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Protein

Ubiquitin-conjugating enzyme E2 R2

Gene

Ube2r2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes monoubiquitination and 'Lys-48'-linked polyubiquitination. May be involved in degradation of katenin.By similarity

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei93Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-8866652. Synthesis of active ubiquitin: roles of E1 and E2 enzymes.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 R2 (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme R2
Ubiquitin carrier protein R2
Ubiquitin-conjugating enzyme E2-CDC34B
Ubiquitin-protein ligase R2
Gene namesi
Name:Ube2r2
Synonyms:Cdc34b, Ubc3b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1914865. Ube2r2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002805141 – 238Ubiquitin-conjugating enzyme E2 R2Add BLAST238

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei233Phosphoserine; by CK2By similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6ZWZ2.
MaxQBiQ6ZWZ2.
PaxDbiQ6ZWZ2.
PeptideAtlasiQ6ZWZ2.
PRIDEiQ6ZWZ2.

PTM databases

iPTMnetiQ6ZWZ2.
PhosphoSitePlusiQ6ZWZ2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000036241.
CleanExiMM_UBE2R2.
GenevisibleiQ6ZWZ2. MM.

Interactioni

Subunit structurei

When phosphorylated, interacts with beta-TrCP (BTRC).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi212312. 2 interactors.
IntActiQ6ZWZ2. 4 interactors.
MINTiMINT-4609410.
STRINGi10090.ENSMUSP00000038813.

Structurei

3D structure databases

ProteinModelPortaliQ6ZWZ2.
SMRiQ6ZWZ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi200 – 238Asp/Glu-rich (acidic)Add BLAST39

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0425. Eukaryota.
COG5078. LUCA.
GeneTreeiENSGT00730000110436.
HOGENOMiHOG000233454.
HOVERGENiHBG063308.
InParanoidiQ6ZWZ2.
KOiK02207.
OMAiNQDDSGN.
OrthoDBiEOG091G0O9F.
PhylomeDBiQ6ZWZ2.
TreeFamiTF101107.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZWZ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQQQMTSSQ KALMLELKSL QEEPVEGFRI TLVDESDLYN WEVAIFGPPN
60 70 80 90 100
TLYEGGYFKA HIKFPIDYPY SPPTFRFLTK MWHPNIYENG DVCISILHPP
110 120 130 140 150
VDDPQSGELP SERWNPTQNV RTILLSVISL LNEPNTFSPA NVDASVMFRK
160 170 180 190 200
WRDSKGKDKE YAEIIRKQVS ATKAEAEKDG VKVPTTLAEY CIKTKVPSND
210 220 230
NSSDLLYDDL YDDDIDDEDE EEEDADCYDD DDSGNEES
Length:238
Mass (Da):27,166
Last modified:July 5, 2004 - v1
Checksum:iE896CF0116A56308
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16E → D in BAC35899 (PubMed:16141072).Curated1
Sequence conflicti29R → L in BAC35899 (PubMed:16141072).Curated1
Sequence conflicti33V → L in BAC35899 (PubMed:16141072).Curated1
Sequence conflicti35E → Y in BAC35899 (PubMed:16141072).Curated1
Sequence conflicti37D → Y in BAC35899 (PubMed:16141072).Curated1
Sequence conflicti149R → T in CAC80335 (PubMed:12037680).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ240086 mRNA. Translation: CAC80335.1.
AK003550 mRNA. Translation: BAB22850.1.
AK007517 mRNA. Translation: BAB25085.1.
AK075703 mRNA. Translation: BAC35899.1.
AK075714 mRNA. Translation: BAC35904.1.
AL807823, AL954379 Genomic DNA. Translation: CAM20979.1.
AL807823, AL954379 Genomic DNA. Translation: CAM27658.1.
BC011112 mRNA. Translation: AAH11112.1.
CCDSiCCDS18057.1.
RefSeqiNP_080551.1. NM_026275.4.
UniGeneiMm.389540.

Genome annotation databases

EnsembliENSMUST00000040008; ENSMUSP00000038813; ENSMUSG00000036241.
GeneIDi67615.
KEGGimmu:67615.
UCSCiuc008sij.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ240086 mRNA. Translation: CAC80335.1.
AK003550 mRNA. Translation: BAB22850.1.
AK007517 mRNA. Translation: BAB25085.1.
AK075703 mRNA. Translation: BAC35899.1.
AK075714 mRNA. Translation: BAC35904.1.
AL807823, AL954379 Genomic DNA. Translation: CAM20979.1.
AL807823, AL954379 Genomic DNA. Translation: CAM27658.1.
BC011112 mRNA. Translation: AAH11112.1.
CCDSiCCDS18057.1.
RefSeqiNP_080551.1. NM_026275.4.
UniGeneiMm.389540.

3D structure databases

ProteinModelPortaliQ6ZWZ2.
SMRiQ6ZWZ2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212312. 2 interactors.
IntActiQ6ZWZ2. 4 interactors.
MINTiMINT-4609410.
STRINGi10090.ENSMUSP00000038813.

PTM databases

iPTMnetiQ6ZWZ2.
PhosphoSitePlusiQ6ZWZ2.

Proteomic databases

EPDiQ6ZWZ2.
MaxQBiQ6ZWZ2.
PaxDbiQ6ZWZ2.
PeptideAtlasiQ6ZWZ2.
PRIDEiQ6ZWZ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040008; ENSMUSP00000038813; ENSMUSG00000036241.
GeneIDi67615.
KEGGimmu:67615.
UCSCiuc008sij.1. mouse.

Organism-specific databases

CTDi54926.
MGIiMGI:1914865. Ube2r2.

Phylogenomic databases

eggNOGiKOG0425. Eukaryota.
COG5078. LUCA.
GeneTreeiENSGT00730000110436.
HOGENOMiHOG000233454.
HOVERGENiHBG063308.
InParanoidiQ6ZWZ2.
KOiK02207.
OMAiNQDDSGN.
OrthoDBiEOG091G0O9F.
PhylomeDBiQ6ZWZ2.
TreeFamiTF101107.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-MMU-8866652. Synthesis of active ubiquitin: roles of E1 and E2 enzymes.

Miscellaneous databases

ChiTaRSiUbe2r2. mouse.
PROiQ6ZWZ2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036241.
CleanExiMM_UBE2R2.
GenevisibleiQ6ZWZ2. MM.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUB2R2_MOUSE
AccessioniPrimary (citable) accession number: Q6ZWZ2
Secondary accession number(s): Q8BW18, Q8VDE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.