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Protein

Histone H2B type 1-C/E/G

Gene

Hist1h2bc

more
Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-1221632. Meiotic synapsis.
R-MMU-1221633. Meiotic Synapsis.
R-MMU-3214847. HATs acetylate histones.
R-MMU-427389. ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression.
R-MMU-427413. NoRC negatively regulates rRNA expression.
R-MMU-5334118. DNA methylation.
R-MMU-5617472. Activation of anterior HOX genes in hindbrain development during early embryogenesis.
R-MMU-573389. NoRC negatively regulates rRNA expression.
R-MMU-912497. Meiotic Recombination.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2B type 1-C/E/G
Gene namesi
AND
AND
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1915274. Hist1h2bc.
MGI:2448380. Hist1h2be.
MGI:2448386. Hist1h2bg.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002448312 – 126Histone H2B type 1-C/E/GAdd BLAST125

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylprolineBy similarity1
Modified residuei6N6-acetyllysine; alternateBy similarity1
Modified residuei6N6-crotonyllysine; alternate1 Publication1
Cross-linki6Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei12N6-acetyllysine; alternateBy similarity1
Modified residuei12N6-crotonyllysine; alternate1 Publication1
Modified residuei13N6-acetyllysine; alternateBy similarity1
Modified residuei13N6-crotonyllysine; alternate1 Publication1
Modified residuei15Phosphoserine; by STK4/MST12 Publications1
Modified residuei16N6-acetyllysine; alternateBy similarity1
Modified residuei16N6-crotonyllysine; alternate1 Publication1
Modified residuei17N6-acetyllysine; alternateBy similarity1
Modified residuei17N6-crotonyllysine; alternate1 Publication1
Modified residuei21N6-acetyllysine; alternateBy similarity1
Modified residuei21N6-crotonyllysine; alternate1 Publication1
Modified residuei24N6-acetyllysine; alternateBy similarity1
Modified residuei24N6-crotonyllysine; alternate1 Publication1
Modified residuei35N6-crotonyllysine; alternate1 Publication1
Cross-linki35Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity
Modified residuei37Phosphoserine; by AMPK1 Publication1
Modified residuei47N6-methyllysineBy similarity1
Modified residuei58N6,N6-dimethyllysineBy similarity1
Modified residuei80Dimethylated arginineBy similarity1
Modified residuei86N6,N6,N6-trimethyllysine; alternateBy similarity1
Modified residuei86N6-acetyllysine; alternateBy similarity1
Modified residuei87Omega-N-methylarginineBy similarity1
Modified residuei93Omega-N-methylarginineBy similarity1
Modified residuei109N6-methyllysineBy similarity1
Glycosylationi113O-linked (GlcNAc)By similarity1
Modified residuei116PhosphothreonineBy similarity1
Modified residuei117N6-methylated lysineBy similarity1
Cross-linki121Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Post-translational modificationi

Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons (By similarity).By similarity
Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination. Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription.3 Publications
GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).By similarity
Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.1 Publication

Keywords - PTMi

Acetylation, Glycoprotein, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ6ZWY9.
MaxQBiQ6ZWY9.
PaxDbiQ6ZWY9.
PeptideAtlasiQ6ZWY9.
PRIDEiQ6ZWY9.
TopDownProteomicsiQ6ZWY9.

PTM databases

iPTMnetiQ6ZWY9.
PhosphoSitePlusiQ6ZWY9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000018102.
CleanExiMM_HIST1H2BC.
MM_HIST1H2BE.
GenevisibleiQ6ZWY9. MM.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

Protein-protein interaction databases

BioGridi212605. 2 interactors.
STRINGi10090.ENSMUSP00000078239.

Structurei

3D structure databases

ProteinModelPortaliQ6ZWY9.
SMRiQ6ZWY9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H2B family.Curated

Phylogenomic databases

eggNOGiKOG1744. Eukaryota.
ENOG4111NV5. LUCA.
GeneTreeiENSGT00760000118976.
HOGENOMiHOG000231213.
HOVERGENiHBG007774.
InParanoidiQ6ZWY9.
KOiK11252.
OMAiIGPILWK.
OrthoDBiEOG091G0XGD.
PhylomeDBiQ6ZWY9.
TreeFamiTF300212.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR007125. Histone_H2A/H2B/H3.
IPR000558. Histone_H2B.
[Graphical view]
PfamiPF00125. Histone. 1 hit.
[Graphical view]
PRINTSiPR00621. HISTONEH2B.
SMARTiSM00427. H2B. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00357. HISTONE_H2B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6ZWY9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEPAKSAPA PKKGSKKAVT KAQKKDGKKR KRSRKESYSV YVYKVLKQVH
60 70 80 90 100
PDTGISSKAM GIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREIQTAVR
110 120
LLLPGELAKH AVSEGTKAVT KYTSSK
Length:126
Mass (Da):13,906
Last modified:January 23, 2007 - v3
Checksum:iFAE1479F44BE703D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY158934 Genomic DNA. Translation: AAO06244.1.
AY158936 Genomic DNA. Translation: AAO06246.1.
AY158937 Genomic DNA. Translation: AAO06247.1.
AK005407 mRNA. Translation: BAB24007.1.
AK011516 mRNA. Translation: BAB27670.1.
AK030546 mRNA. Translation: BAC27014.1.
AK049948 mRNA. Translation: BAC34000.1.
AL592149 Genomic DNA. Translation: CAI24894.1.
BC019673 mRNA. Translation: AAH19673.1.
BC060304 mRNA. Translation: AAH60304.1.
BC069889 mRNA. Translation: AAH69889.1.
CCDSiCCDS26349.1.
CCDS26354.1.
CCDS26357.1.
RefSeqiNP_001171124.1. NM_001177653.1.
NP_001277309.1. NM_001290380.1.
NP_001277459.1. NM_001290530.1.
NP_075911.2. NM_023422.3.
NP_835501.1. NM_178194.4.
NP_835503.1. NM_178196.4.
UniGeneiMm.261673.
Mm.261676.
Mm.440391.

Genome annotation databases

EnsembliENSMUST00000018246; ENSMUSP00000018246; ENSMUSG00000018102.
ENSMUST00000051091; ENSMUSP00000061247; ENSMUSG00000047246.
ENSMUST00000079251; ENSMUSP00000078239; ENSMUSG00000058385.
ENSMUST00000091704; ENSMUSP00000089296; ENSMUSG00000047246.
GeneIDi319179.
319181.
68024.
KEGGimmu:319179.
mmu:319181.
mmu:68024.
UCSCiuc007pue.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY158934 Genomic DNA. Translation: AAO06244.1.
AY158936 Genomic DNA. Translation: AAO06246.1.
AY158937 Genomic DNA. Translation: AAO06247.1.
AK005407 mRNA. Translation: BAB24007.1.
AK011516 mRNA. Translation: BAB27670.1.
AK030546 mRNA. Translation: BAC27014.1.
AK049948 mRNA. Translation: BAC34000.1.
AL592149 Genomic DNA. Translation: CAI24894.1.
BC019673 mRNA. Translation: AAH19673.1.
BC060304 mRNA. Translation: AAH60304.1.
BC069889 mRNA. Translation: AAH69889.1.
CCDSiCCDS26349.1.
CCDS26354.1.
CCDS26357.1.
RefSeqiNP_001171124.1. NM_001177653.1.
NP_001277309.1. NM_001290380.1.
NP_001277459.1. NM_001290530.1.
NP_075911.2. NM_023422.3.
NP_835501.1. NM_178194.4.
NP_835503.1. NM_178196.4.
UniGeneiMm.261673.
Mm.261676.
Mm.440391.

3D structure databases

ProteinModelPortaliQ6ZWY9.
SMRiQ6ZWY9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212605. 2 interactors.
STRINGi10090.ENSMUSP00000078239.

PTM databases

iPTMnetiQ6ZWY9.
PhosphoSitePlusiQ6ZWY9.

Proteomic databases

EPDiQ6ZWY9.
MaxQBiQ6ZWY9.
PaxDbiQ6ZWY9.
PeptideAtlasiQ6ZWY9.
PRIDEiQ6ZWY9.
TopDownProteomicsiQ6ZWY9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000018246; ENSMUSP00000018246; ENSMUSG00000018102.
ENSMUST00000051091; ENSMUSP00000061247; ENSMUSG00000047246.
ENSMUST00000079251; ENSMUSP00000078239; ENSMUSG00000058385.
ENSMUST00000091704; ENSMUSP00000089296; ENSMUSG00000047246.
GeneIDi319179.
319181.
68024.
KEGGimmu:319179.
mmu:319181.
mmu:68024.
UCSCiuc007pue.3. mouse.

Organism-specific databases

CTDi8339.
8344.
8347.
MGIiMGI:1915274. Hist1h2bc.
MGI:2448380. Hist1h2be.
MGI:2448386. Hist1h2bg.

Phylogenomic databases

eggNOGiKOG1744. Eukaryota.
ENOG4111NV5. LUCA.
GeneTreeiENSGT00760000118976.
HOGENOMiHOG000231213.
HOVERGENiHBG007774.
InParanoidiQ6ZWY9.
KOiK11252.
OMAiIGPILWK.
OrthoDBiEOG091G0XGD.
PhylomeDBiQ6ZWY9.
TreeFamiTF300212.

Enzyme and pathway databases

ReactomeiR-MMU-1221632. Meiotic synapsis.
R-MMU-1221633. Meiotic Synapsis.
R-MMU-3214847. HATs acetylate histones.
R-MMU-427389. ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression.
R-MMU-427413. NoRC negatively regulates rRNA expression.
R-MMU-5334118. DNA methylation.
R-MMU-5617472. Activation of anterior HOX genes in hindbrain development during early embryogenesis.
R-MMU-573389. NoRC negatively regulates rRNA expression.
R-MMU-912497. Meiotic Recombination.

Miscellaneous databases

PROiQ6ZWY9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018102.
CleanExiMM_HIST1H2BC.
MM_HIST1H2BE.
GenevisibleiQ6ZWY9. MM.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR007125. Histone_H2A/H2B/H3.
IPR000558. Histone_H2B.
[Graphical view]
PfamiPF00125. Histone. 1 hit.
[Graphical view]
PRINTSiPR00621. HISTONEH2B.
SMARTiSM00427. H2B. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00357. HISTONE_H2B. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiH2B1C_MOUSE
AccessioniPrimary (citable) accession number: Q6ZWY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 129 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.