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Protein

60S ribosomal protein L35

Gene

Rpl35

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the large ribosomal subunit.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-MMU-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-MMU-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-MMU-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-MMU-72689. Formation of a pool of free 40S subunits.
R-MMU-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-MMU-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-MMU-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L35
Gene namesi
Name:Rpl35
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componentsi: Chromosome 1, Chromosome 2

Organism-specific databases

MGIiMGI:1913739. Rpl35.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003200631 – 12360S ribosomal protein L35Add BLAST123

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19N6-acetyllysineBy similarity1
Cross-linki25Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei29PhosphoserineBy similarity1
Modified residuei43N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ6ZWV7.
MaxQBiQ6ZWV7.
PaxDbiQ6ZWV7.
PeptideAtlasiQ6ZWV7.
PRIDEiQ6ZWV7.
TopDownProteomicsiQ6ZWV7.

PTM databases

iPTMnetiQ6ZWV7.
PhosphoSitePlusiQ6ZWV7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000062997.
CleanExiMM_RPL35.
GenevisibleiQ6ZWV7. MM.

Interactioni

Subunit structurei

Component of the large ribosomal subunit.By similarity

Protein-protein interaction databases

BioGridi211511. 249 interactors.
IntActiQ6ZWV7. 254 interactors.
MINTiMINT-1862907.
STRINGi10090.ENSMUSP00000099843.

Structurei

3D structure databases

ProteinModelPortaliQ6ZWV7.
SMRiQ6ZWV7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3436. Eukaryota.
COG0255. LUCA.
GeneTreeiENSGT00390000016384.
HOGENOMiHOG000207749.
HOVERGENiHBG000862.
InParanoidiQ6ZWV7.
KOiK02918.
OMAiTVINAKQ.
OrthoDBiEOG091G1422.
PhylomeDBiQ6ZWV7.
TreeFamiTF314951.

Family and domain databases

HAMAPiMF_00374. Ribosomal_L29. 1 hit.
InterProiView protein in InterPro
IPR001854. Ribosomal_L29/L35.
IPR036049. Ribosomal_L29/L35_sf.
IPR018254. Ribosomal_L29_CS.
PfamiView protein in Pfam
PF00831. Ribosomal_L29. 1 hit.
SUPFAMiSSF46561. SSF46561. 1 hit.
TIGRFAMsiTIGR00012. L29. 1 hit.
PROSITEiView protein in PROSITE
PS00579. RIBOSOMAL_L29. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6ZWV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKIKARDLR GKKKEELLKQ LDDLKVELSQ LRVAKVTGGA ASKLSKIRVV
60 70 80 90 100
RKSIARVLTV INQTQKENLR KFYKGKKYKP LDLRPKKTRA MRRRLTKHEE
110 120
KLKTKKQQRK ERLYPLRKYA VKA
Length:123
Mass (Da):14,553
Last modified:July 5, 2004 - v1
Checksum:i67B76951361674EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010639 mRNA. Translation: BAB27082.1.
AK012335 mRNA. Translation: BAB28169.1.
AK151707 mRNA. Translation: BAE30629.1.
AK169650 mRNA. Translation: BAE41274.1.
AL844588 Genomic DNA. Translation: CAM46062.1.
BC094634 mRNA. Translation: AAH94634.1.
BC125652 mRNA. Translation: AAI25653.1.
BC125656 mRNA. Translation: AAI25657.1.
CCDSiCCDS16015.1.
RefSeqiNP_079868.1. NM_025592.3.
UniGeneiMm.345333.

Genome annotation databases

EnsembliENSMUST00000080861; ENSMUSP00000079672; ENSMUSG00000062997.
ENSMUST00000102782; ENSMUSP00000099843; ENSMUSG00000078193.
GeneIDi66489.
KEGGimmu:66489.
UCSCiuc008jnz.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiRL35_MOUSE
AccessioniPrimary (citable) accession number: Q6ZWV7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 5, 2004
Last modified: October 25, 2017
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families