

DNASUi20042.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000073926; ENSMUSP00000073581; ENSMUSG00000061983.
ENSMUST00000086764; ENSMUSP00000083973; ENSMUSG00000067038.
GeneIDi20042.
KEGGimmu:20042.
UCSCiuc007epx.2. mouse.

Organism-specific databases

CTDi6206.
MGIiMGI:98105. Rps12.
MGI:3704503. Rps12-ps3.

Phylogenomic databases

eggNOGiKOG3406. Eukaryota.
COG1358. LUCA.
GeneTreeiENSGT00390000018318.
HOVERGENiHBG001720.
KOiK02951.
OMAiNCDEPTY.
OrthoDBiEOG7H1JP3.
TreeFamiTF300196.

Enzyme and pathway databases

ReactomeiR-MMU-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-MMU-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-MMU-72649. Translation initiation complex formation.
R-MMU-72689. Formation of a pool of free 40S subunits.
R-MMU-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-MMU-72702. Ribosomal scanning and start codon recognition.
R-MMU-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-MMU-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-MMU-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

NextBioi297555.
SOURCEiSearch...

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
InterProiIPR029064. L30e-like.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
IPR000530. Ribosomal_S12e.
[Graphical view]
PANTHERiPTHR11843. PTHR11843. 1 hit.
PfamiPF01248. Ribosomal_L7Ae. 1 hit.
[Graphical view]
PRINTSiPR00972. RIBSOMALS12E.
SUPFAMiSSF55315. SSF55315. 1 hit.
PROSITEiPS01189. RIBOSOMAL_S12E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and DBA/2Imported.
    Tissue: KidneyImported, LiverImported, Small intestineImported and Wolffian duct includes surrounding regionImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and DBA/2Imported.
    Tissue: KidneyImported, LiverImported, Small intestineImported and Wolffian duct includes surrounding regionImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and DBA/2Imported.
    Tissue: KidneyImported, LiverImported, Small intestineImported and Wolffian duct includes surrounding regionImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: KidneyImported and Small intestineImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and DBA/2Imported.
    Tissue: KidneyImported, LiverImported, Small intestineImported and Wolffian duct includes surrounding regionImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Wolffian duct includes surrounding regionImported.
  7. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and DBA/2Imported.
    Tissue: KidneyImported, LiverImported, Small intestineImported and Wolffian duct includes surrounding regionImported.
  8. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6Imported, FVB/NImported, FVB/N-3Imported and Mix FVB/NImported.
    Tissue: BrainImported, ColonImported, Mammary glandImported, Mammary tumor. MMTV-LTR/INT3 model. 5 month old mouse. Taken by biopsy.Imported, Mammary tumor. WAP-TGF alpha model. 7 months oldImported and OocytesImported.
  10. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and DBA/2Imported.
    Tissue: LiverImported.
  11. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and DBA/2Imported.
    Tissue: KidneyImported, LiverImported, Small intestineImported and Wolffian duct includes surrounding regionImported.
  12. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported and DBA/2Imported.
    Tissue: KidneyImported, LiverImported, Small intestineImported and Wolffian duct includes surrounding regionImported.
  13. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  14. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.
  17. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiQ6ZWZ6_MOUSE
AccessioniPrimary (citable) accession number: Q6ZWZ6
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.