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Protein

Thymosin beta-10

Gene

Tmsb10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).By similarity

GO - Molecular functioni

  • actin monomer binding Source: MGI

GO - Biological processi

  • actin cytoskeleton organization Source: MGI
  • actin filament organization Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymosin beta-10
Gene namesi
Name:Tmsb10
Synonyms:Ptmb10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componentsi: Chromosome 6, Chromosome 7

Organism-specific databases

MGIiMGI:109146. Tmsb10.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • cytoskeleton Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 4443Thymosin beta-10PRO_0000045932Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei4 – 41N6-acetyllysineBy similarity
Modified residuei12 – 121PhosphoserineBy similarity
Modified residuei15 – 151N6-acetyllysineBy similarity
Modified residuei21 – 211PhosphothreonineCombined sources
Modified residuei23 – 231PhosphothreonineBy similarity
Modified residuei34 – 341PhosphothreonineBy similarity
Modified residuei39 – 391N6-acetyllysineBy similarity
Modified residuei41 – 411PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ6ZWY8.
PaxDbiQ6ZWY8.
PRIDEiQ6ZWY8.

PTM databases

iPTMnetiQ6ZWY8.
PhosphoSiteiQ6ZWY8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000050347.
CleanExiMM_TMSB10.
ExpressionAtlasiQ6ZWY8. baseline and differential.
GenevisibleiQ6ZWY8. MM.

Interactioni

GO - Molecular functioni

  • actin monomer binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000136301.

Structurei

3D structure databases

ProteinModelPortaliQ6ZWY8.
SMRiQ6ZWY8. Positions 6-41.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymosin beta family.Curated

Phylogenomic databases

eggNOGiKOG4794. Eukaryota.
ENOG410Y3I4. LUCA.
GeneTreeiENSGT00390000007040.
HOVERGENiHBG012534.
InParanoidiQ6ZWY8.
KOiK13785.
OrthoDBiEOG091G1AVI.
PhylomeDBiQ6ZWY8.

Family and domain databases

Gene3Di1.20.5.520. 1 hit.
InterProiIPR001152. Beta-thymosin.
[Graphical view]
PANTHERiPTHR12021. PTHR12021. 1 hit.
PfamiPF01290. Thymosin. 1 hit.
[Graphical view]
PIRSFiPIRSF001828. Thymosin_beta. 1 hit.
ProDomiPD005116. Thymosin_b4. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00152. THY. 1 hit.
[Graphical view]
PROSITEiPS00500. THYMOSIN_B4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6ZWY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
MADKPDMGEI ASFDKAKLKK TETQEKNTLP TKETIEQEKR SEIS
Length:44
Mass (Da):5,026
Last modified:January 23, 2007 - v3
Checksum:i5485277C275A1C70
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003178 mRNA. Translation: BAB22622.1.
AK005512 mRNA. Translation: BAB24091.1.
AK008557 mRNA. Translation: BAB25742.1.
AK012361 mRNA. Translation: BAB28189.1.
AK019212 mRNA. Translation: BAB31603.1.
AK019232 mRNA. Translation: BAB31614.1.
AK131711 mRNA. Translation: BAE20774.1.
AK161987 mRNA. Translation: BAE36668.1.
CCDSiCCDS39519.1.
RefSeqiNP_001034481.1. NM_001039392.2.
NP_001177256.1. NM_001190327.1.
NP_079560.1. NM_025284.4.
UniGeneiMm.3532.
Mm.391824.
Mm.436717.

Genome annotation databases

EnsembliENSMUST00000114048; ENSMUSP00000109682; ENSMUSG00000079523.
ENSMUST00000114049; ENSMUSP00000109683; ENSMUSG00000079523.
ENSMUST00000114050; ENSMUSP00000109684; ENSMUSG00000079523.
ENSMUST00000170837; ENSMUSP00000137210; ENSMUSG00000091955.
GeneIDi19240.
KEGGimmu:19240.
UCSCiuc009cjf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003178 mRNA. Translation: BAB22622.1.
AK005512 mRNA. Translation: BAB24091.1.
AK008557 mRNA. Translation: BAB25742.1.
AK012361 mRNA. Translation: BAB28189.1.
AK019212 mRNA. Translation: BAB31603.1.
AK019232 mRNA. Translation: BAB31614.1.
AK131711 mRNA. Translation: BAE20774.1.
AK161987 mRNA. Translation: BAE36668.1.
CCDSiCCDS39519.1.
RefSeqiNP_001034481.1. NM_001039392.2.
NP_001177256.1. NM_001190327.1.
NP_079560.1. NM_025284.4.
UniGeneiMm.3532.
Mm.391824.
Mm.436717.

3D structure databases

ProteinModelPortaliQ6ZWY8.
SMRiQ6ZWY8. Positions 6-41.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000136301.

PTM databases

iPTMnetiQ6ZWY8.
PhosphoSiteiQ6ZWY8.

Proteomic databases

MaxQBiQ6ZWY8.
PaxDbiQ6ZWY8.
PRIDEiQ6ZWY8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114048; ENSMUSP00000109682; ENSMUSG00000079523.
ENSMUST00000114049; ENSMUSP00000109683; ENSMUSG00000079523.
ENSMUST00000114050; ENSMUSP00000109684; ENSMUSG00000079523.
ENSMUST00000170837; ENSMUSP00000137210; ENSMUSG00000091955.
GeneIDi19240.
KEGGimmu:19240.
UCSCiuc009cjf.2. mouse.

Organism-specific databases

CTDi9168.
MGIiMGI:109146. Tmsb10.

Phylogenomic databases

eggNOGiKOG4794. Eukaryota.
ENOG410Y3I4. LUCA.
GeneTreeiENSGT00390000007040.
HOVERGENiHBG012534.
InParanoidiQ6ZWY8.
KOiK13785.
OrthoDBiEOG091G1AVI.
PhylomeDBiQ6ZWY8.

Miscellaneous databases

ChiTaRSiTmsb10. mouse.
PROiQ6ZWY8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000050347.
CleanExiMM_TMSB10.
ExpressionAtlasiQ6ZWY8. baseline and differential.
GenevisibleiQ6ZWY8. MM.

Family and domain databases

Gene3Di1.20.5.520. 1 hit.
InterProiIPR001152. Beta-thymosin.
[Graphical view]
PANTHERiPTHR12021. PTHR12021. 1 hit.
PfamiPF01290. Thymosin. 1 hit.
[Graphical view]
PIRSFiPIRSF001828. Thymosin_beta. 1 hit.
ProDomiPD005116. Thymosin_b4. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00152. THY. 1 hit.
[Graphical view]
PROSITEiPS00500. THYMOSIN_B4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTYB10_MOUSE
AccessioniPrimary (citable) accession number: Q6ZWY8
Secondary accession number(s): Q3V2M3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.