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Q6ZWZ2

- UB2R2_MOUSE

UniProt

Q6ZWZ2 - UB2R2_MOUSE

Protein

Ubiquitin-conjugating enzyme E2 R2

Gene

Ube2r2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes monoubiquitination and 'Lys-48'-linked polyubiquitination. May be involved in degradation of katenin By similarity.By similarity

    Catalytic activityi

    ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei93 – 931Glycyl thioester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. acid-amino acid ligase activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW
    3. ubiquitin-protein transferase activity Source: UniProtKB

    GO - Biological processi

    1. protein K48-linked ubiquitination Source: UniProtKB
    2. protein monoubiquitination Source: UniProtKB

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin-conjugating enzyme E2 R2 (EC:6.3.2.19)
    Alternative name(s):
    Ubiquitin carrier protein R2
    Ubiquitin-conjugating enzyme E2-CDC34B
    Ubiquitin-protein ligase R2
    Gene namesi
    Name:Ube2r2
    Synonyms:Cdc34b, Ubc3b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1914865. Ube2r2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 238238Ubiquitin-conjugating enzyme E2 R2PRO_0000280514Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei233 – 2331Phosphoserine; by CK2By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ6ZWZ2.
    PaxDbiQ6ZWZ2.
    PRIDEiQ6ZWZ2.

    PTM databases

    PhosphoSiteiQ6ZWZ2.

    Expressioni

    Gene expression databases

    BgeeiQ6ZWZ2.
    CleanExiMM_UBE2R2.
    GenevestigatoriQ6ZWZ2.

    Interactioni

    Subunit structurei

    When phosphorylated, interacts with beta-TrCP (BTRC).By similarity

    Protein-protein interaction databases

    BioGridi212312. 1 interaction.
    IntActiQ6ZWZ2. 1 interaction.
    MINTiMINT-4609410.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ZWZ2.
    SMRiQ6ZWZ2. Positions 8-184.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi200 – 23839Asp/Glu-rich (acidic)Add
    BLAST

    Sequence similaritiesi

    Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5078.
    GeneTreeiENSGT00730000110436.
    HOGENOMiHOG000233454.
    HOVERGENiHBG063308.
    InParanoidiQ6ZWZ2.
    KOiK02207.
    OMAiNSEETAM.
    OrthoDBiEOG7VB2HT.
    PhylomeDBiQ6ZWZ2.
    TreeFamiTF101107.

    Family and domain databases

    Gene3Di3.10.110.10. 1 hit.
    InterProiIPR000608. UBQ-conjugat_E2.
    IPR023313. UBQ-conjugating_AS.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view]
    PfamiPF00179. UQ_con. 1 hit.
    [Graphical view]
    SUPFAMiSSF54495. SSF54495. 1 hit.
    PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6ZWZ2-1 [UniParc]FASTAAdd to Basket

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    MAQQQMTSSQ KALMLELKSL QEEPVEGFRI TLVDESDLYN WEVAIFGPPN    50
    TLYEGGYFKA HIKFPIDYPY SPPTFRFLTK MWHPNIYENG DVCISILHPP 100
    VDDPQSGELP SERWNPTQNV RTILLSVISL LNEPNTFSPA NVDASVMFRK 150
    WRDSKGKDKE YAEIIRKQVS ATKAEAEKDG VKVPTTLAEY CIKTKVPSND 200
    NSSDLLYDDL YDDDIDDEDE EEEDADCYDD DDSGNEES 238
    Length:238
    Mass (Da):27,166
    Last modified:July 5, 2004 - v1
    Checksum:iE896CF0116A56308
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti16 – 161E → D in BAC35899. (PubMed:16141072)Curated
    Sequence conflicti29 – 291R → L in BAC35899. (PubMed:16141072)Curated
    Sequence conflicti33 – 331V → L in BAC35899. (PubMed:16141072)Curated
    Sequence conflicti35 – 351E → Y in BAC35899. (PubMed:16141072)Curated
    Sequence conflicti37 – 371D → Y in BAC35899. (PubMed:16141072)Curated
    Sequence conflicti149 – 1491R → T in CAC80335. (PubMed:12037680)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ240086 mRNA. Translation: CAC80335.1.
    AK003550 mRNA. Translation: BAB22850.1.
    AK007517 mRNA. Translation: BAB25085.1.
    AK075703 mRNA. Translation: BAC35899.1.
    AK075714 mRNA. Translation: BAC35904.1.
    AL807823, AL954379 Genomic DNA. Translation: CAM20979.1.
    AL807823, AL954379 Genomic DNA. Translation: CAM27658.1.
    BC011112 mRNA. Translation: AAH11112.1.
    CCDSiCCDS18057.1.
    RefSeqiNP_080551.1. NM_026275.4.
    UniGeneiMm.389540.

    Genome annotation databases

    EnsembliENSMUST00000040008; ENSMUSP00000038813; ENSMUSG00000036241.
    GeneIDi67615.
    KEGGimmu:67615.
    UCSCiuc008sij.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ240086 mRNA. Translation: CAC80335.1 .
    AK003550 mRNA. Translation: BAB22850.1 .
    AK007517 mRNA. Translation: BAB25085.1 .
    AK075703 mRNA. Translation: BAC35899.1 .
    AK075714 mRNA. Translation: BAC35904.1 .
    AL807823 , AL954379 Genomic DNA. Translation: CAM20979.1 .
    AL807823 , AL954379 Genomic DNA. Translation: CAM27658.1 .
    BC011112 mRNA. Translation: AAH11112.1 .
    CCDSi CCDS18057.1.
    RefSeqi NP_080551.1. NM_026275.4.
    UniGenei Mm.389540.

    3D structure databases

    ProteinModelPortali Q6ZWZ2.
    SMRi Q6ZWZ2. Positions 8-184.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 212312. 1 interaction.
    IntActi Q6ZWZ2. 1 interaction.
    MINTi MINT-4609410.

    PTM databases

    PhosphoSitei Q6ZWZ2.

    Proteomic databases

    MaxQBi Q6ZWZ2.
    PaxDbi Q6ZWZ2.
    PRIDEi Q6ZWZ2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000040008 ; ENSMUSP00000038813 ; ENSMUSG00000036241 .
    GeneIDi 67615.
    KEGGi mmu:67615.
    UCSCi uc008sij.1. mouse.

    Organism-specific databases

    CTDi 54926.
    MGIi MGI:1914865. Ube2r2.

    Phylogenomic databases

    eggNOGi COG5078.
    GeneTreei ENSGT00730000110436.
    HOGENOMi HOG000233454.
    HOVERGENi HBG063308.
    InParanoidi Q6ZWZ2.
    KOi K02207.
    OMAi NSEETAM.
    OrthoDBi EOG7VB2HT.
    PhylomeDBi Q6ZWZ2.
    TreeFami TF101107.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Miscellaneous databases

    ChiTaRSi UBE2R2. mouse.
    NextBioi 325049.
    PROi Q6ZWZ2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6ZWZ2.
    CleanExi MM_UBE2R2.
    Genevestigatori Q6ZWZ2.

    Family and domain databases

    Gene3Di 3.10.110.10. 1 hit.
    InterProi IPR000608. UBQ-conjugat_E2.
    IPR023313. UBQ-conjugating_AS.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view ]
    Pfami PF00179. UQ_con. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54495. SSF54495. 1 hit.
    PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation."
      Semplici F., Meggio F., Pinna L.A., Oliviero S.
      Oncogene 21:3978-3987(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Liver, Lung and Pancreas.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiUB2R2_MOUSE
    AccessioniPrimary (citable) accession number: Q6ZWZ2
    Secondary accession number(s): Q8BW18, Q8VDE5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3