Reviewed,
UniProtKB/Swiss-Prot Q6ZWZ2 (UB2R2_MOUSE)
Last modified
November 25, 2008.
Version 47.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Ubiquitin-conjugating enzyme E2 R2 EC=6.3.2.19 Alternative name(s): Ubiquitin-protein ligase R2 Ubiquitin carrier protein R2 E2-CDC34B | ||||
| Gene names |
| ||||
| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 238 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Catalyzes the covalent attachment of ubiquitin to other proteins. May be involved in degradation of katenin By similarity. |
| Catalytic activity | ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. |
| Pathway | |
| Subunit structure | When phosphorylated, interacts with beta-TrCP (BTRC) By similarity. |
| Sequence similarities | Belongs to the ubiquitin-conjugating enzyme family. |
Ontologies
Keywords | |
|---|---|
| Biological process | Ubl conjugation pathway |
| Molecular function | Ligase |
| PTM | Phosphoprotein |
Gene Ontology (GO) | |
| Biological process | post-translational protein modification Inferred from electronic annotation. Source: InterPro regulation of protein metabolic processInferred from electronic annotation. Source: InterPro ubiquitin-dependent protein catabolic processInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | ubiquitin-protein ligase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 238 | 238 | Ubiquitin-conjugating enzyme E2 R2 | PRO_0000280514 | |||||
Regions | |||||||||
| Compositional bias | 200 – 238 | 39 | Asp/Glu-rich (acidic) | ||||||
Sites | |||||||||
| Active site | 93 | 1 | Glycyl thioester intermediate By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 233 | 1 | Phosphoserine; by CK2 By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 16 | 1 | E → D in BAC35899. Ref.2 | ||||||
| Sequence conflict | 29 | 1 | R → L in BAC35899. Ref.2 | ||||||
| Sequence conflict | 33 | 1 | V → L in BAC35899. Ref.2 | ||||||
| Sequence conflict | 35 | 1 | E → Y in BAC35899. Ref.2 | ||||||
| Sequence conflict | 37 | 1 | D → Y in BAC35899. Ref.2 | ||||||
| Sequence conflict | 149 | 1 | R → T in CAC80335. Ref.1 | ||||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation." Semplici F., Meggio F., Pinna L.A., Oliviero S. Oncogene 21:3978-3987(2002) [PubMed: 12037680] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Liver, Lung and Pancreas. |
| [3] | The mouse genome sequencing consortium Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Czech II. Tissue: Mammary tumor. |
Cross-references
Sequence databases | |
|---|---|
| AJ240086 mRNA. Translation: CAC80335.1. AK003550 mRNA. Translation: BAB22850.1. AK007517 mRNA. Translation: BAB25085.1. AK075703 mRNA. Translation: BAC35899.1. AK075714 mRNA. Translation: BAC35904.1. AL807823, AL954379 Genomic DNA. Translation: CAM20979.1. AL807823, AL954379 Genomic DNA. Translation: CAM27658.1. BC011112 mRNA. Translation: AAH11112.1. | |
| RefSeq | NP_080551.1. |
| UniGene | Mm.389540 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1A3S based on UniProtKB P50550. |
| SMR | Q6ZWZ2. Positions 9-181. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q6ZWZ2. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000036241. Mus musculus. [Contig view] |
| GeneID | 67615. |
| KEGG | mmu:67615. |
Organism-specific databases | |
| MGI | MGI:1914865. Ube2r2. |
Phylogenomic databases | |
| HOVERGEN | Q6ZWZ2. |
Gene expression databases | |
| ArrayExpress | Q6ZWZ2. |
| CleanEx | MM_UBE2R2. |
Family and domain databases | |
| InterPro | IPR016135. UBQ-conjugat/RWD-like. IPR000608. UBQ-conjugat_E2. [Graphical view] |
| Gene3D | G3DSA:3.10.110.10. UBQ-conjugat_E2. 1 hit. |
| PANTHER | PTHR11621. UBQ-conjugat_E2. 1 hit. |
| Pfam | PF00179. UQ_con. 1 hit. [Graphical view] |
| ProDom | PD000461. UBQ_conjugat. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00212. UBCc. 1 hit. [Graphical view] |
| PROSITE | PS00183. UBIQUITIN_CONJUGAT_1. 1 hit. PS50127. UBIQUITIN_CONJUGAT_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 325049. |
| SOURCE | Search... |
Entry information
| Entry name | UB2R2_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q6ZWZ2 Secondary accession number(s): Q8BW18, Q8VDE5 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| UniProtKB secondary accession numbers Index of UniProtKB secondary accession numbers |
| SIMILARITY comments Index of protein domains and families |

Clusters with


